Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Chad A. Cowan, Ph.D.

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Mentoring
Characterizing Disease-Associated Genomic Loci Utilizing Human Embryonic Stem Cells
Summer, 06/01/09 - 08/28/09

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01TR001810 (KOTTON, DARRELL N.) Sep 15, 2016 - Jun 30, 2021
    NIH/NCATS
    A National iPS Cell Network with Deep Phenotyping for Translational Research
    Role: Principal Investigator
  2. R33HL120781 (KATHIRESAN, SEKAR) Aug 7, 2014 - Jun 30, 2019
    NIH/NHLBI
    Systematic cell-based functional screening for LDL and triglyceride genes
    Role: Principal Investigator
  3. R21HL120781 (KATHIRESAN, SEKAR) Aug 7, 2014 - Jun 30, 2016
    NIH/NHLBI
    Systematic cell-based functional screening for LDL and triglyceride genes
    Role: Principal Investigator
  4. R01DK097768 (COWAN, CHAD ALBERT) Sep 25, 2012 - Jun 30, 2017
    NIH/NIDDK
    Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
    Role: Principal Investigator
  5. R01DK095384 (COWAN, CHAD ALBERT) Apr 1, 2012 - Mar 31, 2017
    NIH/NIDDK
    Human Cell-Based Models of Primary Adipocyte Disorders
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Roudnicky F, Kim BK, Lan Y, Schmucki R, Küppers V, Christensen K, Graf M, Patsch C, Burcin M, Meyer CA, Westenskow PD, Cowan CA. Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance. Sci Rep. 2020 Mar 03; 10(1):3886. PMID: 32127614.
    Citations:    
  2. Roudnicky F, Lan Y, Friesen M, Dernick G, Zhang JD, Staempfli A, Bordag N, Wagner-Golbs A, Christensen K, Ebeling M, Graf M, Burcin M, Meyer CA, Cowan CA, Patsch C. Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype. Int J Mol Sci. 2019 Dec 09; 20(24). PMID: 31835296.
    Citations:    
  3. Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F, Ferreira LMR, Chen Z, Chen T, Loaiza N, Horwitz NB, Kacergis MC, Zhao L, Soukas AA, Kuivenhoven JA, Kathiresan S, Cowan CA. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell. 2019 Nov 27; 179(6):1276-1288.e14. PMID: 31778654.
    Citations:    
  4. Chen Z, Yu H, Shi X, Warren CR, Lotta LA, Friesen M, Meissner TB, Langenberg C, Wabitsch M, Wareham N, Benson MD, Gerszten RE, Cowan CA. Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes. Circ Res. 2020 Jan 31; 126(3):330-346. PMID: 31739742.
    Citations:    
  5. Friesen M, Cowan CA. Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics. Trends Endocrinol Metab. 2019 06; 30(6):396-406. PMID: 31072658.
    Citations:    
  6. Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA. Generation of hypoimmunogenic human pluripotent stem cells. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10441-10446. PMID: 31040209.
    Citations:    
  7. Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 08; 102(8):1223-1229. PMID: 29781950.
    Citations:    Fields:    
  8. Lang J, Cheng Y, Rolfe A, Hammack C, Vera D, Kyle K, Wang J, Meissner TB, Ren Y, Cowan C, Tang H. An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. Stem Cell Reports. 2018 08 14; 11(2):348-362. PMID: 29983385.
    Citations:    Fields:    
  9. Warren CR, Cowan CA. Humanity in a Dish: Population Genetics with iPSCs. Trends Cell Biol. 2018 01; 28(1):46-57. PMID: 29054332.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Friesen M, Cowan CA. FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism. Biochem Biophys Res Commun. 2018 01 01; 495(1):254-260. PMID: 29108996.
    Citations: 2     Fields:    Translation:HumansCells
  11. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee F, Khera AV, Klarin D, Koistinen HA, Kooner JS, Kooperberg C, Kuulasmaa K, Kuusisto J, Laakso M, Lakka T, Langenberg C, Langsted A, Launer LJ, Lauritzen T, Liewald DCM, Lin LA, Linneberg A, Loos RJF, Lu Y, Lu X, Mägi R, Malarstig A, Manichaikul A, Manning AK, Mäntyselkä P, Marouli E, Masca NGD, Maschio A, Meigs JB, Melander O, Metspalu A, Morris AP, Morrison AC, Mulas A, Müller-Nurasyid M, Munroe PB, Neville MJ, Nielsen JB, Nielsen SF, Nordestgaard BG, Ordovas JM, Mehran R, O'Donnell CJ, Orho-Melander M, Molony CM, Muntendam P, Padmanabhan S, Palmer CNA, Pasko D, Patel AP, Pedersen O, Perola M, Peters A, Pisinger C, Pistis G, Polasek O, Poulter N, Psaty BM, Rader DJ, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Rich SS, Ridker PM, Rioux JD, Robertson NR, Roden DM, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sanna S, Sattar N, Schmidt EM, Scott RA, Sever P, Sevilla RS, Shaffer CM, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith BH, Somayajula S, Southam L, Spector TD, Speliotes EK, Starr JM, Stirrups KE, Stitziel N, Strauch K, Stringham HM, Surendran P, Tada H, Tall AR, Tang H, Tardif JC, Taylor KD, Trompet S, Tsao PS, Tuomilehto J, Tybjaerg-Hansen A, van Zuydam NR, Varbo A, Varga TV, Virtamo J, Waldenberger M, Wang N, Wareham NJ, Warren HR, Weeke PE, Weinstock J, Wessel J, Wilson JG, Wilson PWF, Xu M, Yaghootkar H, Young R, Zeggini E, Zhang H, Zheng NS, Zhang W, Zhang Y, Zhou W, Zhou Y, Zoledziewska M, Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S. Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet. 2017 Dec; 49(12):1758-1766. PMID: 29083408.
    Citations: 17     Fields:    Translation:Humans
  12. Xu YX, Redon V, Yu H, Querbes W, Pirruccello J, Liebow A, Deik A, Trindade K, Wang X, Musunuru K, Clish CB, Cowan C, Fizgerald K, Rader D, Kathiresan S. Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. Atherosclerosis. 2018 01; 268:196-206. PMID: 29183623.
    Citations: 4     Fields:    
  13. Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J. Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. Cell Stem Cell. 2017 09 07; 21(3):305-318.e8. PMID: 28803920.
    Citations: 5     Fields:    Translation:HumansCells
  14. Lucas D, O'Leary HA, Ebert BL, Cowan CA, Tremblay CS. Utility of CRISPR/Cas9 systems in hematology research. Exp Hematol. 2017 10; 54:1-3. PMID: 28668351.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA. Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease. Stem Cell Reports. 2017 05 09; 8(5):1164-1173. PMID: 28416283.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 04 06; 20(4):547-557.e7. PMID: 28388431.
    Citations: 9     Fields:    Translation:HumansCells
  17. Warren CR, Jaquish CE, Cowan CA. The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics. Cell Stem Cell. 2017 04 06; 20(4):431-433. PMID: 28388427.
    Citations: 2     Fields:    Translation:HumansCells
  18. Naylor RW, McGhee CN, Cowan CA, Davidson AJ, Holm TM, Sherwin T. Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells. PLoS One. 2016; 11(10):e0165464. PMID: 27792791.
    Citations: 5     Fields:    Translation:HumansCells
  19. Pope BD, Warren CR, Parker KK, Cowan CA. Microenvironmental Control of Adipocyte Fate and Function. Trends Cell Biol. 2016 10; 26(10):745-755. PMID: 27268909.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Friesen M, Hudak CS, Warren CR, Xia F, Cowan CA. Adipocyte insulin receptor activity maintains adipose tissue mass and lifespan. Biochem Biophys Res Commun. 2016 08 05; 476(4):487-492. PMID: 27246738.
    Citations: 1     Fields:    Translation:AnimalsCells
  21. Peters DT, Henderson CA, Warren CR, Friesen M, Xia F, Becker CE, Musunuru K, Cowan CA. Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells. Development. 2016 05 01; 143(9):1475-81. PMID: 27143754.
    Citations: 2     Fields:    Translation:HumansCells
  22. Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5364-9. PMID: 27078102.
    Citations: 12     Fields:    Translation:HumansCells
  23. Yu H, Cowan CA. Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease. Mol Endocrinol. 2016 Jun; 30(6):575-86. PMID: 27075706.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Hendriks WT, Warren CR, Cowan CA. Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions. Cell Stem Cell. 2016 Jan 07; 18(1):53-65. PMID: 26748756.
    Citations: 19     Fields:    Translation:HumansCells
  25. Gupta RM, Meissner TB, Cowan CA, Musunuru K. Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1):15-8. PMID: 26543098.
    Citations: 10     Fields:    Translation:HumansCells
  26. Warren CR, Cowan CA. Type 1 Diabetes and MicroRNA: It's Complicated. Cell Metab. 2015 Aug 04; 22(2):202-3. PMID: 26244930.
    Citations:    Fields:    Translation:Humans
  27. Hendriks WT, Jiang X, Daheron L, Cowan CA. TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection. Curr Protoc Stem Cell Biol. 2015 Aug 03; 34:5B.3.1-5B.3.25. PMID: 26237572.
    Citations: 8     Fields:    Translation:HumansCells
  28. Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgård PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug; 17(8):994-1003. PMID: 26214132.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  29. Balhara B, Burkart A, Topcu V, Lee YK, Cowan C, Kahn CR, Patti ME. Severe insulin resistance alters metabolism in mesenchymal progenitor cells. Endocrinology. 2015 Jun; 156(6):2039-48. PMID: 25811318.
    Citations: 2     Fields:    Translation:HumansCells
  30. Moisan A, Lee YK, Zhang JD, Hudak CS, Meyer CA, Prummer M, Zoffmann S, Truong HH, Ebeling M, Kiialainen A, Gérard R, Xia F, Schinzel RT, Amrein KE, Cowan CA. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan; 17(1):57-67. PMID: 25487280.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  31. Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. PMID: 25437882.
    Citations: 78     Fields:    Translation:HumansCells
  32. Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 2014 Nov 06; 15(5):643-52. PMID: 25517468.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  33. Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014 Dec; 24(12):1420-32. PMID: 25367124.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Leschik J, Caron L, Yang H, Cowan C, Pucéat M. A view of bivalent epigenetic marks in two human embryonic stem cell lines reveals a different cardiogenic potential. Stem Cells Dev. 2015 Feb 01; 24(3):384-92. PMID: 25202820.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  35. Veres A, Gosis BS, Ding Q, Collins R, Ragavendran A, Brand H, Erdin S, Cowan CA, Talkowski ME, Musunuru K. Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Cell Stem Cell. 2014 Jul 03; 15(1):27-30. PMID: 24996167.
    Citations: 163     Fields:    Translation:HumansCells
  36. Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ Res. 2014 Aug 15; 115(5):488-92. PMID: 24916110.
    Citations: 78     Fields:    Translation:AnimalsCells
  37. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 07; 19(1):96-108. PMID: 24411942.
    Citations: 85     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  38. Lee YK, Cowan CA. Differentiation of white and brown adipocytes from human pluripotent stem cells. Methods Enzymol. 2014; 538:35-47. PMID: 24529432.
    Citations: 2     Fields:    Translation:HumansCells
  39. Meissner TB, Mandal PK, Ferreira LM, Rossi DJ, Cowan CA. Genome editing for human gene therapy. Methods Enzymol. 2014; 546:273-95. PMID: 25398345.
    Citations: 5     Fields:    Translation:HumansCells
  40. Ding Q, Cowan CA. Liver in a dish. Cell Res. 2013 Nov; 23(11):1242-3. PMID: 23979015.
    Citations:    Fields:    Translation:HumansAnimalsCells
  41. Lee YK, Cowan CA. White to brite adipocyte transition and back again. Nat Cell Biol. 2013 Jun; 15(6):568-9. PMID: 23728463.
    Citations: 9     Fields:    Translation:AnimalsCells
  42. Ding Q, Regan SN, Xia Y, Oostrom LA, Cowan CA, Musunuru K. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Cell Stem Cell. 2013 Apr 04; 12(4):393-4. PMID: 23561441.
    Citations: 153     Fields:    Translation:HumansCells
  43. Zhu J, Adli M, Zou JY, Verstappen G, Coyne M, Zhang X, Durham T, Miri M, Deshpande V, De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R, Cowan CA, Meissner A, Epstein CB, Shoresh N, Bernstein BE. Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell. 2013 Jan 31; 152(3):642-54. PMID: 23333102.
    Citations: 202     Fields:    Translation:HumansCells
  44. Mae SI, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun. 2013; 4:1367. PMID: 23340407.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  45. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 07; 12(2):238-51. PMID: 23246482.
    Citations: 187     Fields:    Translation:HumansCells
  46. Lau FH, Xia F, Kaplan A, Cerrato F, Greene AK, Taghinia A, Cowan CA, Labow BI. Expression analysis of macrodactyly identifies pleiotrophin upregulation. PLoS One. 2012; 7(7):e40423. PMID: 22848377.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  47. Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 2012 Apr 06; 10(4):385-97. PMID: 22482504.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  48. Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012 Jan 15; 14(2):209-19. PMID: 22246346.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  49. Camahort R, Cowan CA. Cbx proteins help ESCs walk the line between self-renewal and differentiation. Cell Stem Cell. 2012 Jan 06; 10(1):4-6. PMID: 22226347.
    Citations: 3     Fields:    
  50. Schinzel RT, Ahfeldt T, Lau FH, Lee YK, Cowley A, Shen T, Peters D, Lum DH, Cowan CA. Efficient culturing and genetic manipulation of human pluripotent stem cells. PLoS One. 2011; 6(12):e27495. PMID: 22194785.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  51. Lau FH, Deo RC, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA. Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue. PLoS One. 2011; 6(10):e26092. PMID: 22022522.
    Citations: 3     Fields:    Translation:HumansCells
  52. Staal FJ, Baum C, Cowan C, Dzierzak E, Hacein-Bey-Abina S, Karlsson S, Lapidot T, Lemischka I, Mendez-Ferrer S, Mikkers H, Moore K, Moreno E, Mummery CL, Robin C, Suda T, Van Pel M, Vanden Brink G, Zwaginga JJ, Fibbe WE. Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia. 2011 Jul; 25(7):1095-102. PMID: 21527933.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  53. Rigamonti A, Brennand K, Lau F, Cowan CA. Rapid cellular turnover in adipose tissue. PLoS One. 2011 Mar 02; 6(3):e17637. PMID: 21407813.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  54. Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011 Feb 03; 470(7332):95-100. PMID: 21270795.
    Citations: 80     Fields:    Translation:AnimalsCells
  55. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010 Nov 05; 7(5):618-30. PMID: 20888316.
    Citations: 786     Fields:    Translation:HumansCells
  56. Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010 Aug 05; 466(7307):714-9. PMID: 20686566.
    Citations: 371     Fields:    Translation:HumansAnimalsCells
  57. Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, Binder P, Hagège A, Desnos M, Renaud JF, Menasché P, Pucéat M. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest. 2010 Apr; 120(4):1125-39. PMID: 20335662.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  58. Xie D, Chen CC, Ptaszek LM, Xiao S, Cao X, Fang F, Ng HH, Lewin HA, Cowan C, Zhong S. Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species. Genome Res. 2010 Jun; 20(6):804-15. PMID: 20219939.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  59. Tenzen T, Zembowicz F, Cowan CA. Genome modification in human embryonic stem cells. J Cell Physiol. 2010 Feb; 222(2):278-81. PMID: 19877154.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  60. Lau F, Ahfeldt T, Osafune K, Akustsu H, Cowan CA. Induced pluripotent stem (iPS) cells: an up-to-the-minute review. F1000 Biol Rep. 2009 Nov 16; 1:84. PMID: 20948605.
    Citations: 5     
  61. Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol. 2009 Sep 07; 186(5):665-73. PMID: 19736317.
    Citations: 42     Fields:    Translation:HumansCells
  62. Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 06; 4(2):103-6. PMID: 19200798.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  63. Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 2008 Oct; 4(10):e1000242. PMID: 18974828.
    Citations: 456     Fields:    Translation:HumansAnimalsCells
  64. Maherali N, Ahfeldt T, Rigamonti A, Utikal J, Cowan C, Hochedlinger K. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008 Sep 11; 3(3):340-5. PMID: 18786420.
    Citations: 183     Fields:    Translation:HumansCells
  65. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell. 2008 Sep 05; 134(5):877-86. PMID: 18691744.
    Citations: 763     Fields:    Translation:HumansCells
  66. Fenno LE, Ptaszek LM, Cowan CA. Human embryonic stem cells: emerging technologies and practical applications. Curr Opin Genet Dev. 2008 Aug; 18(4):324-9. PMID: 18625311.
    Citations: 8     Fields:    Translation:HumansCells
  67. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. PMID: 18278034.
    Citations: 275     Fields:    Translation:HumansCells
  68. Ptaszek LM, Cowan CA. New tools for genome modification in human embryonic stem cells. Cell Stem Cell. 2007 Dec 13; 1(6):600-2. PMID: 18371400.
    Citations: 1     Fields:    Translation:HumansCells
  69. Arora N, Tewari D, Cowan C, Saffari B, Monk BJ, Burger RA. Bevacizumab demonstrates activity in advanced refractory fallopian tube carcinoma. Int J Gynecol Cancer. 2008 Mar-Apr; 18(2):369-72. PMID: 17624986.
    Citations: 2     Fields:    Translation:Humans
  70. Akutsu H, Cowan CA, Melton D. Human embryonic stem cells. Methods Enzymol. 2006; 418:78-92. PMID: 17141030.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  71. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005 Aug 26; 309(5739):1369-73. PMID: 16123299.
    Citations: 222     Fields:    Translation:HumansAnimalsCells
  72. Wang S, Cowan CA, Chipperfield H, Powers RD. Gene expression in the preimplantation embryo: in-vitro developmental changes. Reprod Biomed Online. 2005 May; 10(5):607-16. PMID: 15949218.
    Citations: 15     Fields:    Translation:AnimalsCells
  73. Dravis C, Yokoyama N, Chumley MJ, Cowan CA, Silvany RE, Shay J, Baker LA, Henkemeyer M. Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol. 2004 Jul 15; 271(2):272-90. PMID: 15223334.
    Citations: 83     Fields:    Translation:AnimalsCells
  74. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol. 2004 Jul 15; 271(2):263-71. PMID: 15223333.
    Citations: 45     Fields:    Translation:AnimalsCells
  75. Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem. 2004 Jul 23; 279(30):31590-8. PMID: 15148312.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  76. Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med. 2004 Mar 25; 350(13):1353-6. PMID: 14999088.
    Citations: 226     Fields:    Translation:HumansCells
  77. Cowan CA, Henkemeyer M. Ephrins in reverse, park and drive. Trends Cell Biol. 2002 Jul; 12(7):339-46. PMID: 12185851.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  78. Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB. Crystal structure of an Eph receptor-ephrin complex. Nature. 2001 Dec 20-27; 414(6866):933-8. PMID: 11780069.
    Citations: 94     Fields:    Translation:AnimalsCells
  79. Cowan CA, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001 Sep 13; 413(6852):174-9. PMID: 11557983.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  80. Yokoyama N, Romero MI, Cowan CA, Galvan P, Helmbacher F, Charnay P, Parada LF, Henkemeyer M. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron. 2001 Jan; 29(1):85-97. PMID: 11182083.
    Citations: 59     Fields:    Translation:AnimalsCells
  81. Cowan CA, Henkemeyer M. More cables to Abl. Neuron. 2000 Jun; 26(3):543-4. PMID: 10896146.
    Citations:    Fields:    Translation:Animals
  82. Cowan CA, Yokoyama N, Bianchi LM, Henkemeyer M, Fritzsch B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000 May; 26(2):417-30. PMID: 10839360.
    Citations: 57     Fields:    Translation:AnimalsCells
  83. Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000 Mar; 127(6):1231-41. PMID: 10683176.
    Citations: 52     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.