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Ulf Dettmer, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS121826 (DETTMER, ULF) Apr 1, 2021 - Sep 30, 2022
    Contrasting pathomechanisms of membrane versus cytosol alpha-synuclein excess
    Role: Principal Investigator
  2. R01NS099328 (DETTMER, ULF) Aug 1, 2017 - May 31, 2022
    Stabilizing native ?-synuclein homeostasis to prevent insoluble ?-synuclein aggregates
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neve E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 Apr 20. PMID: 35445353.
    Citations:    Fields:    
  2. de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, Jaunmuktane Z, Bartels T. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by a-synuclein conformations. Acta Neuropathol. 2022 Apr; 143(4):453-469. PMID: 35141810.
    Citations:    Fields:    Translation:HumansCells
  3. Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched a-Synuclein Converge on Fatty Acid Homeostasis. J Neurosci. 2022 03 09; 42(10):2116-2130. PMID: 35086904.
    Citations:    Fields:    Translation:AnimalsCells
  4. Tripathi A, Fanning S, Dettmer U. Lipotoxicity Downstream of a-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies? Biomolecules. 2021 12 28; 12(1). PMID: 35053188.
    Citations: 1     Fields:    Translation:HumansCells
  5. Kim TE, Newman AJ, Imberdis T, Brontesi L, Tripathi A, Ramalingam N, Fanning S, Selkoe D, Dettmer U. Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity. Hum Mol Genet. 2021 11 16; 30(23):2332-2346. PMID: 34254125.
    Citations:    Fields:    Translation:HumansCells
  6. Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the a-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34326260.
    Citations: 2     Fields:    Translation:Animals
  7. Ericsson M, von Saucken V, Newman AJ, Doehr L, Hoesch C, Kim TE, Dettmer U. Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced a-synuclein membrane interaction. Brain Res. 2021 05 01; 1758:147349. PMID: 33571519.
    Citations: 5     Fields:    Translation:HumansCells
  8. Ramalingam N, Dettmer U. Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. J Biol Chem. 2021 Jan-Jun; 296:100271. PMID: 33428933.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Ho GPH, Ramalingam N, Imberdis T, Wilkie EC, Dettmer U, Selkoe DJ. Upregulation of Cellular Palmitoylation Mitigates a-Synuclein Accumulation and Neurotoxicity. Mov Disord. 2021 02; 36(2):348-359. PMID: 33103814.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  10. Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in a-Synuclein Mice. Ann Neurol. 2021 01; 89(1):74-90. PMID: 32996158.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  11. Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. Int J Mol Sci. 2020 Jul 22; 21(15). PMID: 32707907.
    Citations: 5     Fields:    Translation:HumansCells
  12. Fanning S, Selkoe D, Dettmer U. Vesicle trafficking and lipid metabolism in synucleinopathy. Acta Neuropathol. 2021 04; 141(4):491-510. PMID: 32607605.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  13. Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinsons Dis. 2020 Jan 03; 6(1):3. PMID: 33386391.
    Citations: 2     
  14. Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinsons Dis. 2020; 6:3. PMID: 31909184.
    Citations: 42     
  15. Kayed R, Dettmer U, Lesné SE. Soluble endogenous oligomeric a-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk. J Parkinsons Dis. 2020; 10(3):791-818. PMID: 32508330.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  16. Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich a-synuclein aggregation validate known modifiers of a-synuclein biology and identify stearoyl-CoA desaturase. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20760-20769. PMID: 31548371.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  17. Yeboah F, Kim TE, Bill A, Dettmer U. Dynamic behaviors of a-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiol Dis. 2019 12; 132:104543. PMID: 31351173.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U. Studying a-Synuclein Conformation by Intact-Cell Cross-Linking. Methods Mol Biol. 2019; 1948:77-91. PMID: 30771172.
    Citations: 6     Fields:    Translation:Cells
  19. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. PMID: 30527540.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  20. Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native a-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 10 10; 100(1):75-90.e5. PMID: 30308173.
    Citations: 47     Fields:    Translation:AnimalsCells
  21. Dettmer U. Rationally Designed Variants of a-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease. Front Neurosci. 2018; 12:623. PMID: 30319334.
    Citations: 18     
  22. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481. PMID: 28911198.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  23. Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL. Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiol Dis. 2017 Oct; 106:191-204. PMID: 28711409.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Dettmer U, Selkoe D, Bartels T. New insights into cellular a-synuclein homeostasis in health and disease. Curr Opin Neurobiol. 2016 Feb; 36:15-22. PMID: 26282834.
    Citations: 42     Fields:    Translation:HumansCells
  25. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jul 30; 6:8008. PMID: 26224447.
    Citations: 5     Fields:    
  26. Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal a-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9596-601. PMID: 26153422.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  27. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jun 16; 6:7314. PMID: 26076669.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  28. Dettmer U, Bartels T. ExPLAining early synucleinopathies. Brain. 2015 Jun; 138(Pt 6):1449-51. PMID: 26013805.
    Citations: 2     Fields:    Translation:Humans
  29. Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of a-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 2015 Jan 20; 54(2):279-92. PMID: 25490121.
    Citations: 35     Fields:    Translation:HumansCells
  30. Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous a-synuclein. PLoS One. 2013; 8(11):e81314. PMID: 24278419.
    Citations: 20     Fields:    Translation:HumansCells
  31. Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of a-synuclein. Neurodegener Dis. 2014; 13(2-3):114-7. PMID: 24192542.
    Citations: 19     Fields:    Translation:HumansAnimals
  32. Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of a-synuclein and ß-synuclein in neurons and non-neural cells. J Biol Chem. 2013 Mar 01; 288(9):6371-85. PMID: 23319586.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  33. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J Biol Chem. 2010 Aug 20; 285(34):26174-81. PMID: 20538592.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  34. Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. J Biol Chem. 2007 Apr 06; 282(14):10632-8. PMID: 17261586.
    Citations: 9     Fields:    Translation:HumansCells
  35. Chelius HH, Böhme K, Dettmer U. [Effect of hyperbilirubinemia on the physical and mental development of the diseased newborn infant]. Geburtshilfe Frauenheilkd. 1971 Sep; 31(9):823-32. PMID: 5098810.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.