Harvard Catalyst Profiles

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Ruei-Zeng Lin, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vorisek C, Weixler V, Dominguez M, Axt-Fliedner R, Hammer PE, Lin RZ, Melero-Martin JM, Del Nido PJ, Friehs I. Mechanical strain triggers endothelial-to-mesenchymal transition of the endocardium in the immature heart. Pediatr Res. 2021 Nov 26. PMID: 34837068.
    Citations:    Fields:    
  2. Kim HD, Hong X, An YH, Park MJ, Kim DG, Greene AK, Padwa BL, Hwang NS, Lin RZ, Melero-Martin JM. A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification. Adv Healthc Mater. 2021 07; 10(13):e2100070. PMID: 33882194.
    Citations:    Fields:    Translation:Animals
  3. Hong X, Oh N, Wang K, Neumeyer J, Lee CN, Lin RZ, Piekarski B, Emani S, Greene AK, Friehs I, Del Nido PJ, Melero-Martin JM. Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1. Angiogenesis. 2021 05; 24(2):327-344. PMID: 33454888.
    Citations:    Fields:    Translation:HumansCells
  4. Kim HD, Lin RZ, Melero-Martin JM. In Vivo Vascular Network Forming Assay. Methods Mol Biol. 2021; 2206:193-203. PMID: 32754819.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Wang K, Lin RZ, Hong X, Ng AH, Lee CN, Neumeyer J, Wang G, Wang X, Ma M, Pu WT, Church GM, Melero-Martin JM. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 07; 6(30):eaba7606. PMID: 32832668.
    Citations: 15     Fields:    
  6. Neumeyer J, Lin RZ, Wang K, Hong X, Hua T, Croteau SE, Neufeld EJ, Melero-Martin JM. Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream. Blood Adv. 2019 12 23; 3(24):4166-4176. PMID: 31851760.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Wang K, Lin RZ, Melero-Martin JM. Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources. Cell Mol Life Sci. 2019 Feb; 76(3):421-439. PMID: 30315324.
    Citations: 19     Fields:    Translation:HumansCells
  8. Chuang CH, Lin RZ, Melero-Martin JM, Chen YC. Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue. Artif Cells Nanomed Biotechnol. 2018; 46(sup3):S434-S447. PMID: 30146913.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. PMID: 28851877.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  10. Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1. PMID: 28868207.
    Citations: 26     Fields:    
  11. Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J. Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation. Adv Funct Mater. 2017 Jul 19; 27(27). PMID: 32863817.
    Citations: 1     
  12. Kang KT, Lin RZ, Kuppermann D, Melero-Martin JM, Bischoff J. Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle. Sci Rep. 2017 04 10; 7(1):770. PMID: 28396600.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  13. Kuo KC, Lin RZ, Tien HW, Wu PY, Li YC, Melero-Martin JM, Chen YC. Bioengineering vascularized tissue constructs using an injectable cell-laden enzymatically crosslinked collagen hydrogel derived from dermal extracellular matrix. Acta Biomater. 2015 Nov; 27:151-166. PMID: 26348142.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Chuang CH, Lin RZ, Tien HW, Chu YC, Li YC, Melero-Martin JM, Chen YC. Enzymatic regulation of functional vascular networks using gelatin hydrogels. Acta Biomater. 2015 Jun; 19:85-99. PMID: 25749296.
    Citations: 11     Fields:    Translation:HumansCells
  15. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9. PMID: 25257468.
    Citations: 21     Fields:    Translation:AnimalsCells
  16. Lin RZ, Hatch A, Antontsev VG, Murthy SK, Melero-Martin JM. Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo. Tissue Eng Part C Methods. 2015 Mar; 21(3):274-83. PMID: 25091645.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  17. Lin RZ, Moreno-Luna R, Li D, Jaminet SC, Greene AK, Melero-Martin JM. Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10137-42. PMID: 24982174.
    Citations: 71     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  18. Muñoz-Hernandez R, Miranda ML, Stiefel P, Lin RZ, Praena-Fernández JM, Dominguez-Simeon MJ, Villar J, Moreno-Luna R, Melero-Martin JM. Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia. Hypertension. 2014 Jul; 64(1):165-71. PMID: 24752434.
    Citations: 30     Fields:    Translation:HumansCells
  19. Moreno-Luna R, Muñoz-Hernandez R, Lin RZ, Miranda ML, Vallejo-Vaz AJ, Stiefel P, Praena-Fernández JM, Bernal-Bermejo J, Jimenez-Jimenez LM, Villar J, Melero-Martin JM. Maternal body-mass index and cord blood circulating endothelial colony-forming cells. J Pediatr. 2014 Mar; 164(3):566-571. PMID: 24315508.
    Citations: 8     Fields:    Translation:HumansCells
  20. Ho CT, Lin RZ, Chen RJ, Chin CK, Gong SE, Chang HY, Peng HL, Hsu L, Yew TR, Chang SF, Liu CH. Liver-cell patterning lab chip: mimicking the morphology of liver lobule tissue. Lab Chip. 2013 Sep 21; 13(18):3578-87. PMID: 23743812.
    Citations: 39     Fields:    Translation:HumansCells
  21. Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM. Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel. Biomaterials. 2013 Sep; 34(28):6785-96. PMID: 23773819.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  22. Lin RZ, Moreno-Luna R, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM. Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential. Angiogenesis. 2013 Oct; 16(4):735-44. PMID: 23636611.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  23. Wagner M, Bjerkvig R, Wiig H, Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley AC. Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 2012 Sep; 15(3):481-95. PMID: 22614697.
    Citations: 32     Fields:    Translation:AnimalsCells
  24. Lin RZ, Moreno-Luna R, Zhou B, Pu WT, Melero-Martin JM. Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55. PMID: 22527199.
    Citations: 51     Fields:    Translation:AnimalsCells
  25. Chen YC, Lin RZ, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini A. Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels. Adv Funct Mater. 2012 May 23; 22(10):2027-2039. PMID: 22907987.
    Citations: 166     
  26. Lin RZ, Melero-Martin JM. Fibroblast growth factor-2 facilitates rapid anastomosis formation between bioengineered human vascular networks and living vasculature. Methods. 2012 Mar; 56(3):440-51. PMID: 22326880.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  27. Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM. Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release. Blood. 2011 Nov 17; 118(20):5420-8. PMID: 21937702.
    Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  28. Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7. PMID: 21907210.
    Citations: 52     Fields:    Translation:AnimalsCells
  29. Lin RZ, Melero-Martin JM. Bioengineering human microvascular networks in immunodeficient mice. J Vis Exp. 2011 Jul 11; (53):e3065. PMID: 21775960.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Lin RZ, Wang TP, Hung RJ, Chuang YJ, Chien CC, Chang HY. Tumor-induced endothelial cell apoptosis: roles of NAD(P)H oxidase-derived reactive oxygen species. J Cell Physiol. 2011 Jul; 226(7):1750-62. PMID: 21506107.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  31. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise Av, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May; 121(5):1894-904. PMID: 21505261.
    Citations: 253     Fields:    Translation:AnimalsCells
  32. Lin RZ, Dreyzin A, Aamodt K, Dudley AC, Melero-Martin JM. Functional endothelial progenitor cells from cryopreserved umbilical cord blood. Cell Transplant. 2011; 20(4):515-22. PMID: 20887663.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  33. Lin RZ, Lin RZ, Chang HY. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J. 2008 Oct; 3(9-10):1172-84. PMID: 18566957.
    Citations: 335     Fields:    Translation:HumansAnimalsCells
  34. Lin RZ, Chu WC, Chiang CC, Lai CH, Chang HY. Magnetic reconstruction of three-dimensional tissues from multicellular spheroids. Tissue Eng Part C Methods. 2008 Sep; 14(3):197-205. PMID: 18781835.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  35. Hung RJ, Chien HS, Lin RZ, Lin CT, Vatsyayan J, Peng HL, Chang HY. Comparative analysis of two UDP-glucose dehydrogenases in Pseudomonas aeruginosa PAO1. J Biol Chem. 2007 Jun 15; 282(24):17738-48. PMID: 17442666.
    Citations: 11     Fields:    Translation:Cells
  36. Lin RZ, Ho CT, Liu CH, Chang HY. Dielectrophoresis based-cell patterning for tissue engineering. Biotechnol J. 2006 Sep; 1(9):949-57. PMID: 16941445.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Ho CT, Lin RZ, Chang WY, Chang HY, Liu CH. Rapid heterogeneous liver-cell on-chip patterning via the enhanced field-induced dielectrophoresis trap. Lab Chip. 2006 Jun; 6(6):724-34. PMID: 16738722.
    Citations: 45     Fields:    Translation:HumansCells
  38. Lin RZ, Chou LF, Chien CC, Chang HY. Dynamic analysis of hepatoma spheroid formation: roles of E-cadherin and beta1-integrin. Cell Tissue Res. 2006 Jun; 324(3):411-22. PMID: 16489443.
    Citations: 83     Fields:    Translation:HumansCells
  39. Ho CT, Lin RZ, Chang HY, Liu CH. Micromachined electrochemical T-switches for cell sorting applications. Lab Chip. 2005 Nov; 5(11):1248-58. PMID: 16234948.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.