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Alfredo Hernandez, Ph.D.

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  1. F32GM101761 (HERNANDEZ, ALFREDO JOSE) May 1, 2012 - Apr 30, 2015
    NIH/NIGMS
    Primer Synthesis and Handoff by Bacteriophage T7 DNA Primase
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hernandez AJ, Lee SJ, Chang S, Lee JA, Loparo JJ, Richardson CC. Catalytically inactive T7 DNA polymerase imposes a lethal replication roadblock. J Biol Chem. 2020 Jul 10; 295(28):9542-9550. PMID: 32430399.
    Citations:    Fields:    
  2. Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT. B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):415-425. PMID: 31871160.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Hernandez AJ, Richardson CC. Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein. Semin Cell Dev Biol. 2019 02; 86:92-101. PMID: 29588157.
    Citations: 2     Fields:    Translation:Cells
  4. Ilic S, Akabayov SR, Froimovici R, Meiry R, Vilenchik D, Hernandez A, Arthanari H, Akabayov B. Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase. Sci Rep. 2017 07 19; 7(1):5797. PMID: 28724886.
    Citations: 1     Fields:    Translation:Cells
  5. Zhu B, Wang L, Mitsunobu H, Lu X, Hernandez AJ, Yoshida-Takashima Y, Nunoura T, Tabor S, Richardson CC. Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2310-E2318. PMID: 28265063.
    Citations: 4     Fields:    Translation:Cells
  6. Hernandez AJ, Richardson CC. Kinetics of Lagging-strand DNA Synthesis In Vitro by the Bacteriophage T7 Replication Proteins. J Vis Exp. 2017 02 25; (120). PMID: 28287575.
    Citations:    Fields:    Translation:Cells
  7. Zovoilis A, Cifuentes-Rojas C, Chu HP, Hernandez AJ, Lee JT. Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell. 2016 Dec 15; 167(7):1788-1802.e13. PMID: 27984727.
    Citations: 13     Fields:    Translation:AnimalsCells
  8. Hernandez AJ, Lee SJ, Richardson CC. Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):5916-21. PMID: 27162371.
    Citations: 6     Fields:    Translation:Cells
  9. Zhu B, Hernandez A, Tan M, Wollenhaupt J, Tabor S, Richardson CC. Synthesis of 2'-Fluoro RNA by Syn5 RNA polymerase. Nucleic Acids Res. 2015 Aug 18; 43(14):e94. PMID: 25897116.
    Citations: 8     Fields:    Translation:Cells
  10. Cifuentes-Rojas C, Hernandez AJ, Sarma K, Lee JT. Regulatory interactions between RNA and polycomb repressive complex 2. Mol Cell. 2014 Jul 17; 55(2):171-85. PMID: 24882207.
    Citations: 102     Fields:    Translation:AnimalsCells
  11. Zhu B, Tabor S, Raytcheva DA, Hernandez A, King JA, Richardson CC. The RNA polymerase of marine cyanophage Syn5. J Biol Chem. 2013 Feb 01; 288(5):3545-52. PMID: 23258537.
    Citations: 7     Fields:    Translation:Cells
  12. Hernandez A, Madina BR, Ro K, Wohlschlegel JA, Willard B, Kinter MT, Cruz-Reyes J. REH2 RNA helicase in kinetoplastid mitochondria: ribonucleoprotein complexes and essential motifs for unwinding and guide RNA (gRNA) binding. J Biol Chem. 2010 Jan 08; 285(2):1220-8. PMID: 19850921.
    Citations: 35     Fields:    Translation:AnimalsCells
  13. Hernandez A, Panigrahi A, Cifuentes-Rojas C, Sacharidou A, Stuart K, Cruz-Reyes J. Determinants for association and guide RNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei. J Mol Biol. 2008 Aug 01; 381(1):35-48. PMID: 18572190.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Cifuentes-Rojas C, Pavia P, Hernandez A, Osterwisch D, Puerta C, Cruz-Reyes J. Substrate determinants for RNA editing and editing complex interactions at a site for full-round U insertion. J Biol Chem. 2007 Feb 16; 282(7):4265-76. PMID: 17158098.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Sacharidou A, Cifuentes-Rojas C, Halbig K, Hernandez A, Dangott LJ, De Nova-Ocampo M, Cruz-Reyes J. RNA editing complex interactions with a site for full-round U deletion in Trypanosoma brucei. RNA. 2006 Jul; 12(7):1219-28. PMID: 16690999.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.