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Maria Mota, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Marreiros IM, Marques S, Parreira A, Mastrodomenico V, Mounce BC, Harris CT, Kafsack BF, Billker O, Zuzarte-Luís V, Mota MM. A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency. Commun Biol. 2023 02 21; 6(1):205. PMID: 36810637; PMCID: PMC9942083.
    Citations:    Translation:AnimalsCells
  2. Chora ÂF, Marques S, Gonçalves JL, Lima P, Gomes da Costa D, Fernandez-Ruiz D, Marreiros MI, Ruivo P, Carvalho T, Ribeiro RM, Serre K, Heath WR, Silva-Santos B, Tate AT, Mota MM. Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via ?d T cells and IL-17-promoted stress erythropoiesis. Immunity. 2023 Mar 14; 56(3):592-605.e8. PMID: 36804959.
    Citations:    Fields:    
  3. Afriat A, Zuzarte-Luís V, Bahar Halpern K, Buchauer L, Marques S, Chora ÂF, Lahree A, Amit I, Mota MM, Itzkovitz S. A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage. Nature. 2022 Nov; 611(7936):563-569. PMID: 36352220.
    Citations:    Fields:    Translation:AnimalsCells
  4. Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nat Commun. 2022 08 25; 13(1):4976. PMID: 36008486; PMCID: PMC9403976.
    Citations:    Fields:    Translation:HumansAnimals
  5. Mukherjee D, Chora ÂF, Lone JC, Ramiro RS, Blankenhaus B, Serre K, Ramirez M, Gordo I, Veldhoen M, Varga-Weisz P, Mota MM. Host lung microbiota promotes malaria-associated acute respiratory distress syndrome. Nat Commun. 2022 06 29; 13(1):3747. PMID: 35768411; PMCID: PMC9243033.
    Citations:    Fields:    Translation:Animals
  6. Lahree A, Baptista SJS, Marques S, Perschin V, Zuzarte-Luís V, Goel M, Choudhary HH, Mishra S, Stigloher C, Zerial M, Sundaramurthy V, Mota MM. Active APPL1 sequestration by Plasmodium favors liver-stage development. Cell Rep. 2022 05 31; 39(9):110886. PMID: 35649358.
    Citations: 1     Fields:    Translation:Animals
  7. M'Bana V, Lahree A, Marques S, Slavic K, Mota MM. Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination. iScience. 2022 May 20; 25(5):104281. PMID: 35573190; PMCID: PMC9095750.
    Citations: 1     
  8. Chora ÂF, Mota MM, Prudêncio M. The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle. Int J Parasitol. 2022 10; 52(11):711-715. PMID: 35367213.
    Citations: 1     Fields:    Translation:Animals
  9. Setua S, Enguita FJ, Chora ÂF, Ranga-Prasad H, Lahree A, Marques S, Sundaramurthy V, Mota MM. Disrupting Plasmodium UIS3-host LC3 interaction with a small molecule causes parasite elimination from host cells. Commun Biol. 2020 11 19; 3(1):688. PMID: 33214643.
    Citations: 6     Translation:HumansAnimalsCells
  10. Mello-Vieira J, Enguita FJ, de Koning-Ward TF, Zuzarte-Luís V, Mota MM. Plasmodium translocon component EXP2 facilitates hepatocyte invasion. Nat Commun. 2020 11 06; 11(1):5654. PMID: 33159090; PMCID: PMC7648069.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Tripathi J, Segeritz CP, Griffiths G, Bushell W, Vallier L, Skarnes WC, Mota MM, Billker O. A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei. Stem Cell Reports. 2020 06 09; 14(6):1123-1134. PMID: 32442532; PMCID: PMC7355138.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Vera IM, Grilo Ruivo MT, Lemos Rocha LF, Marques S, Bhatia SN, Mota MM, Mancio-Silva L. Targeting liver stage malaria with metformin. JCI Insight. 2019 12 19; 4(24). PMID: 31852843; PMCID: PMC6975259.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  13. Mukherjee D, Chora ÂF, Mota MM. Microbiota, a Third Player in the Host-Plasmodium Affair. Trends Parasitol. 2020 01; 36(1):11-18. PMID: 31787522.
    Citations: 8     Fields:    Translation:HumansAnimals
  14. Ribot JC, Neres R, Zuzarte-Luís V, Gomes AQ, Mancio-Silva L, Mensurado S, Pinto-Neves D, Santos MM, Carvalho T, Landry JJM, Rolo EA, Malik A, Silva DV, Mota MM, Silva-Santos B, Pamplona A. ?d-T cells promote IFN-?-dependent Plasmodium pathogenesis upon liver-stage infection. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):9979-9988. PMID: 31028144; PMCID: PMC6525508.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Armistead JS, Jennison C, O'Neill MT, Lopaticki S, Liehl P, Hanson KK, Annoura T, Rajasekaran P, Erickson SM, Tonkin CJ, Khan SM, Mota MM, Boddey JA. Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut. Mol Microbiol. 2018 08; 109(4):458-473. PMID: 29873127.
    Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
  16. Mendes AM, Machado M, Gonçalves-Rosa N, Reuling IJ, Foquet L, Marques C, Salman AM, Yang ASP, Moser KA, Dwivedi A, Hermsen CC, Jiménez-Díaz B, Viera S, Santos JM, Albuquerque I, Bhatia SN, Bial J, Angulo-Barturen I, Silva JC, Leroux-Roels G, Janse CJ, Khan SM, Mota MM, Sauerwein RW, Prudêncio M. A Plasmodium berghei sporozoite-based vaccination platform against human malaria. NPJ Vaccines. 2018; 3:33. PMID: 30155278; PMCID: PMC6109154.
    Citations: 22     
  17. Zuzarte-Luís V, Mota MM. Parasite Sensing of Host Nutrients and Environmental Cues. Cell Host Microbe. 2018 06 13; 23(6):749-758. PMID: 29902440.
    Citations: 35     Fields:    Translation:Animals
  18. Zuzarte-Luis V, Mota MM. Fighting for Resources: Who Started the Battle? Who Is Winning It? Cell Metab. 2018 04 03; 27(4):708-709. PMID: 29617637.
    Citations:    Fields:    Translation:AnimalsCells
  19. Real E, Rodrigues L, Cabal GG, Enguita FJ, Mancio-Silva L, Mello-Vieira J, Beatty W, Vera IM, Zuzarte-Luís V, Figueira TN, Mair GR, Mota MM. Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes. Nat Microbiol. 2018 Jan; 3(1):17-25. PMID: 29109477; PMCID: PMC5739284.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  20. Zuzarte-Luís V, Mello-Vieira J, Marreiros IM, Liehl P, Chora ÂF, Carret CK, Carvalho T, Mota MM. Dietary alterations modulate susceptibility to Plasmodium infection. Nat Microbiol. 2017 Dec; 2(12):1600-1607. PMID: 28947801.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  21. Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM. Nutrient sensing modulates malaria parasite virulence. Nature. 2017 07 13; 547(7662):213-216. PMID: 28678779; PMCID: PMC5511512.
    Citations: 67     Fields:    Translation:AnimalsCells
  22. Ng S, March S, Galstian A, Gural N, Stevens KR, Mota MM, Bhatia SN. Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers. Sci Rep. 2017 03 31; 7:45424. PMID: 28361899.
    Citations: 9     Fields:    Translation:HumansAnimals
  23. Sá E Cunha C, Nyboer B, Heiss K, Sanches-Vaz M, Fontinha D, Wiedtke E, Grimm D, Przyborski JM, Mota MM, Prudêncio M, Mueller AK. Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):E1138-E1147. PMID: 28137845; PMCID: PMC5320984.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  24. Tanowitz HB, Scherer PE, Mota MM, Figueiredo LM. Adipose Tissue: A Safe Haven for Parasites? Trends Parasitol. 2017 04; 33(4):276-284. PMID: 28007406; PMCID: PMC5376508.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  25. Ruivo MTG, Vera IM, Sales-Dias J, Meireles P, Gural N, Bhatia SN, Mota MM, Mancio-Silva L. Host AMPK Is a Modulator of Plasmodium Liver Infection. Cell Rep. 2016 09 06; 16(10):2539-2545. PMID: 27568570.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. Parrella E, Porrini V, Iorio R, Benarese M, Lanzillotta A, Mota M, Fusco M, Tonin P, Spano P, Pizzi M. PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia. Brain Res. 2016 10 01; 1648(Pt A):409-417. PMID: 27423516.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Slavic K, Krishna S, Lahree A, Bouyer G, Hanson KK, Vera I, Pittman JK, Staines HM, Mota MM. A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium. Nat Commun. 2016 Jan 20; 7:10403. PMID: 26786069; PMCID: PMC4735874.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  28. March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, Scull MA, Shlomai A, Mota MM, Fleming HE, Khetani SR, Rice CM, Bhatia SN. Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens. Nat Protoc. 2015 Dec; 10(12):2027-53. PMID: 26584444; PMCID: PMC5867906.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  29. Thieleke-Matos C, Lopes da Silva M, Cabrita-Santos L, Portal MD, Rodrigues IP, Zuzarte-Luis V, Ramalho JS, Futter CE, Mota MM, Barral DC, Seabra MC. Host cell autophagy contributes to Plasmodium liver development. Cell Microbiol. 2016 Mar; 18(3):437-50. PMID: 26399761.
    Citations: 36     Fields:    Translation:Animals
  30. Liehl P, Zuzarte-Luis V, Mota MM. Unveiling the pathogen behind the vacuole. Nat Rev Microbiol. 2015 09; 13(9):589-98. PMID: 26189591.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  31. Inácio P, Zuzarte-Luís V, Ruivo MT, Falkard B, Nagaraj N, Rooijers K, Mann M, Mair G, Fidock DA, Mota MM. Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection. EMBO Rep. 2015 Aug; 16(8):955-64. PMID: 26113366; PMCID: PMC4552488.
    Citations: 33     Fields:    Translation:AnimalsCells
  32. Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20; 7(288):288ra77. PMID: 25995223.
    Citations: 30     Fields:    Translation:AnimalsCells
  33. Mancio-Silva L, Mota MM. A mediator for malaria stickiness in A versus O blood. Nat Med. 2015 Apr; 21(4):307-8. PMID: 25849268.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  34. Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN. Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Stem Cell Reports. 2015 Mar 10; 4(3):348-59. PMID: 25660406.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  35. Liehl P, Meireles P, Albuquerque IS, Pinkevych M, Baptista F, Mota MM, Davenport MP, Prudêncio M. Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections. Infect Immun. 2015 Mar; 83(3):1172-80. PMID: 25583524; PMCID: PMC4333462.
    Citations: 35     Fields:    Translation:AnimalsCells
  36. Itoe MA, Sampaio JL, Cabal GG, Real E, Zuzarte-Luis V, March S, Bhatia SN, Frischknecht F, Thiele C, Shevchenko A, Mota MM. Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection. Cell Host Microbe. 2014 Dec 10; 16(6):778-86. PMID: 25498345; PMCID: PMC4271766.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  37. Hanson KK, March S, Ng S, Bhatia SN, Mota MM. In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection. Eukaryot Cell. 2015 Jan; 14(1):96-103. PMID: 25416236; PMCID: PMC4279013.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  38. Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J. Chemical interrogation of the malaria kinome. Chembiochem. 2014 Sep 05; 15(13):1920-30. PMID: 25111632.
    Citations: 14     Fields:    Translation:HumansAnimals
  39. Carballeira NM, Bwalya AG, Itoe MA, Andricopulo AD, Cordero-Maldonado ML, Kaiser M, Mota MM, Crawford AD, Guido RV, Tasdemir D. 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorg Med Chem Lett. 2014 Sep 01; 24(17):4151-7. PMID: 25103602.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  40. Zuzarte-Luis V, Mota MM, Vigário AM. Malaria infections: what and how can mice teach us. J Immunol Methods. 2014 Aug; 410:113-22. PMID: 24837740.
    Citations: 14     Fields:    Translation:HumansAnimals
  41. Zuzarte-Luis V, Sales-Dias J, Mota MM. Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period. Malar J. 2014 Jan 08; 13:15. PMID: 24400642.
    Citations: 12     Fields:    Translation:Animals
  42. Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2014 Jan; 20(1):47-53. PMID: 24362933.
    Citations: 144     Fields:    Translation:AnimalsCells
  43. Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med Chem Lett. 2014 Feb 13; 5(2):108-12. PMID: 24900781.
    Citations: 13     
  44. Ng S, March S, Galstian A, Hanson K, Carvalho T, Mota MM, Bhatia SN. Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro. Dis Model Mech. 2014 Feb; 7(2):215-24. PMID: 24291761.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  45. Spavieri J, Allmendinger A, Kaiser M, Itoe MA, Blunden G, Mota MM, Tasdemir D. Assessment of dual life stage antiplasmodial activity of british seaweeds. Mar Drugs. 2013 Oct 22; 11(10):4019-34. PMID: 24152562.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  46. Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. J Med Chem. 2013 Oct 10; 56(19):7679-90. PMID: 24020770.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  47. Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM, Rosenthal PJ, Moreira R, Prudêncio M, Lopes F. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem. 2013 Nov; 69:872-80. PMID: 24125849.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. March S, Ng S, Velmurugan S, Galstian A, Shan J, Logan DJ, Carpenter AE, Thomas D, Sim BK, Mota MM, Hoffman SL, Bhatia SN. A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe. 2013 Jul 17; 14(1):104-15. PMID: 23870318; PMCID: PMC3780791.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  49. Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):E2838-47. PMID: 23836641.
    Citations: 42     Fields:    Translation:AnimalsCells
  50. Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem. 2013 Jun 13; 56(11):4811-5. PMID: 23701465.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  51. Rebelo M, Sousa C, Shapiro HM, Mota MM, Grobusch MP, Hänscheid T. A novel flow cytometric hemozoin detection assay for real-time sensitivity testing of Plasmodium falciparum. PLoS One. 2013; 8(4):e61606. PMID: 23637865.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  52. Prudêncio M, Mota MM. Targeting host factors to circumvent anti-malarial drug resistance. Curr Pharm Des. 2013; 19(2):290-9. PMID: 22973886.
    Citations: 19     Fields:    Translation:HumansAnimals
  53. Sinnis P, De La Vega P, Coppi A, Krzych U, Mota MM. Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry. Methods Mol Biol. 2013; 923:385-400. PMID: 22990793.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  54. Derbyshire ER, Prudêncio M, Mota MM, Clardy J. Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8511-6. PMID: 22586124.
    Citations: 59     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  55. da Cruz FP, Martin C, Buchholz K, Lafuente-Monasterio MJ, Rodrigues T, Sönnichsen B, Moreira R, Gamo FJ, Marti M, Mota MM, Hannus M, Prudêncio M. Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug. J Infect Dis. 2012 Apr 15; 205(8):1278-86. PMID: 22396598; PMCID: PMC3308910.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  56. Gomes-Santos CS, Itoe MA, Afonso C, Henriques R, Gardner R, Sepúlveda N, Simões PD, Raquel H, Almeida AP, Moita LF, Frischknecht F, Mota MM. Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes. PLoS One. 2012; 7(1):e29408. PMID: 22238609.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  57. Rodrigues T, Prudêncio M, Moreira R, Mota MM, Lopes F. Targeting the liver stage of malaria parasites: a yet unmet goal. J Med Chem. 2012 Feb 09; 55(3):995-1012. PMID: 22122518.
    Citations: 21     Fields:    Translation:HumansAnimals
  58. Pena AC, Penacho N, Mancio-Silva L, Neres R, Seixas JD, Fernandes AC, Romão CC, Mota MM, Bernardes GJ, Pamplona A. A novel carbon monoxide-releasing molecule fully protects mice from severe malaria. Antimicrob Agents Chemother. 2012 Mar; 56(3):1281-90. PMID: 22155828.
    Citations: 37     Fields:    Translation:HumansAnimals
  59. Guirgis BS, Sá e Cunha C, Gomes I, Cavadas M, Silva I, Doria G, Blatch GL, Baptista PV, Pereira E, Azzazy HM, Mota MM, Prudêncio M, Franco R. Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection. Anal Bioanal Chem. 2012 Jan; 402(3):1019-27. PMID: 22089818.
    Citations: 15     Fields:    Translation:HumansAnimals
  60. Eaton P, Zuzarte-Luis V, Mota MM, Santos NC, Prudêncio M. Infection by Plasmodium changes shape and stiffness of hepatic cells. Nanomedicine. 2012 Jan; 8(1):17-9. PMID: 22033078.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  61. Prudêncio M, Mota MM, Mendes AM. A toolbox to study liver stage malaria. Trends Parasitol. 2011 Dec; 27(12):565-74. PMID: 22015112.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  62. Derbyshire ER, Mota MM, Clardy J. The next opportunity in anti-malaria drug discovery: the liver stage. PLoS Pathog. 2011 Sep; 7(9):e1002178. PMID: 21966266.
    Citations: 25     Fields:    Translation:HumansAnimals
  63. Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob Agents Chemother. 2011 Oct; 55(10):4698-706. PMID: 21807973.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  64. Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Muñoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermöhlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Könen-Waisman S, Kaufmann SH, Howard JC. The IFN-?-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. PLoS One. 2011; 6(6):e20568. PMID: 21698150.
    Citations: 45     Fields:    Translation:Animals
  65. Gomes-Santos CS, Braks J, Prudêncio M, Carret C, Gomes AR, Pain A, Feltwell T, Khan S, Waters A, Janse C, Mair GR, Mota MM. Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio. PLoS Pathog. 2011 May; 7(5):e1002046. PMID: 21625527.
    Citations: 49     Fields:    Translation:AnimalsCells
  66. Portugal S, Carret C, Recker M, Armitage AE, Gonçalves LA, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, Mota MM. Host-mediated regulation of superinfection in malaria. Nat Med. 2011 Jun; 17(6):732-7. PMID: 21572427.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  67. Douradinha B, Augustijn KD, Moore SG, Ramesar J, Mota MM, Waters AP, Janse CJ, Thompson J. Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host. Malar J. 2011 Mar 31; 10:71. PMID: 21453484; PMCID: PMC3083381.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  68. Frita R, Rebelo M, Pamplona A, Vigario AM, Mota MM, Grobusch MP, Hänscheid T. Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing. Malar J. 2011 Mar 31; 10:74. PMID: 21453521.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  69. Slavic K, Delves MJ, Prudêncio M, Talman AM, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM. Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. Antimicrob Agents Chemother. 2011 Jun; 55(6):2824-30. PMID: 21402842; PMCID: PMC3101457.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  70. Langhorne J, Buffet P, Galinski M, Good M, Harty J, Leroy D, Mota MM, Pasini E, Renia L, Riley E, Stins M, Duffy P. The relevance of non-human primate and rodent malaria models for humans. Malar J. 2011 Feb 02; 10:23. PMID: 21288352.
    Citations: 64     Fields:    Translation:HumansAnimals
  71. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem. 2011 Feb 10; 54(3):734-50. PMID: 21207937.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  72. Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . Biochemistry. 2010 Jul 06; 49(26):5600-8. PMID: 20527960.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  73. Baptista FG, Pamplona A, Pena AC, Mota MM, Pied S, Vigário AM. Accumulation of Plasmodium berghei-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice. Infect Immun. 2010 Sep; 78(9):4033-9. PMID: 20605973.
    Citations: 95     Fields:    Translation:AnimalsCells
  74. Epiphanio S, Campos MG, Pamplona A, Carapau D, Pena AC, Ataíde R, Monteiro CA, Félix N, Costa-Silva A, Marinho CR, Dias S, Mota MM. VEGF promotes malaria-associated acute lung injury in mice. PLoS Pathog. 2010 May 20; 6(5):e1000916. PMID: 20502682.
    Citations: 60     Fields:    Translation:Animals
  75. Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. Imidazoquines as antimalarial and antipneumocystis agents. J Med Chem. 2009 Dec 10; 52(23):7800-7. PMID: 19799426.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  76. Ploemen IH, Prudêncio M, Douradinha BG, Ramesar J, Fonager J, van Gemert GJ, Luty AJ, Hermsen CC, Sauerwein RW, Baptista FG, Mota MM, Waters AP, Que I, Lowik CW, Khan SM, Janse CJ, Franke-Fayard BM. Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS One. 2009 Nov 18; 4(11):e7881. PMID: 19924309.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  77. Liehl P, França AR, Prudêncio M, Latz E, Zaidman-Rémy A, Mota MM. Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility. Cell Microbiol. 2010 Apr 01; 12(4):506-15. PMID: 19912239.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  78. Albuquerque SS, Carret C, Grosso AR, Tarun AS, Peng X, Kappe SH, Prudêncio M, Mota MM. Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events. BMC Genomics. 2009 Jun 17; 10:270. PMID: 19534804.
    Citations: 65     Fields:    Translation:AnimalsCells
  79. Prudêncio M, Derbyshire ET, Marques CA, Krishna S, Mota MM, Staines HM. Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cell Microbiol. 2009 Oct; 11(10):1492-501. PMID: 19496788.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  80. Parvanova I, Epiphanio S, Fauq A, Golde TE, Prudêncio M, Mota MM. A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. PLoS One. 2009; 4(4):e5078. PMID: 19337374.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  81. Prudêncio M, Rodrigues CD, Hannus M, Martin C, Real E, Gonçalves LA, Carret C, Dorkin R, Röhl I, Jahn-Hoffmann K, Luty AJ, Sauerwein R, Echeverri CJ, Mota MM. Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection. PLoS Pathog. 2008 Nov; 4(11):e1000201. PMID: 18989463; PMCID: PMC2574010.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  82. Rodrigues CD, Hannus M, Prudêncio M, Martin C, Gonçalves LA, Portugal S, Epiphanio S, Akinc A, Hadwiger P, Jahn-Hofmann K, Röhl I, van Gemert GJ, Franetich JF, Luty AJ, Sauerwein R, Mazier D, Koteliansky V, Vornlocher HP, Echeverri CJ, Mota MM. Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Cell Host Microbe. 2008 Sep 11; 4(3):271-82. PMID: 18779053.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  83. Silvie O, Mota MM, Matuschewski K, Prudêncio M. Interactions of the malaria parasite and its mammalian host. Curr Opin Microbiol. 2008 Aug; 11(4):352-9. PMID: 18644249.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  84. Cunha-Rodrigues M, Portugal S, Prudêncio M, Gonçalves LA, Casalou C, Buger D, Sauerwein R, Haas W, Mota MM. Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy. PLoS One. 2008 Jul 16; 3(7):e2732. PMID: 18628947.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  85. Epiphanio S, Mikolajczak SA, Gonçalves LA, Pamplona A, Portugal S, Albuquerque S, Goldberg M, Rebelo S, Anderson DG, Akinc A, Vornlocher HP, Kappe SH, Soares MP, Mota MM. Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Cell Host Microbe. 2008 May 15; 3(5):331-8. PMID: 18474360.
    Citations: 55     Fields:    Translation:AnimalsCells
  86. Gonçalves LA, Almeida P, Mota MM, Penha-Gonçalves C. Malaria liver stage susceptibility locus identified on mouse chromosome 17 by congenic mapping. PLoS One. 2008 Mar 26; 3(3):e1874. PMID: 18365019.
    Citations: 12     Fields:    Translation:Animals
  87. Ono T, Cabrita-Santos L, Leitao R, Bettiol E, Purcell LA, Diaz-Pulido O, Andrews LB, Tadakuma T, Bhanot P, Mota MM, Rodriguez A. Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. PLoS Pathog. 2008 Feb 29; 4(2):e1000008. PMID: 18389080.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  88. Mota MM, Rodriguez A. New pieces for the malaria liver stage puzzle: where will they fit? Cell Host Microbe. 2008 Feb 14; 3(2):63-5. PMID: 18312840.
    Citations:    Fields:    Translation:HumansAnimalsCells
  89. Prudêncio M, Mota MM. To migrate or to invade: those are the options. Cell Host Microbe. 2007 Nov 15; 2(5):286-8. PMID: 18005748.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  90. Prudêncio M, Rodrigues CD, Ataíde R, Mota MM. Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry. Cell Microbiol. 2008 Jan; 10(1):218-24. PMID: 17697130.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  91. Douradinha B, van Dijk MR, Ataide R, van Gemert GJ, Thompson J, Franetich JF, Mazier D, Luty AJ, Sauerwein R, Janse CJ, Waters AP, Mota MM. Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection. Int J Parasitol. 2007 Nov; 37(13):1511-9. PMID: 17604034.
    Citations: 36     Fields:    Translation:AnimalsCellsPHPublic Health
  92. Pamplona A, Ferreira A, Balla J, Jeney V, Balla G, Epiphanio S, Chora A, Rodrigues CD, Gregoire IP, Cunha-Rodrigues M, Portugal S, Soares MP, Mota MM. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med. 2007 Jun; 13(6):703-10. PMID: 17496899.
    Citations: 263     Fields:    Translation:Animals
  93. Cunha-Rodrigues M, Portugal S, Febbraio M, Mota MM. Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection. Malar J. 2007 Mar 16; 6:32. PMID: 17367535; PMCID: PMC1832198.
    Citations: 7     Fields:    Translation:AnimalsCells
  94. Prudêncio M, Rodrigues CD, Mota MM. The relevance of host genes in malaria. SEB Exp Biol Ser. 2007; 58:47-91. PMID: 17608237.
    Citations: 1     Fields:    Translation:HumansAnimals
  95. Prudêncio M, Rodriguez A, Mota MM. The silent path to thousands of merozoites: the Plasmodium liver stage. Nat Rev Microbiol. 2006 Nov; 4(11):849-56. PMID: 17041632.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  96. Cunha-Rodrigues M, Portugal S, Febbraio M, Mota MM. Infection by and protective immune responses against Plasmodium berghei ANKA are not affected in macrophage scavenger receptors A deficient mice. BMC Microbiol. 2006 Aug 16; 6:73. PMID: 16914051; PMCID: PMC1562429.
    Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
  97. Mota MM. Be in motion . . . Mol Microbiol. 2006 Jun; 60(6):1327-8. PMID: 16796671.
    Citations:    Fields:    Translation:Animals
  98. Cunha-Rodrigues M, Prudêncio M, Mota MM, Haas W. Antimalarial drugs - host targets (re)visited. Biotechnol J. 2006 Mar; 1(3):321-32. PMID: 16897712.
    Citations: 11     Fields:    Translation:HumansAnimals
  99. Jongco AM, Ting LM, Thathy V, Mota MM, Kim K. Improved transfection and new selectable markers for the rodent malaria parasite Plasmodium yoelii. Mol Biochem Parasitol. 2006 Apr; 146(2):242-50. PMID: 16458371.
    Citations: 36     Fields:    Translation:AnimalsCells
  100. van Dijk MR, Douradinha B, Franke-Fayard B, Heussler V, van Dooren MW, van Schaijk B, van Gemert GJ, Sauerwein RW, Mota MM, Waters AP, Janse CJ. Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12194-9. PMID: 16103357; PMCID: PMC1189305.
    Citations: 121     Fields:    Translation:AnimalsCells
  101. Franke-Fayard B, Janse CJ, Cunha-Rodrigues M, Ramesar J, Büscher P, Que I, Löwik C, Voshol PJ, den Boer MA, van Duinen SG, Febbraio M, Mota MM, Waters AP. Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11468-73. PMID: 16051702; PMCID: PMC1183563.
    Citations: 163     Fields:    Translation:AnimalsCells
  102. Leiriao P, Mota MM, Rodriguez A. Apoptotic Plasmodium-infected hepatocytes provide antigens to liver dendritic cells. J Infect Dis. 2005 May 15; 191(10):1576-81. PMID: 15838783.
    Citations: 34     Fields:    Translation:AnimalsCells
  103. Waters AP, Mota MM, van Dijk MR, Janse CJ. Parasitology. Malaria vaccines: back to the future? Science. 2005 Jan 28; 307(5709):528-30. PMID: 15681372.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  104. Mota MM, Rodriguez A. Migration through host cells: the first steps of Plasmodium sporozoites in the mammalian host. Cell Microbiol. 2004 Dec; 6(12):1113-8. PMID: 15527491.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  105. Mota MM, Giordano S, Rodriguez A. Targeting Plasmodium host cells: survival within hepatocytes. Trends Mol Med. 2004 Oct; 10(10):487-92. PMID: 15464448.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  106. Sanchez BA, Mota MM, Sultan AA, Carvalho LH. Plasmodium berghei parasite transformed with green fluorescent protein for screening blood schizontocidal agents. Int J Parasitol. 2004 Mar 29; 34(4):485-90. PMID: 15013738.
    Citations: 6     Fields:    Translation:Animals
  107. Carrolo M, Giordano S, Cabrita-Santos L, Corso S, Vigário AM, Silva S, Leirião P, Carapau D, Armas-Portela R, Comoglio PM, Rodriguez A, Mota MM. Hepatocyte growth factor and its receptor are required for malaria infection. Nat Med. 2003 Nov; 9(11):1363-9. PMID: 14556002.
    Citations: 48     Fields:    Translation:AnimalsCells
  108. Ocaña-Morgner C, Mota MM, Rodriguez A. Malaria blood stage suppression of liver stage immunity by dendritic cells. J Exp Med. 2003 Jan 20; 197(2):143-51. PMID: 12538654; PMCID: PMC2193811.
    Citations: 85     Fields:    Translation:AnimalsCells
  109. Mota MM, Hafalla JC, Rodriguez A. Migration through host cells activates Plasmodium sporozoites for infection. Nat Med. 2002 Nov; 8(11):1318-22. PMID: 12379848.
    Citations: 60     Fields:    Translation:AnimalsCells
  110. Delrieu I, Waller CC, Mota MM, Grainger M, Langhorne J, Holder AA. PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes. Mol Biochem Parasitol. 2002 Apr 30; 121(1):11-20. PMID: 11985859.
    Citations: 18     Fields:    Translation:AnimalsCells
  111. Mota MM, Rodriguez A. Invasion of mammalian host cells by Plasmodium sporozoites. Bioessays. 2002 Feb; 24(2):149-56. PMID: 11835279.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  112. Natarajan R, Thathy V, Mota MM, Hafalla JC, Ménard R, Vernick KD. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: a new tool to study mosquito and mammalian host interactions with malaria parasites. Cell Microbiol. 2001 Jun; 3(6):371-9. PMID: 11422080.
    Citations: 36     Fields:    Translation:AnimalsCells
  113. Mota MM, Thathy V, Nussenzweig RS, Nussenzweig V. Gene targeting in the rodent malaria parasite Plasmodium yoelii. Mol Biochem Parasitol. 2001 Apr 06; 113(2):271-8. PMID: 11295181.
    Citations: 27     Fields:    Translation:Animals
  114. Matuschewski K, Mota MM, Pinder JC, Nussenzweig V, Kappe SH. Identification of the class XIV myosins Pb-MyoA and Py-MyoA and expression in Plasmodium sporozoites. Mol Biochem Parasitol. 2001 Jan 15; 112(1):157-61. PMID: 11166399.
    Citations: 7     Fields:    Translation:AnimalsCells
  115. Mota MM, Rodriguez A. Plasmodium yoelii: efficient in vitro invasion and complete development of sporozoites in mouse hepatic cell lines. Exp Parasitol. 2000 Dec; 96(4):257-9. PMID: 11162379.
    Citations: 10     Fields:    Translation:AnimalsCells
  116. Mota MM, Jarra W. More on adaptive or innate resistance to Plasmodium. Parasitol Today. 1999 May; 15(5):209. PMID: 10322358.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.