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Mingyang Song, Sc.D., M.D.

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Biography
Harvard University, Boston, MASc.D.05/2015Nutrition and Epidemiology
2017
NextGen Star Award
2016
Scholar-in-Training Award
2015
Distinction in Teaching
2015
Teaching Assistant Award
2015
Scholar-in-Training Award
2014
Scholar-in-Training Award

Overview
My research focuses on clinical and translational epidemiology of cancer. One aspect of my work is to integrate large-scale observational studies with biomarker-based randomized clinical trials to identify novel nutritional and gut microbiota-targeted strategies for cancer prevention and treatment. Another part of my work involves integration of electronic health record (EHR) data with molecular profiling for developing cost-effective risk assessment tools for precision cancer screening and surveillance. I was awarded the NextGen Star by the American Association for Cancer Research. My current research is supported by the National Cancer Institute and American Cancer Society. The ultimate goal of my research is to translate epidemiologic advances into the clinic for improved cancer prevention and treatment.

Diet/Lifestyle, Gut Microbiome, and Cancer Prevention and Treatment

Over the past few years, I have studied the role of diet and lifestyle factors, in conjunction with host immune factors and the gut microbiota, in colorectal cancer development and survivorship. Much of my work has been based on three large prospective cohort studies, the Nurses’ Health Study I and II, and the Health Professionals Follow-up Study, in which diet, lifestyle and colorectal cancer diagnosis and mortality have been assessed over decades with blood, stool, and tumor tissue specimens collected in a subset of participants. Building on the findings from observational studies, I am leading two biomarker-based clinical trials of omega-3 fatty acid treatment in colon cancer patients (supported by the American Cancer Society) and individuals with a history of colorectal adenoma resection (supported by the National Cancer Institute) at Massachusetts General Hospital to investigate causality and explore the potential for future clinical translation. I am also chairing the Microbiome Epidemiology Working Group (MEWG) at Harvard Chan School, and serving as a co-investigator of the Microbiome among Nurses Study (MICRO-N), which aims to establish the world’s largest prospective collection of microbiome specimens from 25,000 individuals.

Integration of EHR and Molecular Data for Precision Cancer Screening and Surveillance

While substantial advances have been made in epidemiology to identify environmental and genetic risk factors, this knowledge has not yet been effectively translated into the clinic for better patient care. A particular example is the age-based or “one-size-fits-all” colonoscopy screening approach that does not take into account the individual variation in colorectal cancer risk. Similar issue occurs to colonoscopy surveillance after polypectomy, where histopathologic features of polyps that are being used in clinical guidelines demonstrate poor sensitivity in predicting subsequent risk of colorectal neoplasia. As result, lower-risk patients can undergo unnecessary excess testing, whereas higher-risk patients may receive delayed or no testing. To address these gaps, I am building a longitudinal cohort of patients who had undergone repeated colonoscopy exams in the Partners HealthCare. Detailed clinical and epidemiologic data are being extracted from the EHR systems supplemented by use of validated natural language processing algorithms; and then linked to the state cancer registry for cancer incidence and to the Partners Biobank for genomic information. Tissue specimens will be collected from the pathology departments for tumor profiling. This integrated cohort will allow us to identify novel biomarkers for early detection, validate prediction models in the real clinical setting, and develop and evaluate clinically applicable risk assessment tools for precision screening and surveillance.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00CA215314 (SONG, MINGYANG) Feb 19, 2018 - Jul 31, 2021
    NIH
    Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention
    Role: Principal Investigator
  2. K99CA215314 (SONG, MINGYANG) Feb 19, 2018 - Jul 1, 2018
    NIH
    Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang L, Lo CH, He X, Hang D, Wang M, Wu K, Chan AT, Ogino S, Giovannucci EL, Song M. Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum. Gastroenterology. 2020 07; 159(1):241-256.e13. PMID: 32247020.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  2. Song M, Emilsson L, Bozorg SR, Nguyen LH, Joshi AD, Staller K, Nayor J, Chan AT, Ludvigsson JF. Risk of colorectal cancer incidence and mortality after polypectomy: a Swedish record-linkage study. Lancet Gastroenterol Hepatol. 2020 06; 5(6):537-547. PMID: 32192628.
    Citations: 19     Fields:    Translation:Humans
  3. Song M, Lee IM, Manson JE, Buring JE, Dushkes R, Gordon D, Walter J, Wu K, Chan AT, Ogino S, Fuchs CS, Meyerhardt JA, Giovannucci EL. Effect of Supplementation With Marine ?-3 Fatty Acid on Risk of Colorectal Adenomas and Serrated Polyps in the US General Population: A Prespecified Ancillary Study of a Randomized Clinical Trial. JAMA Oncol. 2020 01 01; 6(1):108-115. PMID: 31750855.
    Citations: 8     Fields:    Translation:Humans
  4. Song M, Chan AT, Sun J. Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer. Gastroenterology. 2020 01; 158(2):322-340. PMID: 31586566.
    Citations: 91     Fields:    Translation:HumansCellsPHPublic Health
  5. Song M, Vogelstein B, Giovannucci EL, Willett WC, Tomasetti C. Cancer prevention: Molecular and epidemiologic consensus. Science. 2018 09 28; 361(6409):1317-1318. PMID: 30262488.
    Citations: 23     Fields:    Translation:Humans
  6. Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, Giovannucci EL, Chan AT. Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol. 2018 Jan 01; 4(1):71-79. PMID: 29098294.
    Citations: 45     Fields:    Translation:Humans
  7. Hu Y, Ding M, Yuan C, Wu K, Smith-Warner SA, Hu FB, Chan AT, Meyerhardt JA, Ogino S, Fuchs CS, Giovannucci EL, Song M. Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology. 2018 03; 154(4):916-926.e9. PMID: 29158191.
    Citations: 19     Fields:    Translation:Humans
  8. Mehta RS, Nishihara R, Cao Y, Song M, Mima K, Qian ZR, Nowak JA, Kosumi K, Hamada T, Masugi Y, Bullman S, Drew DA, Kostic AD, Fung TT, Garrett WS, Huttenhower C, Wu K, Meyerhardt JA, Zhang X, Willett WC, Giovannucci EL, Fuchs CS, Chan AT, Ogino S. Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue. JAMA Oncol. 2017 Jul 01; 3(7):921-927. PMID: 28125762.
    Citations: 105     Fields:    Translation:HumansCells
  9. Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Oct 01; 176(10):1453-1463. PMID: 27479196.
    Citations: 146     Fields:    Translation:HumansAnimals
  10. Song M, Nishihara R, Cao Y, Chun E, Qian ZR, Mima K, Inamura K, Masugi Y, Nowak JA, Nosho K, Wu K, Wang M, Giovannucci E, Garrett WS, Fuchs CS, Ogino S, Chan AT. Marine ?-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells. JAMA Oncol. 2016 Sep 01; 2(9):1197-206. PMID: 27148825.
    Citations: 39     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.