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Julia F. Charles, M.D., Ph.D.

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Biography
Yale University, New Haven, CTBS1992Molecular Biochemistry and Biophysics
UCSF, San Francisco, CAMD, PhD2001Medicine, Biochemistry
Brigham and Women's Hospital, Boston, MA2004Internal Medicine Residency
UCSF, San Francisisco, CA2007Rheumatology Fellowship
1989
Barry Goldwater National Scholarship for Excellence in Science and Mathematics
1992
Phi Beta Kappa
1997
Graduate Teaching Prize
1998
Chancellor's Award for the Advancement of Women
2007
American College of Rheumatology Distinguished Fellow Award
2009
Ira M. Goldstein Award for Outstanding Teaching in Rheumatology
2010
Exceptional Service Award, Arthritis Foundation
2013
Excellence in Research Award
2013
Outstanding Oral Abstract Award
2016
BWH Facutly Development Award
2017
America's Top Doctors
2018
Boston Magazine Top Doctor

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD086050-01A1 (HERNANDEZ, LISA) Jul 20, 2018 - Apr 30, 2023
    NIH/NICHD
    Influence of SSRI use during pregnancy and lactation on maternal bone health
    Role: Co-Investigator
  2. R01AG046257 (CHARLES, JULIA F.) Sep 30, 2013 - Jun 30, 2018
    NIH/NIA
    Myeloid precursors and the microbiome in the osteoimmunology of aging
    Role: Principal Investigator
  3. K08AR062590 (CHARLES, JULIA F.) Jul 1, 2012 - Jun 30, 2017
    NIH/NIAMS
    Osteoclast precursors in bone homeostasis and inflammatory arthritis
    Role: Principal Investigator
  4. R01AR060363 (ALIPRANTIS, ANTONIOS O) Aug 1, 2011 - Jul 31, 2016
    NIH/NIAMS
    Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Role: Co-Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Weaver SR, Fricke HP, Xie C, Aiello RJ, Charles JF, Hernandez LL. Peripartum dietary supplementation of a small molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone. Am J Physiol Endocrinol Metab. 2018 Oct 23. PMID: 30351987.
    View in: PubMed
  2. Weaver SR, Fricke HP, Xie C, Lipinski RJ, Vezina CM, Charles JF, Hernandez LL. Peripartum Fluoxetine Reduces Maternal Trabecular Bone After Weaning and Elevates Mammary Gland Serotonin and PTHrP. Endocrinology. 2018 Aug 01; 159(8):2850-2862. PMID: 29893816.
    View in: PubMed
  3. Carey HA, Hildreth BE, Geisler JA, Nickel MC, Cabrera J, Ghosh S, Jiang Y, Yan J, Lee J, Makam S, Young NA, Valiente GR, Jarjour WN, Huang K, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM. Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation. Bone Res. 2018; 6:8. PMID: 29619268.
    View in: PubMed
  4. Yan J, Charles JF. Gut Microbiota and IGF-1. Calcif Tissue Int. 2018 04; 102(4):406-414. PMID: 29362822.
    View in: PubMed
  5. Bird IM, Kim SH, Schweppe DK, Caetano-Lopes J, Robling AG, Charles JF, Gygi SP, Warman ML, Smits PJ. The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 01 08; 145(1). PMID: 29180569.
    View in: PubMed
  6. Yan J, Takakura A, Zandi-Nejad K, Charles JF. Mechanisms of gut microbiota-mediated bone remodeling. Gut Microbes. 2018 01 02; 9(1):84-92. PMID: 28961041.
    View in: PubMed
  7. Yan J, Charles JF. Gut Microbiome and Bone: to Build, Destroy, or Both? Curr Osteoporos Rep. 2017 08; 15(4):376-384. PMID: 28620867.
    View in: PubMed
  8. Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26; 2(11). PMID: 28763796.
    View in: PubMed
  9. Charles JF, Sury M, Tsang K, Urso K, Henke K, Huang Y, Russell R, Duryea J, Harris MP. Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis. Bone. 2017 Aug; 101:162-171. PMID: 28476577.
    View in: PubMed
  10. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 12; 68(12):2889-2900. PMID: 27563728.
    View in: PubMed
  11. Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563. PMID: 27821775.
    View in: PubMed
  12. Urso K, Charles JF, Shull GE, Aliprantis AO, Balestrieri B. Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans. PLoS One. 2016; 11(7):e0158893. PMID: 27391897; PMCID: PMC4938408.
  13. Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301. PMID: 26195726; PMCID: PMC4516796.
  14. Charles JF, Ermann J, Aliprantis AO. The intestinal microbiome and skeletal fitness: Connecting bugs and bones. Clin Immunol. 2015 Aug; 159(2):163-9. PMID: 25840106.
    View in: PubMed
  15. Charles JF, Aliprantis AO. Osteoclasts: more than 'bone eaters'. Trends Mol Med. 2014 Aug; 20(8):449-59. PMID: 25008556.
    View in: PubMed
  16. Charles JF, Nakamura MC. Bone and the innate immune system. Curr Osteoporos Rep. 2014 Mar; 12(1):1-8. PMID: 24500569; PMCID: PMC3992341.
  17. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec; 122(12):4592-605. PMID: 23114597; PMCID: PMC3533532.
  18. Chitu V, Nacu V, Charles JF, Henne WM, McMahon HT, Nandi S, Ketchum H, Harris R, Nakamura MC, Stanley ER. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Blood. 2012 Oct 11; 120(15):3126-35. PMID: 22923495; PMCID: PMC3471520.
  19. Charles JF, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, Tsang K, Sigrist K, Tollefsen DM, He L, Storm D, Aliprantis AO. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov; 51(5):902-12. PMID: 22985540; PMCID: PMC3457000.
  20. Malladi AS, Gratton SB, Stone D, Scalapino KJ, Charles JF. Recurrent adverse psychiatric effects following intra-articular corticosteroid injection. J Clin Rheumatol. 2011 Aug; 17(5):284-5. PMID: 21778906.
    View in: PubMed
  21. Charles JF, Eberle C, Daikh DI, Rooney T. Resolution of recurrent fusarium arthritis after prolonged antifungal therapy. J Clin Rheumatol. 2011 Jan; 17(1):44-5. PMID: 21169847.
    View in: PubMed
  22. Moberg P, Charles JF, Respicio G, Venna SS, Rooney T. Improvement in psoriasis during rituximab therapy for mixed cryoglobulinemia type II. Cutis. 2010 Sep; 86(3):133-5. PMID: 21049729.
    View in: PubMed
  23. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47. PMID: 18391000; PMCID: PMC2423085.
  24. Jaspersen SL, Charles JF, Morgan DO. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol. 1999 Mar 11; 9(5):227-36. PMID: 10074450.
    View in: PubMed
  25. Jaspersen SL, Charles JF, Tinker-Kulberg RL, Morgan DO. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 1998 Oct; 9(10):2803-17. PMID: 9763445; PMCID: PMC25555.
  26. Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 1998 Apr 23; 8(9):497-507. PMID: 9560342.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.