Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Julia F. Charles, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture
Other Positions
Title
Institution
Department

Biography
Yale University, New Haven, CTBS1992Molecular Biochemistry and Biophysics
UCSF, San Francisco, CAMD, PhD2001Medicine, Biochemistry
Brigham and Women's Hospital, Boston, MA2004Internal Medicine Residency
UCSF, San Francisisco, CA2007Rheumatology Fellowship
1989
Barry Goldwater National Scholarship for Excellence in Science and Mathematics
1992
Phi Beta Kappa
1997
Graduate Teaching Prize
1998
Chancellor's Award for the Advancement of Women
2007
American College of Rheumatology Distinguished Fellow Award
2009
Ira M. Goldstein Award for Outstanding Teaching in Rheumatology
2010
Exceptional Service Award, Arthritis Foundation
2013
Excellence in Research Award
2013
Outstanding Oral Abstract Award
2016
BWH Facutly Development Award
2017
America's Top Doctors
2018
Boston Magazine Top Doctor

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD086050-01A1 (HERNANDEZ, LISA) Jul 20, 2018 - Apr 30, 2023
    NIH/NICHD
    Influence of SSRI use during pregnancy and lactation on maternal bone health
    Role: Co-Investigator
  2. R01AG046257 (CHARLES, JULIA F.) Sep 30, 2013 - Jun 30, 2018
    NIH/NIA
    Myeloid precursors and the microbiome in the osteoimmunology of aging
    Role: Principal Investigator
  3. K08AR062590 (CHARLES, JULIA F.) Jul 1, 2012 - Jun 30, 2017
    NIH/NIAMS
    Osteoclast precursors in bone homeostasis and inflammatory arthritis
    Role: Principal Investigator
  4. R01AR060363 (ALIPRANTIS, ANTONIOS O) Aug 1, 2011 - Jul 31, 2016
    NIH/NIAMS
    Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Weaver SR, Xie C, Charles JF, Hernandez LL. In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning. Sci Rep. 2019 Jan 18; 9(1):238. PMID: 30659249.
    Citations:    Fields:    
  2. Tsang K, Liu H, Yang Y, Charles JF, Ermann J. Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function. Bone. 2019 Jan 16; 121:172-180. PMID: 30659979.
    Citations:    Fields:    
  3. Carey HA, Hildreth BE, Samuvel DJ, Thies KA, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM. Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation. iScience. 2019 Jan 25; 11:238-245. PMID: 30634169.
    Citations:    
  4. Weaver SR, Fricke HP, Xie C, Aiello RJ, Charles JF, Hernandez LL. Peripartum dietary supplementation of a small-molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone. Am J Physiol Endocrinol Metab. 2018 Dec 01; 315(6):E1133-E1142. PMID: 30351987.
    Citations:    Fields:    
  5. Weaver SR, Fricke HP, Xie C, Lipinski RJ, Vezina CM, Charles JF, Hernandez LL. Peripartum Fluoxetine Reduces Maternal Trabecular Bone After Weaning and Elevates Mammary Gland Serotonin and PTHrP. Endocrinology. 2018 Aug 01; 159(8):2850-2862. PMID: 29893816.
    Citations:    Fields:    
  6. Carey HA, Hildreth BE, Geisler JA, Nickel MC, Cabrera J, Ghosh S, Jiang Y, Yan J, Lee J, Makam S, Young NA, Valiente GR, Jarjour WN, Huang K, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM. Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation. Bone Res. 2018; 6:8. PMID: 29619268.
    Citations:    
  7. Yan J, Charles JF. Gut Microbiota and IGF-1. Calcif Tissue Int. 2018 04; 102(4):406-414. PMID: 29362822.
    Citations: 1     Fields:    
  8. Bird IM, Kim SH, Schweppe DK, Caetano-Lopes J, Robling AG, Charles JF, Gygi SP, Warman ML, Smits PJ. The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 01 08; 145(1). PMID: 29180569.
    Citations:    Fields:    Translation:AnimalsCells
  9. Yan J, Takakura A, Zandi-Nejad K, Charles JF. Mechanisms of gut microbiota-mediated bone remodeling. Gut Microbes. 2018 01 02; 9(1):84-92. PMID: 28961041.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Yan J, Charles JF. Gut Microbiome and Bone: to Build, Destroy, or Both? Curr Osteoporos Rep. 2017 08; 15(4):376-384. PMID: 28620867.
    Citations: 5     Fields:    Translation:HumansAnimals
  11. Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26; 2(11). PMID: 28763796.
    Citations:    Fields:    
  12. Charles JF, Sury M, Tsang K, Urso K, Henke K, Huang Y, Russell R, Duryea J, Harris MP. Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis. Bone. 2017 Aug; 101:162-171. PMID: 28476577.
    Citations: 2     Fields:    Translation:Animals
  13. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 12; 68(12):2889-2900. PMID: 27563728.
    Citations: 6     Fields:    Translation:Animals
  14. Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563. PMID: 27821775.
    Citations: 33     Fields:    Translation:Animals
  15. Urso K, Charles JF, Shull GE, Aliprantis AO, Balestrieri B. Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans. PLoS One. 2016; 11(7):e0158893. PMID: 27391897; PMCID: PMC4938408.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts. J Exp Med. 2015 Jul 27; 212(8):1283-301. PMID: 26195726; PMCID: PMC4516796.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  17. Charles JF, Ermann J, Aliprantis AO. The intestinal microbiome and skeletal fitness: Connecting bugs and bones. Clin Immunol. 2015 Aug; 159(2):163-9. PMID: 25840106.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  18. Charles JF, Aliprantis AO. Osteoclasts: more than 'bone eaters'. Trends Mol Med. 2014 Aug; 20(8):449-59. PMID: 25008556.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  19. Charles JF, Nakamura MC. Bone and the innate immune system. Curr Osteoporos Rep. 2014 Mar; 12(1):1-8. PMID: 24500569; PMCID: PMC3992341.
    Citations: 10     Fields:    Translation:HumansCells
  20. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec; 122(12):4592-605. PMID: 23114597.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  21. Chitu V, Nacu V, Charles JF, Henne WM, McMahon HT, Nandi S, Ketchum H, Harris R, Nakamura MC, Stanley ER. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Blood. 2012 Oct 11; 120(15):3126-35. PMID: 22923495; PMCID: PMC3471520.
    Citations: 20     Fields:    Translation:AnimalsCells
  22. Charles JF, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, Tsang K, Sigrist K, Tollefsen DM, He L, Storm D, Aliprantis AO. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov; 51(5):902-12. PMID: 22985540; PMCID: PMC3457000.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Malladi AS, Gratton SB, Stone D, Scalapino KJ, Charles JF. Recurrent adverse psychiatric effects following intra-articular corticosteroid injection. J Clin Rheumatol. 2011 Aug; 17(5):284-5. PMID: 21778906.
    Citations:    Fields:    Translation:Humans
  24. Charles JF, Eberle C, Daikh DI, Rooney T. Resolution of recurrent fusarium arthritis after prolonged antifungal therapy. J Clin Rheumatol. 2011 Jan; 17(1):44-5. PMID: 21169847.
    Citations: 2     Fields:    Translation:HumansAnimals
  25. Moberg P, Charles JF, Respicio G, Venna SS, Rooney T. Improvement in psoriasis during rituximab therapy for mixed cryoglobulinemia type II. Cutis. 2010 Sep; 86(3):133-5. PMID: 21049729.
    Citations: 1     Fields:    Translation:HumansCells
  26. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47. PMID: 18391000; PMCID: PMC2423085.
    Citations: 13     Fields:    Translation:AnimalsCells
  27. Jaspersen SL, Charles JF, Morgan DO. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol. 1999 Mar 11; 9(5):227-36. PMID: 10074450.
    Citations: 166     Fields:    Translation:Cells
  28. Jaspersen SL, Charles JF, Tinker-Kulberg RL, Morgan DO. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 1998 Oct; 9(10):2803-17. PMID: 9763445; PMCID: PMC25555.
    Citations: 136     Fields:    Translation:Animals
  29. Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 1998 Apr 23; 8(9):497-507. PMID: 9560342.
    Citations: 108     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Charles's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (180)
Explore
_
Co-Authors (22)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.