Harvard Catalyst Profiles

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Hao Wu, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014 Dec; 24(12):1420-32. PMID: 25367124.
    Citations: 10     Fields:    Translation:AnimalsCells
  2. Wu H, Wu X, Shen L, Zhang Y. Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing. Nat Biotechnol. 2014 Dec; 32(12):1231-40. PMID: 25362244.
    Citations: 33     Fields:    Translation:AnimalsCells
  3. Wu H, Zhang Y. Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell. 2014 Jan 16; 156(1-2):45-68. PMID: 24439369.
    Citations: 300     Fields:    Translation:HumansAnimalsCells
  4. Shen L, Wu H, Diep D, Yamaguchi S, D'Alessio AC, Fung HL, Zhang K, Zhang Y. Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell. 2013 Apr 25; 153(3):692-706. PMID: 23602152.
    Citations: 188     Fields:    Translation:AnimalsCells
  5. He J, Shen L, Wan M, Taranova O, Wu H, Zhang Y. Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol. 2013 Apr; 15(4):373-84. PMID: 23502314.
    Citations: 96     Fields:    Translation:AnimalsCells
  6. Soh BS, Wu H, Chien KR. Cardiac regenerative medicine 2.0. Nat Biotechnol. 2013 Mar; 31(3):209-11. PMID: 23471068.
    Citations:    Fields:    Translation:Humans
  7. Wu H, Zhang Y. Early embryos reprogram DNA methylation in two steps. Cell Stem Cell. 2012 May 04; 10(5):487-9. PMID: 22560071.
    Citations: 7     Fields:    
  8. Wu H, Tao J, Sun YE. Regulation and function of mammalian DNA methylation patterns: a genomic perspective. Brief Funct Genomics. 2012 May; 11(3):240-50. PMID: 22402507.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Wu H, Zhang Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 2011 Dec 01; 25(23):2436-52. PMID: 22156206.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  10. Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, Chien KR. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Res. 2012 Jan; 22(1):142-54. PMID: 22064699.
    Citations: 29     Fields:    Translation:AnimalsCells
  11. Wu H, Zhang Y. Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells. . 2011 Aug 01; 10(15):2428-36. PMID: 21750410.
    Citations: 58     Translation:AnimalsCells
  12. Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE. Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci. 2011 Jun 01; 31(22):8306-19. PMID: 21632951.
    Citations: 77     Fields:    Translation:AnimalsCells
  13. Wu H, D'Alessio AC, Ito S, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 2011 Apr 01; 25(7):679-84. PMID: 21460036.
    Citations: 237     Fields:    Translation:AnimalsCells
  14. Wu H, D'Alessio AC, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011 May 19; 473(7347):389-93. PMID: 21451524.
    Citations: 278     Fields:    Translation:AnimalsCells
  15. Wu H, Tao J, Chen PJ, Shahab A, Ge W, Hart RP, Ruan X, Ruan Y, Sun YE. Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18161-6. PMID: 20921386.
    Citations: 66     Fields:    Translation:AnimalsCells
  16. Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, Li E, Zhang Y, Sun YE. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science. 2010 Jul 23; 329(5990):444-8. PMID: 20651149.
    Citations: 237     Fields:    Translation:AnimalsCells
  17. Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE, Hart RP. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PLoS One. 2009 Sep 28; 4(9):e7192. PMID: 19784364.
    Citations: 62     Fields:    Translation:HumansCells
  18. Wu H, Sun YE. Reversing DNA methylation: new insights from neuronal activity-induced Gadd45b in adult neurogenesis. Sci Signal. 2009 Mar 31; 2(64):pe17. PMID: 19336837.
    Citations: 13     Fields:    Translation:HumansCells
  19. Tao J, Hu K, Chang Q, Wu H, Sherman NE, Martinowich K, Klose RJ, Schanen C, Jaenisch R, Wang W, Sun YE. Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4882-7. PMID: 19225110.
    Citations: 107     Fields:    Translation:AnimalsCells
  20. Tao J, Wu H, Sun YE. Deciphering Rett syndrome with mouse genetics, epigenomics, and human neurons. Int Rev Neurobiol. 2009; 89:147-60. PMID: 19900619.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. Copy number variant analysis of human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1484-9. PMID: 18369100.
    Citations: 17     Fields:    Translation:HumansCells
  22. Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J, Biancotti JC, Hutnick L, Krueger RC, Fan G, de Vellis J, Sun YE. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1026-31. PMID: 18195354.
    Citations: 109     Fields:    Translation:AnimalsCells
  23. Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE, Kornblum HI, Huang J. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol. 2007 Sep; 14(9):1019-30. PMID: 17884634.
    Citations: 28     Fields:    Translation:HumansCells
  24. Wu H, Xu J, Pang ZP, Ge W, Kim KJ, Blanchi B, Chen C, Südhof TC, Sun YE. Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13821-6. PMID: 17693548.
    Citations: 59     Fields:    Translation:HumansCells
  25. Bredy TW, Wu H, Crego C, Zellhoefer J, Sun YE, Barad M. Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem. 2007 Apr; 14(4):268-76. PMID: 17522015.
    Citations: 204     Fields:    Translation:AnimalsCells
  26. Wu H, Sun YE. Epigenetic regulation of stem cell differentiation. Pediatr Res. 2006 Apr; 59(4 Pt 2):21R-5R. PMID: 16549544.
    Citations: 27     Fields:    Translation:HumansCells
  27. Krueger RC, Wu H, Zandian M, Danielpour M, Kabos P, Yu JS, Sun YE. Neural progenitors populate the cerebrospinal fluid of preterm patients with hydrocephalus. J Pediatr. 2006 Mar; 148(3):337-340. PMID: 16615963.
    Citations: 7     Fields:    Translation:HumansCells
  28. Sun YE, Wu H. The ups and downs of BDNF in Rett syndrome. Neuron. 2006 Feb 02; 49(3):321-3. PMID: 16446133.
    Citations: 16     Fields:    Translation:HumansAnimals
  29. Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1319-24. PMID: 16432194.
    Citations: 76     Fields:    Translation:AnimalsCells
  30. Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 2005 Aug; 132(15):3345-56. PMID: 16014513.
    Citations: 140     Fields:    Translation:AnimalsCells
  31. He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005 May; 8(5):616-25. PMID: 15852015.
    Citations: 131     Fields:    Translation:AnimalsCells
  32. Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z. Crystal structure of human coactosin-like protein at 1.9 A resolution. Protein Sci. 2004 Nov; 13(11):2845-51. PMID: 15459340.
    Citations: 6     Fields:    Translation:HumansCells
  33. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003 Oct 31; 302(5646):890-3. PMID: 14593184.
    Citations: 510     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.