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Thea Brennan-Krohn, M.D.

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Available: 11/30/22, Expires: 12/01/24

My lab performs research investigating novel treatment approaches for multidrug-resistant gram-negative bacteria including E. coli, Klebsiella, Burkholderia, Pseudomonas, and Acinetobacter. We are particularly focused on the identification of combinations of existing antibiotic and non-antibiotic drugs that prevent the emergence of resistance during treatment and on understanding how resistance to these drugs and drug combinations develops using genomic and transcriptomic approaches. A variety of projects in these areas are available for medical students, including antimicrobial susceptibility testing, time-kill assays, and sequencing and analysis of genomic data. Projects can be adapted to the student's areas of interest.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Salamzade R, Manson AL, Walker BJ, Brennan-Krohn T, Worby CJ, Ma P, He LL, Shea TP, Qu J, Chapman SB, Howe W, Young SK, Wurster JI, Delaney ML, Kanjilal S, Onderdonk AB, Bittencourt CE, Gussin GM, Kim D, Peterson EM, Ferraro MJ, Hooper DC, Shenoy ES, Cuomo CA, Cosimi LA, Huang SS, Kirby JE, Pierce VM, Bhattacharyya RP, Earl AM. Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance. Genome Med. 2022 04 05; 14(1):37. PMID: 35379360; PMCID: PMC8981930.
    Citations:    Fields:    Translation:Humans
  2. Brennan-Krohn T, Grote A, Rodriguez S, Kirby JE, Earl AM. Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 2022 03 15; 66(3):e0196921. PMID: 35041511; PMCID: PMC8923212.
    Citations:    Fields:    Translation:Cells
  3. Brennan-Krohn T, Friar L, Ditelberg S, Kirby JE. Evaluation of the Synergistic Activity of Antibacterial and Antifungal Drugs against Candida auris Using an Inkjet Printer-Assisted Method. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0026821. PMID: 34252295; PMCID: PMC8448112.
    Citations:    Fields:    Translation:Animals
  4. Kirby JE, Brennan-Krohn T, Smith KP. Reply to Humphries and Simner, "Verification Is an Integral Part of Antimicrobial Susceptibility Test Quality Assurance," and Wojewoda et al., "College of American Pathologists (CAP) Microbiology Committee Perspective: the Need for Verification Studies". J Clin Microbiol. 2020 03 25; 58(4). PMID: 32213577.
    Citations:    Fields:    Translation:Humans
  5. Brennan-Krohn T, Manetsch R, O'Doherty GA, Kirby JE. New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae. Transl Res. 2020 06; 220:14-32. PMID: 32201344.
    Citations: 4     Fields:    Translation:Cells
  6. Kirby JE, Brennan-Krohn T, Smith KP. Bringing Antimicrobial Susceptibility Testing for New Drugs into the Clinical Laboratory: Removing Obstacles in Our Fight against Multidrug-Resistant Pathogens. J Clin Microbiol. 2019 12; 57(12). PMID: 31533983.
    Citations: 8     Fields:    Translation:HumansCells
  7. Brennan-Krohn T, Kirby JE. Synergistic Combinations and Repurposed Antibiotics Active against the Pandrug-Resistant Klebsiella pneumoniae Nevada Strain. Antimicrob Agents Chemother. 2019 09; 63(9). PMID: 31307981; PMCID: PMC6709503.
    Citations: 8     Fields:    Translation:HumansCells
  8. Brennan-Krohn T, Kirby JE. When One Drug Is Not Enough: Context, Methodology, and Future Prospects in Antibacterial Synergy Testing. Clin Lab Med. 2019 09; 39(3):345-358. PMID: 31383261.
    Citations: 8     Fields:    Translation:HumansAnimals
  9. Brennan-Krohn T, Kirby JE. Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method. J Vis Exp. 2019 04 18; (146). PMID: 31058886; PMCID: PMC6698365.
    Citations: 8     Fields:    
  10. Brennan-Krohn T, Pironti A, Kirby JE. Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2018 10; 62(10). PMID: 30061285; PMCID: PMC6153801.
    Citations: 39     Fields:    Translation:Cells
  11. Truelson KA, Brennan-Krohn T, Smith KP, Kirby JE. Evaluation of apramycin activity against methicillin-resistant, methicillin-sensitive, and vancomycin-intermediate Staphylococcus aureus clinical isolates. Diagn Microbiol Infect Dis. 2018 Oct; 92(2):168-171. PMID: 29934071; PMCID: PMC6131043.
    Citations: 9     Fields:    Translation:HumansCells
  12. Brennan-Krohn T, Ozonoff A, Sandora TJ. Adherence to guidelines for testing and treatment of children with pharyngitis: a retrospective study. BMC Pediatr. 2018 02 09; 18(1):43. PMID: 29426305.
    Citations: 4     Fields:    Translation:Humans
  13. Brennan-Krohn T, Truelson KA, Smith KP, Kirby JE. Screening for synergistic activity of antimicrobial combinations against carbapenem-resistant Enterobacteriaceae using inkjet printer-based technology. J Antimicrob Chemother. 2017 10 01; 72(10):2775-2781. PMID: 29091221; PMCID: PMC5890738.
    Citations: 22     Fields:    Translation:HumansCells
  14. Smith KP, Richmond DL, Brennan-Krohn T, Elliott HL, Kirby JE. Development of MAST: A Microscopy-Based Antimicrobial Susceptibility Testing Platform. SLAS Technol. 2017 12; 22(6):662-674. PMID: 28837780.
    Citations: 11     Fields:    Translation:HumansCells
  15. Brennan-Krohn T, Yoon E, Nishino M, Kirby JE, Riedel S. Arthroconidia in lung tissue: an unusual histopathological finding in pulmonary coccidioidomycosis. Hum Pathol. 2018 01; 71:55-59. PMID: 28778515; PMCID: PMC5936468.
    Citations: 1     Fields:    Translation:HumansCells
  16. Brennan-Krohn T, Smith KP, Kirby JE. The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance. J Clin Microbiol. 2017 08; 55(8):2304-2308. PMID: 28468856; PMCID: PMC5527407.
    Citations: 14     Fields:    
  17. Smith KP, Brennan-Krohn T, Weir S, Kirby JE. Improved Accuracy of Cefepime Susceptibility Testing for Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae with an On-Demand Digital Dispensing Method. J Clin Microbiol. 2017 02; 55(2):470-478. PMID: 27903600; PMCID: PMC5277516.
    Citations: 9     Fields:    Translation:HumansCells
  18. Brennan-Krohn T, Pica N, Sandora TJ, McAdam A. The Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. J Clin Microbiol. 2016 06; 54(6):1414-1415. PMID: 27217385; PMCID: PMC4879302.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  19. Brennan-Krohn T, Pica N, Sandora TJ, McAdam A. Closing the Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. J Clin Microbiol. 2016 06; 54(6):1672. PMID: 27217388; PMCID: PMC4879276.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  20. Brennan-Krohn T, Salloway S, Correia S, Dong M, de la Monte SM. Glial vascular degeneration in CADASIL. J Alzheimers Dis. 2010; 21(4):1393-402. PMID: 21504125.
    Citations: 6     Fields:    Translation:HumansCells
  21. Grant JE, Correia S, Brennan-Krohn T, Malloy PF, Laidlaw DH, Schulz SC. Frontal white matter integrity in borderline personality disorder with self-injurious behavior. J Neuropsychiatry Clin Neurosci. 2007; 19(4):383-90. PMID: 18070840.
    Citations: 16     Fields:    Translation:Humans
  22. Grant JE, Correia S, Brennan-Krohn T. White matter integrity in kleptomania: a pilot study. Psychiatry Res. 2006 Oct 30; 147(2-3):233-7. PMID: 16956753.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.