Harvard Catalyst Profiles

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William Cameron Aird, M.D.

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Department
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Mentoring
Hagfish: A Model for Early Endothelium?
Summer, 05/30/05 - 08/19/05

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13HL132522 (AIRD, WILLIAM C) Jun 1, 2016 - May 31, 2017
    NIH/NHLBI
    19th International Vascular Biology Meeting
    Role: Principal Investigator
  2. R01HL119322 (AIRD, WILLIAM C) Jul 1, 2015 - Apr 30, 2019
    NIH/NHLBI
    Mechanisms of Mosaic Heterogeneity in Endothelium
    Role: Principal Investigator
  3. R01GM088184 (AIRD, WILLIAM C) Sep 15, 2009 - Aug 31, 2011
    NIH/NIGMS
    Role of VEGF and PlGF signaling in sepsis
    Role: Principal Investigator
  4. R01CA131152 (AIRD, WILLIAM C) Jul 1, 2008 - May 31, 2014
    NIH/NCI
    Downstream of Akt in the tumor vessel
    Role: Principal Investigator
  5. R01HL082927 (AIRD, WILLIAM C) Jan 19, 2007 - Dec 31, 2010
    NIH/NHLBI
    VEGF, Transcriptional Networks and Vascular Inflammation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Patell R, Bogue T, Bindal P, Koshy A, Merrill M, Aird WC, Bauer KA, Zwicker JI. Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19. J Thromb Haemost. 2020 Jul 21. PMID: 32692862.
    Citations:    
  2. Patell R, Khan A, Bogue T, Merrill M, Koshy A, Bindal P, Joyce R, Aird WC, Neuberg D, Bauer KA, Zwicker JI. Heparin induced thrombocytopenia antibodies in COVID-19. Am J Hematol. 2020 Jul 13. PMID: 32658337.
    Citations:    
  3. Turgeon PJ, Chan GC, Chen L, Jamal AN, Yan MS, Ho JJD, Yuan L, Ibeh N, Ku KH, Cybulsky MI, Aird WC, Marsden PA. Epigenetic Heterogeneity and Mitotic Heritability Prime Endothelial Cell Gene Induction. J Immunol. 2020 Mar 01; 204(5):1173-1187. PMID: 31996458.
    Citations:    
  4. Cleuren ACA, van der Ent MA, Jiang H, Hunker KL, Yee A, Siemieniak DR, Molema G, Aird WC, Ganesh SK, Ginsburg D. The in vivo endothelial cell translatome is highly heterogeneous across vascular beds. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23618-23624. PMID: 31712416.
    Citations:    
  5. Skibsted S, Bhasin MK, Henning DJ, Jaminet SC, Lewandowski J, Kirkegaard H, Aird WC, Shapiro NI. Leukocyte Transcriptional Response in Sepsis. Shock. 2019 08; 52(2):166-173. PMID: 30211758.
    Citations:    Fields:    
  6. Yang D, Thamcharoen N, Marcus C, Varkaris A, Aird W, Khankin EV, Cardarelli F. Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient. Case Rep Transplant. 2019; 2019:3682378. PMID: 30984439.
    Citations:    
  7. Mojiri A, Alavi P, Lorenzana Carrillo MA, Nakhaei-Nejad M, Sergi CM, Thebaud B, Aird WC, Jahroudi N. Endothelial cells of different organs exhibit heterogeneity in von Willebrand factor expression in response to hypoxia. Atherosclerosis. 2019 03; 282:1-10. PMID: 30665023.
    Citations:    Fields:    
  8. Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y. The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation. J Cell Sci. 2019 01 02; 132(1). PMID: 30510113.
    Citations:    Fields:    
  9. Massey MJ, Hou PC, Filbin M, Wang H, Ngo L, Huang DT, Aird WC, Novack V, Trzeciak S, Yealy DM, Kellum JA, Angus DC, Shapiro NI. Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial. Crit Care. 2018 Nov 20; 22(1):308. PMID: 30458880.
    Citations:    Fields:    
  10. Fabian-Jessing BK, Massey MJ, Filbin MR, Hou PC, Wang HE, Kirkegaard H, Yealy DM, Aird WC, Kellum JA, Angus DC, Shapiro NI. In vivo quantification of rolling and adhered leukocytes in human sepsis. Crit Care. 2018 09 30; 22(1):240. PMID: 30268146.
    Citations:    Fields:    
  11. Beeler DL, Aird WC, Grant MA. Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: reply. J Thromb Haemost. 2018 07; 16(7):1454-1456. PMID: 29734527.
    Citations:    Fields:    
  12. Tanaka T, Izawa K, Maniwa Y, Okamura M, Okada A, Yamaguchi T, Shirakura K, Maekawa N, Matsui H, Ishimoto K, Hino N, Nakagawa O, Aird WC, Mizuguchi H, Kawabata K, Doi T, Okada Y. ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation. Sci Rep. 2018 04 04; 8(1):5653. PMID: 29618782.
    Citations: 1     Fields:    
  13. Beeler DL, Aird WC, Grant MA. Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey. J Thromb Haemost. 2018 04; 16(4):734-748. PMID: 29418058.
    Citations:    Fields:    
  14. Shirakura K, Ishiba R, Kashio T, Sakai M, Fukushima Y, Yamamoto N, Manabe S, Shigesada N, Tanaka T, Hino N, Aird WC, Doi T, Okada Y. Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation. Biochem Biophys Res Commun. 2018 01 01; 495(1):801-806. PMID: 29137978.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Grant MA, Beeler DL, Spokes KC, Chen J, Dharaneeswaran H, Sciuto TE, Dvorak AM, Interlandi G, Lopez JA, Aird WC. Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis. Blood. 2017 12 07; 130(23):2548-2558. PMID: 28899852.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Hou PC, Filbin MR, Wang H, Ngo L, Huang DT, Aird WC, Yealy DM, Angus DC, Kellum JA, Shapiro NI. Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial. Chest. 2017 07; 152(1):22-31. PMID: 28109962.
    Citations: 3     Fields:    Translation:HumansCells
  17. Tanaka T, Maekawa N, Kashio T, Izawa K, Ishiba R, Shirakura K, Ishimoto K, Hino N, Aird WC, Doi T, Okada Y. Tumor Necrosis Factor a Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-?B Pathway. Biol Pharm Bull. 2017; 40(4):504-509. PMID: 28381804.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M. Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin. J Immunol. 2016 06 01; 196(11):4681-91. PMID: 27183587.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Deritei D, Aird WC, Ercsey-Ravasz M, Regan ER. Principles of dynamical modularity in biological regulatory networks. Sci Rep. 2016 Mar 16; 6:21957. PMID: 26979940.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  20. Yuan L, Chan GC, Beeler D, Janes L, Spokes KC, Dharaneeswaran H, Mojiri A, Adams WJ, Sciuto T, Garcia-Cardeña G, Molema G, Kang PM, Jahroudi N, Marsden PA, Dvorak A, Regan ER, Aird WC. A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. Nat Commun. 2016 Jan 08; 7:10160. PMID: 26744078.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  21. O'Donnell RK, Falcon B, Hanson J, Goldstein WE, Perruzzi C, Rafii S, Aird WC, Benjamin LE. VEGF-A/VEGFR Inhibition Restores Hematopoietic Homeostasis in the Bone Marrow and Attenuates Tumor Growth. Cancer Res. 2016 Feb 01; 76(3):517-24. PMID: 26719538.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Okada Y, Naruse H, Tanaka T, Funahashi N, Regan ER, Yamakawa K, Hino N, Ishimoto K, Doi T, Aird WC. Expression of the Robo4 receptor in endothelial cells is regulated by two AP-1 protein complexes. Biochem Biophys Res Commun. 2015 Nov 27; 467(4):987-91. PMID: 26459591.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM. Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med. 2015 Jul; 43(7):e230-40. PMID: 25855898.
    Citations: 10     Fields:    Translation:HumansAnimals
  24. Aird WC. Endothelium and haemostasis. Hamostaseologie. 2015; 35(1):11-6. PMID: 25666572.
    Citations: 7     Fields:    Translation:HumansAnimals
  25. Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z. PGC-1a induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014 Aug 15; 115(5):504-17. PMID: 25009290.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  26. Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler D, Spokes KC, Janes L, Sciuto T, Kang PM, Jaminet SS, Dvorak A, Grant MA, Regan ER, Aird WC. FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis. Circ Res. 2014 Jul 07; 115(2):238-251. PMID: 24874427.
    Citations: 12     Fields:    Translation:AnimalsCells
  27. Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T. Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1531-8. PMID: 24855053.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705.
    Citations: 9     Fields:    Translation:AnimalsCells
  29. Aird WC, Mosnier LO, Fairhurst RM. Plasmodium falciparum picks (on) EPCR. Blood. 2014 Jan 09; 123(2):163-7. PMID: 24246501.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach. Crit Care. 2013 Oct 04; 17(5):231. PMID: 24093155.
    Citations: 15     Fields:    Translation:Humans
  31. Okada Y, Watanabe M, Nakai T, Kamikawa Y, Shimizu M, Fukuhara Y, Yonekura M, Matsuura E, Hoshika Y, Nagai R, Aird WC, Doi T. RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4 gene expression in combination with ETS family proteins. J Thromb Haemost. 2013 Sep; 11(9):1742-50. PMID: 23848403.
    Citations: 2     Fields:    Translation:HumansCells
  32. Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13. PMID: 24052946.
    Citations: 40     Fields:    Translation:HumansCells
  33. O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird WC. Correction: Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice. PLoS One. 2013; 8(6). PMID: 23825515.
    Citations:    Fields:    
  34. Monahan-Earley R, Dvorak AM, Aird WC. Evolutionary origins of the blood vascular system and endothelium. J Thromb Haemost. 2013 Jun; 11 Suppl 1:46-66. PMID: 23809110.
    Citations: 20     Fields:    Translation:HumansAnimals
  35. Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Jul 18; 122(3):443-55. PMID: 23723450.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  36. Skibsted S, Jones AE, Puskarich MA, Arnold R, Sherwin R, Trzeciak S, Schuetz P, Aird WC, Shapiro NI. Biomarkers of endothelial cell activation in early sepsis. Shock. 2013 May; 39(5):427-32. PMID: 23524845.
    Citations: 33     Fields:    Translation:HumansCells
  37. Kurniati NF, Jongman RM, vom Hagen F, Spokes KC, Moser J, Regan ER, Krenning G, Moonen JR, Harmsen MC, Struys MM, Hammes HP, Zijlstra JG, Aird WC, Heeringa P, Molema G, van Meurs M. The flow dependency of Tie2 expression in endotoxemia. Intensive Care Med. 2013 Jul; 39(7):1262-71. PMID: 23563632.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  38. Yuan L, Janes L, Beeler D, Spokes KC, Smith J, Li D, Jaminet SC, Oettgen P, Aird WC. Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium. Blood. 2013 May 23; 121(21):4404-12. PMID: 23529929.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Shirodkar AV, St Bernard R, Gavryushova A, Kop A, Knight BJ, Yan MS, Man HS, Sud M, Hebbel RP, Oettgen P, Aird WC, Marsden PA. A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood. 2013 Apr 25; 121(17):3531-40. PMID: 23449636.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  40. Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek KH, Aird WC, Weiss MJ, Ryeom S. The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood. 2013 Apr 18; 121(16):3205-15. PMID: 23446734.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  41. Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S. Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody. Blood. 2013 Apr 04; 121(14):2804-13. PMID: 23365463.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird WC. Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice. PLoS One. 2013; 8(1):e55095. PMID: 23383068.
    Citations:    Fields:    Translation:HumansAnimalsCells
  43. Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, Beeler D, Spokes K, Aird WC, Baldwin HS, Oettgen P. Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov; 139(21):3973-85. PMID: 22932696.
    Citations: 18     Fields:    Translation:Animals
  44. Regan ER, Aird WC. Dynamical systems approach to endothelial heterogeneity. Circ Res. 2012 Jun 22; 111(1):110-30. PMID: 22723222.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  45. Schuetz P, Kennedy M, Lucas JM, Howell MD, Aird WC, Yealy DM, Shapiro NI. Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med. 2012 Jul; 125(7):670-8. PMID: 22608986.
    Citations: 10     Fields:    Translation:Humans
  46. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8. PMID: 22258235.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Herzig SJ, Aird WC, Shah BJ, McKernan M, Zeidel ML. From hagfish to humans: teaching comparative physiology to internal medicine residents. Acad Med. 2012 Mar; 87(3):372-7. PMID: 22373634.
    Citations: 1     Fields:    Translation:HumansAnimals
  48. Molema G, Aird WC. Vascular heterogeneity in the kidney. Semin Nephrol. 2012 Mar; 32(2):145-55. PMID: 22617763.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  49. Okada Y, Yonekura M, Watanabe M, Nakai T, Wakimura A, Shimizu M, Kamikawa Y, Kitayama M, Kitajima K, Aird WC, Doi T. Embryonic stem cell differentiation system for evaluating gene functions involved in physiological megakaryocytic differentiation. Biochem Biophys Res Commun. 2012 Mar 16; 419(3):477-81. PMID: 22342727.
    Citations:    Fields:    Translation:HumansAnimalsCells
  50. Yuan L, Le Bras A, Sacharidou A, Itagaki K, Zhan Y, Kondo M, Carman CV, Davis GE, Aird WC, Oettgen P. ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. J Biol Chem. 2012 Feb 24; 287(9):6582-91. PMID: 22235125.
    Citations: 30     Fields:    Translation:HumansCells
  51. Aird WC. Endothelial cell heterogeneity. Cold Spring Harb Perspect Med. 2012 Jan; 2(1):a006429. PMID: 22315715.
    Citations: 116     Fields:    Translation:HumansCells
  52. Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T. Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. PLoS One. 2011; 6(9):e24837. PMID: 21931859.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  53. Schuetz P, Jones AE, Aird WC, Shapiro NI. Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock. 2011 Aug; 36(2):104-8. PMID: 21522043.
    Citations: 14     Fields:    Translation:HumansCells
  54. Aird WC. Discovery of the cardiovascular system: from Galen to William Harvey. J Thromb Haemost. 2011 Jul; 9 Suppl 1:118-29. PMID: 21781247.
    Citations: 6     Fields:    Translation:Humans
  55. Schuetz P, Jones AE, Howell MD, Trzeciak S, Ngo L, Younger JG, Aird W, Shapiro NI. Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med. 2011 Nov; 58(5):438-44. PMID: 21683473.
    Citations: 10     Fields:    Translation:Humans
  56. Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood. 2011 Jul 28; 118(4):1145-53. PMID: 21628409.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  57. Tozawa H, Kanki Y, Suehiro J, Tsutsumi S, Kohro T, Wada Y, Aburatani H, Aird WC, Kodama T, Minami T. Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter. Mol Cell Biol. 2011 Jun; 31(11):2196-209. PMID: 21464207.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  58. Shapiro NI, Aird WC. Sepsis and the broken endothelium. Crit Care. 2011 Mar 21; 15(2):135. PMID: 21457513.
    Citations: 6     Fields:    Translation:Humans
  59. Schuetz P, Yano K, Sorasaki M, Ngo L, St Hilaire M, Lucas JM, Aird W, Shapiro NI. Influence of diabetes on endothelial cell response during sepsis. Diabetologia. 2011 May; 54(5):996-1003. PMID: 21286681.
    Citations: 8     Fields:    Translation:Humans
  60. Liu J, Yuan L, Molema G, Regan E, Janes L, Beeler D, Spokes KC, Okada Y, Minami T, Oettgen P, Aird WC. Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood. 2011 Jan 06; 117(1):342-51. PMID: 20980682.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  61. Wada Y, Li D, Merley A, Zukauskas A, Aird WC, Dvorak HF, Shih SC. A multi-gene transcriptional profiling approach to the discovery of cell signature markers. Cytotechnology. 2011 Jan; 63(1):25-33. PMID: 20972619.
    Citations: 9     Fields:    
  62. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182. PMID: 20942957.
    Citations: 59     Fields:    Translation:HumansCells
  63. Fischer CM, Yano K, Aird WC, Shapiro NI. Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection. J Emerg Med. 2012 Feb; 42(2):127-32. PMID: 20542399.
    Citations: 6     Fields:    Translation:Humans
  64. Lee M, Spokes KC, Aird WC, Abid MR. Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells. FEBS Lett. 2010 Jul 16; 584(14):3131-6. PMID: 20621840.
    Citations: 2     Fields:    Translation:HumansCells
  65. Aird WC. Proximate and evolutionary causation of endothelial heterogeneity. Semin Thromb Hemost. 2010 Apr; 36(3):276-85. PMID: 20490978.
    Citations: 2     Fields:    Translation:Humans
  66. Aird WC, Kwaan HC. Under-recognized significance of endothelial heterogeneity: hemostasis, thrombosis, and beyond. Semin Thromb Hemost. 2010 Apr; 36(3):225-6. PMID: 20490974.
    Citations: 1     Fields:    Translation:HumansAnimals
  67. Nassiri M, Liu J, Kulak S, Uwiera RR, Aird WC, Ballermann BJ, Jahroudi N. Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. Arterioscler Thromb Vasc Biol. 2010 Jul; 30(7):1423-9. PMID: 20431063.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  68. Damrauer SM, Fisher MD, Wada H, Siracuse JJ, da Silva CG, Moon K, Csizmadia E, Maccariello ER, Patel VI, Studer P, Essayagh S, Aird WC, Daniel S, Ferran C. A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis. 2010 Aug; 211(2):404-8. PMID: 20430393.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  69. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin SR, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54. PMID: 20351302.
    Citations: 20     Fields:    Translation:Humans
  70. Suehiro J, Hamakubo T, Kodama T, Aird WC, Minami T. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. Blood. 2010 Mar 25; 115(12):2520-32. PMID: 19965691.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  71. Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, Yano K, Janes L, Beeler D, Spokes KC, Li D, Regan E, Shih SC, Oettgen P, Minami T, Aird WC. Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood. 2009 Dec 24; 114(27):5557-66. PMID: 19822898.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  72. Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T. Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem. 2009 Oct 16; 284(42):29109-24. PMID: 19674970.
    Citations: 21     Fields:    Translation:HumansCells
  73. Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest. 2009 Aug; 119(8):2257-70. PMID: 19620774.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  74. Liu J, Kanki Y, Okada Y, Jin E, Yano K, Shih SC, Minami T, Aird WC. A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J Thromb Haemost. 2009 Aug; 7(8):1384-92. PMID: 19496923.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  75. Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009 Jun 25; 459(7250):1126-30. PMID: 19458618.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  76. Yuan L, Nikolova-Krstevski V, Zhan Y, Kondo M, Bhasin M, Varghese L, Yano K, Carman CV, Aird WC, Oettgen P. Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene. Circ Res. 2009 May 08; 104(9):1049-57. PMID: 19359602.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  77. Shapiro NI, Yano K, Sorasaki M, Fischer C, Shih SC, Aird WC. Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis. J Vasc Res. 2009; 46(5):495-502. PMID: 19346756.
    Citations: 12     Fields:    Translation:AnimalsCells
  78. Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008 Nov 14; 322(5904):1101-4. PMID: 19008446.
    Citations: 78     Fields:    Translation:AnimalsCells
  79. Yano K, Okada Y, Beldi G, Shih SC, Bodyak N, Okada H, Kang PM, Luscinskas W, Robson SC, Carmeliet P, Karumanchi SA, Aird WC. Elevated levels of placental growth factor represent an adaptive host response in sepsis. J Exp Med. 2008 Oct 27; 205(11):2623-31. PMID: 18852292.
    Citations: 15     Fields:    Translation:AnimalsCells
  80. Abid MR, Nadeau RJ, Spokes KC, Minami T, Li D, Shih SC, Aird WC. Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):2042-8. PMID: 18787186.
    Citations: 7     Fields:    Translation:HumansCells
  81. Aird WC. Molecular heterogeneity of tumor endothelium. Cell Tissue Res. 2009 Jan; 335(1):271-81. PMID: 18726119.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  82. Ganopolsky JG, Abid MR, Aird WC, Blostein MD. GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. J Thromb Haemost. 2008 Oct; 6(10):1804-11. PMID: 18680538.
    Citations: 3     Fields:    Translation:HumansCells
  83. Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC. A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood. 2008 Sep 15; 112(6):2336-9. PMID: 18519813.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  84. Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, Nakagawa S. Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker. Protein Expr Purif. 2008 Sep; 61(1):78-82. PMID: 18571431.
    Citations: 2     Fields:    Translation:HumansCells
  85. Séguin C, Abid MR, Spokes KC, Aird WC. Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells. Endothelium. 2008 May-Jun; 15(3):143-8. PMID: 18568955.
    Citations: 2     Fields:    Translation:HumansCells
  86. Shapiro NI, Yano K, Okada H, Fischer C, Howell M, Spokes KC, Ngo L, Angus DC, Aird WC. A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis. Shock. 2008 Apr; 29(4):452-7. PMID: 18598002.
    Citations: 44     Fields:    Translation:Humans
  87. Séguin C, Abid MR, Spokes KC, Schoots IG, Brkovic A, Sirois MG, Aird WC. Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells. Biomed Pharmacother. 2008 Jul-Aug; 62(6):395-400. PMID: 18406566.
    Citations: 1     Fields:    Translation:HumansCells
  88. Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells. Mol Pharmacol. 2008 May; 73(5):1454-64. PMID: 18227124.
    Citations: 19     Fields:    Translation:HumansCells
  89. Aird WC. Endothelium in health and disease. Pharmacol Rep. 2008 Jan-Feb; 60(1):139-43. PMID: 18276995.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  90. Abid MR, Spokes KC, Shih SC, Aird WC. NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem. 2007 Nov 30; 282(48):35373-85. PMID: 17908694.
    Citations: 57     Fields:    Translation:HumansCells
  91. Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M. G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol. 2007 Nov; 27(21):7582-93. PMID: 17724077.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  92. Hwa C, Aird WC. The history of the capillary wall: doctors, discoveries, and debates. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H2667-79. PMID: 17693543.
    Citations: 1     Fields:    Translation:HumansAnimals
  93. Aird WC. Vascular bed-specific thrombosis. J Thromb Haemost. 2007 Jul; 5 Suppl 1:283-91. PMID: 17635738.
    Citations: 18     Fields:    Translation:Humans
  94. Feng J, Yano K, Monahan-Earley R, Morgan ES, Dvorak AM, Sellke FW, Aird WC. Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa. Am J Physiol Regul Integr Comp Physiol. 2007 Aug; 293(2):R894-900. PMID: 17537844.
    Citations: 5     Fields:    Translation:Animals
  95. Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC. A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium. Circ Res. 2007 Jun 22; 100(12):1712-22. PMID: 17495228.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  96. Aird WC. Endothelium as a therapeutic target in sepsis. Curr Drug Targets. 2007 Apr; 8(4):501-7. PMID: 17430120.
    Citations: 26     Fields:    Translation:Humans
  97. Aird WC. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res. 2007 Feb 02; 100(2):158-73. PMID: 17272818.
    Citations: 374     Fields:    Translation:HumansAnimalsCells
  98. Aird WC. Phenotypic heterogeneity of the endothelium: II. Representative vascular beds. Circ Res. 2007 Feb 02; 100(2):174-90. PMID: 17272819.
    Citations: 254     Fields:    Translation:HumansAnimalsCells
  99. Inoue K, Kobayashi M, Yano K, Miura M, Izumi A, Mataki C, Doi T, Hamakubo T, Reid PC, Hume DA, Yoshida M, Aird WC, Kodama T, Minami T. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2652-9. PMID: 17008592.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  100. Yano K, Gale D, Massberg S, Cheruvu PK, Monahan-Earley R, Morgan ES, Haig D, von Andrian UH, Dvorak AM, Aird WC. Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium. Blood. 2007 Jan 15; 109(2):613-5. PMID: 16990601.
    Citations: 27     Fields:    Translation:AnimalsCells
  101. Abid MR, Shih SC, Otu HH, Spokes KC, Okada Y, Curiel DT, Minami T, Aird WC. A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. J Biol Chem. 2006 Nov 17; 281(46):35544-53. PMID: 16980307.
    Citations: 26     Fields:    Translation:HumansCells
  102. Abid MR, Yi X, Yano K, Shih SC, Aird WC. Vascular endocan is preferentially expressed in tumor endothelium. Microvasc Res. 2006 Nov; 72(3):136-45. PMID: 16956626.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  103. Aird WC. Endothelium and allotransplantation. Transplantation. 2006 Jul 15; 82(1 Suppl):S6-8. PMID: 16829797.
    Citations: 4     Fields:    Translation:Humans
  104. Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006 Jun 12; 203(6):1447-58. PMID: 16702604.
    Citations: 93     Fields:    Translation:HumansAnimals
  105. Minami T, Miura M, Aird WC, Kodama T. Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium. J Biol Chem. 2006 Jul 21; 281(29):20503-20. PMID: 16627481.
    Citations: 29     Fields:    Translation:HumansCells
  106. Aird WC. Mechanisms of endothelial cell heterogeneity in health and disease. Circ Res. 2006 Feb 03; 98(2):159-62. PMID: 16456105.
    Citations: 31     Fields:    Translation:HumansCells
  107. Aird WC. Endothelial cell heterogeneity and atherosclerosis. Curr Atheroscler Rep. 2006 Jan; 8(1):69-75. PMID: 16455017.
    Citations: 8     Fields:    Translation:HumansCells
  108. Aird WC. Coagulation. Crit Care Med. 2005 Dec; 33(12 Suppl):S485-7. PMID: 16340429.
    Citations: 1     Fields:    Translation:HumansAnimals
  109. Wada Y, Otu H, Wu S, Abid MR, Okada H, Libermann T, Kodama T, Shih SC, Minami T, Aird WC. Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell. FASEB J. 2005 Nov; 19(13):1914-6. PMID: 16172186.
    Citations: 11     Fields:    Translation:HumansCells
  110. Minami T, Aird WC. Endothelial cell gene regulation. Trends Cardiovasc Med. 2005 Jul; 15(5):174-84. PMID: 16165014.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  111. Aird WC. Sepsis and coagulation. Crit Care Clin. 2005 Jul; 21(3):417-31. PMID: 15992665.
    Citations: 9     Fields:    Translation:Humans
  112. Abid MR, Yano K, Guo S, Patel VI, Shrikhande G, Spokes KC, Ferran C, Aird WC. Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia. J Biol Chem. 2005 Aug 19; 280(33):29864-73. PMID: 15961397.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  113. Aird WC. Spatial and temporal dynamics of the endothelium. J Thromb Haemost. 2005 Jul; 3(7):1392-406. PMID: 15892866.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  114. Hwa C, Sebastian A, Aird WC. Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap. Endothelium. 2005 May-Jun; 12(3):139-51. PMID: 16291517.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  115. Wu SQ, Aird WC. Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H873-85. PMID: 15833800.
    Citations: 17     Fields:    Translation:HumansCells
  116. Rice L, Orlow D, Ceonzo K, Stahl GL, Tzianabos AO, Wada H, Aird WC, Buras JA. CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17. J Infect Dis. 2005 Apr 15; 191(8):1368-76. PMID: 15776385.
    Citations: 16     Fields:    Translation:AnimalsCells
  117. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC. Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem. 2004 Nov 26; 279(48):50537-54. PMID: 15448146.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  118. Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C, Aird WC. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J Biol Chem. 2004 Oct 15; 279(42):44030-8. PMID: 15308628.
    Citations: 26     Fields:    Translation:HumansCells
  119. Aird WC. Endothelium as an organ system. Crit Care Med. 2004 May; 32(5 Suppl):S271-9. PMID: 15118530.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  120. Rothermel AL, Wang Y, Schechner J, Mook-Kanamori B, Aird WC, Pober JS, Tellides G, Johnson DR. Endothelial cells present antigens in vivo. BMC Immunol. 2004 Mar 16; 5:5. PMID: 15113397.
    Citations: 15     Fields:    Translation:AnimalsCells
  121. Minami T, Murakami T, Horiuchi K, Miura M, Noguchi T, Miyazaki J, Hamakubo T, Aird WC, Kodama T. Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J Biol Chem. 2004 May 14; 279(20):20626-35. PMID: 15016828.
    Citations: 22     Fields:    Translation:HumansCells
  122. Aird WC. Natural anticoagulant inhibitors: activated Protein C. Best Pract Res Clin Haematol. 2004 Mar; 17(1):161-82. PMID: 15171965.
    Citations: 2     Fields:    Translation:Humans
  123. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):294-300. PMID: 14656735.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  124. Hameed SM, Aird WC, Cohn SM. Oxygen delivery. Crit Care Med. 2003 Dec; 31(12 Suppl):S658-67. PMID: 14724463.
    Citations: 9     Fields:    Translation:Humans
  125. Minami T, Sugiyama A, Wu SQ, Abid R, Kodama T, Aird WC. Thrombin and phenotypic modulation of the endothelium. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):41-53. PMID: 14551154.
    Citations: 41     Fields:    Translation:HumansCells
  126. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem. 2004 Jan 09; 279(2):1513-25. PMID: 14551207.
    Citations: 80     Fields:    Translation:HumansCells
  127. Minami T, Kuivenhoven JA, Evans V, Kodama T, Rosenberg RD, Aird WC. Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol. 2003 Nov 01; 23(11):2041-7. PMID: 12893685.
    Citations: 14     Fields:    Translation:AnimalsCells
  128. Aird WC. The hematologic system as a marker of organ dysfunction in sepsis. Mayo Clin Proc. 2003 Jul; 78(7):869-81. PMID: 12839083.
    Citations: 19     Fields:    Translation:Humans
  129. Aird WC. Endothelial cell heterogeneity. Crit Care Med. 2003 Apr; 31(4 Suppl):S221-30. PMID: 12682444.
    Citations: 60     Fields:    Translation:HumansAnimals
  130. Aird WC. Hemostasis and irreducible complexity. J Thromb Haemost. 2003 Feb; 1(2):227-30. PMID: 12871493.
    Citations: 3     Fields:    Translation:HumansAnimals
  131. Pawlinski R, Pedersen B, Kehrle B, Aird WC, Frank RD, Guha M, Mackman N. Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood. 2003 May 15; 101(10):3940-7. PMID: 12543866.
    Citations: 29     Fields:    Translation:AnimalsCells
  132. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003 May 15; 101(10):3765-77. PMID: 12543869.
    Citations: 256     Fields:    Translation:Humans
  133. Warkentin TE, Aird WC, Rand JH. Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program. 2003; 497-519. PMID: 14633796.
    Citations: 28     Fields:    Translation:HumansCells
  134. Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84. PMID: 12493764.
    Citations: 23     Fields:    Translation:HumansCells
  135. Minami T, Donovan DJ, Tsai JC, Rosenberg RD, Aird WC. Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. Blood. 2002 Dec 01; 100(12):4019-25. PMID: 12393668.
    Citations: 11     Fields:    Translation:AnimalsCells
  136. Aird WC, Glueck SB, Dzau VJ, Pratt RE. Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set". Physiol Genomics. 2002 Jul 12; 10(1):1-3. PMID: 12118099.
    Citations:    Fields:    Translation:HumansAnimals
  137. Wu SQ, Minami T, Donovan DJ, Aird WC. The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood. 2002 Dec 15; 100(13):4454-61. PMID: 12393577.
    Citations: 15     Fields:    Translation:HumansCells
  138. Aird WC, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-2002. A 53-year-old man with a myocardial infarct and thromboses after coronary-artery bypass grafting. N Engl J Med. 2002 05 16; 346(20):1562-70. PMID: 12015397.
    Citations: 4     Fields:    Translation:Humans
  139. Aird WC. Endothelial cell dynamics and complexity theory. Crit Care Med. 2002 May; 30(5 Suppl):S180-5. PMID: 12004233.
    Citations: 5     Fields:    Translation:Humans
  140. Tsai JC, Zhang J, Minami T, Voland C, Zhao S, Yi X, Lassalle P, Oettgen P, Aird WC. Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter. J Vasc Res. 2002 Mar-Apr; 39(2):148-59. PMID: 12011586.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  141. Bao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post MJ. PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2612-8. PMID: 11709430.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  142. Stevens T, Rosenberg R, Aird W, Quertermous T, Johnson FL, Garcia JG, Hebbel RP, Tuder RM, Garfinkel S. NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1422-33. PMID: 11600404.
    Citations: 20     Fields:    Translation:HumansAnimals
  143. Tsai JC, Liu L, Zhang J, Spokes KC, Topper JN, Aird WC. Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo. Am J Physiol Gastrointest Liver Physiol. 2001 Nov; 281(5):G1271-8. PMID: 11668036.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  144. Minami T, Aird WC. Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs. J Biol Chem. 2001 Dec 14; 276(50):47632-41. PMID: 11590177.
    Citations: 25     Fields:    Translation:HumansCells
  145. Abid MR, Tsai JC, Spokes KC, Deshpande SS, Irani K, Aird WC. Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism. FASEB J. 2001 Nov; 15(13):2548-50. PMID: 11641265.
    Citations: 35     Fields:    Translation:HumansCells
  146. Aird WC. Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis. Crit Care Med. 2001 Jul; 29(7 Suppl):S28-34; discussion S34-5. PMID: 11445731.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  147. Abid MR, Kachra Z, Spokes KC, Aird WC. NADPH oxidase activity is required for endothelial cell proliferation and migration. FEBS Lett. 2000 Dec 15; 486(3):252-6. PMID: 11119713.
    Citations: 54     Fields:    Translation:HumansCells
  148. Minami T, Rosenberg RD, Aird WC. Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA site. J Biol Chem. 2001 Feb 16; 276(7):5395-402. PMID: 11098056.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  149. Tsai JC, Liu L, Guan J, Aird WC. The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells. Am J Physiol Cell Physiol. 2000 Nov; 279(5):C1414-24. PMID: 11029289.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  150. Tsai JC, Liu L, Cooley BC, DiChiara MR, Topper JN, Aird WC. The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice. FASEB J. 2000 Oct; 14(13):1870-2. PMID: 11023970.
    Citations: 11     Fields:    Translation:AnimalsCells
  151. Liu L, Tsai JC, Aird WC. Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor. Blood. 2000 Sep 01; 96(5):1772-81. PMID: 10961876.
    Citations: 17     Fields:    Translation:AnimalsCells
  152. Sternberg DW, Aird W, Neuberg D, Thompson L, MacNeill K, Amrein P, Shulman LN. Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen. Cancer. 2000 May 01; 88(9):2037-41. PMID: 10813714.
    Citations: 1     Fields:    Translation:Humans
  153. Evans V, Hatzopoulos A, Aird WC, Rayburn HB, Rosenberg RD, Kuivenhoven JA. Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000 Mar 13; 2(2):67-75. PMID: 11015584.
    Citations: 17     Fields:    Translation:AnimalsCells
  154. Guillot PV, Liu L, Kuivenhoven JA, Guan J, Rosenberg RD, Aird WC. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics. 2000 Mar 13; 2(2):77-83. PMID: 11015585.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  155. Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Sellke F, Carmeliet P, Simons M. PR39, a peptide regulator of angiogenesis. Nat Med. 2000 Jan; 6(1):49-55. PMID: 10613823.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  156. Gross PL, Aird WC. The endothelium and thrombosis. Semin Thromb Hemost. 2000; 26(5):463-78. PMID: 11129402.
    Citations: 13     Fields:    Translation:HumansAnimals
  157. Guan J, Guillot PV, Aird WC. Characterization of the mouse von Willebrand factor promoter. Blood. 1999 Nov 15; 94(10):3405-12. PMID: 10552950.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  158. Rosenberg RD, Aird WC. Vascular-bed--specific hemostasis and hypercoagulable states. N Engl J Med. 1999 May 20; 340(20):1555-64. PMID: 10332019.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  159. Guillot PV, Guan J, Liu L, Kuivenhoven JA, Rosenberg RD, Sessa WC, Aird WC. A vascular bed-specific pathway. J Clin Invest. 1999 Mar; 103(6):799-805. PMID: 10079100.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  160. Edelberg JM, Aird WC, Wu W, Rayburn H, Mamuya WS, Mercola M, Rosenberg RD. PDGF mediates cardiac microvascular communication. J Clin Invest. 1998 Aug 15; 102(4):837-43. PMID: 9710453.
    Citations: 20     Fields:    Translation:AnimalsCells
  161. Edelberg JM, Aird WC, Rosenberg RD. Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J Clin Invest. 1998 Jan 15; 101(2):337-43. PMID: 9435305.
    Citations: 24     Fields:    Translation:Animals
  162. Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 1997 Sep 08; 138(5):1117-24. PMID: 9281588.
    Citations: 52     Fields:    Translation:Animals
  163. Weiler-Guettler H, Aird WC, Rayburn H, Husain M, Rosenberg RD. Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos. Development. 1996 Jul; 122(7):2271-81. PMID: 8681807.
    Citations: 7     Fields:    Translation:AnimalsCells
  164. Weiler-Guettler H, Aird WC, Husain M, Rayburn H, Rosenberg RD. Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus. Circ Res. 1996 Feb; 78(2):180-7. PMID: 8575060.
    Citations: 15     Fields:    Translation:AnimalsCells
  165. Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB, Rosenberg RD. Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4567-71. PMID: 7753844.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  166. Aird WC, Parvin JD, Sharp PA, Rosenberg RD. The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. A model of tissue-specific gene expression. J Biol Chem. 1994 Jan 14; 269(2):883-9. PMID: 8288642.
    Citations: 10     Fields:    Translation:AnimalsCells
  167. Aird W, Labopin M, Gorin NC, Antin JH. Long-term cryopreservation of human stem cells. Bone Marrow Transplant. 1992 Jun; 9(6):487-90. PMID: 1628134.
    Citations: 4     Fields:    Translation:HumansCells
  168. Aird W, Cheema-Dhadli S, Sonnenberg B, Vandenbroucke A, Halperin M. Can oxygen consumption in blood in vitro be detected by a change in PCO2? Clin Invest Med. 1991 Apr; 14(2):125-30. PMID: 1905601.
    Citations:    Fields:    Translation:Humans
  169. Aird W, Douek K, Halperin ML. Profound hypokalemia secondary to modest potassium depletion in a patient with coexisting hyponatremia: therapeutic implications. Am J Kidney Dis. 1988 Aug; 12(2):164-6. PMID: 3400636.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.