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profilePaul DeCaen, Ph.D.

TitleResearch Fellow in Pediatrics (EXT)
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
Cardiology Research - Enders 1309
300 Longwood Ave
Boston MA 02115
Phone617/919-2680
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30):E6079-E6088. PMID: 28696294.
    View in: PubMed
  2. Favero J, Belhabib S, Guessasma S, Decaen P, Reguerre AL, Lourdin D, Leroy E. On the representative elementary size concept to evaluate the compatibilisation of a plasticised biopolymer blend. Carbohydr Polym. 2017 Sep 15; 172:120-129. PMID: 28606518.
    View in: PubMed
  3. Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z. A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. FASEB J. 2017 Jul; 31(7):3167-3178. PMID: 28400471.
    View in: PubMed
  4. Sula A, Booker J, Ng LC, Naylor CE, DeCaen PG, Wallace BA. The complete structure of an activated open sodium channel. Nat Commun. 2017 Feb 16; 8:14205. PMID: 28205548.
    View in: PubMed
  5. Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. J Gen Physiol. 2017 Jan; 149(1):37-47. PMID: 27999145.
    View in: PubMed
  6. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 2016 Oct 20; 167(3):763-773.e11. PMID: 27768895.
    View in: PubMed
  7. DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 2016 Jun 27; 5. PMID: 27348301; PMCID: PMC4922860.
  8. Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. EMBO J. 2016 Apr 15; 35(8):820-30. PMID: 26873592; PMCID: PMC4972137 [Available on 04/15/17].
  9. Vien TN, DeCaen PG. Biophysical Adaptations of Prokaryotic Voltage-Gated Sodium Channels. Curr Top Membr. 2016; 78:39-64. PMID: 27586280.
    View in: PubMed
  10. DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 2014 Nov 11; 3. PMID: 25385530; PMCID: PMC4225499.
  11. Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8428-33. PMID: 24850863; PMCID: PMC4060673.
  12. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. PMID: 24336289; PMCID: PMC4073646.
  13. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. PMID: 24336288; PMCID: PMC4112737.
  14. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. PMID: 23542377; PMCID: PMC3631666.
  15. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun. 2013; 4:2465. PMID: 24051986; PMCID: PMC3791462.
  16. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res. 2013 Mar; 23(3):409-22. PMID: 23247626; PMCID: PMC3587708.
  17. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 May 20; 486(7401):130-4. PMID: 22678295; PMCID: PMC3979295.
  18. Yarov-Yarovoy V, DeCaen PG, Westenbroek RE, Pan CY, Scheuer T, Baker D, Catterall WA. Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):E93-102. PMID: 22160714; PMCID: PMC3258622.
  19. DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18825-30. PMID: 22042870; PMCID: PMC3219111.
  20. DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, Catterall WA. Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22498-503. PMID: 20007787; PMCID: PMC2799717.
  21. DeCaen PG, Yarov-Yarovoy V, Zhao Y, Scheuer T, Catterall WA. Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15142-7. PMID: 18809926; PMCID: PMC2567506.
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