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Amrendra K Ajay, Ph.D.

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Biography
2013
Best abstract Society of Toxicology
2015
Best abstract Society of Toxicology
2015
Best publication award Society of Toxicology
2015
Best poster presentation award Society of Toxicology

Overview
My research focusses on cutting edge mechanistic insight into pathogenesis of acute and chronic kidney diseases using mouse models.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fujiwara M, Raheja R, Garo LP, Ajay AK, Kadowaki-Saga R, Karandikar SH, Gabriely G, Krishnan R, Beynon V, Paul A, Patel A, Saxena S, Hu D, Healy BC, Chitnis T, Gandhi R, Weiner HL, Murugaiyan G. MicroRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance. J Clin Invest. 2022 Mar 17. PMID: 35298438.
    Citations:    Fields:    
  2. González-Sánchez HM, Baek JH, Weinmann-Menke J, Ajay AK, Charles JF, Noda M, Franklin RA, Rodríguez-Morales P, Kelley VR. IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice. Lab Invest. 2022 Mar 14. PMID: 35288653.
    Citations:    Fields:    
  3. Ajay AK, Zhao L, Vig S, Fujiwara M, Thakurela S, Jadhav S, Cho A, Chiu IJ, Ding Y, Ramachandran K, Mithal A, Bhatt A, Chaluvadi P, Gupta MK, Shah SI, Sabbisetti VS, Waaga-Gasser AM, Frank DA, Murugaiyan G, Bonventre JV, Hsiao LL. Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration. Cell Rep. 2022 03 08; 38(10):110473. PMID: 35263586.
    Citations:    Fields:    Translation:AnimalsCells
  4. Ajay AK. Functional Drug Screening using Kidney Cells On-A-Chip: Advances in Disease Modeling and Development of Biomarkers. Kidney360. 2022 Feb 24; 3(2):194-198. PMID: 35373124.
    Citations:    
  5. Cao M, Nawalaniec K, Ajay AK, Luo Y, Moench R, Jin Y, Xiao S, Hsiao LL, Waaga-Gasser AM. PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner. Transl Oncol. 2022 May; 19:101377. PMID: 35196602.
    Citations:    
  6. Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV. KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 2021 05 04; 33(5):1042-1061.e7. PMID: 33951465.
    Citations: 7     Fields:    Translation:HumansAnimals
  7. Garo LP, Ajay AK, Fujiwara M, Gabriely G, Raheja R, Kuhn C, Kenyon B, Skillin N, Kadowaki-Saga R, Saxena S, Murugaiyan G. MicroRNA-146a limits tumorigenic inflammation in colorectal cancer. Nat Commun. 2021 04 23; 12(1):2419. PMID: 33893298.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Shao L, El-Jouni W, Kong F, Ramesh J, Kumar RS, Shen X, Ren J, Devendra S, Dorschel A, Wu M, Barrera I, Tabari A, Hu K, Haque N, Yambayev I, Li S, Kumar A, Behera TR, McDonough G, Furuichi M, Xifaras M, Lu T, Alhayaza RM, Miyabayashi K, Fan Q, Ajay AK, Zhou J. Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease. Kidney Int. 2020 11; 98(5):1225-1241. PMID: 32610050.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Tripathy A, Thakurela S, Sahu MK, Uthansingh K, Singh A, Narayan J, Ajay AK, Singh V, Kumari R. Fatty changes associated with N-Nitrosodiethylamine (DEN) induced hepatocellular carcinoma: a role of sonic hedgehog signaling pathway. Genes Cancer. 2020; 11(1-2):66-82. PMID: 32577158.
    Citations: 2     
  10. Wang X, Zhao L, Ajay AK, Jiao B, Zhang X, Wang C, Gao X, Yuan Z, Liu H, Liu WJ. QiDiTangShen Granules Activate Renal Nutrient-Sensing Associated Autophagy in db/db Mice. Front Physiol. 2019; 10:1224. PMID: 31632286.
    Citations: 3     
  11. Garo LP, Ajay AK, Fujiwara M, Beynon V, Kuhn C, Gabriely G, Sadhukan S, Raheja R, Rubino S, Weiner HL, Murugaiyan G. Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Cell Rep. 2019 09 24; 28(13):3353-3366.e5. PMID: 31553906.
    Citations: 12     Fields:    Translation:HumansCells
  12. Wada Y, Gonzalez-Sanchez HM, Weinmann-Menke J, Iwata Y, Ajay AK, Meineck M, Kelley VR. IL-34-Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice. J Am Soc Nephrol. 2019 02; 30(2):244-259. PMID: 30622154.
    Citations: 17     Fields:    Translation:AnimalsCells
  13. Tripathy A, Thakurela S, Sahu MK, Uthanasingh K, Behera M, Ajay AK, Kumari R. The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways. PLoS One. 2018; 13(12):e0208194. PMID: 30513115.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Kulkarni A, Chandrasekar V, Natarajan SK, Ramesh A, Pandey P, Nirgud J, Bhatnagar H, Ashok D, Ajay AK, Sengupta S. A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer. Nat Biomed Eng. 2018 08; 2(8):589-599. PMID: 30956894.
    Citations: 28     Fields:    Translation:AnimalsCells
  15. Gerarduzzi C, Kumar RK, Trivedi P, Ajay AK, Iyer A, Boswell S, Hutchinson JN, Waikar SS, Vaidya VS. Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation. JCI Insight. 2017 Apr 20; 2(8). PMID: 28422762.
    Citations: 17     Fields:    
  16. Kumari R, Chouhan S, Singh S, Chhipa RR, Ajay AK, Bhat MK. Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. J Biosci. 2017 Mar; 42(1):31-41. PMID: 28229963.
    Citations: 7     Fields:    Translation:HumansCells
  17. Jadhav S, Ajay AK, Trivedi P, Seematti J, Pellegrini K, Craciun F, Vaidya VS. RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA. J Biol Chem. 2016 Jul 01; 291(27):14085-14094. PMID: 27129280.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  18. Gupta MK, Ajay AK. Fat on sale: role of adipose-derived stem cells as anti-fibrosis agent in regenerative medicine. Stem Cell Res Ther. 2015 Dec 01; 6:233. PMID: 26620570.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Singh SV, Ajay AK, Mohammad N, Malvi P, Chaube B, Meena AS, Bhat MK. Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment. Cell Death Dis. 2015 Oct 22; 6:e1934. PMID: 26492368.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  20. Craciun FL, Bijol V, Ajay AK, Rao P, Kumar RK, Hutchinson J, Hofmann O, Joshi N, Luyendyk JP, Kusebauch U, Moss CL, Srivastava A, Himmelfarb J, Waikar SS, Moritz RL, Vaidya VS. RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis. J Am Soc Nephrol. 2016 06; 27(6):1702-13. PMID: 26449608.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  21. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28. PMID: 26260164.
    Citations: 37     Fields:    Translation:HumansCells
  22. Baek JH, Zeng R, Weinmann-Menke J, Valerius MT, Wada Y, Ajay AK, Colonna M, Kelley VR. IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest. 2015 Aug 03; 125(8):3198-214. PMID: 26121749.
    Citations: 51     Fields:    Translation:AnimalsCells
  23. Murugaiyan G, da Cunha AP, Ajay AK, Joller N, Garo LP, Kumaradevan S, Yosef N, Vaidya VS, Weiner HL. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Mar 02; 125(3):1069-80. PMID: 25642768.
    Citations: 97     Fields:    Translation:AnimalsCells
  24. Craciun FL, Ajay AK, Hoffmann D, Saikumar J, Fabian SL, Bijol V, Humphreys BD, Vaidya VS. Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis. Am J Physiol Renal Physiol. 2014 Aug 15; 307(4):F471-84. PMID: 25007874.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  25. Ajay AK, Kim TM, Ramirez-Gonzalez V, Park PJ, Frank DA, Vaidya VS. A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury. J Am Soc Nephrol. 2014 Jan; 25(1):105-18. PMID: 24158981.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  26. Parvatkar PT, Ajay AK, Bhat, MK, Parameswaran, PS, Tilve SG. Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines. 2013; 22:88.
  27. Ajay AK, Saikumar J, Bijol V, Vaidya VS. Heterozygosity for fibrinogen results in efficient resolution of kidney ischemia reperfusion injury. PLoS One. 2012; 7(9):e45628. PMID: 23029147.
    Citations: 11     Fields:    Translation:AnimalsCells
  28. Ajay AK, Meena AS, Bhat MK. Human papillomavirus 18 E6 inhibits phosphorylation of p53 expressed in HeLa cells. Cell Biosci. 2012 Jan 13; 2:2. PMID: 22244155.
    Citations: 13     
  29. Kumar A, Mitra A, Ajay AK, Bhat MK, Rao CP. Cu(II) complexes of glyco-imino-aromatic conjugates in DNA binding, plasmid cleavage and cell cytotoxicity. Cu(II) complexes of glyco-imino-aromatic conjugates in DNA binding, plasmid cleavage and cell cytotoxicity. 2012; 124:1217.
  30. Tripathi RP, Bisht SS, Ajay A, Sharma A, Misra M, Gupt MP. Developments in chemical approaches to treat tuberculosis in the last decade. Curr Med Chem. 2012; 19(4):488-517. PMID: 22204345.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  31. Kumar A, Chinta JP, Ajay AK, Bhat MK, Rao CP. Synthesis, characterization, plasmid cleavage and cytotoxicity of cancer cells by a copper(II) complex of anthracenyl-terpyridine. Dalton Trans. 2011 Nov 07; 40(41):10865-72. PMID: 21709916.
    Citations: 5     Fields:    Translation:HumansCells
  32. Krishnamoorthy A, Ajay AK, Hoffmann D, Kim TM, Ramirez V, Campanholle G, Bobadilla NA, Waikar SS, Vaidya VS. Fibrinogen ß-derived Bß(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood. 2011 Aug 18; 118(7):1934-42. PMID: 21685370.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Pandey V, Vijayakumar MV, Ajay AK, Malvi P, Bhat MK. Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN. Int J Cancer. 2012 Feb 01; 130(3):497-508. PMID: 21387314.
    Citations: 41     Fields:    Translation:AnimalsCells
  34. Vijayakumar MV, Ajay AK, Bhat MK. Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time. J Biosci. 2010 Dec; 35(4):525-31. PMID: 21289434.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Ajay AK, Upadhyay AK, Singh S, Vijayakumar MV, Kumari R, Pandey V, Boppana R, Bhat MK. Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. Mol Cancer. 2010 Jul 31; 9:204. PMID: 20673369.
    Citations: 25     Fields:    Translation:HumansCells
  36. Kumari R, Sharma A, Ajay AK, Bhat MK. Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models. Mol Cancer. 2009 Oct 21; 8:87. PMID: 19845939.
    Citations: 13     Fields:    Translation:HumansCells
  37. Upadhyay AK, Ajay AK, Singh S, Bhat MK. Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Curr Cancer Drug Targets. 2008 Dec; 8(8):741-52. PMID: 19075597.
    Citations: 12     Fields:    Translation:HumansCells
  38. Ajay AK, Srivastava DN. Microtubular conductometric biosensor for ethanol detection. Biosens Bioelectron. 2007 Sep 30; 23(2):281-4. PMID: 17555954.
    Citations: 2     Fields:    
  39. Singh S, Upadhyay AK, Ajay AK, Bhat MK. Gadd45alpha does not modulate the carboplatin or 5-fluorouracil-induced apoptosis in human papillomavirus-positive cells. J Cell Biochem. 2007 Apr 01; 100(5):1191-9. PMID: 17063488.
    Citations:    Fields:    Translation:HumansCells
  40. Singh S, Upadhyay AK, Ajay AK, Bhat MK. p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis. FEBS Lett. 2007 Jan 23; 581(2):289-95. PMID: 17208232.
    Citations: 23     Fields:    Translation:HumansCells
  41. Upadhyay AK, Singh S, Chhipa RR, Vijayakumar MV, Ajay AK, Bhat MK. Methyl-beta-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: involvement of Akt, NF-kappaB and Bcl-2. Toxicol Appl Pharmacol. 2006 Oct 15; 216(2):177-85. PMID: 16806341.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.