Harvard Catalyst Profiles

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Jonathan George Hoggatt, Ph.D.

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Institution
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Biography
2001
Eli Lilly Pharmacy Scholarship
2001 - 2002
Health Sciences Freshman Scholar
2002 - 2004
Angelo J. Carnaghi Pharmacy Scholarship
2002
Emily Mauzy Vogel Outstanding Leader Award
2003
Betty M. Nelson Skilled Leader Award
2003
Varsity Letter Winner in Cross Country
2003 - 2005
Varsity Letter Winner in Track and Field
2003 - 2005
Academic All Big Ten in Track and Field
2004
Academic All Big Ten in Cross Country
2005
Merck Award Winner
2010
Sigma Xi Graduate Student Research First Place Award Winner
2010
Cancer Research Day Award Winner
2011
Most Outstanding Poster Award Winner
2011
Esther L. Kinsley Ph.D. Dissertation Award
2013
Thomas T. Hoopes Prize Mentor Awardee

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL144752 (HOGGATT, JONATHAN GEORGE) Jan 15, 2019 - Dec 31, 2023
    NIH/NHLBI
    Enhancing Bone Marrow Transplantation With Highly Engraftable Hematopoietic Stem Cells
    Role: Principal Investigator
  2. R00HL119559 (HOGGATT, JONATHAN GEORGE) Aug 1, 2013 - Jul 31, 2018
    NIH/NHLBI
    Macrophage Regulation of the Hematopoietic Stem Cell Niche
    Role: Principal Investigator
  3. K99HL119559 (HOGGATT, JONATHAN GEORGE) Aug 1, 2013 - Jun 30, 2015
    NIH/NHLBI
    Macrophage Regulation of the Hematopoietic Stem Cell Niche
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat Commun. 2019 02 06; 10(1):617. PMID: 30728354.
    Citations:    
  2. Hoggatt J, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, Pelus LM. Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell. 2018 01 11; 172(1-2):191-204.e10. PMID: 29224778.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. Cell Stem Cell. 2016 10 06; 19(4):530-543. PMID: 27524439.
    Citations: 14     Fields:    Translation:AnimalsCells
  4. Hoggatt J. Gene Therapy for "Bubble Boy" Disease. Cell. 2016 Jul 14; 166(2):263. PMID: 27419862.
    Citations: 3     Fields:    
  5. Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol. 2016 07; 34(7):738-45. PMID: 27272386.
    Citations: 20     Fields:    Translation:AnimalsCells
  6. Hoggatt J, Kfoury Y, Scadden DT. Hematopoietic Stem Cell Niche in Health and Disease. Annu Rev Pathol. 2016 05 23; 11:555-81. PMID: 27193455.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  7. Hoggatt J, Hoggatt AF, Tate TA, Fortman J, Pelus LM. Bleeding the laboratory mouse: Not all methods are equal. Exp Hematol. 2016 Feb; 44(2):132-137.e1. PMID: 26644183.
    Citations: 3     Fields:    Translation:Animals
  8. Hoggatt J, Tate TA, Pelus LM. Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia. Int J Nanomedicine. 2015; 10:2647-52. PMID: 25878498.
    Citations: 3     Fields:    Translation:Humans
  9. Hoggatt J, Tate TA, Pelus LM. Hematopoietic stem and progenitor cell mobilization in mice. Methods Mol Biol. 2014; 1185:43-64. PMID: 25062621.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Hoggatt J, Speth JM, Pelus LM. Concise review: Sowing the seeds of a fruitful harvest: hematopoietic stem cell mobilization. Stem Cells. 2013 Dec; 31(12):2599-606. PMID: 24123398.
    Citations: 7     Fields:    Translation:HumansAnimals
  11. Speth JM, Hoggatt J, Singh P, Pelus LM. Pharmacologic increase in HIF1a enhances hematopoietic stem and progenitor homing and engraftment. Blood. 2014 Jan 09; 123(2):203-7. PMID: 24167196.
    Citations: 17     Fields:    Translation:AnimalsCells
  12. Hoggatt J, Pelus LM. How beneficial is the use of NSAIDs in stem-cell transplantation? Expert Opin Pharmacother. 2013 Dec; 14(18):2453-6. PMID: 24138174.
    Citations:    Fields:    Translation:HumansAnimals
  13. Hoggatt J, Pelus LM. New G-CSF agonists for neutropenia therapy. Expert Opin Investig Drugs. 2014 Jan; 23(1):21-35. PMID: 24073859.
    Citations: 7     Fields:    Translation:HumansAnimals
  14. Hoggatt J, Mohammad KS, Singh P, Pelus LM. Prostaglandin E2 enhances long-term repopulation but does not permanently alter inherent stem cell competitiveness. Blood. 2013 Oct 24; 122(17):2997-3000. PMID: 24047650.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. PMID: 23996087.
    Citations: 92     Fields:    Translation:HumansCellsCTClinical Trials
  16. Zhao W, Breese E, Bowers A, Hoggatt J, Pelus LM, Broxmeyer HE, Goebl M, Harrington MA. SIMPL enhancement of tumor necrosis factor-a dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function. PLoS One. 2013; 8(4):e61123. PMID: 23630580.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM. Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature. 2013 Mar 21; 495(7441):365-9. PMID: 23485965.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  18. Hoggatt J, Singh P, Stilger KN, Plett PA, Sampson CH, Chua HL, Orschell CM, Pelus LM. Recovery from hematopoietic injury by modulating prostaglandin E(2) signaling post-irradiation. Blood Cells Mol Dis. 2013 Mar; 50(3):147-53. PMID: 23206586.
    Citations: 12     Fields:    Translation:AnimalsCells
  19. Broxmeyer HE, Hoggatt J, O'Leary HA, Mantel C, Chitteti BR, Cooper S, Messina-Graham S, Hangoc G, Farag S, Rohrabaugh SL, Ou X, Speth J, Pelus LM, Srour EF, Campbell TB. Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis. Nat Med. 2012 Dec; 18(12):1786-96. PMID: 23160239.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  20. Hoggatt J, Scadden DT. The stem cell niche: tissue physiology at a single cell level. J Clin Invest. 2012 Sep; 122(9):3029-34. PMID: 22945635.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  21. Singh P, Hu P, Hoggatt J, Moh A, Pelus LM. Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cells. Leukemia. 2012 Nov; 26(11):2375-83. PMID: 22543963.
    Citations: 19     Fields:    Translation:AnimalsCells
  22. Hoggatt J, Pelus LM. Hematopoietic stem cell mobilization with agents other than G-CSF. Methods Mol Biol. 2012; 904:49-67. PMID: 22890921.
    Citations: 7     Fields:    Translation:HumansCells
  23. Singh P, Hoggatt J, Hu P, Speth JM, Fukuda S, Breyer RM, Pelus LM. Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells. Blood. 2012 Feb 16; 119(7):1671-82. PMID: 22110249.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  24. Hoggatt J, Pelus LM. Many mechanisms mediating mobilization: an alliterative review. Curr Opin Hematol. 2011 Jul; 18(4):231-8. PMID: 21537168.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  25. Pelus LM, Hoggatt J. Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):3-9. PMID: 21722751.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  26. Pelus LM, Hoggatt J, Singh P. Pulse exposure of haematopoietic grafts to prostaglandin E2 in vitro facilitates engraftment and recovery. Cell Prolif. 2011 Apr; 44 Suppl 1:22-9. PMID: 21481039.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  27. Hoggatt J, Pelus LM. Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment. Stem Cell Res Ther. 2011 Mar 14; 2(2):13. PMID: 21418553.
    Citations: 14     Fields:    Translation:HumansCells
  28. Hoggatt J, Pelus LM. Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking. Leukemia. 2010 Dec; 24(12):1993-2002. PMID: 20882043.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  29. Hoggatt AF, Hoggatt J, Honerlaw M, Pelus LM. A spoonful of sugar helps the medicine go down: a novel technique to improve oral gavage in mice. J Am Assoc Lab Anim Sci. 2010 May; 49(3):329-34. PMID: 20587165.
    Citations: 16     Fields:    Translation:Animals
  30. Hoggatt J, Singh P, Sampath J, Pelus LM. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood. 2009 May 28; 113(22):5444-55. PMID: 19324903.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.