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Se Hoon Choi, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). PMID: 30190379.
    Citations: 175     Fields:    Translation:HumansAnimals
  2. Chatila ZK, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram MK, Gupta D, Kwak SS, Kim YH, Kim DY, Choi SH, Tanzi RE. BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice. eNeuro. 2018 Jul-Aug; 5(4). PMID: 30079376.
    Citations: 7     Fields:    Translation:AnimalsCells
  3. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. PMID: 28919280.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  4. Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. 3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish". Mol Neurodegener. 2016 12 09; 11(1):75. PMID: 27938410.
    Citations: 43     Fields:    Translation:HumansCells
  5. Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. Amyloid-ß peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016 05 25; 8(340):340ra72. PMID: 27225182.
    Citations: 357     Fields:    Translation:HumansAnimalsCells
  6. D'Avanzo C, Aronson J, Kim YH, Choi SH, Tanzi RE, Kim DY. Alzheimer's in 3D culture: challenges and perspectives. Bioessays. 2015 Oct; 37(10):1139-48. PMID: 26252541.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  7. Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY. A 3D human neural cell culture system for modeling Alzheimer's disease. Nat Protoc. 2015 Jul; 10(7):985-1006. PMID: 26068894.
    Citations: 86     Fields:    Translation:HumansCells
  8. Choi SH, Kim YH, D'Avanzo C, Aronson J, Tanzi RE, Kim DY. Recapitulating amyloid ß and tau pathology in human neural cell culture models: clinical implications. US Neurol. 2015; 11(2):102-105. PMID: 27019672; PMCID: PMC4803079.
    Citations: 7     
  9. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057.
    Citations: 410     Fields:    Translation:HumansCells
  10. Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors. Mol Neurodegener. 2013 Oct 20; 8:41. PMID: 24138759.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  11. Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate ß-amyloid accumulation by impairing prodomain chaperone function. Neuron. 2013 Oct 16; 80(2):385-401. PMID: 24055016.
    Citations: 87     Fields:    Translation:HumansAnimals
  12. Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013 May 22; 78(4):631-43. PMID: 23623698.
    Citations: 387     Fields:    Translation:HumansAnimalsCells
  13. Choi SH, Tanzi RE. iPSCs to the rescue in Alzheimer's research. Cell Stem Cell. 2012 Mar 02; 10(3):235-6. PMID: 22385650.
    Citations: 12     Fields:    
  14. Choi SH, Li Y. Elevated levels of BMP6 impair neurogenesis in Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):371-2. PMID: 21228148.
    Citations:    Fields:    
  15. Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19; 30(20):6903-15. PMID: 20484632.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  16. Veeraraghavalu K, Choi SH, Sisodia SS. Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis. Neurodegener Dis. 2010; 7(1-3):46-9. PMID: 20160458.
    Citations: 3     Fields:    Translation:HumansAnimals
  17. Choi SH, Li Y, Parada LF, Sisodia SS. Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener. 2009 Dec 21; 4:52. PMID: 20025751.
    Citations: 45     Fields:    
  18. Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF. Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angew Chem Int Ed Engl. 2009; 48(8):1487-9. PMID: 19152390.
    Citations: 11     Fields:    Translation:Animals
  19. Mirnics K, Norstrom EM, Garbett K, Choi SH, Zhang X, Ebert P, Sisodia SS. Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice. Mol Neurodegener. 2008 Oct 03; 3:14. PMID: 18834536.
    Citations: 12     Fields:    
  20. Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron. 2008 Aug 28; 59(4):568-80. PMID: 18760694.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  21. Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP. Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse. J Neurosci Res. 2008 May 15; 86(7):1615-25. PMID: 18189321.
    Citations: 24     Fields:    Translation:Animals
  22. Choi SH, Norstrom E. Moderate reduction of gamma-secretase: is there a therapeutic sweet spot? J Neurosci. 2007 Dec 12; 27(50):13579-80. PMID: 18077669.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP. Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis. 2008 Feb; 29(2):316-26. PMID: 17980611.
    Citations: 38     Fields:    Translation:AnimalsCells
  24. Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci. 2007 Jun 27; 27(26):7006-10. PMID: 17596449; PMCID: PMC6672232.
    Citations: 64     Fields:    Translation:AnimalsCells
  25. Choi SH, Woodlee MT, Hong JJ, Schallert T. A simple modification of the water maze test to enhance daily detection of spatial memory in rats and mice. J Neurosci Methods. 2006 Sep 30; 156(1-2):182-93. PMID: 16621016.
    Citations: 39     Fields:    Translation:Animals
  26. Kim S, Jeon BS, Heo C, Im PS, Ahn TB, Seo JH, Kim HS, Park CH, Choi SH, Cho SH, Lee WJ, Suh YH. Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson's disease. FASEB J. 2004 Oct; 18(13):1615-7. PMID: 15289452.
    Citations: 31     Fields:    Translation:HumansCells
  27. Lee HJ, Bach JH, Chae HS, Lee SH, Joo WS, Choi SH, Kim KY, Lee WB, Kim SS. Mitogen-activated protein kinase/extracellular signal-regulated kinase attenuates 3-hydroxykynurenine-induced neuronal cell death. J Neurochem. 2004 Feb; 88(3):647-56. PMID: 14720214.
    Citations: 16     Fields:    Translation:HumansCells
  28. Koo JW, Park CH, Choi SH, Kim NJ, Kim HS, Choe JC, Suh YH. The postnatal environment can counteract prenatal effects on cognitive ability, cell proliferation, and synaptic protein expression. FASEB J. 2003 Aug; 17(11):1556-8. PMID: 12824278.
    Citations: 29     Fields:    Translation:AnimalsCellsPHPublic Health
  29. Park CH, Choi SH, Kim CH, Seo JH, Koo JW, Rah JC, Kim HS, Jeong SJ, Joo WS, Lee YJ, Kim YS, Kim MS, Suh YH. General pharmacology of indole [2',3':3,4]pyrido[2,1-b]quinazolinium- 5,7,8,13-tetrahydro-14-methyl-5-oxo-chloride, a new anti-dementia agent. Arzneimittelforschung. 2003; 53(6):393-401. PMID: 12872609.
    Citations: 1     Fields:    Translation:Animals
  30. Park CH, Choi SH, Koo JW, Seo JH, Kim HS, Jeong SJ, Suh YH. Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. J Neurosci Res. 2002 Nov 01; 70(3):484-92. PMID: 12391609.
    Citations: 32     Fields:    Translation:AnimalsCells
  31. Kim HS, Lee JH, Lee JP, Kim EM, Chang KA, Park CH, Jeong SJ, Wittendorp MC, Seo JH, Choi SH, Suh YH. Amyloid beta peptide induces cytochrome C release from isolated mitochondria. Neuroreport. 2002 Oct 28; 13(15):1989-93. PMID: 12395106.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  32. Seo JH, Rah JC, Choi SH, Shin JK, Min K, Kim HS, Park CH, Kim S, Kim EM, Lee SH, Lee S, Suh SW, Suh YH. Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB J. 2002 Nov; 16(13):1826-8. PMID: 12223445.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  33. Chae HS, Bach JH, Lee MW, Kim HS, Kim YS, Kim KY, Choo KY, Choi SH, Park CH, Lee SH, Suh YH, Kim SS, Lee WB. Estrogen attenuates cell death induced by carboxy-terminal fragment of amyloid precursor protein in PC12 through a receptor-dependent pathway. J Neurosci Res. 2001 Sep 01; 65(5):403-7. PMID: 11536323.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Choi SH, Park CH, Koo JW, Seo JH, Kim HS, Jeong SJ, Lee JH, Kim SS, Suh YH. Memory impairment and cholinergic dysfunction by centrally administered Abeta and carboxyl-terminal fragment of Alzheimer's APP in mice. FASEB J. 2001 Aug; 15(10):1816-8. PMID: 11481240.
    Citations: 19     Fields:    Translation:AnimalsCells
  35. Bach JH, Chae HS, Rah JC, Lee MW, Park CH, Choi SH, Choi JK, Lee SH, Kim YS, Kim KY, Lee WB, Suh YH, Kim SS. C-terminal fragment of amyloid precursor protein induces astrocytosis. J Neurochem. 2001 Jul; 78(1):109-20. PMID: 11432978.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  36. Seo J, Kim S, Kim H, Park CH, Jeong S, Lee J, Choi SH, Chang K, Rah J, Koo J, Kim E, Suh Y. Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity. Biol Psychiatry. 2001 Feb 01; 49(3):240-7. PMID: 11230875.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  37. Jeong SJ, Kim HS, Chang KA, Geum DH, Park CH, Seo JH, Rah JC, Lee JH, Choi SH, Lee SG, Kim K, Suh YH. Subcellular localization of presenilins during mouse preimplantation development. FASEB J. 2000 Nov; 14(14):2171-6. PMID: 11053237.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  38. Park CH, Choi SH, Piao Y, Kim S, Lee YJ, Kim HS, Jeong SJ, Rah JC, Seo JH, Lee JH, Chang K, Jung YJ, Suh YH. Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice. Toxicol Lett. 2000 May 19; 115(2):117-25. PMID: 10802387.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Park CH, Lee YJ, Lee SH, Choi SH, Kim HS, Jeong SJ, Kim SS, Suh YH. Dehydroevodiamine.HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. J Neurochem. 2000 Jan; 74(1):244-53. PMID: 10617126.
    Citations: 11     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.