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Ulf Dettmer, Ph.D.

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Research
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  1. R21NS121826 (DETTMER, ULF) Apr 1, 2021 - Sep 30, 2022
    NIH
    Contrasting pathomechanisms of membrane versus cytosol alpha-synuclein excess
    Role: Principal Investigator
  2. R01NS099328 (DETTMER, ULF) Aug 1, 2017 - May 31, 2022
    NIH
    Stabilizing native ?-synuclein homeostasis to prevent insoluble ?-synuclein aggregates
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Dynamic physiological a-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis. 2023 Jan 16; 9(1):4. PMID: 36646701; PMCID: PMC9842642.
    Citations:    
  2. Brontesi L, Imberdis T, Ramalingam N, Dettmer U. The effect of KTKEGV repeat motif and intervening ATVA sequence on a-synuclein solubility and assembly. J Neurochem. 2023 Jan 10. PMID: 36625497.
    Citations:    Fields:    
  3. Fonseca-Ornelas L, Stricker JMS, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore CR, Scherzer CR, Selkoe DJ. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous a-synuclein in human neurons. NPJ Parkinsons Dis. 2022 Sep 16; 8(1):118. PMID: 36114228; PMCID: PMC9481630.
    Citations:    
  4. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 Jul; 19(4):1434. PMID: 35792968; PMCID: PMC9587197.
    Citations:    Fields:    
  5. Fortin JS, Shimanaka K, Saraswati AP, Liu M, Wang KW, Hagar HT, Maity S, Ganegamage SK, Ellsworth E, Counts SE, Borhan B, Dettmer U, Kuo MH. Anti-fibrillization effects of sulfonamide derivatives on a-synuclein and hyperphosphorylated tau isoform 1N4R. J Mol Struct. 2022 Nov 05; 1267. PMID: 36310922; PMCID: PMC9614895.
    Citations:    
  6. Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, Caldwell KA, Selkoe D. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. NPJ Parkinsons Dis. 2022 Jun 09; 8(1):74. PMID: 35680956; PMCID: PMC9184586.
    Citations:    
  7. Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses a-Synuclein Toxicity. Neurotherapeutics. 2022 04; 19(3):1018-1036. PMID: 35445353; PMCID: PMC9294123.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, Jaunmuktane Z, Bartels T. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by a-synuclein conformations. Acta Neuropathol. 2022 04; 143(4):453-469. PMID: 35141810; PMCID: PMC8960659.
    Citations: 1     Fields:    Translation:HumansCells
  9. Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched a-Synuclein Converge on Fatty Acid Homeostasis. J Neurosci. 2022 03 09; 42(10):2116-2130. PMID: 35086904; PMCID: PMC8916762.
    Citations:    Fields:    Translation:AnimalsCells
  10. Tripathi A, Fanning S, Dettmer U. Lipotoxicity Downstream of a-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies? Biomolecules. 2021 12 28; 12(1). PMID: 35053188; PMCID: PMC8774010.
    Citations: 1     Fields:    Translation:HumansCells
  11. Kim TE, Newman AJ, Imberdis T, Brontesi L, Tripathi A, Ramalingam N, Fanning S, Selkoe D, Dettmer U. Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity. Hum Mol Genet. 2021 11 16; 30(23):2332-2346. PMID: 34254125; PMCID: PMC8600006.
    Citations:    Fields:    Translation:HumansCells
  12. Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the a-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34326260; PMCID: PMC8346893.
    Citations: 2     Fields:    Translation:Animals
  13. Ericsson M, von Saucken V, Newman AJ, Doehr L, Hoesch C, Kim TE, Dettmer U. Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced a-synuclein membrane interaction. Brain Res. 2021 05 01; 1758:147349. PMID: 33571519; PMCID: PMC7988302.
    Citations: 5     Fields:    Translation:HumansCells
  14. Ramalingam N, Dettmer U. Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. J Biol Chem. 2021 Jan-Jun; 296:100271. PMID: 33428933.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Ho GPH, Ramalingam N, Imberdis T, Wilkie EC, Dettmer U, Selkoe DJ. Upregulation of Cellular Palmitoylation Mitigates a-Synuclein Accumulation and Neurotoxicity. Mov Disord. 2021 02; 36(2):348-359. PMID: 33103814; PMCID: PMC8887921.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in a-Synuclein Mice. Ann Neurol. 2021 01; 89(1):74-90. PMID: 32996158.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  17. Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. Int J Mol Sci. 2020 Jul 22; 21(15). PMID: 32707907.
    Citations: 6     Fields:    Translation:HumansCells
  18. Fanning S, Selkoe D, Dettmer U. Vesicle trafficking and lipid metabolism in synucleinopathy. Acta Neuropathol. 2021 04; 141(4):491-510. PMID: 32607605; PMCID: PMC7772270.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinsons Dis. 2020 Jan 03; 6(1):3. PMID: 33386391.
    Citations: 2     
  20. Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinsons Dis. 2020; 6:3. PMID: 31909184.
    Citations: 54     
  21. Kayed R, Dettmer U, Lesné SE. Soluble endogenous oligomeric a-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk. J Parkinsons Dis. 2020; 10(3):791-818. PMID: 32508330.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  22. Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich a-synuclein aggregation validate known modifiers of a-synuclein biology and identify stearoyl-CoA desaturase. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20760-20769. PMID: 31548371.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  23. Yeboah F, Kim TE, Bill A, Dettmer U. Dynamic behaviors of a-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiol Dis. 2019 12; 132:104543. PMID: 31351173.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U. Studying a-Synuclein Conformation by Intact-Cell Cross-Linking. Methods Mol Biol. 2019; 1948:77-91. PMID: 30771172.
    Citations: 6     Fields:    Translation:Cells
  25. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. PMID: 30527540; PMCID: PMC6408259.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  26. Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native a-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 10 10; 100(1):75-90.e5. PMID: 30308173; PMCID: PMC6211795.
    Citations: 48     Fields:    Translation:AnimalsCells
  27. Dettmer U. Rationally Designed Variants of a-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease. Front Neurosci. 2018; 12:623. PMID: 30319334; PMCID: PMC6167557.
    Citations: 18     
  28. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481. PMID: 28911198; PMCID: PMC5884392.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  29. Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL. Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiol Dis. 2017 Oct; 106:191-204. PMID: 28711409; PMCID: PMC5793922.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Dettmer U, Selkoe D, Bartels T. New insights into cellular a-synuclein homeostasis in health and disease. Curr Opin Neurobiol. 2016 Feb; 36:15-22. PMID: 26282834.
    Citations: 42     Fields:    Translation:HumansCells
  31. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jul 30; 6:8008. PMID: 26224447.
    Citations: 5     Fields:    
  32. Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal a-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9596-601. PMID: 26153422; PMCID: PMC4534262.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  33. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jun 16; 6:7314. PMID: 26076669.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  34. Dettmer U, Bartels T. ExPLAining early synucleinopathies. Brain. 2015 Jun; 138(Pt 6):1449-51. PMID: 26013805; PMCID: PMC4614127.
    Citations: 2     Fields:    Translation:Humans
  35. Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of a-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 2015 Jan 20; 54(2):279-92. PMID: 25490121.
    Citations: 36     Fields:    Translation:HumansCells
  36. Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous a-synuclein. PLoS One. 2013; 8(11):e81314. PMID: 24278419.
    Citations: 20     Fields:    Translation:HumansCells
  37. Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of a-synuclein. Neurodegener Dis. 2014; 13(2-3):114-7. PMID: 24192542.
    Citations: 19     Fields:    Translation:HumansAnimals
  38. Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of a-synuclein and ß-synuclein in neurons and non-neural cells. J Biol Chem. 2013 Mar 01; 288(9):6371-85. PMID: 23319586.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  39. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J Biol Chem. 2010 Aug 20; 285(34):26174-81. PMID: 20538592.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  40. Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. J Biol Chem. 2007 Apr 06; 282(14):10632-8. PMID: 17261586.
    Citations: 9     Fields:    Translation:HumansCells
  41. Chelius HH, Böhme K, Dettmer U. [Effect of hyperbilirubinemia on the physical and mental development of the diseased newborn infant]. Geburtshilfe Frauenheilkd. 1971 Sep; 31(9):823-32. PMID: 5098810.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.