Harvard Catalyst Profiles

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Alfredo Hernandez, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32GM101761 (HERNANDEZ, ALFREDO JOSE) May 1, 2012 - Apr 30, 2015
    Primer Synthesis and Handoff by Bacteriophage T7 DNA Primase
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hernandez AJ. Measuring the Complex Effects of the Single-Stranded DNA-Binding Protein gp2.5 on Primer Synthesis and Extension by the Bacteriophage T7 Replisome. Methods Mol Biol. 2021; 2281:323-332. PMID: 33847969.
    Citations:    Fields:    Translation:Cells
  2. Hernandez AJ. Interview with Elijah Petersen, 2020 Chemical Research in Toxicology Young Investigator Award, American Chemical Society Division of Chemical Toxicology. Chem Res Toxicol. 2021 01 18; 34(1):5-6. PMID: 33356159.
    Citations:    Fields:    Translation:Humans
  3. Hernandez AJ, Lee SJ, Chang S, Lee JA, Loparo JJ, Richardson CC. Catalytically inactive T7 DNA polymerase imposes a lethal replication roadblock. J Biol Chem. 2020 07 10; 295(28):9542-9550. PMID: 32430399.
    Citations:    Fields:    Translation:Cells
  4. Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT. B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):415-425. PMID: 31871160.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  5. Hernandez AJ, Richardson CC. Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein. Semin Cell Dev Biol. 2019 02; 86:92-101. PMID: 29588157.
    Citations: 13     Fields:    Translation:Cells
  6. Ilic S, Akabayov SR, Froimovici R, Meiry R, Vilenchik D, Hernandez A, Arthanari H, Akabayov B. Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase. Sci Rep. 2017 07 19; 7(1):5797. PMID: 28724886.
    Citations: 1     Fields:    Translation:Cells
  7. Zhu B, Wang L, Mitsunobu H, Lu X, Hernandez AJ, Yoshida-Takashima Y, Nunoura T, Tabor S, Richardson CC. Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2310-E2318. PMID: 28265063.
    Citations: 10     Fields:    Translation:Cells
  8. Hernandez AJ, Richardson CC. Kinetics of Lagging-strand DNA Synthesis In Vitro by the Bacteriophage T7 Replication Proteins. J Vis Exp. 2017 02 25; (120). PMID: 28287575.
    Citations: 1     Fields:    Translation:Cells
  9. Zovoilis A, Cifuentes-Rojas C, Chu HP, Hernandez AJ, Lee JT. Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell. 2016 Dec 15; 167(7):1788-1802.e13. PMID: 27984727.
    Citations: 28     Fields:    Translation:AnimalsCells
  10. Hernandez AJ, Lee SJ, Richardson CC. Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):5916-21. PMID: 27162371.
    Citations: 8     Fields:    Translation:Cells
  11. Zhu B, Hernandez A, Tan M, Wollenhaupt J, Tabor S, Richardson CC. Synthesis of 2'-Fluoro RNA by Syn5 RNA polymerase. Nucleic Acids Res. 2015 Aug 18; 43(14):e94. PMID: 25897116.
    Citations: 14     Fields:    Translation:Cells
  12. Cifuentes-Rojas C, Hernandez AJ, Sarma K, Lee JT. Regulatory interactions between RNA and polycomb repressive complex 2. Mol Cell. 2014 Jul 17; 55(2):171-85. PMID: 24882207.
    Citations: 143     Fields:    Translation:AnimalsCells
  13. Zhu B, Tabor S, Raytcheva DA, Hernandez A, King JA, Richardson CC. The RNA polymerase of marine cyanophage Syn5. J Biol Chem. 2013 Feb 01; 288(5):3545-52. PMID: 23258537.
    Citations: 8     Fields:    Translation:Cells
  14. Hernandez A, Madina BR, Ro K, Wohlschlegel JA, Willard B, Kinter MT, Cruz-Reyes J. REH2 RNA helicase in kinetoplastid mitochondria: ribonucleoprotein complexes and essential motifs for unwinding and guide RNA (gRNA) binding. J Biol Chem. 2010 Jan 08; 285(2):1220-8. PMID: 19850921.
    Citations: 41     Fields:    Translation:AnimalsCells
  15. Hernandez A, Panigrahi A, Cifuentes-Rojas C, Sacharidou A, Stuart K, Cruz-Reyes J. Determinants for association and guide RNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei. J Mol Biol. 2008 Aug 01; 381(1):35-48. PMID: 18572190.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Cifuentes-Rojas C, Pavia P, Hernandez A, Osterwisch D, Puerta C, Cruz-Reyes J. Substrate determinants for RNA editing and editing complex interactions at a site for full-round U insertion. J Biol Chem. 2007 Feb 16; 282(7):4265-4276. PMID: 17158098.
    Citations: 5     Fields:    Translation:AnimalsCells
  17. Sacharidou A, Cifuentes-Rojas C, Halbig K, Hernandez A, Dangott LJ, De Nova-Ocampo M, Cruz-Reyes J. RNA editing complex interactions with a site for full-round U deletion in Trypanosoma brucei. RNA. 2006 Jul; 12(7):1219-28. PMID: 16690999.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.