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profileTaranjit Singh Gujral, PH.D.

TitleResearch Fellow in Systems Biology (INT)
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology
200 Longwood Ave
Boston MA 02115
Phone617/417-7278
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014 Nov 6; 159(4):844-56. PMID: 25417160; PMCID: PMC4243058.
  2. Gujral TS, Peshkin L, Kirschner MW. Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13):5048-53. PMID: 24707051; PMCID: PMC3977247.
  3. Gujral TS, Karp ES, Chan M, Chang BH, MacBeath G. Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates ß-catenin in maintaining the integrity of tight junctions. Chem Biol. 2013 Jun 20; 20(6):816-27. PMID: 23790492; PMCID: PMC3728706.
  4. Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene. 2013 Jul 18; 32(29):3470-6. PMID: 22945653; PMCID: PMC3670968.
  5. Hyndman BD, Gujral TS, Krieger JR, Cockburn JG, Mulligan LM. Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease. Hum Mutat. 2013 Jan; 34(1):132-42. PMID: 22837065.
    View in: PubMed
  6. Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O. A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Sci Signal. 2012 Jan 10; 5(206):pl1. PMID: 22234610; PMCID: PMC3465074.
  7. Chang BH, Gujral TS, Karp ES, BuKhalid R, Grantcharova VP, MacBeath G. A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions. Chem Biol. 2011 Sep 23; 18(9):1143-52. PMID: 21944753; PMCID: PMC3442787.
  8. Cockburn JG, Richardson DS, Gujral TS, Mulligan LM. RET-mediated cell adhesion and migration require multiple integrin subunits. J Clin Endocrinol Metab. 2010 Nov; 95(11):E342-6. PMID: 20702524.
    View in: PubMed
  9. Gujral TS, MacBeath G. A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PLoS One. 2010; 5(4):e10024. PMID: 20383323; PMCID: PMC2850918.
  10. Shalek AK, Robinson JT, Karp ES, Lee JS, Ahn DR, Yoon MH, Sutton A, Jorgolli M, Gertner RS, Gujral TS, MacBeath G, Yang EG, Park H. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):1870-5. PMID: 20080678; PMCID: PMC2836617.
  11. Gujral TS, MacBeath G. Emerging miniaturized proteomic technologies to study cell signaling in clinical samples. Sci Signal. 2009; 2(93):pe65. PMID: 19843955.
    View in: PubMed
  12. Richardson DS, Gujral TS, Peng S, Asa SL, Mulligan LM. Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins. Cancer Res. 2009 Jun 1; 69(11):4861-9. PMID: 19487296.
    View in: PubMed
  13. Gujral TS, van Veelen W, Richardson DS, Myers SM, Meens JA, Acton DS, Duñach M, Elliott BE, Höppener JW, Mulligan LM. A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma. Cancer Res. 2008 Mar 1; 68(5):1338-46. PMID: 18316596.
    View in: PubMed
  14. Lai AZ, Gujral TS, Mulligan LM. RET signaling in endocrine tumors: delving deeper into molecular mechanisms. Endocr Pathol. 2007; 18(2):57-67. PMID: 17916994.
    View in: PubMed
  15. Gujral TS, Singh VK, Jia Z, Mulligan LM. Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B. Cancer Res. 2006 Nov 15; 66(22):10741-9. PMID: 17108110.
    View in: PubMed
  16. Gujral TS, Mulligan LM. Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2. Ann N Y Acad Sci. 2006 Aug; 1073:234-40. PMID: 17102091.
    View in: PubMed
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