Harvard Catalyst Profiles

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Mark Allister Currie, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D. Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability. Nature. 2018 08; 560(7719):504-508. PMID: 30051891.
    Citations:    Fields:    
  2. Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D. Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription. Nature. 2017 07 27; 547(7664):463-467. PMID: 28682306.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z. Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases. RNA. 2017 03; 23(3):346-354. PMID: 27932585.
    Citations: 1     Fields:    Translation:Cells
  4. Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D. Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes. Elife. 2016 11 11; 5. PMID: 27835568.
    Citations: 4     Fields:    Translation:AnimalsCells
  5. Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z. Structural basis of calcineurin activation by calmodulin. Cell Signal. 2013 Dec; 25(12):2661-7. PMID: 24018048.
    Citations: 5     Fields:    Translation:AnimalsCells
  6. Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D. Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8495-500. PMID: 23650358.
    Citations: 26     Fields:    Translation:AnimalsCells
  7. Currie MA, Cameron K, Dias FM, Spencer HL, Bayer EA, Fontes CM, Smith SP, Jia Z. Small angle X-ray scattering analysis of Clostridium thermocellum cellulosome N-terminal complexes reveals a highly dynamic structure. J Biol Chem. 2013 Mar 15; 288(11):7978-85. PMID: 23341454.
    Citations: 4     Fields:    Translation:Cells
  8. Rao S, Lembo AJ, Shiff SJ, Lavins BJ, Currie MG, Jia XD, Shi K, MacDougall JE, Shao JZ, Eng P, Fox SM, Schneier HA, Kurtz CB, Johnston JM. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol. 2012 Nov; 107(11):1714-24; quiz p.1725. PMID: 22986440.
    Citations: 79     Fields:    Translation:HumansCTClinical Trials
  9. Chey WD, Lembo AJ, Lavins BJ, Shiff SJ, Kurtz CB, Currie MG, MacDougall JE, Jia XD, Shao JZ, Fitch DA, Baird MJ, Schneier HA, Johnston JM. Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol. 2012 Nov; 107(11):1702-12. PMID: 22986437.
    Citations: 95     Fields:    Translation:HumansCTClinical Trials
  10. Busby RW, Kessler MM, Bartolini WP, Bryant AP, Hannig G, Higgins CS, Solinga RM, Tobin JV, Wakefield JD, Kurtz CB, Currie MG. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther. 2013 Jan; 344(1):196-206. PMID: 23090647.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  11. Currie MA, Adams JJ, Faucher F, Bayer EA, Jia Z, Smith SP. Scaffoldin conformation and dynamics revealed by a ternary complex from the Clostridium thermocellum cellulosome. J Biol Chem. 2012 Aug 03; 287(32):26953-61. PMID: 22707718.
    Citations: 11     Fields:    Translation:Cells
  12. Lembo AJ, Schneier HA, Shiff SJ, Kurtz CB, MacDougall JE, Jia XD, Shao JZ, Lavins BJ, Currie MG, Fitch DA, Jeglinski BI, Eng P, Fox SM, Johnston JM. Two randomized trials of linaclotide for chronic constipation. N Engl J Med. 2011 Aug 11; 365(6):527-36. PMID: 21830967.
    Citations: 77     Fields:    Translation:HumansCTClinical Trials
  13. Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Mahajan-Miklos S, Pierce CM, Solinga RM, Sun LJ, Tobin JV, Kurtz CB, Currie MG. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharmacol. 2010 Dec 15; 649(1-3):328-35. PMID: 20863829.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  14. Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, O'Dea C, Baird M, Lembo AJ. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology. 2010 Dec; 139(6):1877-1886.e2. PMID: 20801122.
    Citations: 55     Fields:    Translation:HumansCTClinical Trials
  15. Bryant AP, Busby RW, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Pierce CM, Solinga RM, Tobin JV, Mahajan-Miklos S, Cohen MB, Kurtz CB, Currie MG. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 08; 86(19-20):760-5. PMID: 20307554.
    Citations: 45     Fields:    Translation:Animals
  16. Currie MA, Adams JJ, Ali S, Smith SP, Jia Z. Purification and crystallization of a multimodular heterotrimeric complex containing both type I and type II cohesin-dockerin interactions from the cellulosome of Clostridium thermocellum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 01; 66(Pt 3):327-9. PMID: 20208173.
    Citations: 1     Fields:    Translation:Cells
  17. Adams JJ, Currie MA, Ali S, Bayer EA, Jia Z, Smith SP. Insights into higher-order organization of the cellulosome revealed by a dissect-and-build approach: crystal structure of interacting Clostridium thermocellum multimodular components. J Mol Biol. 2010 Mar 05; 396(4):833-9. PMID: 20070943.
    Citations: 7     Fields:    Translation:Cells
  18. Lembo AJ, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, Jeglinski BI, Johnston JM. Efficacy of linaclotide for patients with chronic constipation. Gastroenterology. 2010 Mar; 138(3):886-95.e1. PMID: 20045700.
    Citations: 58     Fields:    Translation:HumansCTClinical Trials
  19. Matte A, Kozlov G, Trempe JF, Currie MA, Burk D, Jia Z, Gehring K, Ekiel I, Berghuis AM, Cygler M. Preparation and characterization of bacterial protein complexes for structural analysis. Adv Protein Chem Struct Biol. 2009; 76:1-42. PMID: 20663477.
    Citations:    Fields:    
  20. Currie MA, Merino F, Skarina T, Wong AH, Singer A, Brown G, Savchenko A, Caniuguir A, Guixé V, Yakunin AF, Jia Z. ADP-dependent 6-phosphofructokinase from Pyrococcus horikoshii OT3: structure determination and biochemical characterization of PH1645. J Biol Chem. 2009 Aug 21; 284(34):22664-71. PMID: 19553681.
    Citations: 5     Fields:    Translation:Cells
  21. Johnston JM, Kurtz CB, Drossman DA, Lembo AJ, Jeglinski BI, MacDougall JE, Antonelli SM, Currie MG. Pilot study on the effect of linaclotide in patients with chronic constipation. Am J Gastroenterol. 2009 Jan; 104(1):125-32. PMID: 19098860.
    Citations: 42     Fields:    Translation:Humans
  22. Andresen V, Camilleri M, Busciglio IA, Grudell A, Burton D, McKinzie S, Foxx-Orenstein A, Kurtz CB, Sharma V, Johnston JM, Currie MG, Zinsmeister AR. Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology. 2007 Sep; 133(3):761-8. PMID: 17854590.
    Citations: 74     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.