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Kathleen Joan Sweadner, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS081558 (SWEADNER, KATHLEEN J) Jul 1, 2013 - Oct 31, 2015
    Genetics and biology of a viable mutant mouse with dystonic movements
    Role: Principal Investigator
  2. R01NS050696 (SWEADNER, KATHLEEN J) Aug 15, 2007 - Mar 31, 2012
    Cellular/molecular Na,K-ATPase regulation in choroid plexus
    Role: Principal Investigator
  3. R13GM080136 (SWEADNER, KATHLEEN J) Jun 1, 2007 - May 31, 2008
    FASEB Conference: Transport ATPases
    Role: Principal Investigator
  4. R03EY014390 (SWEADNER, KATHLEEN J) May 1, 2003 - Apr 30, 2006
    Novel Target for Ciliary Epithelium Transport Regulation
    Role: Principal Investigator
  5. R21NS045083 (SWEADNER, KATHLEEN J) Dec 1, 2002 - Nov 30, 2005
    New Modulators of Na, K-ATPase in the CNS
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hoshino K, Sweadner KJ, Kawarai T, Saute JA, Freitas J, Damásio J, Donis KC, Kimura K, Fukuda H, Hayashi M, Higuchi T, Ikeda Y, Ozelius LJ, Kaji R. Rapid-Onset Dystonia-Parkinsonism Phenotype Consistency for a Novel Variant of ATP1A3 in Patients Across 3 Global Populations. Neurol Genet. 2021 Apr; 7(2):e562. PMID: 33977143; PMCID: PMC8105889.
  2. Arystarkhova E, Ozelius LJ, Brashear A, Sweadner KJ. Misfolding, altered membrane distributions, and the unfolded protein response contribute to pathogenicity differences in Na,K-ATPase ATP1A3 mutations. J Biol Chem. 2020 Nov 22; 296:100019. PMID: 33454454.
    Citations:    Fields:    
  3. Arystarkhova E, Ozelius LJ, Brashear A, Sweadner KJ. Misfolding, altered membrane distributions, and the unfolded protein response contribute to pathogenicity differences in Na,K-ATPase ATP1A3 mutations. J Biol Chem. 2021 Jan-Jun; 296:100019. PMID: 33144327.
    Citations: 5     Fields:    Translation:HumansCells
  4. Arystarkhova E, Haq IU, Luebbert T, Mochel F, Saunders-Pullman R, Bressman SB, Feschenko P, Salazar C, Cook JF, Demarest S, Brashear A, Ozelius LJ, Sweadner KJ. Factors in the disease severity of ATP1A3 mutations: Impairment, misfolding, and allele competition. Neurobiol Dis. 2019 12; 132:104577. PMID: 31425744.
    Citations: 14     Fields:    Translation:HumansCells
  5. Haq IU, Snively BM, Sweadner KJ, Suerken CK, Cook JF, Ozelius LJ, Miller C, McCall WV, Whitlow CT, Brashear A. Revising rapid-onset dystonia-parkinsonism: Broadening indications for ATP1A3 testing. Mov Disord. 2019 10; 34(10):1528-1536. PMID: 31361359; PMCID: PMC6879786.
    Citations: 9     Fields:    Translation:Humans
  6. Sweadner KJ, Arystarkhova E, Penniston JT, Swoboda KJ, Brashear A, Ozelius LJ. Genotype-structure-phenotype relationships diverge in paralogs ATP1A1, ATP1A2, and ATP1A3. Neurol Genet. 2019 Feb; 5(1):e303. PMID: 30842972; PMCID: PMC6384024.
    Citations: 13     
  7. Torres A, Brownstein CA, Tembulkar SK, Graber K, Genetti C, Kleiman RJ, Sweadner KJ, Mavros C, Liu KX, Smedemark-Margulies N, Maski K, Yang E, Agrawal PB, Shi J, Beggs AH, D'Angelo E, Lincoln SH, Carroll D, Dedeoglu F, Gahl WA, Biggs CM, Swoboda KJ, Berry GT, Gonzalez-Heydrich J. De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018 Sep; 16:23-29. PMID: 29922587; PMCID: PMC6005789.
    Citations: 4     
  8. Arystarkhova E, Bouley R, Liu YB, Sweadner KJ. Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport. PLoS One. 2017; 12(11):e0188006. PMID: 29155857.
    Citations: 6     Fields:    Translation:AnimalsCells
  9. Sweadner KJ. Structural biology: An ion-transport enzyme that rocks. Nature. 2017 05 11; 545(7653):162-164. PMID: 28467825.
    Citations: 1     Fields:    
  10. Rosewich H, Sweney MT, DeBrosse S, Ess K, Ozelius L, Andermann E, Andermann F, Andrasco G, Belgrade A, Brashear A, Ciccodicola S, Egan L, George AL, Lewelt A, Magelby J, Merida M, Newcomb T, Platt V, Poncelin D, Reyna S, Sasaki M, Sotero de Menezes M, Sweadner K, Viollet L, Zupanc M, Silver K, Swoboda K. Research conference summary from the 2014 International Task Force on ATP1A3-Related Disorders. Neurol Genet. 2017 Apr; 3(2):e139. PMID: 28293679; PMCID: PMC5335249.
    Citations: 19     
  11. Sweadner KJ, Toro C, Whitlow CT, Snively BM, Cook JF, Ozelius LJ, Markello TC, Brashear A. ATP1A3 Mutation in Adult Rapid-Onset Ataxia. PLoS One. 2016; 11(3):e0151429. PMID: 26990090.
    Citations: 20     Fields:    Translation:Humans
  12. Arystarkhova E, Sweadner KJ. Functional Studies of Na(+),K(+)-ATPase Using Transfected Cell Cultures. Methods Mol Biol. 2016; 1377:321-32. PMID: 26695043.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Sweadner KJ. Colorimetric Assays of Na,K-ATPase. Methods Mol Biol. 2016; 1377:89-104. PMID: 26695025.
    Citations: 1     Fields:    Translation:HumansCells
  14. Liu YB, Tewari A, Salameh J, Arystarkhova E, Hampton TG, Brashear A, Ozelius LJ, Khodakhah K, Sweadner KJ. A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin ß1 subunit, Lamb1. Elife. 2015 Dec 24; 4. PMID: 26705335.
    Citations: 9     Fields:    Translation:Animals
  15. Paciorkowski AR, McDaniel SS, Jansen LA, Tully H, Tuttle E, Ghoneim DH, Tupal S, Gunter SA, Vasta V, Zhang Q, Tran T, Liu YB, Ozelius LJ, Brashear A, Sweadner KJ, Dobyns WB, Hahn S. Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly. Epilepsia. 2015 Mar; 56(3):422-30. PMID: 25656163.
    Citations: 46     Fields:    Translation:HumansCells
  16. Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ. Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 01; 2(12). PMID: 25472608.
    Citations: 5     Fields:    
  17. Oblak AL, Hagen MC, Sweadner KJ, Haq I, Whitlow CT, Maldjian JA, Epperson F, Cook JF, Stacy M, Murrell JR, Ozelius LJ, Brashear A, Ghetti B. Rapid-onset dystonia-parkinsonism associated with the I758S mutation of the ATP1A3 gene: a neuropathologic and neuroanatomical study of four siblings. Acta Neuropathol. 2014 Jul; 128(1):81-98. PMID: 24803225.
    Citations: 22     Fields:    Translation:Humans
  18. Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Jóhannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B. Distinct neurological disorders with ATP1A3 mutations. Lancet Neurol. 2014 May; 13(5):503-14. PMID: 24739246.
    Citations: 91     Fields:    Translation:HumansAnimals
  19. Cook JF, Hill DF, Snively BM, Boggs N, Suerken CK, Haq I, Stacy M, McCall WV, Ozelius LJ, Sweadner KJ, Brashear A. Cognitive impairment in rapid-onset dystonia-parkinsonism. Mov Disord. 2014 Mar; 29(3):344-50. PMID: 24436111.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  20. Brashear A, Ozelius LJ, Sweadner KJ. ATP1A3 mutations: what is the phenotype? Neurology. 2014 Feb 11; 82(6):468-9. PMID: 24431297.
    Citations: 4     Fields:    Translation:Humans
  21. Liu CC, Karimi Galougahi K, Weisbrod RM, Hansen T, Ravaie R, Nunez A, Liu YB, Fry N, Garcia A, Hamilton EJ, Sweadner KJ, Cohen RA, Figtree GA. Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent ß1-subunit glutathionylation: implications for angiotensin II-induced vascular dysfunction. Free Radic Biol Med. 2013 Dec; 65:563-572. PMID: 23816524.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  22. Arystarkhova E, Liu YB, Salazar C, Stanojevic V, Clifford RJ, Kaplan JH, Kidder GM, Sweadner KJ. Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,K-ATPase. J Biol Chem. 2013 Mar 08; 288(10):7077-85. PMID: 23344951.
    Citations: 16     Fields:    Translation:AnimalsCells
  23. Brashear A, Cook JF, Hill DF, Amponsah A, Snively BM, Light L, Boggs N, Suerken CK, Stacy M, Ozelius L, Sweadner KJ, McCall WV. Psychiatric disorders in rapid-onset dystonia-parkinsonism. Neurology. 2012 Sep 11; 79(11):1168-73. PMID: 22933743; PMCID: PMC3525305.
    Citations: 25     Fields:    Translation:Humans
  24. Brashear A, Mink JW, Hill DF, Boggs N, McCall WV, Stacy MA, Snively B, Light LS, Sweadner KJ, Ozelius LJ, Morrison L. ATP1A3 mutations in infants: a new rapid-onset dystonia-Parkinsonism phenotype characterized by motor delay and ataxia. Dev Med Child Neurol. 2012 Nov; 54(11):1065-7. PMID: 22924536.
    Citations: 37     Fields:    Translation:Humans
  25. Barbano RL, Hill DF, Snively BM, Light LS, Boggs N, McCall WV, Stacy M, Ozelius L, Sweadner KJ, Brashear A. New triggers and non-motor findings in a family with rapid-onset dystonia-parkinsonism. Parkinsonism Relat Disord. 2012 Jul; 18(6):737-41. PMID: 22534615.
    Citations: 10     Fields:    Translation:Humans
  26. Sweadner KJ, Pascoa JL, Salazar CA, Arystarkhova E. Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA. J Biol Chem. 2011 May 20; 286(20):18290-300. PMID: 21460224.
    Citations: 6     Fields:    Translation:AnimalsCells
  27. Bibert S, Liu CC, Figtree GA, Garcia A, Hamilton EJ, Marassi FM, Sweadner KJ, Cornelius F, Geering K, Rasmussen HH. FXYD proteins reverse inhibition of the Na+-K+ pump mediated by glutathionylation of its beta1 subunit. J Biol Chem. 2011 May 27; 286(21):18562-72. PMID: 21454534.
    Citations: 38     Fields:    Translation:AnimalsCells
  28. Tarsy D, Sweadner KJ, Song PC. Case records of the Massachusetts General Hospital. Case 17-2010 - a 29-year-old woman with flexion of the left hand and foot and difficulty speaking. N Engl J Med. 2010 Jun 10; 362(23):2213-9. PMID: 20558373.
    Citations: 6     Fields:    Translation:HumansCells
  29. Anselm IA, Sweadner KJ, Gollamudi S, Ozelius LJ, Darras BT. Rapid-onset dystonia-parkinsonism in a child with a novel atp1a3 gene mutation. Neurology. 2009 Aug 04; 73(5):400-1. PMID: 19652145; PMCID: PMC2833268.
    Citations: 28     Fields:    Translation:Humans
  30. Sweadner KJ. A third mode of ouabain signaling. Focus on "Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells". Am J Physiol Cell Physiol. 2008 Sep; 295(3):C588-9. PMID: 18684986.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  31. Arystarkhova E, Donnet C, Muñoz-Matta A, Specht SC, Sweadner KJ. Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma-subunit in response to stress. Am J Physiol Cell Physiol. 2007 Mar; 292(3):C1179-91. PMID: 17050615.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  32. Arystarkhova E, Sweadner KJ. Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na, K-ATPase in kidney. J Bioenerg Biomembr. 2005 Dec; 37(6):381-6. PMID: 16691469.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  33. Sweadner KJ. Phospholemman: a new force in cardiac contractility. Circ Res. 2005 Sep 16; 97(6):510-1. PMID: 16166561.
    Citations: 2     Fields:    Translation:HumansAnimals
  34. Jones DH, Li TY, Arystarkhova E, Barr KJ, Wetzel RK, Peng J, Markham K, Sweadner KJ, Fong GH, Kidder GM. Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem. 2005 May 13; 280(19):19003-11. PMID: 15755730.
    Citations: 36     Fields:    Translation:AnimalsCells
  35. Jia LG, Donnet C, Bogaev RC, Blatt RJ, McKinney CE, Day KH, Berr SS, Jones LR, Moorman JR, Sweadner KJ, Tucker AL. Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1982-8. PMID: 15563542.
    Citations: 39     Fields:    Translation:AnimalsCells
  36. de Carvalho Aguiar P, Sweadner KJ, Penniston JT, Zaremba J, Liu L, Caton M, Linazasoro G, Borg M, Tijssen MA, Bressman SB, Dobyns WB, Brashear A, Ozelius LJ. Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron. 2004 Jul 22; 43(2):169-75. PMID: 15260953.
    Citations: 178     Fields:    Translation:HumansCells
  37. Ellis DZ, Sweadner KJ. NO regulation of Na,K-ATPase: nitric oxide regulation of the Na,K-ATPase in physiological and pathological states. Ann N Y Acad Sci. 2003 Apr; 986:534-5. PMID: 12763880.
    Citations: 2     Fields:    Translation:HumansAnimals
  38. Donnet C, Sweadner KJ. The mechanism of Na-K interaction on Na,K-ATPase. Ann N Y Acad Sci. 2003 Apr; 986:249-51. PMID: 12763810.
    Citations: 1     Fields:    Translation:Animals
  39. Sweadner KJ, Arystarkhova E, Donnet C, Wetzel RK. FXYD proteins as regulators of the Na,K-ATPase in the kidney. Ann N Y Acad Sci. 2003 Apr; 986:382-7. PMID: 12763854.
    Citations: 11     Fields:    Translation:Animals
  40. Wetzel RK, Sweadner KJ. Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus. Am J Physiol Renal Physiol. 2003 Jul; 285(1):F121-9. PMID: 12657562.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  41. Feschenko MS, Donnet C, Wetzel RK, Asinovski NK, Jones LR, Sweadner KJ. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. J Neurosci. 2003 Mar 15; 23(6):2161-9. PMID: 12657675; PMCID: PMC6742001.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  42. Ellis DZ, Rabe J, Sweadner KJ. Global loss of Na,K-ATPase and its nitric oxide-mediated regulation in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci. 2003 Jan 01; 23(1):43-51. PMID: 12514200; PMCID: PMC6742130.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  43. Moseley AE, Lieske SP, Wetzel RK, James PF, He S, Shelly DA, Paul RJ, Boivin GP, Witte DP, Ramirez JM, Sweadner KJ, Lingrel JB. The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice. J Biol Chem. 2003 Feb 14; 278(7):5317-24. PMID: 12458206.
    Citations: 55     Fields:    Translation:AnimalsCells
  44. Feschenko MS, Stevenson E, Nairn AC, Sweadner KJ. A novel cAMP-stimulated pathway in protein phosphatase 2A activation. J Pharmacol Exp Ther. 2002 Jul; 302(1):111-8. PMID: 12065707.
    Citations: 31     Fields:    Translation:AnimalsCells
  45. Arystarkhova E, Wetzel RK, Sweadner KJ. Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney. Am J Physiol Renal Physiol. 2002 Mar; 282(3):F393-407. PMID: 11832419.
    Citations: 25     Fields:    Translation:AnimalsCells
  46. Arystarkhova E, Donnet C, Asinovski NK, Sweadner KJ. Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit. J Biol Chem. 2002 Mar 22; 277(12):10162-72. PMID: 11756431.
    Citations: 15     Fields:    Translation:AnimalsCells
  47. Ellis DZ, Nathanson JA, Rabe J, Sweadner KJ. Carbachol and nitric oxide inhibition of Na,K-ATPase activity in bovine ciliary processes. Invest Ophthalmol Vis Sci. 2001 Oct; 42(11):2625-31. PMID: 11581209.
    Citations: 16     Fields:    Translation:Animals
  48. Wetzel RK, Sweadner KJ. Immunocytochemical localization of Na-K-ATPase alpha- and gamma-subunits in rat kidney. Am J Physiol Renal Physiol. 2001 Sep; 281(3):F531-45. PMID: 11502602.
    Citations: 29     Fields:    Translation:AnimalsCells
  49. Sweadner KJ, Donnet C. Structural similarities of Na,K-ATPase and SERCA, the Ca(2+)-ATPase of the sarcoplasmic reticulum. Biochem J. 2001 Jun 15; 356(Pt 3):685-704. PMID: 11389677; PMCID: PMC1221896.
    Citations: 51     Fields:    Translation:Cells
  50. Sweadner KJ, Feschenko MS. Predicted location and limited accessibility of protein kinase A phosphorylation site on Na-K-ATPase. Am J Physiol Cell Physiol. 2001 Apr; 280(4):C1017-26. PMID: 11245618.
    Citations: 11     Fields:    Translation:AnimalsCells
  51. Wetzel RK, Sweadner KJ. Immunocytochemical localization of NaK-ATPase isoforms in the rat and mouse ocular ciliary epithelium. Invest Ophthalmol Vis Sci. 2001 Mar; 42(3):763-9. PMID: 11222539.
    Citations: 10     Fields:    Translation:Animals
  52. Sweadner KJ, Wetzel RK, Arystarkhova E. Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. Biochem Biophys Res Commun. 2000 Dec 09; 279(1):196-201. PMID: 11112438.
    Citations: 12     Fields:    Translation:HumansCells
  53. Ellis DZ, Nathanson JA, Sweadner KJ. Carbachol inhibits Na(+)-K(+)-ATPase activity in choroid plexus via stimulation of the NO/cGMP pathway. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1685-93. PMID: 11078682.
    Citations: 17     Fields:    Translation:AnimalsCells
  54. Donnet C, Arystarkhova E, Sweadner KJ. Thermal denaturation of the Na,K-ATPase provides evidence for alpha-alpha oligomeric interaction and gamma subunit association with the C-terminal domain. J Biol Chem. 2001 Mar 09; 276(10):7357-65. PMID: 11099502.
    Citations: 20     Fields:    Translation:AnimalsCells
  55. Feschenko MS, Stevenson E, Sweadner KJ. Interaction of protein kinase C and cAMP-dependent pathways in the phosphorylation of the Na,K-ATPase. J Biol Chem. 2000 Nov 03; 275(44):34693-700. PMID: 10940309.
    Citations: 18     Fields:    Translation:AnimalsCells
  56. Martín-Vasallo P, Wetzel RK, García-Segura LM, Molina-Holgado E, Arystarkhova E, Sweadner KJ. Oligodendrocytes in brain and optic nerve express the beta3 subunit isoform of Na,K-ATPase. Glia. 2000 Sep; 31(3):206-18. PMID: 10941147.
    Citations: 13     Fields:    Translation:AnimalsCells
  57. Sweadner KJ, Rael E. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics. 2000 Aug 15; 68(1):41-56. PMID: 10950925.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  58. Arystarkhova E, Wetzel RK, Asinovski NK, Sweadner KJ. The gamma subunit modulates Na(+) and K(+) affinity of the renal Na,K-ATPase. J Biol Chem. 1999 Nov 19; 274(47):33183-5. PMID: 10559186.
    Citations: 50     Fields:    Translation:AnimalsCells
  59. Wetzel RK, Arystarkhova E, Sweadner KJ. Cellular and subcellular specification of Na,K-ATPase alpha and beta isoforms in the postnatal development of mouse retina. J Neurosci. 1999 Nov 15; 19(22):9878-89. PMID: 10559397; PMCID: PMC6782968.
    Citations: 48     Fields:    Translation:AnimalsCells
  60. Sharabani-Yosef O, Bak A, Langzam L, Lui Z, Nir U, Braiman L, Sweadner KJ, Sampson SR. Rat skeletal muscle in culture expresses the alpha1 but not the alpha2 protein subunit isoform of the Na+/K+ pump. J Cell Physiol. 1999 Aug; 180(2):236-44. PMID: 10395293.
    Citations: 6     Fields:    Translation:AnimalsCells
  61. Peng L, Arystarkhova E, Sweadner KJ. Plasticity of Na,K-ATPase isoform expression in cultures of flat astrocytes: species differences in gene expression. Glia. 1998 Nov; 24(3):257-71. PMID: 9775978.
    Citations: 7     Fields:    Translation:AnimalsCells
  62. Feschenko MS, Wetzel RK, Sweadner KJ. Phosphorylation of Na,K-ATPase by protein kinases. Sites, susceptibility, and consequences. Ann N Y Acad Sci. 1997 Nov 03; 834:479-88. PMID: 9405850.
    Citations: 6     Fields:    Translation:AnimalsCells
  63. Arystarkhova E, Sweadner KJ. Tissue-specific expression of the Na,K-ATPase beta3 subunit. The presence of beta3 in lung and liver addresses the problem of the missing subunit. J Biol Chem. 1997 Sep 05; 272(36):22405-8. PMID: 9278390.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  64. Arystarkhova E, Sweadner KJ. Hormonal and neurogenic control of Na-K-ATPase and myosin isoforms in neonatal rat cardiac myocytes. Am J Physiol. 1997 Aug; 273(2 Pt 1):C489-99. PMID: 9277346.
    Citations: 1     Fields:    Translation:AnimalsCells
  65. Feschenko MS, Sweadner KJ. Phosphorylation of Na,K-ATPase by protein kinase C at Ser18 occurs in intact cells but does not result in direct inhibition of ATP hydrolysis. J Biol Chem. 1997 Jul 11; 272(28):17726-33. PMID: 9211924.
    Citations: 24     Fields:    Translation:AnimalsCells
  66. Pacholczyk T, Sweadner KJ. Epitope and mimotope for an antibody to the Na, K-ATPase. Protein Sci. 1997 Jul; 6(7):1537-48. PMID: 9232655; PMCID: PMC2143741.
    Citations: 3     Fields:    Translation:AnimalsCells
  67. Peng L, Martin-Vasallo P, Sweadner KJ. Isoforms of Na,K-ATPase alpha and beta subunits in the rat cerebellum and in granule cell cultures. J Neurosci. 1997 May 15; 17(10):3488-502. PMID: 9133374; PMCID: PMC6573685.
    Citations: 63     Fields:    Translation:AnimalsCells
  68. Arystarkhova E, Sweadner KJ. Isoform-specific monoclonal antibodies to Na,K-ATPase alpha subunits. Evidence for a tissue-specific post-translational modification of the alpha subunit. J Biol Chem. 1996 Sep 20; 271(38):23407-17. PMID: 8798546.
    Citations: 25     Fields:    Translation:AnimalsCells
  69. Repke KR, Sweadner KJ, Weiland J, Megges R, Schön R. In search of ideal inotropic steroids: recent progress. Prog Drug Res. 1996; 47:9-52. PMID: 8961763.
    Citations: 3     Fields:    Translation:HumansAnimals
  70. Feschenko MS, Sweadner KJ. Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C. J Biol Chem. 1995 Jun 09; 270(23):14072-7. PMID: 7775468.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  71. Arystarkhova E, Gibbons DL, Sweadner KJ. Topology of the Na,K-ATPase. Evidence for externalization of a labile transmembrane structure during heating. J Biol Chem. 1995 Apr 14; 270(15):8785-96. PMID: 7721785.
    Citations: 9     Fields:    Translation:AnimalsCells
  72. Feschenko MS, Sweadner KJ. Conformation-dependent phosphorylation of Na,K-ATPase by protein kinase A and protein kinase C. J Biol Chem. 1994 Dec 02; 269(48):30436-44. PMID: 7982958.
    Citations: 20     Fields:    Translation:AnimalsCells
  73. Sweadner KJ, Herrera VL, Amato S, Moellmann A, Gibbons DK, Repke KR. Immunologic identification of Na+,K(+)-ATPase isoforms in myocardium. Isoform change in deoxycorticosterone acetate-salt hypertension. Circ Res. 1994 Apr; 74(4):669-78. PMID: 8137503.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  74. Mohraz M, Arystarkhova E, Sweadner KJ. Immunoelectron microscopy of epitopes on Na,K-ATPase catalytic subunit. Implications for the transmembrane organization of the C-terminal domain. J Biol Chem. 1994 Jan 28; 269(4):2929-36. PMID: 7507930.
    Citations: 1     Fields:    Translation:AnimalsCells
  75. Barlet-Bas C, Arystarkhova E, Cheval L, Marsy S, Sweadner K, Modyanov N, Doucet A. Are there several isoforms of Na,K-ATPase alpha subunit in the rabbit kidney? J Biol Chem. 1993 Jun 05; 268(16):11512-5. PMID: 8389354.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  76. Russo JJ, Sweadner KJ. Na(+)-K(+)-ATPase subunit isoform pattern modification by mitogenic insulin concentration in 3T3-L1 preadipocytes. Am J Physiol. 1993 Feb; 264(2 Pt 1):C311-6. PMID: 7680529.
    Citations: 7     Fields:    Translation:AnimalsCells
  77. Sweadner KJ. Multiple digitalis receptors A molecular perspective. Trends Cardiovasc Med. 1993 Jan-Feb; 3(1):2-6. PMID: 21244963.
    Citations: 2     Fields:    
  78. Sweadner KJ, Arystarkhova E. Constraints on models for the folding of the Na,K-ATPase. Ann N Y Acad Sci. 1992 Nov 30; 671:217-27. PMID: 1283814.
    Citations: 2     Fields:    Translation:AnimalsCells
  79. Arystarkhova E, Gasparian M, Modyanov NN, Sweadner KJ. Na,K-ATPase extracellular surface probed with a monoclonal antibody that enhances ouabain binding. J Biol Chem. 1992 Jul 05; 267(19):13694-701. PMID: 1377691.
    Citations: 7     Fields:    Translation:AnimalsCells
  80. Sweadner KJ, McGrail KM, Khaw BA. Discoordinate regulation of isoforms of Na,K-ATPase and myosin heavy chain in the hypothyroid postnatal rat heart and skeletal muscle. J Biol Chem. 1992 Jan 15; 267(2):769-73. PMID: 1309775.
    Citations: 10     Fields:    Translation:Animals
  81. Sweadner KJ. Overlapping and diverse distribution of Na-K ATPase isozymes in neurons and glia. Can J Physiol Pharmacol. 1992; 70 Suppl:S255-9. PMID: 1338295.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  82. Lucchesi PA, Sweadner KJ. Postnatal changes in Na,K-ATPase isoform expression in rat cardiac ventricle. Conservation of biphasic ouabain affinity. J Biol Chem. 1991 May 15; 266(14):9327-31. PMID: 1851176.
    Citations: 37     Fields:    Translation:AnimalsCells
  83. Sweadner KJ. Trypsin inhibitor paradoxically stabilizes trypsin activity in sodium dodecyl sulfate, facilitating proteolytic fingerprinting. Anal Biochem. 1991 Apr; 194(1):130-5. PMID: 1867377.
    Citations: 4     Fields:    Translation:AnimalsCells
  84. McGrail KM, Phillips JM, Sweadner KJ. Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na,K-ATPase. J Neurosci. 1991 Feb; 11(2):381-91. PMID: 1846906; PMCID: PMC6575210.
    Citations: 145     Fields:    Translation:AnimalsCells
  85. Sweadner KJ. Overview: subunit diversity in the Na,K-ATPase. Soc Gen Physiol Ser. 1991; 46:63-76. PMID: 1653994.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  86. Russo JJ, Manuli MA, Ismail-Beigi F, Sweadner KJ, Edelman IS. Na(+)-K(+)-ATPase in adipocyte differentiation in culture. Am J Physiol. 1990 Dec; 259(6 Pt 1):C968-77. PMID: 2175549.
    Citations: 9     Fields:    Translation:AnimalsCells
  87. Sweadner KJ. Anomalies in the electrophoretic resolution of Na+/K(+)-ATPase catalytic subunit isoforms reveal unusual protein--detergent interactions. Biochim Biophys Acta. 1990 Nov 02; 1029(1):13-23. PMID: 2171651.
    Citations: 4     Fields:    Translation:AnimalsCells
  88. McGrail KM, Sweadner KJ. Complex Expression Patterns for Na+,K+-ATPase Isoforms in Retina and Optic Nerve. Eur J Neurosci. 1990 Feb; 2(2):170-176. PMID: 12106060.
    Citations: 12     Fields:    
  89. Gloor S, Antonicek H, Sweadner KJ, Pagliusi S, Frank R, Moos M, Schachner M. The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase. J Cell Biol. 1990 Jan; 110(1):165-74. PMID: 1688561; PMCID: PMC2115981.
    Citations: 84     Fields:    Translation:AnimalsCells
  90. Urayama O, Shutt H, Sweadner KJ. Identification of three isozyme proteins of the catalytic subunit of the Na,K-ATPase in rat brain. J Biol Chem. 1989 May 15; 264(14):8271-80. PMID: 2542271.
    Citations: 42     Fields:    Translation:AnimalsCells
  91. Sweadner KJ. Isozymes of the Na+/K+-ATPase. Biochim Biophys Acta. 1989 May 09; 988(2):185-220. PMID: 2541792.
    Citations: 193     Fields:    Translation:AnimalsCells
  92. Urayama O, Sweadner KJ. Ouabain sensitivity of the alpha 3 isozyme of rat Na,K-ATPase. Biochem Biophys Res Commun. 1988 Oct 31; 156(2):796-800. PMID: 2847718.
    Citations: 18     Fields:    Translation:AnimalsCells
  93. Felsenfeld DP, Sweadner KJ. Fine specificity mapping and topography of an isozyme-specific epitope of the Na,K-ATPase catalytic subunit. J Biol Chem. 1988 Aug 05; 263(22):10932-42. PMID: 2455720.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  94. Sweadner KJ. Preparation of the alpha(+) isozyme of the Na+,K+-ATPase from mammalian axolemma. Methods Enzymol. 1988; 156:65-71. PMID: 2835628.
    Citations: 3     Fields:    Translation:AnimalsCells
  95. Sweadner KJ, Farshi SK. Two forms of the Na,K-ATPase catalytic subunit detected by their immunological and electrophoretic differences. Alpha and alpha+ in mammalian heart. Prog Clin Biol Res. 1988; 268B:149-56. PMID: 2851794.
    Citations: 2     Fields:    Translation:Animals
  96. Sweadner KJ, Farshi SK. Rat cardiac ventricle has two Na+,K+-ATPases with different affinities for ouabain: developmental changes in immunologically different catalytic subunits. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8404-7. PMID: 2825190; PMCID: PMC299551.
    Citations: 8     Fields:    Translation:AnimalsCells
  97. McGrail KM, Sweadner KJ. Immunofluorescent localization of two different Na,K-ATPases in the rat retina and in identified dissociated retinal cells. J Neurosci. 1986 May; 6(5):1272-83. PMID: 3012013; PMCID: PMC6568552.
    Citations: 15     Fields:    Translation:AnimalsCells
  98. Sweadner KJ. Enzymatic properties of separated isozymes of the Na,K-ATPase. Substrate affinities, kinetic cooperativity, and ion transport stoichiometry. J Biol Chem. 1985 Sep 25; 260(21):11508-13. PMID: 2995339.
    Citations: 30     Fields:    Translation:Animals
  99. Sweadner KJ. Ouabain-evoked norepinephrine release from intact rat sympathetic neurons: evidence for carrier-mediated release. J Neurosci. 1985 Sep; 5(9):2397-406. PMID: 2993543; PMCID: PMC6565319.
    Citations: 5     Fields:    Translation:AnimalsCells
  100. Schneider JW, Mercer RW, Caplan M, Emanuel JR, Sweadner KJ, Benz EJ, Levenson R. Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6357-61. PMID: 2994074; PMCID: PMC391053.
    Citations: 22     Fields:    Translation:AnimalsCells
  101. Sweadner KJ, Gilkeson RC. Two isozymes of the Na,K-ATPase have distinct antigenic determinants. J Biol Chem. 1985 Jul 25; 260(15):9016-22. PMID: 2410405.
    Citations: 20     Fields:    Translation:AnimalsPHPublic Health
  102. Specht SC, Sweadner KJ. Two different Na,K-ATPases in the optic nerve: cells of origin and axonal transport. Proc Natl Acad Sci U S A. 1984 Feb; 81(4):1234-8. PMID: 6199796; PMCID: PMC344801.
    Citations: 11     Fields:    Translation:AnimalsCells
  103. Sweadner KJ. Size, shape, and solubility of a class of releasable cell surface proteins of sympathetic neurons. J Neurosci. 1983 Dec; 3(12):2518-24. PMID: 6655497; PMCID: PMC6564661.
    Citations: 5     Fields:    Translation:AnimalsCells
  104. Sweadner KJ. Post-translational modification and evoked release of two large surface proteins of sympathetic neurons. J Neurosci. 1983 Dec; 3(12):2504-17. PMID: 6361221; PMCID: PMC6564650.
    Citations: 10     Fields:    Translation:AnimalsCells
  105. Gozes I, Sweadner KJ. Multiple tubulin forms are expressed by a single neurone. Nature. 1981 Dec 03; 294(5840):477-80. PMID: 7312039.
    Citations: 35     Fields:    Translation:Cells
  106. Braun SJ, Sweadner KJ, Patterson PH. Neuronal cell surfaces: distinctive glycoproteins of cultured adrenergic and cholinergic sympathetic neurons. J Neurosci. 1981 Dec; 1(12):1397-406. PMID: 7320752; PMCID: PMC6564125.
    Citations: 2     Fields:    Translation:AnimalsCells
  107. Sweadner KJ. Environmentally regulated expression of soluble extracellular proteins of sympathetic neurons. J Biol Chem. 1981 Apr 25; 256(8):4063-70. PMID: 7217069.
    Citations: 3     Fields:    Translation:AnimalsCells
  108. Sweadner KJ, Goldin SM. Active transport of sodium and potassium ions: mechanism, function, and regulation. N Engl J Med. 1980 Apr 03; 302(14):777-83. PMID: 6243739.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  109. Sweadner KJ. Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin. J Biol Chem. 1979 Jul 10; 254(13):6060-7. PMID: 221488.
    Citations: 81     Fields:    Translation:AnimalsCells
  110. Sweadner KJ. Purification from brain of an intrinsic membrane protein fraction enriched in (Na+ + K+)-ATPase. Biochim Biophys Acta. 1978 Apr 20; 508(3):486-99. PMID: 147708.
    Citations: 6     Fields:    Translation:AnimalsCells
  111. Sweadner KJ. Crosslinking and modification of Na,K-ATPase by ethyl acetimidate. Biochem Biophys Res Commun. 1977 Oct 10; 78(3):962-9. PMID: 143939.
    Citations: 4     Fields:    Translation:AnimalsCells
  112. Sweadner KJ, Forte M, Nelsen LL. Filtration removal of endotoxin (pyrogens) in solution in different states of aggregation. Appl Environ Microbiol. 1977 Oct; 34(4):382-5. PMID: 335971.
    Citations: 18     Fields:    Translation:CellsPHPublic Health
  113. Bass R, Heffernan L, Sweadner K, Englesberg E. The site for catabolite deactivation in the L-arabinose BAD operon in Escherichia coli B/r. Arch Microbiol. 1976 Oct 11; 110(1):135-43. PMID: 189718.
    Citations: 10     Fields:    Translation:Cells
  114. Goldin SM, Sweadner KJ. Reconstitution of active transport by kidney and brain (Na+ + K+)-ATPase. Ann N Y Acad Sci. 1975 Dec 30; 264:387-97. PMID: 130820.
    Citations:    Fields:    Translation:Cells
  115. Sweadner KJ, Goldin SM. Reconstitution of active ion transport by the sodium and potassium ion-stimulated adenosine triphosphatase from canine brain. J Biol Chem. 1975 May 25; 250(10):4022-4. PMID: 123920.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.