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Clemens Grassberger, Ph.D.

Title
Institution
Department
Address

Overview
- Impact of radiotherapy on lymphocytes & patient immunity
- How to integrate radiotherapy with checkpoint inhibitors
- Resistance development to targeted agents (EGFR inhibitors) & role of radiotherapy
- Mechanistic and data-driven modeling to predict treatment outcome

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21CA241918 (GRASSBERGER, CLEMENS) Jul 1, 2019 - Jun 30, 2021
    NIH
    Bio-Physical Modeling of Immuno-Radiotherapy Combinations based on Patient Data
    Role: Principal Investigator
  2. R21CA248118 (Grassberger)
    NIH/NCI
    A Computational Method to Calculate the Radiation Dose to Circulating Lymphocytes
    Role: PI

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C. Modeling Resistance and Recurrence Patterns of Combined Targeted- Chemoradiotherapy Predicts Benefit of Shorter Induction Period. Cancer Res. 2020 Sep 09. PMID: 32907839.
    Citations:    
  2. Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR. Proton Therapy Reduces the Likelihood of High-Grade Radiation-Induced Lymphopenia in Glioblastoma Patients: Phase II Randomized Study of Protons vs. Photons. Neuro Oncol. 2020 Aug 05. PMID: 32750703.
    Citations:    
  3. Baliga S, Bajaj BVM, Kabarriti R, Grassberger C, Patteson B, Yeap B, Fox JL, Garg MK, Yock TI. Prolongation of radiotherapy duration is associated with inferior overall survival in patients with pediatric medulloblastoma and central nervous system primitive neuroectodermal tumors. Pediatr Blood Cancer. 2020 Jul 25; e28558. PMID: 32710698.
    Citations:    
  4. Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H. A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy. Radiother Oncol. 2020 Jul 15; 151:73-81. PMID: 32679308.
    Citations:    
  5. Ho AY, Wright JL, Blitzblau RC, Mutter RW, Duda DG, Norton L, Bardia A, Spring L, Isakoff SJ, Chen JH, Grassberger C, Bellon JR, Beriwal S, Khan AJ, Speers C, Dunn SA, Thompson A, Santa-Maria CA, Krop IE, Mittendorf E, King TA, Gupta GP. Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists. Int J Radiat Oncol Biol Phys. 2020 Sep 01; 108(1):227-241. PMID: 32417409.
    Citations:    
  6. Pursley J, El Naqa I, Sanford NN, Noe B, Wo JY, Eyler CE, Hwang M, Brock KK, Yeap BY, Wolfgang JA, Hong TS, Grassberger C. Dosimetric Analysis and Normal-Tissue Complication Probability Modeling of Child-Pugh Score and Albumin-Bilirubin Grade Increase After Hepatic Irradiation. Int J Radiat Oncol Biol Phys. 2020 Aug 01; 107(5):986-995. PMID: 32353390.
    Citations:    
  7. Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H. End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. Int J Radiat Oncol Biol Phys. 2020 Jul 01; 107(3):449-454. PMID: 32240774.
    Citations:    
  8. Hammi A, Paganetti H, Grassberger C. 4D blood flow model for dose calculation to circulating blood and lymphocytes. Phys Med Biol. 2020 03 02; 65(5):055008. PMID: 32119649.
    Citations:    
  9. Grassberger C, Huber K, Jacob NK, Green MD, Mahler P, Prisciandaro J, Dominello M, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response. J Appl Clin Med Phys. 2019 10; 20(10):6-12. PMID: 31573143.
    Citations:    
  10. Grassberger C, Ellsworth SG, Wilks MQ, Keane FK, Loeffler JS. Assessing the interactions between radiotherapy and antitumour immunity. Nat Rev Clin Oncol. 2019 12; 16(12):729-745. PMID: 31243334.
    Citations:    
  11. Grassberger C, McClatchy D, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H. Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies. Cancer Res. 2019 07 15; 79(14):3776-3788. PMID: 31113818.
    Citations:    
  12. Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A. Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics. Radiat Res. 2019 06; 191(6):532-544. PMID: 31008688.
    Citations:    
  13. Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175. PMID: 31015121.
    Citations:    
  14. Sanford NN, Pursley J, Noe B, Yeap BY, Goyal L, Clark JW, Allen JN, Blaszkowsky LS, Ryan DP, Ferrone CR, Tanabe KK, Qadan M, Crane CH, Koay EJ, Eyler C, DeLaney TF, Zhu AX, Wo JY, Grassberger C, Hong TS. Protons versus Photons for Unresectable Hepatocellular Carcinoma: Liver Decompensation and Overall Survival. Int J Radiat Oncol Biol Phys. 2019 09 01; 105(1):64-72. PMID: 30684667.
    Citations:    Fields:    
  15. Hong TS, Grassberger C, Yeap BY, Jiang W, Wo JY, Goyal L, Clark JW, Crane CH, Koay EJ, Dima S, Eyler CE, Popescu I, DeLaney TF, Zhu AX, Duda DG. Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy. NPJ Precis Oncol. 2018; 2:22. PMID: 30374460.
    Citations:    
  16. Chen Y, Grassberger C, Li J, Hong TS, Paganetti H. Impact of potentially variable RBE in liver proton therapy. Phys Med Biol. 2018 09 21; 63(19):195001. PMID: 30183674.
    Citations:    Fields:    
  17. Sung W, Jeong Y, Kim H, Jeong H, Grassberger C, Jung S, Ahn GO, Kim IH, Schuemann J, Lee K, Ye SJ. Computational Modeling and Clonogenic Assay for Radioenhancement of Gold Nanoparticles Using 3D Live Cell Images. Radiat Res. 2018 11; 190(5):558-564. PMID: 30142031.
    Citations:    Fields:    
  18. Geng C, Paganetti H, Grassberger C. Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2018 Aug 17; 8(1):12631. PMID: 30115991.
    Citations:    Fields:    
  19. Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, Jain RK, Zhu AX, Duda DG. Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer. Int J Radiat Oncol Biol Phys. 2018 08 01; 101(5):1222-1225. PMID: 29859792.
    Citations:    Fields:    
  20. Underwood TSA, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H. Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1. Int J Radiat Oncol Biol Phys. 2018 07 15; 101(4):809-819. PMID: 29976493.
    Citations:    Fields:    
  21. St James S, Grassberger C, Lu HM. Considerations when treating lung cancer with passive scatter or active scanning proton therapy. Transl Lung Cancer Res. 2018 Apr; 7(2):210-215. PMID: 29876321.
    Citations:    
  22. Botas P, Grassberger C, Sharp G, Paganetti H. Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Phys Med Biol. 2018 01 30; 63(3):035023. PMID: 29219119.
    Citations: 2     Fields:    Translation:Humans
  23. Geng C, Paganetti H, Grassberger C. Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2017 10 19; 7(1):13542. PMID: 29051600.
    Citations: 1     Fields:    
  24. Manem VSK, Grassberger C, Paganetti H. Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers (Basel). 2017 Sep 06; 9(9). PMID: 28878202.
    Citations:    
  25. Grassberger C, Paganetti H. Varying relative biological effectiveness in proton therapy: knowledge gaps versus clinical significance. Acta Oncol. 2017 Jun; 56(6):761-762. PMID: 28464735.
    Citations: 1     Fields:    Translation:HumansCells
  26. Grassberger C, Scott JG, Paganetti H. Biomathematical Optimization of Radiation Therapy in the Era of Targeted Agents. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):13-17. PMID: 27979444.
    Citations:    Fields:    Translation:Humans
  27. Grassberger C, Paganetti H. Methodologies in the modeling of combined chemo-radiation treatments. Phys Med Biol. 2016 11 07; 61(21):R344-R367. PMID: 27758980.
    Citations: 1     Fields:    
  28. Underwood T, Grassberger C, Willers H, MacDonald S, Jimenez R, Paganetti H. WE-FG-202-03: Quantitative CT-Based Analysis to Assess Lung Injury Following Proton Radiotherapy. Med Phys. 2016 Jun; 43(6):3827. PMID: 28048337.
    Citations:    
  29. Botas P, Grassberger C, Sharp G, Qin N, Jia X, Jiang S, Paganetti H. SU-G-TeP1-06: Fast GPU Framework for Four-Dimensional Monte Carlo in Adaptive Intensity Modulated Proton Therapy (IMPT) for Mobile Tumors. Med Phys. 2016 Jun; 43(6):3653. PMID: 28048238.
    Citations:    
  30. Grassberger C, Paganetti H. WE-H-BRA-03: Development of a Model to Include the Evolution of Resistant Tumor Subpopulations Into the Treatment Optimization Process for Schedules Involving Targeted Agents in Chemoradiation Therapy. Med Phys. 2016 Jun; 43(6):3843. PMID: 28046274.
    Citations:    
  31. Verburg JM, Grassberger C, Dowdell S, Schuemann J, Seco J, Paganetti H. Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technol Cancer Res Treat. 2016 12; 15(6):NP35-NP46. PMID: 26596915.
    Citations: 3     Fields:    Translation:Humans
  32. Varlotto J, DiMaio C, Grassberger C, Tangel M, Mackley H, Pavelic M, Specht C, Sogge S, Nguyen D, Glantz M, Saw C, Upadhyay U, Moser R, Yunus S, Rava P, Fitzgerald T, Glanzman J, Sheehan J. Multi-modality management of craniopharyngioma: a review of various treatments and their outcomes. Neurooncol Pract. 2016 Sep; 3(3):173-187. PMID: 31386091.
    Citations:    
  33. Dowdell S, Grassberger C, Sharp G, Paganetti H. Fractionated Lung IMPT Treatments: Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technol Cancer Res Treat. 2016 10; 15(5):689-96. PMID: 26208837.
    Citations: 1     Fields:    Translation:Humans
  34. Kooy HM, Grassberger C. Intensity modulated proton therapy. Br J Radiol. 2015 Jul; 88(1051):20150195. PMID: 26084352.
    Citations: 6     Fields:    Translation:Humans
  35. Grassberger C, Dowdell S, Sharp G, Paganetti H. Motion mitigation for lung cancer patients treated with active scanning proton therapy. Med Phys. 2015 May; 42(5):2462-9. PMID: 25979039.
    Citations: 6     Fields:    Translation:Humans
  36. Schuemann J, Giantsoudi D, Grassberger C, Moteabbed M, Min CH, Paganetti H. Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1157-1164. PMID: 26025779.
    Citations: 9     Fields:    Translation:Humans
  37. Grassberger C, Lomax A, Paganetti H. Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Phys Med Biol. 2015 Jan 21; 60(2):633-45. PMID: 25549079.
    Citations: 4     Fields:    Translation:Humans
  38. Knopf A, Nill S, Yohannes I, Graeff C, Dowdell S, Kurz C, Sonke JJ, Biegun AK, Lang S, McClelland J, Champion B, Fast M, Wölfelschneider J, Gianoli C, Rucinski A, Baroni G, Richter C, van de Water S, Grassberger C, Weber D, Poulsen P, Shimizu S, Bert C. Challenges of radiotherapy: report on the 4D treatment planning workshop 2013. Phys Med. 2014 Nov; 30(7):809-15. PMID: 25172392.
    Citations: 3     Fields:    
  39. Phillips J, Gueorguiev G, Shackleford JA, Grassberger C, Dowdell S, Paganetti H, Sharp GC. Computing proton dose to irregularly moving targets. Phys Med Biol. 2014 Aug 07; 59(15):4261-73. PMID: 25029239.
    Citations: 3     Fields:    Translation:Humans
  40. Schuemann J, Dowdell S, Grassberger C, Min CH, Paganetti H. Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Phys Med Biol. 2014 Aug 07; 59(15):4007-31. PMID: 24990623.
    Citations: 17     Fields:    Translation:Humans
  41. Dowdell S, Grassberger C, Paganetti H. SU-E-T-292: Sensitivity of Fractionated Lung IMPT Treatments to Setup Uncertainties and Motion Effects. Med Phys. 2014 Jun; 41(6):291. PMID: 28036966.
    Citations:    
  42. Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H. TH-A-19A-03: Impact of Proton Dose Calculation Method On Delivered Dose to Lung Tumors: Experiments in Thorax Phantom and Planning Study in Patient Cohort. Med Phys. 2014 Jun; 41(6):533. PMID: 28036612.
    Citations:    
  43. Schuemann J, Dowdell S, Grassberger C, Paganetti H. TH-A-19A-06: Site-Specific Comparison of Analytical and Monte Carlo Based Dose Calculations. Med Phys. 2014 Jun; 41(6):534. PMID: 28037127.
    Citations:    
  44. Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H. Quantification of proton dose calculation accuracy in the lung. Int J Radiat Oncol Biol Phys. 2014 Jun 01; 89(2):424-30. PMID: 24726289.
    Citations: 12     Fields:    Translation:Humans
  45. Dowdell S, Grassberger C, Paganetti H. Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments. Med Phys. 2013 Dec; 40(12):121713. PMID: 24320499.
    Citations: 3     Fields:    Translation:Humans
  46. Giantsoudi D, Grassberger C, Craft D, Niemierko A, Trofimov A, Paganetti H. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. Int J Radiat Oncol Biol Phys. 2013 Sep 01; 87(1):216-22. PMID: 23790771.
    Citations: 19     Fields:    Translation:HumansCells
  47. Dowdell S, Grassberger C, Sharp GC, Paganetti H. TU-A-108-02: A 4D Monte Carlo Study Quantifying Changes in the Interplay Effect as a Function of Treatment Delivery Parameters in Proton Beam Scanning for Lung. Med Phys. 2013 Jun; 40(6Part25):419-420. PMID: 28518840.
    Citations:    
  48. Dowdell S, Grassberger C, Paganetti H. TU-A-108-08: Comparison of Full Intensity Modulated and Single Field Uniform Dose Proton Beam Scanning Lung Treatments. Med Phys. 2013 Jun; 40(6Part25):421. PMID: 28518849.
    Citations:    
  49. Phillips J, Gueorguiev G, Shackleford J, Grassberger C, Dowdell S, Paganetti H, Sharp G. TU-A-108-06: Computing Proton Dose to Irregularly Moving Targets. Med Phys. 2013 Jun; 40(6Part25):420. PMID: 28518846.
    Citations:    
  50. Grassberger C, Dowdell S, Sharp G, Paganetti H. SU-F-500-04: Motion Mitigation in Active Scanning Proton Therapy for Lung Cancer: A 4D Monte Carlo Study. Med Phys. 2013 Jun; 40(6Part23):383. PMID: 28518357.
    Citations:    
  51. Grassberger C, Daartz J, Dowdell S, Verburg J, Sharp G, Paganetti H. MO-G-137-02: Experimental Validation of Clinical as Well as Monte Carlo Dose Calculation for Proton Therapy of Lung Cancer Patients. Med Phys. 2013 Jun; 40(6Part25):416. PMID: 28518883.
    Citations:    
  52. Dowdell S, Grassberger C, Sharp GC, Paganetti H. Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Phys Med Biol. 2013 Jun 21; 58(12):4137-56. PMID: 23689035.
    Citations: 18     Fields:    Translation:Humans
  53. Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Efstathiou JA, Trofimov A. Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions. Med Phys. 2013 May; 40(5):051708. PMID: 23635256.
    Citations: 1     Fields:    Translation:Humans
  54. Carabe A, España S, Grassberger C, Paganetti H. Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol. 2013 Apr 07; 58(7):2103-17. PMID: 23470339.
    Citations: 7     Fields:    Translation:HumansCells
  55. Grassberger C, Dowdell S, Lomax A, Sharp G, Shackleford J, Choi N, Willers H, Paganetti H. Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer. Int J Radiat Oncol Biol Phys. 2013 Jun 01; 86(2):380-6. PMID: 23462423.
    Citations: 24     Fields:    Translation:Humans
  56. Schuemann J, Shin J, Perl J, Grassberger C, Verburg J, Faddegon B, Paganetti H. SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System. Med Phys. 2012 Jun; 39(6Part18):3820. PMID: 28518479.
    Citations: 2     Fields:    
  57. Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Trofimov A. SU-E-T-552: Maximizing the Biological Effect of Proton Dose Delivered with Scanned Beam. Med Phys. 2012 Jun; 39(6Part18):3832. PMID: 28518512.
    Citations:    Fields:    
  58. Grassberger C, Paganetti H. Elevated LET components in clinical proton beams. Phys Med Biol. 2011 Oct 21; 56(20):6677-91. PMID: 21965268.
    Citations: 12     Fields:    Translation:HumansCells
  59. Grassberger C, Trofimov A, Lomax A, Paganetti H. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011 Aug 01; 80(5):1559-66. PMID: 21163588.
    Citations: 24     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.