Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Julia F. Charles, M.D., Ph.D.

Profile Picture
Other Positions

Yale University, New Haven, CTBS1992Molecular Biochemistry and Biophysics
UCSF, San Francisco, CAMD, PhD2001Medicine, Biochemistry
Brigham and Women's Hospital, Boston, MA2004Internal Medicine Residency
UCSF, San Francisisco, CA2007Rheumatology Fellowship
Barry Goldwater National Scholarship for Excellence in Science and Mathematics
Phi Beta Kappa
Graduate Teaching Prize
Chancellor's Award for the Advancement of Women
American College of Rheumatology Distinguished Fellow Award
Ira M. Goldstein Award for Outstanding Teaching in Rheumatology
Exceptional Service Award, Arthritis Foundation
Excellence in Research Award
Outstanding Oral Abstract Award
BWH Facutly Development Award
America's Top Doctors
Boston Magazine Top Doctor


Rare bone disease [login at prompt]
Available: 04/05/22, Expires: 06/01/23

I study bone physiology in mouse models. Available projects involve using mouse models of rare bone disease (osteopetrosis; fibrous dysplasia) to understand disease mechanisms and gain insight into normal bone physiology. Check out the lab website for more information: https://charleslab.bwh.harvard.edu/

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AR077768 (CHARLES, JULIA F.) Apr 1, 2021 - Mar 31, 2023
    Talking Back: leveraging dysfunctional osteoclasts to identify novel pathways of osteoclast-osteoblast communication
    Role: Principal Investigator
  2. R01HD086050-01A1 (HERNANDEZ, LISA) Jul 20, 2018 - Apr 30, 2023
    Influence of SSRI use during pregnancy and lactation on maternal bone health
    Role: Co-Investigator
  3. R01AG046257 (CHARLES, JULIA F.) Sep 30, 2013 - Jun 30, 2018
    Myeloid precursors and the microbiome in the osteoimmunology of aging
    Role: Principal Investigator
  4. K08AR062590 (CHARLES, JULIA F.) Jul 1, 2012 - Jun 30, 2017
    Osteoclast precursors in bone homeostasis and inflammatory arthritis
    Role: Principal Investigator
  5. R01AR060363 (CHARLES, JULIA F.) Aug 1, 2011 - Jul 31, 2016
    Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. González-Sánchez HM, Baek JH, Weinmann-Menke J, Ajay AK, Charles JF, Noda M, Franklin RA, Rodríguez-Morales P, Kelley VR. IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice. Lab Invest. 2022 Mar 14. PMID: 35288653.
    Citations:    Fields:    
  2. Seyok T, Collins JE, Erikson SJ, Charles JF, Earp BE. Future Fracture Risk in Upper Extremity Fracture and Non-Fracture Patients. Hand (N Y). 2022 Feb 26; 15589447211049521. PMID: 35220774.
    Citations:    Fields:    
  3. Khedgikar V, Charles JF, Lehoczky JA. Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use. Bone. 2022 Feb; 155:116267. PMID: 34856421.
    Citations:    Fields:    
  4. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med. 2021 12 06; 218(12). PMID: 34698806.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Martínez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA. IL-1ß-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. J Clin Invest. 2021 09 15; 131(18). PMID: 34343136.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 10 06; 32(4):665-675.e6. PMID: 32941798.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  7. Caetano-Lopes J, Henke K, Urso K, Duryea J, Charles JF, Warman ML, Harris MP. Correction: Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development. 2020 May 18; 147(10). PMID: 32423978.
    Citations: 3     Fields:    
  8. Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08; 11(1):2289. PMID: 32385263.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Caetano-Lopes J, Henke K, Urso K, Duryea J, Charles JF, Warman ML, Harris MP. Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development. 2020 01 22; 147(2). PMID: 31932352.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Matzkin EG, DeMaio M, Charles JF, Franklin CC. Diagnosis and Treatment of Osteoporosis: What Orthopaedic Surgeons Need to Know. J Am Acad Orthop Surg. 2019 Oct 15; 27(20):e902-e912. PMID: 31021891.
    Citations: 6     Fields:    Translation:Humans
  11. Urso K, Caetano-Lopes J, Lee PY, Yan J, Henke K, Sury M, Liu H, Zgoda M, Jacome-Galarza C, Nigrovic PA, Duryea J, Harris MP, Charles JF. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 2019 10; 127:104-113. PMID: 31173907.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Weaver SR, Xie C, Charles JF, Hernandez LL. In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning. Sci Rep. 2019 01 18; 9(1):238. PMID: 30659249.
    Citations: 1     Fields:    Translation:AnimalsPHPublic Health
  13. Tsang K, Liu H, Yang Y, Charles JF, Ermann J. Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function. Bone. 2019 04; 121:172-180. PMID: 30659979.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Carey HA, Hildreth BE, Samuvel DJ, Thies KA, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM. Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation. iScience. 2019 Jan 25; 11:238-245. PMID: 30634169.
    Citations: 6     
  15. Weaver SR, Fricke HP, Xie C, Aiello RJ, Charles JF, Hernandez LL. Peripartum dietary supplementation of a small-molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1133-E1142. PMID: 30351987.
    Citations:    Fields:    Translation:Animals
  16. Weaver SR, Fricke HP, Xie C, Lipinski RJ, Vezina CM, Charles JF, Hernandez LL. Peripartum Fluoxetine Reduces Maternal Trabecular Bone After Weaning and Elevates Mammary Gland Serotonin and PTHrP. Endocrinology. 2018 08 01; 159(8):2850-2862. PMID: 29893816.
    Citations: 7     Fields:    Translation:Animals
  17. Carey HA, Hildreth BE, Geisler JA, Nickel MC, Cabrera J, Ghosh S, Jiang Y, Yan J, Lee J, Makam S, Young NA, Valiente GR, Jarjour WN, Huang K, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM. Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation. Bone Res. 2018; 6:8. PMID: 29619268.
    Citations: 10     
  18. Yan J, Charles JF. Gut Microbiota and IGF-1. Calcif Tissue Int. 2018 04; 102(4):406-414. PMID: 29362822.
    Citations: 28     Fields:    Translation:HumansAnimals
  19. Bird IM, Kim SH, Schweppe DK, Caetano-Lopes J, Robling AG, Charles JF, Gygi SP, Warman ML, Smits PJ. The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 01 08; 145(1). PMID: 29180569.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Yan J, Takakura A, Zandi-Nejad K, Charles JF. Mechanisms of gut microbiota-mediated bone remodeling. Gut Microbes. 2018 01 02; 9(1):84-92. PMID: 28961041.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  21. Yan J, Charles JF. Gut Microbiome and Bone: to Build, Destroy, or Both? Curr Osteoporos Rep. 2017 08; 15(4):376-384. PMID: 28620867.
    Citations: 33     Fields:    Translation:HumansAnimals
  22. Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26; 2(11). PMID: 28763796.
    Citations: 10     Fields:    
  23. Charles JF, Sury M, Tsang K, Urso K, Henke K, Huang Y, Russell R, Duryea J, Harris MP. Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis. Bone. 2017 Aug; 101:162-171. PMID: 28476577.
    Citations: 18     Fields:    Translation:Animals
  24. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 12; 68(12):2889-2900. PMID: 27563728.
    Citations: 44     Fields:    Translation:Animals
  25. Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563. PMID: 27821775.
    Citations: 178     Fields:    Translation:Animals
  26. Urso K, Charles JF, Shull GE, Aliprantis AO, Balestrieri B. Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans. PLoS One. 2016; 11(7):e0158893. PMID: 27391897.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301. PMID: 26195726.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  28. Charles JF, Ermann J, Aliprantis AO. The intestinal microbiome and skeletal fitness: Connecting bugs and bones. Clin Immunol. 2015 Aug; 159(2):163-9. PMID: 25840106.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  29. Charles JF, Aliprantis AO. Osteoclasts: more than 'bone eaters'. Trends Mol Med. 2014 Aug; 20(8):449-59. PMID: 25008556.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  30. Charles JF, Nakamura MC. Bone and the innate immune system. Curr Osteoporos Rep. 2014 Mar; 12(1):1-8. PMID: 24500569.
    Citations: 17     Fields:    Translation:HumansCells
  31. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec; 122(12):4592-605. PMID: 23114597.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  32. Chitu V, Nacu V, Charles JF, Henne WM, McMahon HT, Nandi S, Ketchum H, Harris R, Nakamura MC, Stanley ER. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Blood. 2012 Oct 11; 120(15):3126-35. PMID: 22923495.
    Citations: 34     Fields:    Translation:AnimalsCells
  33. Charles JF, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, Tsang K, Sigrist K, Tollefsen DM, He L, Storm D, Aliprantis AO. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov; 51(5):902-12. PMID: 22985540.
    Citations: 18     Fields:    Translation:AnimalsCells
  34. Malladi AS, Gratton SB, Stone D, Scalapino KJ, Charles JF. Recurrent adverse psychiatric effects following intra-articular corticosteroid injection. J Clin Rheumatol. 2011 Aug; 17(5):284-5. PMID: 21778906.
    Citations:    Fields:    Translation:Humans
  35. Charles JF, Eberle C, Daikh DI, Rooney T. Resolution of recurrent fusarium arthritis after prolonged antifungal therapy. J Clin Rheumatol. 2011 Jan; 17(1):44-5. PMID: 21169847.
    Citations: 1     Fields:    Translation:HumansAnimals
  36. Moberg P, Charles JF, Respicio G, Venna SS, Rooney T. Improvement in psoriasis during rituximab therapy for mixed cryoglobulinemia type II. Cutis. 2010 Sep; 86(3):133-5. PMID: 21049729.
    Citations: 1     Fields:    Translation:HumansCells
  37. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47. PMID: 18391000.
    Citations: 21     Fields:    Translation:AnimalsCells
  38. Jaspersen SL, Charles JF, Morgan DO. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol. 1999 Mar 11; 9(5):227-36. PMID: 10074450.
    Citations: 192     Fields:    Translation:Cells
  39. Jaspersen SL, Charles JF, Tinker-Kulberg RL, Morgan DO. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 1998 Oct; 9(10):2803-17. PMID: 9763445.
    Citations: 151     Fields:    Translation:Animals
  40. Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 1998 Apr 23; 8(9):497-507. PMID: 9560342.
    Citations: 118     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Charles's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (238)
Co-Authors (52)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.