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Sun Hee Yim, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee KE, Kim JK, Han SK, Lee DY, Lee HJ, Yim SV, Kim DH. The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment. Microbiome. 2020 Jul 15; 8(1):107. PMID: 32669127.
  2. Yim SH, Clish CB, Gladyshev VN. Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019 05 28; 27(9):2785-2797.e3. PMID: 31141699.
  3. Lee SG, Mikhalchenko AE, Yim SH, Gladyshev VN. A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts. Stem Cell Res. 2018 08; 31:197-200. PMID: 30107334.
    Citations:    Fields:    
  4. Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN. Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Rep. 2018 05 01; 23(5):1387-1398. PMID: 29719252.
    Citations: 1     Fields:    
  5. Yim SH, Tobe R, Turanov AA, Carlson BA. Radioactive 75Se Labeling and Detection of Selenoproteins. Methods Mol Biol. 2018; 1661:177-192. PMID: 28917045.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Lee SG, Mikhalchenko AE, Yim SH, Lobanov AV, Park JK, Choi KH, Bronson RT, Lee CK, Park TJ, Gladyshev VN. Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera. Stem Cell Reports. 2017 11 14; 9(5):1706-1720. PMID: 29107591.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Ma S, Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R, Lewis KN, Park TJ, Miller RA, Clish CB, Gladyshev VN. Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. Cell Metab. 2015 Aug 04; 22(2):332-43. PMID: 26244935.
    Citations: 18     Fields:    Translation:Animals
  8. Mariotti M, Santesmasses D, Capella-Gutierrez S, Mateo A, Arnan C, Johnson R, D'Aniello S, Yim SH, Gladyshev VN, Serras F, Corominas M, Gabaldón T, Guigó R. Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization. Genome Res. 2015 Sep; 25(9):1256-67. PMID: 26194102.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, Buffenstein R, Lee SR, Chang KT, Rhee H, Kim JS, Yang KS, Gladyshev VN. Gene expression defines natural changes in mammalian lifespan. Aging Cell. 2015 Jun; 14(3):352-65. PMID: 25677554.
    Citations: 28     Fields:    Translation:HumansAnimals
  10. Turanov AA, Shchedrina VA, Everley RA, Lobanov AV, Yim SH, Marino SM, Gygi SP, Hatfield DL, Gladyshev VN. Selenoprotein S is involved in maintenance and transport of multiprotein complexes. Biochem J. 2014 Sep 15; 462(3):555-65. PMID: 24897171.
    Citations: 11     Fields:    Translation:HumansCells
  11. Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN. Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 2014 Sep 11; 8(5):1354-64. PMID: 25176646.
    Citations: 29     Fields:    Translation:AnimalsCells
  12. Avanesov AS, Ma S, Pierce KA, Yim SH, Lee BC, Clish CB, Gladyshev VN. Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation. Elife. 2014 Apr 29; 3:e02077. PMID: 24843015.
    Citations: 12     Fields:    Translation:Animals
  13. Han SJ, Lee BC, Yim SH, Gladyshev VN, Lee SR. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. PLoS One. 2014; 9(4):e95518. PMID: 24751718.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Lee BC, Kaya A, Ma S, Kim G, Gerashchenko MV, Yim SH, Hu Z, Harshman LG, Gladyshev VN. Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status. Nat Commun. 2014 Apr 07; 5:3592. PMID: 24710037.
    Citations: 35     Fields:    Translation:AnimalsCells
  15. Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN. Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Nat Commun. 2013; 4:2212. PMID: 23962925.
    Citations: 51     Fields:    Translation:AnimalsCells
  16. Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011 Oct 12; 479(7372):223-7. PMID: 21993625.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  17. Yim SH, Kim YJ, Oh SY, Fujii J, Zhang Y, Gladyshev VN, Rhee SG. Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis. J Biol Chem. 2011 Nov 11; 286(45):39002-12. PMID: 21835919.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Ryan LK, Dai J, Yin Z, Megjugorac N, Uhlhorn V, Yim S, Schwartz KD, Abrahams JM, Diamond G, Fitzgerald-Bocarsly P. Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. J Leukoc Biol. 2011 Aug; 90(2):343-56. PMID: 21551252.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  19. Bertolotti M, Yim SH, Garcia-Manteiga JM, Masciarelli S, Kim YJ, Kang MH, Iuchi Y, Fujii J, Vené R, Rubartelli A, Rhee SG, Sitia R. B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. Antioxid Redox Signal. 2010 Oct; 13(8):1133-44. PMID: 20486764.
    Citations: 16     Fields:    Translation:AnimalsCells
  20. Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest. 2010 Jun; 120(6):2171-83. PMID: 20440072.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  21. Lee MN, Lee SN, Kim SH, Kim B, Jung BK, Seo JH, Park JH, Choi JH, Yim SH, Lee MR, Park JG, Yoo JY, Kim JH, Lee ST, Kim HM, Ryeom S, Kim KW, Oh GT. Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. J Natl Cancer Inst. 2010 Mar 17; 102(6):426-42. PMID: 20194889.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Woo HA, Yim SH, Shin DH, Kang D, Yu DY, Rhee SG. Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell. 2010 Feb 19; 140(4):517-28. PMID: 20178744.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  23. Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O. The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. Carcinogenesis. 2009 Nov; 30(11):1957-61. PMID: 19755658.
    Citations: 9     Fields:    Translation:Animals
  24. Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab. 2009 Feb; 9(2):152-64. PMID: 19147412.
    Citations: 108     Fields:    Translation:AnimalsCells
  25. Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis. 2008 Jul; 14(7):908-20. PMID: 18338782.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  26. Kim JS, Yim SV, Koh IS, Choi JS, Yoo JY, Lee KS, Lim Y, Lee KH. Single-nucleotide polymorphisms (SNPs) and haplotype analysis in vascular endothelial growth factor (VEGF) gene in the patients with Parkinson disease and lung cancer. Arch Gerontol Geriatr. 2009 May-Jun; 48(3):287-90. PMID: 18359110.
    Citations: 3     Fields:    Translation:Humans
  27. Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology. 2008 Jun; 134(7):2036-48, 2048.e1-3. PMID: 18439915.
    Citations: 66     Fields:    Translation:AnimalsCells
  28. Ito S, Chen C, Satoh J, Yim S, Gonzalez FJ. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J Clin Invest. 2007 Jul; 117(7):1940-50. PMID: 17607366.
    Citations: 34     Fields:    Translation:Animals
  29. Jung KH, Kim MJ, Ha E, Kim HK, Kim YO, Kang SA, Chung JH, Yim SV. The suppressive effect of beta-glucan on the production of tumor necrosis factor-alpha in BV2 microglial cells. Biosci Biotechnol Biochem. 2007 May; 71(5):1360-4. PMID: 17485824.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. Arpiainen S, Lämsä V, Pelkonen O, Yim SH, Gonzalez FJ, Hakkola J. Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. J Mol Biol. 2007 Jun 08; 369(3):640-52. PMID: 17466327.
    Citations: 8     Fields:    Translation:AnimalsCells
  31. Jung K, Ha E, Uhm Y, Park H, Kim MJ, Kim H, Baik H, Hong M, Yang J, Yim SV. Suppressive effect by Hizikia fusiforme on the production of tumor necrosis factor in BV2 murine microglial cells. Neurol Res. 2007; 29 Suppl 1:S88-92. PMID: 17359647.
    Citations:    Fields:    Translation:AnimalsCells
  32. Yim SH, Shah Y, Tomita S, Morris HD, Gavrilova O, Lambert G, Ward JM, Gonzalez FJ. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology. 2006 Sep; 44(3):550-60. PMID: 16941684.
    Citations: 23     Fields:    Translation:Animals
  33. Jung KH, Kim MJ, Ha E, Uhm YK, Kim HK, Chung JH, Yim SV. Suppressive effect of Punica granatum on the production of tumor necrosis factor (Tnf) in BV2 microglial cells. Biol Pharm Bull. 2006 Jun; 29(6):1258-61. PMID: 16755029.
    Citations: 3     Fields:    Translation:AnimalsCells
  34. Park YH, Park HJ, Kim BS, Ha E, Jung KH, Yoon SH, Yim SV, Chung JH. BNP as a marker of the heart failure in the treatment of imatinib mesylate. Cancer Lett. 2006 Nov 08; 243(1):16-22. PMID: 16388897.
  35. Inoue Y, Peters LL, Yim SH, Inoue J, Gonzalez FJ. Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression. J Mol Med (Berl). 2006 Apr; 84(4):334-44. PMID: 16389552.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, Inoue J, Xiang CC, Brownstein MJ, Eggertsen G, Björkhem I, Gonzalez FJ. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res. 2006 Jan; 47(1):215-27. PMID: 16264197.
    Citations: 46     Fields:    Translation:AnimalsCells
  37. Park HJ, Yoon SH, Han LS, Zheng LT, Jung KH, Uhm YK, Lee JH, Jeong JS, Joo WS, Yim SV, Chung JH, Hong SP. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol. 2005 Sep 07; 11(33):5156-61. PMID: 16127745.
    Citations: 4     Fields:    Translation:HumansCells
  38. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49. PMID: 16096055.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  39. Fang H, Tong W, Perkins R, Shi L, Hong H, Cao X, Xie Q, Yim SH, Ward JM, Pitot HC, Dragan YP. Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling. BMC Bioinformatics. 2005 Jul 15; 6 Suppl 2:S6. PMID: 16026603.
    Citations: 13     Fields:    Translation:HumansAnimals
  40. Kim MJ, Kim HK, Kim BS, Yim SV. Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats. J Pineal Res. 2004 Oct; 37(3):193-7. PMID: 15357664.
    Citations: 7     Fields:    Translation:Animals
  41. Inoue Y, Inoue J, Lambert G, Yim SH, Gonzalez FJ. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem. 2004 Oct 22; 279(43):44740-8. PMID: 15292250.
    Citations: 25     Fields:    Translation:AnimalsCells
  42. Jung SK, Hong MS, Suh GJ, Jin SY, Lee HJ, Kim BS, Lim YJ, Kim MK, Park HK, Chung JH, Yim SV. Association between polymorphism in intron 1 of cocaine- and amphetamine-regulated transcript gene with alcoholism, but not with bipolar disorder and schizophrenia in Korean population. Neurosci Lett. 2004 Jul 15; 365(1):54-7. PMID: 15234472.
    Citations: 8     Fields:    Translation:Humans
  43. Lee BC, Ahn SY, Doo HK, Yim SV, Lee HJ, Jin SY, Hong SJ, Lee SH, Kim SD, Seo JC, Leem KH, Chung JH. Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene. Neurosci Lett. 2004 Feb 26; 357(1):33-6. PMID: 15036607.
    Citations: 19     Fields:    Translation:Humans
  44. Yim SH, Ward JM, Dragan Y, Yamada A, Scacheri PC, Kimura S, Gonzalez FJ. Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles. Toxicol Pathol. 2003 May-Jun; 31(3):295-303. PMID: 12746117.
    Citations: 9     Fields:    Translation:Animals
  45. Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B, Reitman ML, Gonzalez FJ. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest. 2003 Mar; 111(5):737-47. PMID: 12618528.
    Citations: 150     Fields:    Translation:Animals
  46. Yim SH, Hee SS. Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures. Mutat Res. 2001 May 31; 492(1-2):13-27. PMID: 11377240.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Tomita S, Sinal CJ, Yim SH, Gonzalez FJ. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol. 2000 Oct; 14(10):1674-81. PMID: 11043581.
    Citations: 56     Fields:    Translation:AnimalsCells
  48. Yim SH, Hee SS. Genotoxicity of nicotine and cotinine in the bacterial luminescence test. Mutat Res. 1995 Dec; 335(3):275-83. PMID: 8524343.
    Citations: 1     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.