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Howard Raymond Katz, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Apr 30, 2026
    NIH
    Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease
    Role: Co-Principal Investigator
  2. R01HL070946 (KATZ, HOWARD R) May 1, 2003 - Apr 30, 2013
    NIH
    Group V Phospholipase A2 and Pulmonary Inflammation
    Role: Principal Investigator
  3. R01AI041144 (KATZ, HOWARD R) Jan 1, 1998 - Feb 28, 2009
    NIH
    Control of inflammatory diseases by gp49 receptors
    Role: Principal Investigator
  4. R01AI032101 (KATZ, HOWARD R) Jul 1, 1992 - Jun 30, 1996
    NIH
    MAST CELL DIVERSITY IN HYPERSENSITIVITY AND INFLAMMATION
    Role: Principal Investigator
  5. U19AI031599 (KATZ, HOWARD R) Sep 1, 1991 - Aug 31, 1999
    NIH/NIAID
    EXPRESSION OF THE GP49 FAMILY ON MAST CELLS AND MONONUCLEAR PHAGOCYTES
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK, Barrett NA, Boyce JA. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021 02 26; 6(56). PMID: 33637594; PMCID: PMC8362933.
    Citations: 25     Fields:    Translation:HumansCells
  2. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 06; 145(6):1574-1584. PMID: 32199912; PMCID: PMC7282948.
    Citations: 23     Fields:    Translation:HumansCells
  3. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709; PMCID: PMC6462243.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  4. Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920. PMID: 28514613.
    Citations: 69     Fields:    Translation:HumansCells
  5. Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA. Phosphoinositide 3-Kinase d Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol. 2016 07 01; 197(1):278-87. PMID: 27194783; PMCID: PMC4912906.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  6. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435; PMCID: PMC4860132.
    Citations: 61     Fields:    Translation:HumansCells
  7. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029; PMCID: PMC4592820.
    Citations: 50     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  8. Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J Immunol. 2015 Jun 01; 194(11):5061-8. PMID: 25904552; PMCID: PMC4433852.
    Citations: 10     Fields:    Translation:AnimalsCells
  9. Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014 Feb 15; 192(4):1361-71. PMID: 24453247; PMCID: PMC4024442.
    Citations: 25     Fields:    Translation:AnimalsCells
  10. Liu T, Laidlaw TM, Katz HR, Boyce JA. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16987-92. PMID: 24085850.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  11. Fanning LB, Buckley CC, Xing W, Breslow RG, Katz HR. Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation. PLoS One. 2013; 8(2):e57007. PMID: 23431396.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Liu AY, Dwyer DF, Jones TG, Bankova LG, Shen S, Katz HR, Austen KF, Gurish MF. Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6. J Immunol. 2013 Feb 15; 190(4):1758-66. PMID: 23319739; PMCID: PMC3563837.
    Citations: 9     Fields:    Translation:AnimalsCells
  13. Katz HR, Austen KF. Mast cell deficiency, a game of kit and mouse. Immunity. 2011 Nov 23; 35(5):668-70. PMID: 22118523.
    Citations: 22     Fields:    
  14. Giannattasio G, Fujioka D, Xing W, Katz HR, Boyce JA, Balestrieri B. Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol. 2010 Oct 01; 185(7):4430-8. PMID: 20817863; PMCID: PMC3003260.
    Citations: 22     Fields:    Translation:AnimalsCells
  15. Breslow RG, Rao JJ, Xing W, Hong DI, Barrett NA, Katz HR. Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells. J Immunol. 2010 Jan 15; 184(2):1003-13. PMID: 19966208; PMCID: PMC2836496.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Balestrieri B, Maekawa A, Xing W, Gelb MH, Katz HR, Arm JP. Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. J Immunol. 2009 Apr 15; 182(8):4891-8. PMID: 19342668; PMCID: PMC2746418.
    Citations: 42     Fields:    Translation:AnimalsCells
  17. Murphy TR, Legere HJ, Katz HR. Activation of protein kinase D1 in mast cells in response to innate, adaptive, and growth factor signals. J Immunol. 2007 Dec 01; 179(11):7876-82. PMID: 18025234.
    Citations: 9     Fields:    Translation:AnimalsCells
  18. Zhou JS, Xing W, Friend DS, Austen KF, Katz HR. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med. 2007 Nov 26; 204(12):2797-802. PMID: 17998392.
    Citations: 79     Fields:    Translation:AnimalsCells
  19. Katz HR. Inhibition of pathologic inflammation by leukocyte Ig-like receptor B4 and related inhibitory receptors. Immunol Rev. 2007 Jun; 217:222-30. PMID: 17498062.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  20. Katz HR. Inhibition of inflammatory responses by leukocyte Ig-like receptors. Adv Immunol. 2006; 91:251-72. PMID: 16938543.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  21. Zhou JS, Friend DS, Lee DM, Li L, Austen KF, Katz HR. gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb. Eur J Immunol. 2005 May; 35(5):1530-8. PMID: 15827966.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. Zhou JS, Friend DS, Feldweg AM, Daheshia M, Li L, Austen KF, Katz HR. Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. J Exp Med. 2003 Oct 20; 198(8):1243-51. PMID: 14557414; PMCID: PMC2194230.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Feldweg AM, Friend DS, Zhou JS, Kanaoka Y, Daheshia M, Li L, Austen KF, Katz HR. gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. Eur J Immunol. 2003 Aug; 33(8):2262-8. PMID: 12884301.
    Citations: 12     Fields:    Translation:AnimalsCells
  24. Gu X, Laouar A, Wan J, Daheshia M, Lieberman J, Yokoyama WM, Katz HR, Manjunath N. The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. J Immunol. 2003 Apr 15; 170(8):4095-101. PMID: 12682239.
    Citations: 15     Fields:    Translation:AnimalsCells
  25. Katz HR. Inhibitory receptors and allergy. Curr Opin Immunol. 2002 Dec; 14(6):698-704. PMID: 12413518.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  26. Katz HR. Inhibition of anaphylactic inflammation by the gp49B1 receptor on mast cells. Mol Immunol. 2002 Sep; 38(16-18):1301-5. PMID: 12217399.
    Citations: 3     Fields:    Translation:AnimalsCells
  27. Daheshia M, Friend DS, Grusby MJ, Austen KF, Katz HR. Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med. 2001 Jul 16; 194(2):227-34. PMID: 11457897; PMCID: PMC2193448.
    Citations: 15     Fields:    Translation:AnimalsCells
  28. Castells MC, Klickstein LB, Hassani K, Cumplido JA, Lacouture ME, Austen KF, Katz HR. gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. Nat Immunol. 2001 May; 2(5):436-42. PMID: 11323698.
    Citations: 25     Fields:    Translation:AnimalsCells
  29. Lu-Kuo JM, Fruman DA, Joyal DM, Cantley LC, Katz HR. Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. J Biol Chem. 2000 Feb 25; 275(8):6022-9. PMID: 10681597.
    Citations: 20     Fields:    Translation:AnimalsCells
  30. McCormick MJ, Castells MC, Austen KF, Katz HR. The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily. Immunogenetics. 1999 Dec; 50(5-6):286-94. PMID: 10630292.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  31. Pivniouk VI, Martin TR, Lu-Kuo JM, Katz HR, Oettgen HC, Geha RS. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43. PMID: 10377180; PMCID: PMC408386.
    Citations: 50     Fields:    Translation:AnimalsCells
  32. Lu-Kuo JM, Joyal DM, Austen KF, Katz HR. gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. J Biol Chem. 1999 Feb 26; 274(9):5791-6. PMID: 10026201.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Katz HR. gp49B1 and its related family of counterregulatory receptors of the immunoglobulin superfamily. Int Arch Allergy Immunol. 1999 Feb-Apr; 118(2-4):177-9. PMID: 10224370.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  34. Katz HR, Austen KF. A newly recognized pathway for the negative regulation of mast cell-dependent hypersensitivity and inflammation mediated by an endogenous cell surface receptor of the gp49 family. J Immunol. 1997 Jun 01; 158(11):5065-70. PMID: 9164917.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Katz HR, Vivier E, Castells MC, McCormick MJ, Chambers JM, Austen KF. Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10809-14. PMID: 8855262; PMCID: PMC38237.
    Citations: 22     Fields:    Translation:AnimalsCells
  36. Du T, Friend DS, Austen KF, Katz HR. Tissue-dependent differences in the asynchronous appearance of mast cells in normal mice and in congenic mast cell-deficient mice after infusion of normal bone marrow cells. Clin Exp Immunol. 1996 Feb; 103(2):316-21. PMID: 8565318; PMCID: PMC2200335.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Katz HR, Lobell RB. Expression and function of Fc gamma R in mouse mast cells. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):76-8. PMID: 7613221.
    Citations: 6     Fields:    Translation:AnimalsCells
  38. Castells MC, Wu X, Arm JP, Austen KF, Katz HR. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem. 1994 Mar 18; 269(11):8393-401. PMID: 8132564.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  39. Lobell RB, Austen KF, Katz HR. Fc gamma R-mediated endocytosis and expression of cell surface Fc gamma RIIb1 and Fc gamma RIIb2 by mouse bone marrow culture-derived progenitor mast cells. J Immunol. 1994 Jan 15; 152(2):811-8. PMID: 8283054.
    Citations: 7     Fields:    Translation:AnimalsCells
  40. Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM, Galli SJ. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest. 1993 Mar; 91(3):1176-82. PMID: 8450046; PMCID: PMC288074.
    Citations: 22     Fields:    Translation:AnimalsCells
  41. Lobell RB, Arm JP, Raizman MB, Austen KF, Katz HR. Intracellular degradation of Fc gamma RIII in mouse bone marrow culture-derived progenitor mast cells prevents its surface expression and associated function. J Biol Chem. 1993 Jan 15; 268(2):1207-12. PMID: 8419324.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Katz HR, Raizman MB, Gartner CS, Scott HC, Benson AC, Austen KF. Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. J Immunol. 1992 Feb 01; 148(3):868-71. PMID: 1309842.
    Citations: 22     Fields:    Translation:Cells
  43. Katz HR, Kaye RE, Austen KF. Mast cell biochemical and functional heterogeneity. Transplant Proc. 1991 Dec; 23(6):2900-4. PMID: 1721308.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Arm JP, Gurish MF, Reynolds DS, Scott HC, Gartner CS, Austen KF, Katz HR. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. J Biol Chem. 1991 Aug 25; 266(24):15966-73. PMID: 1714901.
    Citations: 15     Fields:    Translation:AnimalsCells
  45. Katz HR, Arm JP, Benson AC, Austen KF. Maturation-related changes in the expression of Fc gamma RII and Fc gamma RIII on mouse mast cells derived in vitro and in vivo. J Immunol. 1990 Nov 15; 145(10):3412-7. PMID: 1700009.
    Citations: 7     Fields:    Translation:AnimalsCells
  46. Raizman MB, Austen KF, Katz HR. Mast cell heterogeneity. Differential synthesis and expression of glycosphingolipids by mouse serosal mast cells as compared to IL-3-dependent bone marrow culture-derived mast cells before or after coculture with 3T3 fibroblasts. J Immunol. 1990 Sep 01; 145(5):1463-8. PMID: 2200824.
    Citations: 3     Fields:    Translation:AnimalsCells
  47. Katz HR, Benson AC, Austen KF. Activation- and phorbol ester-stimulated phosphorylation of a plasma membrane glycoprotein antigen expressed on mouse IL-3-dependent mast cells and serosal mast cells. J Immunol. 1989 Feb 01; 142(3):919-26. PMID: 2464032.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Katz HR, Dayton ET, Levi-Schaffer F, Benson AC, Austen KF, Stevens RL. Coculture of mouse IL-3-dependent mast cells with 3T3 fibroblasts stimulates synthesis of globopentaosylceramide (Forssman glycolipid) by fibroblasts and surface expression on both populations. J Immunol. 1988 May 01; 140(9):3090-7. PMID: 2452198.
    Citations: 3     Fields:    Translation:AnimalsCells
  49. Otsu K, Nakano T, Kanakura Y, Asai H, Katz HR, Austen KF, Stevens RL, Galli SJ, Kitamura Y. Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. J Exp Med. 1987 Mar 01; 165(3):615-27. PMID: 3102674; PMCID: PMC2188296.
    Citations: 29     Fields:    Translation:AnimalsCells
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