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Last Name

profileOren Levy, Ph.D.

TitleStaff Scientist - In Vitro Assays/Therapeutics
InstitutionHarvard University
DepartmentWyss Institute
AddressCenter for Life Science
3 Blackfan Circle, 508-4
3 Blackfan Circle
Boston MA 02115
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Other Positions
TitleInstructor in Medicine, Part-time
InstitutionBrigham and Women's Hospital
DivisionRenal/Engineering in Medicine

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jalili-Firoozinezhad S, Prantil-Baun R, Jiang A, Potla R, Mammoto T, Weaver JC, Ferrante TC, Kim HJ, Cabral JMS, Levy O, Ingber DE. Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip. Cell Death Dis. 2018 Feb 14; 9(2):223. PMID: 29445080.
    View in: PubMed
  2. Sun X, Aimé P, Dai D, Ramalingam N, Crary JF, Burke RE, Greene LA, Levy OA. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May; 303:95-107. PMID: 29432724.
    View in: PubMed
  3. Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE. Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro. Cell Rep. 2017 Oct 10; 21(2):508-516. PMID: 29020635.
    View in: PubMed
  4. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481. PMID: 28911198.
    View in: PubMed
  5. Chen HK, Wang LH, Chen WU, Mayfield AB, Levy O, Lin CS, Chen CS. Coral lipid bodies as the relay center interconnecting diel-dependent lipidomic changes in different cellular compartments. Sci Rep. 2017 Jun 12; 7(1):3244. PMID: 28607345.
    View in: PubMed
  6. Chan RB, Perotte AJ, Zhou B, Liong C, Shorr EJ, Marder KS, Kang UJ, Waters CH, Levy OA, Xu Y, Shim HB, Pe'er I, Di Paolo G, Alcalay RN. Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis. PLoS One. 2017; 12(2):e0172348. PMID: 28212433.
    View in: PubMed
  7. Maor-Landaw K, Waldman Ben-Asher H, Karako-Lampert S, Salmon-Divon M, Prada F, Caroselli E, Goffredo S, Falini G, Dubinsky Z, Levy O. Mediterranean versus Red sea corals facing climate change, a transcriptome analysis. Sci Rep. 2017 Feb 09; 7:42405. PMID: 28181588.
    View in: PubMed
  8. Yang Z, Concannon J, Ng KS, Seyb K, Mortensen LJ, Ranganath S, Gu F, Levy O, Tong Z, Martyn K, Zhao W, Lin CP, Glicksman MA, Karp JM. Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation. Sci Rep. 2016 07 26; 6:30263. PMID: 27457881.
    View in: PubMed
  9. Stolarski J, Bosellini FR, Wallace CC, Gothmann AM, Mazur M, Domart-Coulon I, Gutner-Hoch E, Neuser RD, Levy O, Shemesh A, Meibom A. A unique coral biomineralization pattern has resisted 40 million years of major ocean chemistry change. Sci Rep. 2016 06 15; 6:27579. PMID: 27302371.
    View in: PubMed
  10. Ranganath SH, Tong Z, Levy O, Martyn K, Karp JM, Inamdar MS. Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering. Stem Cell Reports. 2016 06 14; 6(6):926-39. PMID: 27264972; PMCID: PMC4911501.
  11. Robakis D, Cortes E, Clark LN, Vonsattel JP, Virmani T, Alcalay RN, Crary JF, Levy OA. The effect of MAPT haplotype on neocortical Lewy body pathology in Parkinson disease. J Neural Transm (Vienna). 2016 06; 123(6):583-8. PMID: 27098667.
    View in: PubMed
  12. Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials. 2016 Jun; 91:140-150. PMID: 27019026; PMCID: PMC4824400 [Available on 06/01/17].
  13. Alcalay RN, Levy OA, Wolf P, Oliva P, Zhang XK, Waters CH, Fahn S, Kang U, Liong C, Ford B, Mazzoni P, Kuo S, Johnson A, Xiong L, Rouleau GA, Chung W, Marder KS, Gan-Or Z. SCARB2 variants and glucocerebrosidase activity in Parkinson's disease. NPJ Parkinsons Dis. 2016; 2. PMID: 27110593.
    View in: PubMed
  14. Gutner-Hoch E, Schneider K, Stolarski J, Domart-Coulon I, Yam R, Meibom A, Shemesh A, Levy O. Evidence for Rhythmicity Pacemaker in the Calcification Process of Scleractinian Coral. Sci Rep. 2016 Feb 05; 6:20191. PMID: 26847144; PMCID: PMC4742845.
  15. Fischer SCL, Levy O, Kroner E, Hensel R, Karp JM, Arzt E. Bioinspired polydimethylsiloxane-based composites with high shear resistance against wet tissue. J Mech Behav Biomed Mater. 2016 08; 61:87-95. PMID: 26849031.
    View in: PubMed
  16. Yin X, Mead BE, Safaee H, Langer R, Karp JM, Levy O. Engineering Stem Cell Organoids. Cell Stem Cell. 2016 Jan 07; 18(1):25-38. PMID: 26748754; PMCID: PMC4728053 [Available on 01/07/17].
  17. Heinelt M, Karp JM, Levy O. Cell therapy--showing cells the way home. Oncotarget. 2015 Jul 20; 6(20):17857-8. PMID: 26257004; PMCID: PMC4627214.
  18. Fantazzini P, Mengoli S, Pasquini L, Bortolotti V, Brizi L, Mariani M, Di Giosia M, Fermani S, Capaccioni B, Caroselli E, Prada F, Zaccanti F, Levy O, Dubinsky Z, Kaandorp JA, Konglerd P, Hammel JU, Dauphin Y, Cuif JP, Weaver JC, Fabricius KE, Wagermaier W, Fratzl P, Falini G, Goffredo S. Gains and losses of coral skeletal porosity changes with ocean acidification acclimation. Nat Commun. 2015 Jul 17; 6:7785. PMID: 26183259; PMCID: PMC4518299.
  19. Alcalay RN, Levy OA, Waters CC, Fahn S, Ford B, Kuo SH, Mazzoni P, Pauciulo MW, Nichols WC, Gan-Or Z, Rouleau GA, Chung WK, Wolf P, Oliva P, Keutzer J, Marder K, Zhang X. Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations. Brain. 2015 Sep; 138(Pt 9):2648-58. PMID: 26117366; PMCID: PMC4564023.
  20. Oren M, Tarrant AM, Alon S, Simon-Blecher N, Elbaz I, Appelbaum L, Levy O. Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Sci Rep. 2015 Jun 17; 5:11418. PMID: 26081482; PMCID: PMC4476465.
  21. Tong Z, Solanki A, Hamilos A, Levy O, Wen K, Yin X, Karp JM. Application of biomaterials to advance induced pluripotent stem cell research and therapy. EMBO J. 2015 Apr 15; 34(8):987-1008. PMID: 25766254; PMCID: PMC4406648.
  22. Levy O, Mortensen LJ, Boquet G, Tong Z, Perrault C, Benhamou B, Zhang J, Stratton T, Han E, Safaee H, Musabeyezu J, Yang Z, Multon MC, Rothblatt J, Deleuze JF, Lin CP, Karp JM. A small-molecule screen for enhanced homing of systemically infused cells. Cell Rep. 2015 Mar 03; 10(8):1261-1268. PMID: 25732817; PMCID: PMC4361231.
  23. Ankrum JA, Dastidar RG, Ong JF, Levy O, Karp JM. Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids. Sci Rep. 2014 Apr 10; 4:4645. PMID: 24717973; PMCID: PMC3982175.
  24. Oren M, Brickner I, Brikner I, Appelbaum L, Levy O. Fast neurotransmission related genes are expressed in non nervous endoderm in the sea anemone Nematostella vectensis. PLoS One. 2014; 9(4):e93832. PMID: 24705400.
    View in: PubMed
  25. Airi V, Gizzi F, Falini G, Levy O, Dubinsky Z, Goffredo S. Reproductive efficiency of a Mediterranean endemic zooxanthellate coral decreases with increasing temperature along a wide latitudinal gradient. PLoS One. 2014; 9(3):e91792. PMID: 24618568.
    View in: PubMed
  26. Karako-Lampert S, Zoccola D, Salmon-Divon M, Katzenellenbogen M, Tambutté S, Bertucci A, Hoegh-Guldberg O, Deleury E, Allemand D, Levy O. Transcriptome analysis of the scleractinian coral Stylophora pistillata. PLoS One. 2014; 9(2):e88615. PMID: 24551124.
    View in: PubMed
  27. Choi S, Levy O, Coelho MB, Cabral JM, Karp JM, Karnik R. A cell rolling cytometer reveals the correlation between mesenchymal stem cell dynamic adhesion and differentiation state. Lab Chip. 2014 Jan 07; 14(1):161-6. PMID: 24146063; PMCID: PMC3886723.
  28. Mortensen LJ, Levy O, Phillips JP, Stratton T, Triana B, Ruiz JP, Gu F, Karp JM, Lin CP. Quantification of Mesenchymal Stem Cell (MSC) delivery to a target site using in vivo confocal microscopy. PLoS One. 2013; 8(10):e78145. PMID: 24205131; PMCID: PMC3812161.
  29. Levy O, Anandakumaran P, Ngai J, Karnik R, Karp JM. Systematic analysis of in vitro cell rolling using a multi-well plate microfluidic system. J Vis Exp. 2013 Oct 16; (80):e50866. PMID: 24193253; PMCID: PMC3892982.
  30. Levy O, Zhao W, Mortensen LJ, Leblanc S, Tsang K, Fu M, Phillips JA, Sagar V, Anandakumaran P, Ngai J, Cui CH, Eimon P, Angel M, Lin CP, Yanik MF, Karp JM. mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation. Blood. 2013 Oct 03; 122(14):e23-32. PMID: 23980067; PMCID: PMC3790516.
  31. Sternberg EJ, Alcalay RN, Levy OA, Louis ED. Postural and Intention Tremors: A Detailed Clinical Study of Essential Tremor vs. Parkinson's Disease. Front Neurol. 2013; 4:51. PMID: 23717300; PMCID: PMC3650675.
  32. Sternberg EJ, Alcalay RN, Levy OA, Louis ED. The "head snap": a subtle clinical feature during the finger-nose-finger maneuver in essential tremor. Tremor Other Hyperkinet Mov (N Y). 2013; 3. PMID: 23724360; PMCID: PMC3636493.
  33. Sun X, Liu J, Crary JF, Malagelada C, Sulzer D, Greene LA, Levy OA. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J Neurosci. 2013 Feb 06; 33(6):2398-407. PMID: 23392669; PMCID: PMC3711618.
  34. Roopin M, Levy O. Melatonin distribution reveals clues to its biological significance in basal metazoans. PLoS One. 2012; 7(12):e52266. PMID: 23300630.
    View in: PubMed
  35. Sorek M, Levy O. Influence of the quantity and quality of light on photosynthetic periodicity in coral endosymbiotic algae. PLoS One. 2012; 7(8):e43264. PMID: 22912840; PMCID: PMC3422335.
  36. Sorek M, Levy O. The effect of temperature compensation on the circadian rhythmicity of photosynthesis in Symbiodinium, coral-symbiotic alga. Sci Rep. 2012; 2:536. PMID: 22837816; PMCID: PMC3405291.
  37. Caroselli E, Zaccanti F, Mattioli G, Falini G, Levy O, Dubinsky Z, Goffredo S. Growth and demography of the solitary scleractinian coral Leptopsammia pruvoti along a sea surface temperature gradient in the Mediterranean Sea. PLoS One. 2012; 7(6):e37848. PMID: 22675495.
    View in: PubMed
  38. Ranganath SH, Levy O, Inamdar MS, Karp JM. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell. 2012 Mar 02; 10(3):244-58. PMID: 22385653; PMCID: PMC3294273.
  39. Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25; 6(11):720-5. PMID: 21946708; PMCID: PMC3208725.
  40. Goffredo S, Vergni P, Reggi M, Caroselli E, Sparla F, Levy O, Dubinsky Z, Falini G. The skeletal organic matrix from Mediterranean coral Balanophyllia europaea influences calcium carbonate precipitation. PLoS One. 2011; 6(7):e22338. PMID: 21799830; PMCID: PMC3142144.
  41. Greene LA, Levy O, Malagelada C. Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment. Cell Mol Neurobiol. 2011 Oct; 31(7):969-78. PMID: 21547489; PMCID: PMC3678379.
  42. Levy O, Ruvinov E, Reem T, Granot Y, Cohen S. Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling. Int J Biochem Cell Biol. 2010 Nov; 42(11):1823-30. PMID: 20691278.
    View in: PubMed
  43. Dvir T, Kedem A, Ruvinov E, Levy O, Freeman I, Landa N, Holbova R, Feinberg MS, Dror S, Etzion Y, Leor J, Cohen S. Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14990-5. PMID: 19706385; PMCID: PMC2736451.
  44. Levy OA, Malagelada C, Greene LA. Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis. 2009 Apr; 14(4):478-500. PMID: 19165601; PMCID: PMC2754154.
  45. Levy O, Dvir T, Tsur-Gang O, Granot Y, Cohen S. Signal transducer and activator of transcription 3-A key molecular switch for human mesenchymal stem cell proliferation. Int J Biochem Cell Biol. 2008; 40(11):2606-18. PMID: 18583177.
    View in: PubMed
  46. Philbin VJ, Levy O. Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities. Biochem Soc Trans. 2007 Dec; 35(Pt 6):1485-91. PMID: 18031250.
    View in: PubMed
  47. Dvir T, Levy O, Shachar M, Granot Y, Cohen S. Activation of the ERK1/2 cascade via pulsatile interstitial fluid flow promotes cardiac tissue assembly. Tissue Eng. 2007 Sep; 13(9):2185-93. PMID: 17518740.
    View in: PubMed
  48. Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y, Levy O, Aboud M. Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications. Carcinogenesis. 2006 Apr; 27(4):673-81. PMID: 16308315.
    View in: PubMed
  49. Levy O. A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein. Antimicrob Agents Chemother. 2000 Nov; 44(11):2925-31. PMID: 11036002; PMCID: PMC101582.
  50. Levy O. Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. Blood. 2000 Oct 15; 96(8):2664-72. PMID: 11023496.
    View in: PubMed
  51. Levy O, Martin S, Eichenwald E, Ganz T, Valore E, Carroll SF, Lee K, Goldmann D, Thorne GM. Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics. 1999 Dec; 104(6):1327-33. PMID: 10585984.
    View in: PubMed
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