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Martin Villiger, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P41EB015903 (BOUMA, BRETT E) Jul 21, 2011 - Jun 30, 2021
    Center for Biomedical OCT Research and Translation
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hariri LP, Adams DC, Applegate MB, Miller AJ, Roop BW, Villiger M, Bouma BE, Suter MJ. Distinguishing tumor from associated fibrosis to increase diagnostic biopsy yield with polarization-sensitive optical coherence tomography. Clin Cancer Res. 2019 Jun 07. PMID: 31175092.
  2. Doradla P, Otsuka K, Nadkarni A, Villiger M, Karanasos A, Zandvoort LJCV, Dijkstra J, Zijlstra F, Soest GV, Daemen J, Regar E, Bouma BE, Nadkarni SK. Biomechanical Stress Profiling of Coronary Atherosclerosis: Identifying a Multifactorial Metric to Evaluate Plaque Rupture Risk. JACC Cardiovasc Imaging. 2019 Apr 10. PMID: 31005542.
  3. Lo WCY, Uribe-Patarroyo N, Hoebel K, Beaudette K, Villiger M, Nishioka NS, Vakoc BJ, Bouma BE. Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography. Biomed Opt Express. 2019 Apr 01; 10(4):2067-2089. PMID: 31086717.
  4. Walther J, Li Q, Villiger M, Farah CS, Koch E, Karnowski K, Sampson DD. Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo. Biomed Opt Express. 2019 Apr 01; 10(4):1942-1956. PMID: 31086712.
  5. Li X, Saeidi N, Villiger M, Albadawi H, Jones JD, Quinn KP, Austin WG, Golberg A, Yarmush ML. Rejuvenation of aged rat skin with pulsed electric fields. J Tissue Eng Regen Med. 2018 Dec; 12(12):2309-2318. PMID: 30353675.
    Citations:    Fields:    
  6. Villiger M, Braaf B, Lippok N, Otsuka K, Nadkarni SK, Bouma BE. Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography. Optica. 2018 Oct 20; 5(10):1329-1337. PMID: 31214632.
  7. Li Q, Karnowski K, Noble PB, Cairncross A, James A, Villiger M, Sampson DD. Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography. Biomed Opt Express. 2018 Nov 01; 9(11):5437-5455. PMID: 30460138.
  8. Nam AS, Easow JM, Chico-Calero I, Villiger M, Welt J, Borschel GH, Winograd JM, Randolph MA, Redmond RW, Vakoc BJ. Wide-Field Functional Microscopy of Peripheral Nerve Injury and Regeneration. Sci Rep. 2018 Sep 18; 8(1):14004. PMID: 30228335.
    Citations:    Fields:    
  9. Lippok N, Braaf B, Villiger M, Oh WY, Vakoc BJ, Bouma BE. Quantitative depolarization measurements for fiber-based polarization-sensitive optical frequency domain imaging of the retinal pigment epithelium. J Biophotonics. 2019 Jan; 12(1):e201800156. PMID: 30009506.
    Citations:    Fields:    
  10. Villiger M, Otsuka K, Karanasos A, Doradla P, Ren J, Lippok N, Shishkov M, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, Dijkstra J, van Soest G, Regar E, Nadkarni SK, Bouma BE. Repeatability Assessment of Intravascular Polarimetry in Patients. IEEE Trans Med Imaging. 2018 07; 37(7):1618-1625. PMID: 29969412.
    Citations:    Fields:    
  11. Uribe-Patarroyo N, Kassani SH, Villiger M, Bouma BE. Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography. Opt Express. 2018 Apr 02; 26(7):9081-9094. PMID: 29715866.
    Citations: 2     Fields:    
  12. Villiger M, Otsuka K, Karanasos A, Doradla P, Ren J, Lippok N, Shishkov M, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, van Soest G, Libby P, Regar E, Nadkarni SK, Bouma BE. Coronary Plaque Microstructure and Composition Modify Optical Polarization: A New Endogenous Contrast Mechanism for Optical Frequency Domain Imaging. JACC Cardiovasc Imaging. 2018 Nov; 11(11):1666-1676. PMID: 29248662.
    Citations: 3     Fields:    
  13. Kravez E, Villiger M, Bouma B, Yarmush M, Yakhini Z, Golberg A. Prediction of Scar Size in Rats Six Months after Burns Based on Early Post-injury Polarization-Sensitive Optical Frequency Domain Imaging. Front Physiol. 2017; 8:967. PMID: 29249978.
    Citations: 1     
  14. van Ditzhuijzen NS, Kurata M, van den Heuvel M, Sorop O, van Duin RWB, Krabbendam-Peters I, Ligthart J, Witberg K, Murawska M, Bouma B, Villiger M, Garcia-Garcia HM, Serruys PW, Zijlstra F, van Soest G, Duncker DJ, Regar E, van Beusekom HMM. Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. PLoS One. 2017; 12(9):e0183419. PMID: 28898243.
    Citations:    Fields:    Translation:Animals
  15. Liu X, Beaudette K, Wang X, Liu L, Bouma BE, Villiger M. Tissue-like phantoms for quantitative birefringence imaging. Biomed Opt Express. 2017 Oct 01; 8(10):4454-4465. PMID: 29082077.
  16. Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE. Depolarization signatures map gold nanorods within biological tissue. Nat Photonics. 2017; 11:583-588. PMID: 29201136.
    Citations: 2     
  17. Golberg A, Villiger M, Felix Broelsch G, Quinn KP, Albadawi H, Khan S, Watkins MT, Georgakoudi I, Austen WG, Bei M, Bouma BE, Mihm MC, Yarmush ML. Skin regeneration with all accessory organs following ablation with irreversible electroporation. J Tissue Eng Regen Med. 2018 Jan; 12(1):98-113. PMID: 27976527.
    Citations:    Fields:    
  18. Bouma BE, Villiger M, Otsuka K, Oh WY. Intravascular optical coherence tomography [Invited]. Biomed Opt Express. 2017 May 01; 8(5):2660-2686. PMID: 28663897.
    Citations: 2     
  19. Kassani SH, Villiger M, Uribe-Patarroyo N, Jun C, Khazaeinezhad R, Lippok N, Bouma BE. Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging. Opt Express. 2017 Apr 03; 25(7):8255-8266. PMID: 28380940.
    Citations:    Fields:    Translation:HumansAnimals
  20. Adams DC, Hariri LP, Miller AJ, Wang Y, Cho JL, Villiger M, Holz JA, Szabari MV, Hamilos DL, Scott Harris R, Griffith JW, Bouma BE, Luster AD, Medoff BD, Suter MJ. Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo. Sci Transl Med. 2016 10 05; 8(359):359ra131. PMID: 27708064.
    Citations: 9     Fields:    Translation:HumansAnimals
  21. Rico-Jimenez JJ, Campos-Delgado DU, Villiger M, Otsuka K, Bouma BE, Jo JA. Automatic classification of atherosclerotic plaques imaged with intravascular OCT. Biomed Opt Express. 2016 Oct 01; 7(10):4069-4085. PMID: 27867716.
    Citations: 2     
  22. Lo WC, Uribe-Patarroyo N, Nam AS, Villiger M, Vakoc BJ, Bouma BE. Laser thermal therapy monitoring using complex differential variance in optical coherence tomography. J Biophotonics. 2017 01; 10(1):84-91. PMID: 27623742.
    Citations: 1     Fields:    Translation:Animals
  23. Golberg A, Villiger M, Khan S, Quinn KP, Lo WCY, Bouma BE, Mihm MC, Austen WG, Yarmush ML. Preventing Scars after Injury with Partial Irreversible Electroporation. J Invest Dermatol. 2016 11; 136(11):2297-2304. PMID: 27393126.
    Citations: 2     Fields:    Translation:Animals
  24. Villiger M, Lorenser D, McLaughlin RA, Quirk BC, Kirk RW, Bouma BE, Sampson DD. Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour. Sci Rep. 2016 07 01; 6:28771. PMID: 27364229.
    Citations: 15     Fields:    Translation:Humans
  25. van der Sijde JN, Karanasos A, Villiger M, Bouma BE, Regar E. First-in-man assessment of plaque rupture by polarization-sensitive optical frequency domain imaging in vivo. Eur Heart J. 2016 06 21; 37(24):1932. PMID: 27174288.
    Citations: 7     Fields:    Translation:Humans
  26. Curatolo A, Villiger M, Lorenser D, Wijesinghe P, Fritz A, Kennedy BF, Sampson DD. Ultrahigh-resolution optical coherence elastography. Opt Lett. 2016 Jan 01; 41(1):21-4. PMID: 26696148.
    Citations: 6     Fields:    Translation:Animals
  27. Lo WCY, Villiger M, Golberg A, Broelsch GF, Khan S, Lian CG, Austen WG, Yarmush M, Bouma BE. Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging. J Invest Dermatol. 2016 Jan; 136(1):84-92. PMID: 26763427.
    Citations: 12     Fields:    Translation:Animals
  28. Berclaz C, Schmidt-Christensen A, Szlag D, Extermann J, Hansen L, Bouwens A, Villiger M, Goulley J, Schuit F, Grapin-Botton A, Lasser T, Holmberg D. Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging. Diabetologia. 2016 Mar; 59(3):550-9. PMID: 26613896.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  29. Lippok N, Villiger M, Bouma BE. Degree of polarization (uniformity) and depolarization index: unambiguous depolarization contrast for optical coherence tomography. Opt Lett. 2015 Sep 01; 40(17):3954-7. PMID: 26368685.
    Citations: 6     Fields:    
  30. Lippok N, Villiger M, Jun C, Bouma BE. Single input state, single-mode fiber-based polarization-sensitive optical frequency domain imaging by eigenpolarization referencing. Opt Lett. 2015 May 01; 40(9):2025-8. PMID: 25927775.
    Citations: 2     Fields:    Translation:HumansAnimals
  31. Beaudette K, Baac HW, Madore WJ, Villiger M, Godbout N, Bouma BE, Boudoux C. Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler. Biomed Opt Express. 2015 Apr 01; 6(4):1293-303. PMID: 25909013.
    Citations: 2     
  32. Quinn KP, Golberg A, Broelsch GF, Khan S, Villiger M, Bouma B, Austen WG, Sheridan RL, Mihm MC, Yarmush ML, Georgakoudi I. An automated image processing method to quantify collagen fibre organization within cutaneous scar tissue. Exp Dermatol. 2015 Jan; 24(1):78-80. PMID: 25256009.
    Citations: 10     Fields:    Translation:AnimalsCells
  33. Jun C, Villiger M, Oh WY, Bouma BE. All-fiber wavelength swept ring laser based on Fabry-Perot filter for optical frequency domain imaging. Opt Express. 2014 Oct 20; 22(21):25805-14. PMID: 25401614.
    Citations: 6     Fields:    Translation:Cells
  34. Uribe-Patarroyo N, Villiger M, Bouma BE. Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography. Opt Express. 2014 Oct 06; 22(20):24411-29. PMID: 25322018.
    Citations: 7     Fields:    
  35. Villiger M, Bouma BE. Practical decomposition for physically admissible differential Mueller matrices. Opt Lett. 2014 Apr 01; 39(7):1779-82. PMID: 24686603.
    Citations: 5     Fields:    
  36. Villiger M, Zhang EZ, Nadkarni SK, Oh WY, Vakoc BJ, Bouma BE. Spectral binning for mitigation of polarization mode dispersion artifacts in catheter-based optical frequency domain imaging. Opt Express. 2013 Jul 15; 21(14):16353-69. PMID: 23938487.
    Citations: 24     Fields:    Translation:Humans
  37. Villiger M, Zhang EZ, Nadkarni S, Oh WY, Bouma BE, Vakoc BJ. Artifacts in polarization-sensitive optical coherence tomography caused by polarization mode dispersion. Opt Lett. 2013 Mar 15; 38(6):923-5. PMID: 23503261.
    Citations: 12     Fields:    
  38. Hariri LP, Villiger M, Applegate MB, Mino-Kenudson M, Mark EJ, Bouma BE, Suter MJ. Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):125-9. PMID: 23322794.
    Citations: 7     Fields:    Translation:Humans
  39. Zhang EZ, Oh WY, Villiger ML, Chen L, Bouma BE, Vakoc BJ. Numerical compensation of system polarization mode dispersion in polarization-sensitive optical coherence tomography. Opt Express. 2013 Jan 14; 21(1):1163-80. PMID: 23389009.
    Citations: 13     Fields:    Translation:Animals
  40. Yang SY, O'Cearbhaill ED, Sisk GC, Park KM, Cho WK, Villiger M, Bouma BE, Pomahac B, Karp JM. A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue. Nat Commun. 2013; 4:1702. PMID: 23591869.
    Citations: 26     Fields:    
  41. Bolmont T, Bouwens A, Pache C, Dimitrov M, Berclaz C, Villiger M, Wegenast-Braun BM, Lasser T, Fraering PC. Label-free imaging of cerebral ß-amyloidosis with extended-focus optical coherence microscopy. J Neurosci. 2012 Oct 17; 32(42):14548-56. PMID: 23077040.
    Citations: 15     Fields:    Translation:HumansAnimals
  42. van Soest G, Villiger M, Regar E, Tearney GJ, Bouma BE, van der Steena AF. Errata: Frequency domain multiplexing for speckle reduction in optical coherence tomography. J Biomed Opt. 2012 Sep 28; 17(9):99801-1. PMID: 23085929.
  43. Pache C, Bocchio NL, Bouwens A, Villiger M, Berclaz C, Goulley J, Gibson MI, Santschi C, Lasser T. Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy. Opt Express. 2012 Sep 10; 20(19):21385-99. PMID: 23037262.
    Citations: 13     Fields:    Translation:HumansCells
  44. van Soest G, Villiger M, Regar E, Tearney GJ, Bouma BE, van der Steen AF. Frequency domain multiplexing for speckle reduction in optical coherence tomography. J Biomed Opt. 2012 Jul; 17(7):076018. PMID: 22894501.
    Citations: 5     Fields:    Translation:Humans
  45. Berclaz C, Goulley J, Villiger M, Pache C, Bouwens A, Martin-Williams E, Van de Ville D, Davison AC, Grapin-Botton A, Lasser T. Diabetes imaging-quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy. Biomed Opt Express. 2012 Jun 01; 3(6):1365-80. PMID: 22741082.
    Citations: 5     
  46. Villiger M, Soroka A, Tearney GJ, Bouma BE, Vakoc BJ. Injury depth control from combined wavelength and power tuning in scanned beam laser thermal therapy. J Biomed Opt. 2011 Nov; 16(11):118001. PMID: 22112139.
    Citations: 1     Fields:    Translation:Animals
  47. Villiger M, Pache C, Lasser T. Dark-field optical coherence microscopy. Opt Lett. 2010 Oct 15; 35(20):3489-91. PMID: 20967109.
    Citations: 10     Fields:    Translation:AnimalsCells
  48. Villiger M, Lasser T. Image formation and tomogram reconstruction in optical coherence microscopy. J Opt Soc Am A Opt Image Sci Vis. 2010 Oct 01; 27(10):2216-28. PMID: 20922012.
    Citations: 1     Fields:    
  49. Villiger M, Goulley J, Martin-Williams EJ, Grapin-Botton A, Lasser T. Towards high resolution optical imaging of beta cells in vivo. Curr Pharm Des. 2010 May; 16(14):1595-608. PMID: 20146662.
    Citations: 4     Fields:    Translation:HumansCells
  50. Villiger M, Goulley J, Friedrich M, Grapin-Botton A, Meda P, Lasser T, Leitgeb RA. In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy. Diabetologia. 2009 Aug; 52(8):1599-607. PMID: 19484218.
    Citations: 13     Fields:    Translation:AnimalsCells
  51. Seelamantula CS, Villiger ML, Leitgeb RA, Unser M. Exact and efficient signal reconstruction in frequency-domain optical-coherence tomography. J Opt Soc Am A Opt Image Sci Vis. 2008 Jul; 25(7):1762-71. PMID: 18594634.
    Citations: 1     Fields:    
  52. Michaely R, Bachmann AH, Villiger ML, Blatter C, Lasser T, Leitgeb RA. Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography. J Biomed Opt. 2007 Jul-Aug; 12(4):041213. PMID: 17867802.
    Citations: 24     Fields:    Translation:Humans
  53. Bachmann AH, Villiger ML, Blatter C, Lasser T, Leitgeb RA. Resonant Doppler flow imaging and optical vivisection of retinal blood vessels. Opt Express. 2007 Jan 22; 15(2):408-22. PMID: 19532258.
    Citations: 21     Fields:    
  54. Leitgeb RA, Villiger M, Bachmann AH, Steinmann L, Lasser T. Extended focus depth for Fourier domain optical coherence microscopy. Opt Lett. 2006 Aug 15; 31(16):2450-2. PMID: 16880852.
    Citations: 46     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.