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Florence Keane, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Trofimov AV, Aronow ME, Gragoudas ES, Keane FK, Kim IK, Shih HA, Bhagwat MS. A Systematic Comparison of Dose Distributions Delivered in 125I Plaque Brachytherapy and Proton Radiation Therapy for Ocular Melanoma. Int J Radiat Oncol Biol Phys. 2022 Jul 22. PMID: 35878716.
    Citations:    Fields:    
  2. Tahir I, Marquardt JP, Mercaldo ND, Bourgouin PP, Wrobel MM, Mrah S, Sharp GC, Khandekar MJ, Willers H, Keane FK, Fintelmann FJ. Utility of Noncancerous Chest CT Features for Predicting Overall Survival and Noncancer Death in Patients With Stage I Lung Cancer Treated With Stereotactic Body Radiotherapy. AJR Am J Roentgenol. 2022 Oct; 219(4):579-589. PMID: 35416054.
    Citations:    Fields:    
  3. Milligan MG, Lennes IT, Hawari S, Khandekar MJ, Colson Y, Shepard JO, Frank A, Sequist LV, Willers H, Keane FK. Incidence of Radiation Therapy Among Patients Enrolled in a Multidisciplinary Pulmonary Nodule and Lung Cancer Screening Clinic. JAMA Netw Open. 2022 03 01; 5(3):e224840. PMID: 35357454; PMCID: PMC8972030.
    Citations:    Fields:    Translation:Humans
  4. Bowes CL, Naranbhai V, St Denis KJ, Lam EC, Bertaux B, Keane FK, Khandekar MJ, Balazs AB, Iafrate JA, Gainor JF, Willers H. Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy. Radiother Oncol. 2022 01; 166:88-91. PMID: 34838892; PMCID: PMC8613981.
    Citations:    Fields:    Translation:HumansCells
  5. Khandekar MJ, Keane FK. Radiation Dose and Fractionation in Locally Advanced Lung Cancer: A Simple Question With a Complicated Answer. JAMA Oncol. 2021 10 01; 7(10):1505-1506. PMID: 34383023.
    Citations:    Fields:    Translation:Humans
  6. Kim DW, Lee G, Hong TS, Li G, Horick NK, Roeland E, Keane FK, Eyler C, Drapek LC, Ryan DP, Allen JN, Berger D, Parikh AR, Mullen JT, Klempner S, Clark JW, Wo JY. ASO Visual Abstract: Neoadjuvant versus Postoperative Chemoradiotherapy Is Associated with Improved Survival in Patients with Resectable Gastric and Gastroesophageal Cancer. Ann Surg Oncol. 2021 Dec; 28(Suppl 3):690-691. PMID: 34490528.
    Citations:    Fields:    
  7. Kim DW, Lee G, Hong TS, Li G, Horick NK, Roeland E, Keane FK, Eyler C, Drapek LC, Ryan DP, Allen JN, Berger D, Parikh AR, Mullen JT, Klempner SJ, Clark JW, Wo JY. Neoadjuvant versus Postoperative Chemoradiotherapy is Associated with Improved Survival for Patients with Resectable Gastric and Gastroesophageal Cancer. Ann Surg Oncol. 2022 Jan; 29(1):242-252. PMID: 34480285.
    Citations: 1     Fields:    Translation:Humans
  8. Xie Y, Kang K, Wang Y, Khandekar MJ, Willers H, Keane FK, Bortfeld TR. Automated clinical target volume delineation using deep 3D neural networks in radiation therapy of Non-small Cell Lung Cancer. Phys Imaging Radiat Oncol. 2021 Jul; 19:131-137. PMID: 34485718; PMCID: PMC8397906.
  9. Wo JY, Clark JW, Eyler CE, Mino-Kenudson M, Klempner SJ, Allen JN, Keane FK, Parikh AR, Roeland E, Drapek LC, Ryan DP, Corcoran RB, Van Seventer E, Fetter IJ, Shahzade HA, Khandekar MJ, Lanuti M, Morse CR, Heist RS, Ulysse CA, Christopher B, Baglini C, Yeap BY, Mullen JT, Hong TS. Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas. Clin Cancer Res. 2021 12 01; 27(23):6343-6353. PMID: 34330715.
    Citations: 1     Fields:    Translation:Humans
  10. Zhang EW, Shepard JO, Kuo A, Chintanapakdee W, Keane F, Gainor JF, Mino-Kenudson M, Lanuti M, Lennes IT, Digumarthy SR. Characteristics and Outcomes of Lung Cancers Detected on Low-Dose Lung Cancer Screening CT. Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1472-1479. PMID: 34108138.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  11. Kamran SC, Yeap BY, Ulysse CA, Cronin C, Bowes CL, Durgin B, Gainor JF, Khandekar MJ, Tansky JY, Keane FK, Olsen CC, Willers H. Assessment of a Contralateral Esophagus-Sparing Technique in Locally Advanced Lung Cancer Treated With High-Dose Chemoradiation: A Phase 1 Nonrandomized Clinical Trial. JAMA Oncol. 2021 Jun 01; 7(6):910-914. PMID: 33830168; PMCID: PMC8033505.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  12. Keane FK, Driscoll E, Bowes C, Durgin B, Khandekar MJ, Willers H. Low Rates of Chest Wall Toxicity When Individualizing the Planning Target Volume Margin in Patients With Early Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy. Pract Radiat Oncol. 2021 May-Jun; 11(3):e282-e291. PMID: 33239160.
    Citations: 1     Fields:    Translation:Humans
  13. Chang DT, Pollom EL, Keane FK, Wo JY. Treating Oligometastatic Disease With SABR: More Than Just a Numbers Game? Int J Radiat Oncol Biol Phys. 2020 06 01; 107(2):257-260. PMID: 32386736.
    Citations: 2     Fields:    Translation:Humans
  14. Harrison JM, Wo JY, Ferrone CR, Horick NK, Keane FK, Qadan M, Lillemoe KD, Hong TS, Clark JW, Blaszkowsky LS, Allen JN, Castillo CF. Intraoperative Radiation Therapy (IORT) for Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma (BR/LA PDAC) in the Era of Modern Neoadjuvant Treatment: Short-Term and Long-Term Outcomes. Ann Surg Oncol. 2020 May; 27(5):1400-1406. PMID: 31758284.
    Citations: 4     Fields:    Translation:Humans
  15. Willers H, Keane FK, Kamran SC. Toward a New Framework for Clinical Radiation Biology. Hematol Oncol Clin North Am. 2019 12; 33(6):929-945. PMID: 31668212.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  16. Grassberger C, Ellsworth SG, Wilks MQ, Keane FK, Loeffler JS. Assessing the interactions between radiotherapy and antitumour immunity. Nat Rev Clin Oncol. 2019 12; 16(12):729-745. PMID: 31243334.
    Citations: 56     Fields:    Translation:Humans
  17. Sebastian N, Wu T, Driscoll E, Willers H, Kelly S, Musunuru HB, Mo X, Tan Y, Bazan J, Haglund K, Xu-Welliver M, Baschnagel AM, Ju A, Keane F, Williams TM. Pre-treatment serum bicarbonate predicts for primary tumor control after stereotactic body radiation therapy in patients with localized non-small cell lung cancer. Radiother Oncol. 2019 11; 140:26-33. PMID: 31176206; PMCID: PMC7080525.
    Citations:    Fields:    Translation:Humans
  18. Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175. PMID: 31015121.
    Citations: 6     Fields:    Translation:Humans
  19. Sebastian N, Wu T, Bazan J, Driscoll E, Willers H, Yegya-Raman N, Bond L, Dwivedi A, Mo X, Tan Y, Xu-Welliver M, Haglund K, Jabbour SK, Keane FK, Williams TM. Pre-treatment neutrophil-lymphocyte ratio is associated with overall mortality in localized non-small cell lung cancer treated with stereotactic body radiotherapy. Radiother Oncol. 2019 05; 134:151-157. PMID: 31005209.
    Citations: 9     Fields:    Translation:HumansCells
  20. Keane FK, Zhu AX, Hong TS. Radiotherapy for Biliary Tract Cancers. Semin Radiat Oncol. 2018 10; 28(4):342-350. PMID: 30309644.
    Citations: 1     Fields:    Translation:Humans
  21. Keane FK, Hong TS, Zhu AX. Evolving Systemic Therapy in Hepatocellular Carcinoma: Current Management and Opportunities for Integration With Radiotherapy. Semin Radiat Oncol. 2018 10; 28(4):332-341. PMID: 30309643.
    Citations: 7     Fields:    Translation:HumansAnimals
  22. Keane FK, Wo JY, Ferrone CR, Clark JW, Blaszkowsky LS, Allen JN, Kwak EL, Ryan DP, Lillemoe KD, Fernandez-Del Castillo C, Hong TS. Intraoperative Radiotherapy in the Era of Intensive Neoadjuvant Chemotherapy and Chemoradiotherapy for Pancreatic Adenocarcinoma. Am J Clin Oncol. 2018 06; 41(6):607-612. PMID: 27740973.
    Citations: 11     Fields:    Translation:Humans
  23. Cartwright E, Keane FK, Enzinger PC, Hong T, Chau I. Is There a Precise Adjuvant Therapy for Esophagogastric Carcinoma? Am Soc Clin Oncol Educ Book. 2018 May 23; 38:280-291. PMID: 30231360.
    Citations: 2     Fields:    Translation:Humans
  24. Hwang WL, Niemierko A, Hwang KL, Hubbeling H, Schapira E, Gainor JF, Keane FK. Clinical Outcomes in Patients With Metastatic Lung Cancer Treated With PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy. JAMA Oncol. 2018 Feb 01; 4(2):253-255. PMID: 28973343.
    Citations: 31     Fields:    Translation:Humans
  25. Farago AF, Keane FK. Current standards for clinical management of small cell lung cancer. Transl Lung Cancer Res. 2018 Feb; 7(1):69-79. PMID: 29535913; PMCID: PMC5835595.
    Citations: 51     
  26. Gottumukkala RV, Fintelmann FJ, Keane FK, Shepard JO. Cystic Lesions on Lung Cancer Screening Chest Computed Tomography: When Should We Be Concerned? Ann Am Thorac Soc. 2018 02; 15(2):263-265. PMID: 29388814.
    Citations: 1     Fields:    Translation:Humans
  27. Keane FK, Hong TS. Role and Future Directions of External Beam Radiotherapy for Primary Liver Cancer. Cancer Control. 2017 Jul-Sep; 24(3):1073274817729242. PMID: 28975835.
    Citations: 5     Fields:    Translation:Humans
  28. Keane FK, D'Amico AV. Androgen deprivation therapy use and risk of death in men treated with high-dose radiation for intermediate-risk prostate cancer. Cancer. 2016 08 01; 122(15):2296-8. PMID: 27191800.
    Citations:    Fields:    Translation:Humans
  29. Keane FK, Wo JY, Zhu AX, Hong TS. Liver-Directed Radiotherapy for Hepatocellular Carcinoma. Liver Cancer. 2016 Jul; 5(3):198-209. PMID: 27493895; PMCID: PMC4960357.
    Citations: 15     
  30. Keane FK, Chen YH, Tishler RB, Schoenfeld JD, Haddad RI, Goguen LA, Catalano P, Neville BA, Margalit DN. Population-based validation of the recursive partitioning analysis-based staging system for oropharyngeal cancer. Head Neck. 2016 10; 38(10):1530-8. PMID: 27080700.
    Citations: 4     Fields:    Translation:HumansCells
  31. Keane FK, Hong TS. Charged particle therapy for hepatocellular carcinoma: a commentary on a recently published meta-analysis. Ann Transl Med. 2015 Dec; 3(22):365. PMID: 26807420; PMCID: PMC4701515.
  32. Niska JR, Keane FK, Wolfgang JA, Hahn PF, Wo JY, Zhu AX, Hong TS. Impact of intravenous contrast enhancement phase on target definition for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC): Observations from patients enrolled on a prospective phase 2 trial. Pract Radiat Oncol. 2016 Jan-Feb; 6(1):e9-16. PMID: 26598907.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  33. Keane FK, Chen MH, Zhang D, Moran BJ, Braccioforte MH, D'Amico AV. Androgen deprivation therapy and the risk of death from prostate cancer among men with favorable or unfavorable intermediate-risk disease. Cancer. 2015 Aug 15; 121(16):2713-9. PMID: 25925789.
    Citations: 6     Fields:    Translation:Humans
  34. Keane FK, Tanguturi SK, Zhu AX, Dawson LA, Hong TS. Radiotherapy for liver tumors. Hepat Oncol. 2015 Apr; 2(2):133-146. PMID: 30190993; PMCID: PMC6095425.
    Citations: 5     
  35. Keane FK, Chen YH, Neville BA, Tishler RB, Schoenfeld JD, Catalano PJ, Margalit DN. Changing prognostic significance of tumor stage and nodal stage in patients with squamous cell carcinoma of the oropharynx in the human papillomavirus era. Cancer. 2015 Aug 01; 121(15):2594-602. PMID: 25873094.
    Citations: 18     Fields:    Translation:HumansCells
  36. Keane FK, Chen MH, Zhang D, Loffredo MJ, Kantoff PW, Renshaw AA, D'Amico AV. The likelihood of death from prostate cancer in men with favorable or unfavorable intermediate-risk disease. Cancer. 2014 Jun 15; 120(12):1787-93. PMID: 24604289.
    Citations: 10     Fields:    Translation:Humans
  37. Ratner ES, Keane FK, Lindner R, Tassi RA, Paranjape T, Glasgow M, Nallur S, Deng Y, Lu L, Steele L, Sand S, Muller RU, Bignotti E, Bellone S, Boeke M, Yao X, Pecorelli S, Ravaggi A, Katsaros D, Zelterman D, Cristea MC, Yu H, Rutherford TJ, Weitzel JN, Neuhausen SL, Schwartz PE, Slack FJ, Santin AD, Weidhaas JB. A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer. Oncogene. 2012 Oct 18; 31(42):4559-66. PMID: 22139083.
    Citations: 36     Fields:    Translation:HumansCells
  38. Paranjape T, Heneghan H, Lindner R, Keane FK, Hoffman A, Hollestelle A, Dorairaj J, Geyda K, Pelletier C, Nallur S, Martens JW, Hooning MJ, Kerin M, Zelterman D, Zhu Y, Tuck D, Harris L, Miller N, Slack F, Weidhaas J. A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis. Lancet Oncol. 2011 Apr; 12(4):377-86. PMID: 21435948.
    Citations: 67     Fields:    Translation:Humans
  39. Keane FK, Ratner ES. The KRAS-Variant Genetic Test As a Marker of Increased Risk of Ovarian Cancer. Rev Obstet Gynecol. 2010; 3(3):118-21. PMID: 21364863.
    Citations: 2     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.