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Paolo Antonio S. Silva, M.D.

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Thelma J Yambao Memorial Award
Award of Recognition
Certificate of Distinction
Best Clinical Poster
ARVO Travel Scholarship
Yasuo Tano Travel Award
Awardee for Medicine, The Outstanding Young Men, Philippines 2013
2013 - 2014
Young Clinician Award
2013 - 2014
Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine
Outstanding Young Scientist
Presidential Award for Filipino Individuals and Organizations Overseas
International Ophthalmologist Education Award
2015 - 2016
Sight First Award

Paolo Antonio S. Silva, MD is Staff Ophthalmologist and Assistant Chief of Telemedicine at the Beetham Eye Institute of the Joslin Diabetes Center. He holds an academic appointment as assistant professor of ophthalmology at Harvard Medical School. He is an associate surgeon at Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center in Boston, MA.

Dr. Silva's work is focused on innovative and investigative work at a field that is at the intersection of clinical care and technology with the hope of providing an ideal model for the delivery of evidence based highly effective and efficient diabetes eye care to the population that needs it the most.

His interests include ocular telemedicine, anti-angiogenic therapeutic modalities for diabetic retinal disease, wide-field retinal imaging to identify novel retinal lesions, development of decision-support algorithms through clinical outcome analysis and telemedicine approaches for diabetic retinal disease. Dr. Silva actively directs the efforts of the Joslin Vision Network to the ultimate goal of delivering the highest quality of diabetes eye care and promoting collaborative research that is free from disparities induced by geographic, political, or cultural boundaries.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Peterson SR, Silva PA, Murtha TJ, Sun JK. Cataract Surgery in Patients with Diabetes: Management Strategies. Semin Ophthalmol. 2018; 33(1):75-82. PMID: 29144826.
    Citations: 14     Fields:    Translation:Humans
  2. Silva PS, El-Rami H, Barham R, Gupta A, Fleming A, van Hemert J, Cavallerano JD, Sun JK, Aiello LP. Hemorrhage and/or Microaneurysm Severity and Count in Ultrawide Field Images and Early Treatment Diabetic Retinopathy Study Photography. Ophthalmology. 2017 07; 124(7):970-976. PMID: 28336057.
    Citations: 18     Fields:    Translation:Humans
  3. Silva PS, Horton MB, Clary D, Lewis DG, Sun JK, Cavallerano JD, Aiello LP. Identification of Diabetic Retinopathy and Ungradable Image Rate with Ultrawide Field Imaging in a National Teleophthalmology Program. Ophthalmology. 2016 06; 123(6):1360-7. PMID: 26949120.
    Citations: 27     Fields:    Translation:Humans
  4. Silva PS, Cavallerano JD, Haddad NM, Tolls D, Thakore K, Patel B, Sehizadeh M, Tolson AM, Sun JK, Aiello LP. Comparison of Nondiabetic Retinal Findings Identified With Nonmydriatic Fundus Photography vs Ultrawide Field Imaging in an Ocular Telehealth Program. JAMA Ophthalmol. 2016 Mar; 134(3):330-4. PMID: 26795026.
    Citations: 12     Fields:    Translation:Humans
  5. Sun JK, Cavallerano JD, Silva PS. Future Promise of and Potential Pitfalls for Automated Detection of Diabetic Retinopathy. JAMA Ophthalmol. 2016 Feb; 134(2):210-1. PMID: 26720257.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  6. Silva PS, Dela Cruz AJ, Ledesma MG, van Hemert J, Radwan A, Cavallerano JD, Aiello LM, Sun JK, Aiello LP. Diabetic Retinopathy Severity and Peripheral Lesions Are Associated with Nonperfusion on Ultrawide Field Angiography. Ophthalmology. 2015 Dec; 122(12):2465-72. PMID: 26350546.
    Citations: 64     Fields:    Translation:Humans
  7. Silva PS, Cavallerano JD, Tolson AM, Rodriguez J, Rodriguez S, Ajlan R, Tolls D, Patel B, Sehizadeh M, Thakore K, Sun JK, Aiello LP. Real-Time Ultrawide Field Image Evaluation of Retinopathy in a Diabetes Telemedicine Program. Diabetes Care. 2015 Sep; 38(9):1643-9. PMID: 26033507.
    Citations: 16     Fields:    Translation:Humans
  8. Marra KV, Wagley S, Omar A, Kinoshita T, Kovacs KD, Silva P, Kuperwaser MC, Arroyo JG. Case-matched comparison of vitrectomy, peripheral retinal endolaser, and endocyclophotocoagulation versus standard care in neovascular glaucoma. Retina. 2015 Jun; 35(6):1072-83. PMID: 25621944.
    Citations: 4     Fields:    Translation:Humans
  9. Bressler SB, Almukhtar T, Bhorade A, Bressler NM, Glassman AR, Huang SS, Jampol LM, Kim JE, Melia M. Repeated intravitreous ranibizumab injections for diabetic macular edema and the risk of sustained elevation of intraocular pressure or the need for ocular hypotensive treatment. JAMA Ophthalmol. 2015 May; 133(5):589-97. PMID: 25719991.
    Citations: 22     Fields:    Translation:HumansCTClinical Trials
  10. Silva PS, Aiello LP. Telemedicine and eye examinations for diabetic retinopathy: a time to maximize real-world outcomes. JAMA Ophthalmol. 2015 May; 133(5):525-6. PMID: 25742322.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  11. Sim DA, Keane PA, Tufail A, Egan CA, Aiello LP, Silva PS. Automated retinal image analysis for diabetic retinopathy in telemedicine. Curr Diab Rep. 2015 Mar; 15(3):14. PMID: 25697773.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  12. Silva PS, Cavallerano JD, Haddad NM, Kwak H, Dyer KH, Omar AF, Shikari H, Aiello LM, Sun JK, Aiello LP. Peripheral Lesions Identified on Ultrawide Field Imaging Predict Increased Risk of Diabetic Retinopathy Progression over 4 Years. Ophthalmology. 2015 May; 122(5):949-56. PMID: 25704318.
    Citations: 75     Fields:    Translation:Humans
  13. Wells JA, Glassman AR, Ayala AR, Jampol LM, Aiello LP, Antoszyk AN, Arnold-Bush B, Baker CW, Bressler NM, Browning DJ, Elman MJ, Ferris FL, Friedman SM, Melia M, Pieramici DJ, Sun JK, Beck RW. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015 Mar 26; 372(13):1193-203. PMID: 25692915.
    Citations: 427     Fields:    Translation:Humans
  14. Sun JK, Radwan SH, Soliman AZ, Lammer J, Lin MM, Prager SG, Silva PS, Aiello LB, Aiello LP. Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema. Diabetes. 2015 Jul; 64(7):2560-70. PMID: 25633419.
    Citations: 64     Fields:    Translation:Humans
  15. Sun JK, Lin MM, Lammer J, Prager S, Sarangi R, Silva PS, Aiello LP. Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema. JAMA Ophthalmol. 2014 Nov; 132(11):1309-16. PMID: 25058813.
    Citations: 111     Fields:    Translation:Humans
  16. Silva PS, Diala PA, Hamam RN, Arrigg PG, Shah ST, Murtha TL, Schlossman DK, Cavallerano JD, Sun JK, Aiello LP. Visual outcomes from pars plana vitrectomy versus combined pars plana vitrectomy, phacoemulsification, and intraocular lens implantation in patients with diabetes. Retina. 2014 Oct; 34(10):1960-8. PMID: 24830822.
    Citations: 9     Fields:    Translation:Humans
  17. Haddad NM, Sun JK, Abujaber S, Schlossman DK, Silva PS. Cataract surgery and its complications in diabetic patients. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):329-37. PMID: 25325858.
    Citations: 19     Fields:    Translation:Humans
  18. Deschler EK, Sun JK, Silva PS. Side-effects and complications of laser treatment in diabetic retinal disease. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):290-300. PMID: 25325854.
    Citations: 16     Fields:    Translation:Humans
  19. Shikari H, Silva PS, Sun JK. Complications of intravitreal injections in patients with diabetes. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):276-89. PMID: 25325853.
    Citations: 15     Fields:    Translation:Humans
  20. Santiago JG, Walia S, Sun JK, Cavallerano JD, Haddad ZA, Aiello LP, Silva PS. Influence of diabetes and diabetes type on anatomic and visual outcomes following central rein vein occlusion. Eye (Lond). 2014 Mar; 28(3):259-68. PMID: 24525865.
    Citations: 5     Fields:    Translation:Humans
  21. Haddad NM, Cavallerano JD, Silva PS. Von hippel-lindau disease: a genetic and clinical review. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):377-86. PMID: 24138046.
    Citations: 16     Fields:    Translation:Humans
  22. Dyer KH, Silva PS, Sun JK. Vascular endothelial growth factor gene polymorphisms and vitreous proteome changes in diabetic retinopathy. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):347-54. PMID: 24138044.
    Citations: 1     Fields:    Translation:Humans
  23. Omar AF, Silva PS, Sun JK. Genetics of diabetic retinopathy. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):337-46. PMID: 24138043.
    Citations: 8     Fields:    Translation:Humans
  24. Silva PS, Cavallerano JD, Tolls D, Omar A, Thakore K, Patel B, Sehizadeh M, Tolson AM, Sun JK, Aiello LM, Aiello LP. Potential efficiency benefits of nonmydriatic ultrawide field retinal imaging in an ocular telehealth diabetic retinopathy program. Diabetes Care. 2014; 37(1):50-5. PMID: 23939541.
    Citations: 34     Fields:    Translation:Humans
  25. Bressler SB, Qin H, Melia M, Bressler NM, Beck RW, Chan CK, Grover S, Miller DG. Exploratory analysis of the effect of intravitreal ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial. JAMA Ophthalmol. 2013 Aug; 131(8):1033-40. PMID: 23807371.
    Citations: 40     Fields:    Translation:Humans
  26. Silva PS, Cavallerano JD, Sun JK, Soliman AZ, Aiello LM, Aiello LP. Peripheral lesions identified by mydriatic ultrawide field imaging: distribution and potential impact on diabetic retinopathy severity. Ophthalmology. 2013 Dec; 120(12):2587-2595. PMID: 23778092.
    Citations: 67     Fields:    Translation:Humans
  27. Aranda J, Motiejunaite R, Silva P, Aiello LP, Kazlauskas A. Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy. Diabetologia. 2013 Jun; 56(6):1444-53. PMID: 23508305.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  28. Randomized clinical trial evaluating intravitreal ranibizumab or saline for vitreous hemorrhage from proliferative diabetic retinopathy. JAMA Ophthalmol. 2013 Mar; 131(3):283-93. PMID: 23370902.
    Citations: 32     Fields:    Translation:HumansCTClinical Trials
  29. Silva PS, Cavallerano JD, Pacheco EP, Aiello LP. Diabetic Retinopathy in Southeast Asia: A Call for Ocular Telehealth Programs. JAFES. 2012; 2(27):176-179.
  30. Soliman AZ, Silva PS, Aiello LP, Sun JK. Ultra-wide field retinal imaging in detection, classification, and management of diabetic retinopathy. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):221-7. PMID: 23163280.
    Citations: 23     Fields:    Translation:Humans
  31. Silva PS, Walia S, Cavallerano JD, Sun JK, Dunn C, Bursell SE, Aiello LM, Aiello LP. Comparison of low-light nonmydriatic digital imaging with 35-mm ETDRS seven-standard field stereo color fundus photographs and clinical examination. Telemed J E Health. 2012 Sep; 18(7):492-9. PMID: 22827402.
    Citations: 8     Fields:    Translation:Humans
  32. Al-Latayfeh M, Silva PS, Sun JK, Aiello LP. Antiangiogenic therapy for ischemic retinopathies. Cold Spring Harb Perspect Med. 2012 Jun; 2(6):a006411. PMID: 22675660.
    Citations: 27     Fields:    Translation:Humans
  33. Silva PS, Cavallerano JD, Sun JK, Noble J, Aiello LM, Aiello LP. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy. Am J Ophthalmol. 2012 Sep; 154(3):549-559.e2. PMID: 22626617.
    Citations: 58     Fields:    Translation:Humans
  34. Maker MP, Noble J, Silva PS, Cavallerano JD, Murtha TJ, Sun JK, Aiello LM, Bursell SE, Aiello LP. Automated Retinal Imaging System (ARIS) compared with ETDRS protocol color stereoscopic retinal photography to assess level of diabetic retinopathy. Diabetes Technol Ther. 2012 Jun; 14(6):515-22. PMID: 22385213.
    Citations: 5     Fields:    Translation:Humans
  35. Kovacs K, Wagley S, Quirk MT, Ceron OM, Silva PA, Singh RJ, Gukasyan HJ, Arroyo JG. Pharmacokinetic study of vitreous and serum concentrations of triamcinolone acetonide after posterior sub-tenon's injection. Am J Ophthalmol. 2012 May; 153(5):939-48. PMID: 22310078.
    Citations: 14     Fields:    Translation:Humans
  36. Cavallerano JD, Silva PS, Tolson AM, Francis T, Tolls D, Patel B, Eagan S, Aiello LM, Aiello LP. Imager evaluation of diabetic retinopathy at the time of imaging in a telemedicine program. Diabetes Care. 2012 Mar; 35(3):482-4. PMID: 22238278.
    Citations: 6     Fields:    Translation:Humans
  37. Gangaputra S, Almukhtar T, Glassman AR, Aiello LP, Bressler N, Bressler SB, Danis RP, Davis MD. Comparison of film and digital fundus photographs in eyes of individuals with diabetes mellitus. Invest Ophthalmol Vis Sci. 2011 Aug 03; 52(9):6168-73. PMID: 21571677.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  38. Silva PS, Cavallerano JD, Aiello LM, Aiello LP. Telemedicine and diabetic retinopathy: moving beyond retinal screening. Arch Ophthalmol. 2011 Feb; 129(2):236-42. PMID: 21320974.
    Citations: 22     Fields:    Translation:Humans
  39. Silva PS, Haddad ZA, Sun JK, Cavallerano JD, Aiello LP. Therapy of Ocular Angiogenesis: Principles and Practice. Anti-VEGF Therapies in Diabetic Macular Edema. Das A, Friedberg T (eds). 2011; 154-169.
  40. Sanchez CR, Silva PS, Cavallerano JD, Aiello LP, Aiello LM. Ocular telemedicine for diabetic retinopathy and the Joslin Vision Network. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):218-24. PMID: 21091003.
    Citations: 8     Fields:    Translation:Humans
  41. Silva PS, Cavallerano JD, Sun JK, Aiello LM, Aiello LP. Effect of systemic medications on onset and progression of diabetic retinopathy. Nat Rev Endocrinol. 2010 Sep; 6(9):494-508. PMID: 20664533.
    Citations: 12     Fields:    Translation:Humans
  42. Elman MJ, Aiello LP, Beck RW, Bressler NM, Bressler SB, Edwards AR, Ferris FL, Friedman SM, Glassman AR, Miller KM, Scott IU, Stockdale CR, Sun JK. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010 Jun; 117(6):1064-1077.e35. PMID: 20427088.
    Citations: 480     Fields:    Translation:Humans
  43. Aiello LP, Silva PS, Cavallerano JD, Klein R. . Endocrinology. De Groot LJ, Jameson JL (eds). Diabetic eye disease. 2010; 971-984.
  44. Silva PS, Cavallerano JD, Aiello LM. Ocular telehealth initiatives in diabetic retinopathy. Curr Diab Rep. 2009 Aug; 9(4):265-71. PMID: 19640338.
    Citations: 7     Fields:    Translation:Humans
  45. Silva PS, Singh RJ, Bakri SJ, Lising RS, Santiago DE, Uy HS. Vitreous concentration of triamcinolone acetonide after a single transseptal depot injection. Ocul Immunol Inflamm. 2009 May-Jun; 17(3):216-20. PMID: 19585367.
    Citations: 3     Fields:    Translation:Humans
  46. Silva PS, Sun JK, Aiello LP. Role of steroids in the management of diabetic macular edema and proliferative diabetic retinopathy. Semin Ophthalmol. 2009 Mar-Apr; 24(2):93-9. PMID: 19373693.
    Citations: 18     Fields:    Translation:Humans
  47. Silva PS, Cavallerano JD, Aiello LP. Therapy of Diabetes and Related Disorders, Lebovitz H (ed). Ocular Complications of Diabetes. 2009; 458-473.
  48. Florcruz NL, Quino RJ, Silva PS, Khu PT. Profile of Glaucoma Patients at the Philippine General Hospital. Philipp J of Ophthal. 2005; 4(30):161-165.
  49. Aguilar, RN, Silva PS. Globe-sparing Interventions in the Management of Intraocular Retinoblastoma. Philipp J of Ophthal. 2005; 2(30):78-81.
  50. Silva PS, Trio KF, Yap CB, Aguilar RN. . Progression of Diabetic Retinopathy after Phacoemulsification: A Meta-Analysis. Philipp J of Ophthal. 2005; 2(30):62-66.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.