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Eric Lieberman Greer, Ph.D.

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2006 - 2009
National Science Foundation (NSF) Graduate Research Fellowship (GRF)
Selected speaker - Molecular Genetics of Aging - scientific meeting
Selected speaker - Molecular Genetics of Aging - scientific meeting
Life Science Research Foundation Fellowship Finalist (declined)
Runner up for the Aging Cell Best paper prize for 2009
2011 - 2013
Helen Hay Whitney Fellowship
Selected speaker - Epigenetics and the Inheritance of Acquired States
Selected speaker - Chromatin: Structure & Function 2011
Invited Age UK speaker - Ageing and Basic Bioscience Conference
Invited Keynote speaker - Epigenetics 2012 - 4th Australian Scientific Conference
Invited speaker - Transcriptional Regulation During Cell Growth, Dif, and Dev.
Invited talk NIH NCI CEICBG Seminar Series
2013 - 2018
NIH Pathway to Independence Award (K99/R00)
Selected speaker - Chromatin Mechanisms and Cell Physiology
Selected speaker - Epigenetic Programming and Inheritance
Invited speaker - The XXIII North American Testis Workshop
Invited speaker - Non-coding RNA: New Mechanisms and Approaches
Invited speaker - Chromatin Changes in Differentiation and Malignancy
Invited speaker - Epigenetics Obesity and Metabolism

I am an Assistant Professor at Boston Children's Hospital and Harvard Medical School (http://thegreerlab.com). I did my post-doctoral research in Dr. Yang Shi's laboratory (http://www.shilab.info/ShiLab/Welcome.html) at Boston Children's Hospital and Harvard Medical School. I did my graduate work in the lab of Dr. Anne Brunet (http://www.stanford.edu/group/brunet/) at Stanford University. I am interested in identifying how epigenetic information is transmitted from parents to their descendants in a non-Mendelian manner.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI151215 (WHELAN, SEAN PJ) Jul 26, 2021 - Jun 30, 2025
    Cap specific N6 methylation of viral mRNA by the cellular methyltransferase PCIF1
    Role: Co-Principal Investigator
  2. R21HG010066 (GREER, ERIC LIEBERMAN) Sep 1, 2018 - Feb 28, 2021
    Base-resolution sequencing of 6mA in eukaryotic DNA
    Role: Principal Investigator
  3. DP2AG055947 (GREER, ERIC LIEBERMAN) Sep 30, 2016 - Aug 31, 2022
    Characterization of DNA N6-methyl adenine and its role in epigenetic memory
    Role: Principal Investigator
  4. R00AG043550 (GREER, ERIC LIEBERMAN) Jul 15, 2015 - Jun 30, 2018
    Identifying the molecular mechanisms of transgenerational epigenetic inheritance
    Role: Principal Investigator
  5. K99AG043550 (GREER, ERIC LIEBERMAN) Sep 1, 2013 - May 31, 2015
    Identifying the molecular mechanisms of transgenerational epigenetic inheritance
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Boulias K, Greer EL. Means, mechanisms and consequences of adenine methylation in DNA. Nat Rev Genet. 2022 Mar 07. PMID: 35256817.
    Citations:    Fields:    
  2. Boulias K, Greer EL. The adenine methylation debate. Science. 2022 02 04; 375(6580):494-495. PMID: 35113697.
    Citations:    Fields:    Translation:Cells
  3. Burton NO, Greer EL. Multigenerational epigenetic inheritance: Transmitting information across generations. Semin Cell Dev Biol. 2021 Aug 20. PMID: 34426067.
    Citations: 1     Fields:    
  4. Tartell MA, Boulias K, Hoffmann GB, Bloyet LM, Greer EL, Whelan SPJ. Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-ß. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). PMID: 34266951.
    Citations: 4     Fields:    Translation:HumansCells
  5. Coe A, Biller SJ, Thomas E, Boulias K, Bliem C, Arellano A, Dooley K, Rasmussen AN, LeGault K, O'Keefe TJ, Stover S, Greer EL, Chisholm SW. Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation. Limnol Oceanogr. 2021 Sep; 66(9):3300-3312. PMID: 34690365.
  6. Wang SY, Pollina EA, Wang IH, Pino LK, Bushnell HL, Takashima K, Fritsche C, Sabin G, Garcia BA, Greer PL, Greer EL. Role of epigenetics in unicellular to multicellular transition in Dictyostelium. Genome Biol. 2021 05 04; 22(1):134. PMID: 33947439.
    Citations:    Fields:    Translation:AnimalsCells
  7. Boulias K, Greer EL. Detection of DNA Methylation in Genomic DNA by UHPLC-MS/MS. Methods Mol Biol. 2021; 2198:79-90. PMID: 32822024.
    Citations: 6     Fields:    Translation:Cells
  8. Lizarraga A, O'Brown ZK, Boulias K, Roach L, Greer EL, Johnson PJ, Strobl-Mazzulla PH, de Miguel N. Adenine DNA methylation, 3D genome organization, and gene expression in the parasite Trichomonas vaginalis. Proc Natl Acad Sci U S A. 2020 06 09; 117(23):13033-13043. PMID: 32461362.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Liberman N, O'Brown ZK, Earl AS, Boulias K, Gerashchenko MV, Wang SY, Fritsche C, Fady PE, Dong A, Gladyshev VN, Greer EL. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Sci Adv. 2020 04; 6(17):eaaz4370. PMID: 32494643.
    Citations: 11     Fields:    
  10. Liberman N, Wang SY, Greer EL. Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms. Curr Opin Neurobiol. 2019 12; 59:189-206. PMID: 31634674.
    Citations: 11     Fields:    Translation:Cells
  11. Wang SY, Mao H, Shibuya H, Uzawa S, O'Brown ZK, Wesenberg S, Shin N, Saito TT, Gao J, Meyer BJ, Colaiácovo MP, Greer EL. The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline. PLoS Genet. 2019 07; 15(7):e1008252. PMID: 31283754.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Boulias K, Toczydlowska-Socha D, Hawley BR, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL. Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome. Mol Cell. 2019 08 08; 75(3):631-643.e8. PMID: 31279658.
    Citations: 59     Fields:    Translation:HumansCells
  13. Boulias K, Greer EL. Put the Pedal to the METTL1: Adding Internal m7G Increases mRNA Translation Efficiency and Augments miRNA Processing. Mol Cell. 2019 06 20; 74(6):1105-1107. PMID: 31226274.
    Citations: 5     Fields:    Translation:Cells
  14. O'Brown ZK, Boulias K, Wang J, Wang SY, O'Brown NM, Hao Z, Shibuya H, Fady PE, Shi Y, He C, Megason SG, Liu T, Greer EL. Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA. BMC Genomics. 2019 Jun 03; 20(1):445. PMID: 31159718.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  15. Boulias K, Lieberman J, Greer EL. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 04 21; 62(2):153-155. PMID: 27105110.
    Citations: 11     Fields:    Translation:HumansCells
  16. O'Brown ZK, Greer EL. N6-Methyladenine: A Conserved and Dynamic DNA Mark. Adv Exp Med Biol. 2016; 945:213-246. PMID: 27826841.
    Citations: 31     Fields:    Translation:AnimalsCells
  17. Greer EL, Becker B, Latza C, Antebi A, Shi Y. Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Cell Res. 2016 Feb; 26(2):229-38. PMID: 26691751.
    Citations: 24     Fields:    Translation:AnimalsCells
  18. Luo GZ, Blanco MA, Greer EL, He C, Shi Y. DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes? Nat Rev Mol Cell Biol. 2015 Dec; 16(12):705-10. PMID: 26507168.
    Citations: 72     Fields:    Translation:AnimalsCells
  19. Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y. DNA Methylation on N6-Adenine in C. elegans. Cell. 2015 May 07; 161(4):868-78. PMID: 25936839.
    Citations: 231     Fields:    Translation:AnimalsCells
  20. Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizábal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiácovo MP, Shi Y. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Cell Rep. 2014 Apr 10; 7(1):113-26. PMID: 24685137.
    Citations: 70     Fields:    Translation:AnimalsCells
  21. Greer EL, Shi Y. What's the Mtrr with your grandparents? Cell Metab. 2013 Oct 01; 18(4):457-9. PMID: 24093670.
    Citations:    Fields:    Translation:Animals
  22. Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012 Apr 03; 13(5):343-57. PMID: 22473383.
    Citations: 796     Fields:    Translation:HumansAnimalsCells
  23. Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011 Oct 19; 479(7373):365-71. PMID: 22012258.
    Citations: 265     Fields:    Translation:AnimalsCells
  24. Maures TJ, Greer EL, Hauswirth AG, Brunet A. The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Aging Cell. 2011 Dec; 10(6):980-90. PMID: 21834846.
    Citations: 112     Fields:    Translation:AnimalsCells
  25. Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature. 2010 Jul 15; 466(7304):383-7. PMID: 20555324.
    Citations: 221     Fields:    Translation:AnimalsCells
  26. Greer EL, Banko MR, Brunet A. AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Ann N Y Acad Sci. 2009 Jul; 1170:688-92. PMID: 19686213.
    Citations: 60     Fields:    Translation:AnimalsCells
  27. Greer EL, Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell. 2009 Apr; 8(2):113-27. PMID: 19239417.
    Citations: 270     Fields:    Translation:AnimalsCells
  28. Greer EL, Brunet A. Signaling networks in aging. J Cell Sci. 2008 Feb 15; 121(Pt 4):407-12. PMID: 18256383.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  29. Greer EL, Brunet A. FOXO transcription factors in ageing and cancer. Acta Physiol (Oxf). 2008 Jan; 192(1):19-28. PMID: 18171426.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  30. Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol. 2007 Oct 09; 17(19):1646-56. PMID: 17900900.
    Citations: 362     Fields:    Translation:AnimalsCells
  31. Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem. 2007 Oct 12; 282(41):30107-19. PMID: 17711846.
    Citations: 355     Fields:    Translation:HumansAnimalsCells
  32. Pondarré C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, Deck KM, McDonald A, Han AP, Medlock A, Kutok JL, Anderson SA, Eisenstein RS, Fleming MD. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet. 2006 Mar 15; 15(6):953-64. PMID: 16467350.
    Citations: 88     Fields:    Translation:AnimalsCells
  33. Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. 2005 Nov 14; 24(50):7410-25. PMID: 16288288.
    Citations: 531     Fields:    Translation:HumansAnimalsCells
  34. Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005 Nov; 37(11):1264-9. PMID: 16227996.
    Citations: 221     Fields:    Translation:AnimalsCells
  35. Gunshin H, Starr CN, Direnzo C, Fleming MD, Jin J, Greer EL, Sellers VM, Galica SM, Andrews NC. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005 Oct 15; 106(8):2879-83. PMID: 15961514.
    Citations: 47     Fields:    Translation:AnimalsCells
  36. Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem. 2001 Nov 16; 276(46):43285-93. PMID: 11555662.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.