Rachel Laura Wolfson, M.D., Ph.D.
This page shows the publications Rachel Wolfson has written about TOR Serine-Threonine Kinases.
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 03 16; 543(7645):438-442.
Sestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 01; 351(6268):43-8.
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis. 2018 03; 111:91-101.
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Cell. 2017 Oct 19; 171(3):642-654.e12.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet. 2016 Feb; 48(2):183-8.
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science. 2016 Jan 01; 351(6268):53-8.
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94.
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 09; 9(1):1-8.
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 2013 Jan 31; 493(7434):679-83.
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