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Benjamin Bleier, M.D.

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Overview
I am a surgeon scientist with a clinical focus in endoscopic sinonasal and skull base surgery. My research focus is on the role of mucosal barrier function in the pathogenesis of chronic inflammatory upper airway disease, the development of in vitro and in vivo topical drug delivery models, and surgical wound repair using laser tissue welding.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Miyake MM, Bleier BS. Future topical medications in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019 May; 9(S1):S32-S46. PMID: 31087632.
    Citations:    
  2. El Rassi E, Adappa ND, Battaglia P, Castelnuovo P, Dallan I, Freitag SK, Gardner PA, Lenzi R, Lubbe D, Metson R, Moe KS, Muscatello L, Mustak H, Nogueira JF, Palmer JN, Prepageran N, Ramakirshnan VR, Sacks R, Snyderman CH, Stefko ST, Turri-Zanoni M, Wang EW, Zhou B, Bleier BS. Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system. Int Forum Allergy Rhinol. 2019 Feb 27. PMID: 30809970.
    Citations:    
  3. Yamasaki A, Levesque PA, Bleier BS, Busaba NY, Gray ST, Holbrook EH, Sedaghat AR, Lindsay RW. Improvement in nasal obstruction and quality of life after septorhinoplasty and turbinate surgery. Laryngoscope. 2019 Feb 27. PMID: 30810237.
    Citations:    
  4. Mueller SK, Nocera AL, Dillon ST, Libermann TA, Wendler O, Bleier BS. Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps. Am J Rhinol Allergy. 2019 Feb 27; 1945892419831108. PMID: 30810048.
    Citations:    
  5. Workman AD, Nocera AL, Mueller SK, Otu HH, Libermann TA, Bleier BS. Translating transcription: proteomics in chronic rhinosinusitis with nasal polyps reveals significant discordance with messenger RNA expression. Int Forum Allergy Rhinol. 2019 Feb 18. PMID: 30775848.
    Citations:    
  6. Cassano P, Tran AP, Katnani H, Bleier BS, Hamblin MR, Yuan Y, Fang Q. Selective photobiomodulation for emotion regulation: model-based dosimetry study. Neurophotonics. 2019 Jan; 6(1):015004. PMID: 30796882.
    Citations:    
  7. Scangas GA, Bleier BS, Husain Q, Holbrook EH, Gray ST, Metson R. Does bilateral inferior turbinate reduction affect long-term quality-of-life outcomes in patients undergoing endoscopic sinus surgery? Int Forum Allergy Rhinol. 2019 Jun; 9(6):601-606. PMID: 30702220.
    Citations:    Fields:    
  8. Wu D, Nocera AL, Mueller SK, Finn K, Libermann TA, Bleier BS. Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps. Laryngoscope. 2019 03; 129(3):E102-E109. PMID: 30537181.
    Citations:    Fields:    
  9. Pawar GN, Parayath NN, Nocera AL, Bleier BS, Amiji MM. Direct CNS delivery of proteins using thermosensitive liposome-in-gel carrier by heterotopic mucosal engrafting. PLoS One. 2018; 13(12):e0208122. PMID: 30517163.
    Citations:    Fields:    
  10. Stephan JR, Yu F, Costello RM, Bleier BS, Nolan EM. Oxidative Post-translational Modifications Accelerate Proteolytic Degradation of Calprotectin. J Am Chem Soc. 2018 Dec 19; 140(50):17444-17455. PMID: 30380834.
    Citations:    Fields:    
  11. Mueller SK, Nocera AL, Dillon ST, Gu X, Wendler O, Otu HH, Libermann TA, Bleier BS. Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2019 Feb; 9(2):177-186. PMID: 30485711.
    Citations:    Fields:    
  12. Nocera AL, Mueller SK, Stephan JR, Hing L, Seifert P, Han X, Lin DT, Amiji MM, Libermann T, Bleier BS. Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide. J Allergy Clin Immunol. 2019 Apr; 143(4):1525-1535.e1. PMID: 30442371.
    Citations:    Fields:    
  13. Locketz GD, Brant JD, Adappa ND, Palmer JN, Goldberg AN, Loftus PA, Chandra RK, Bleier BS, Mueller SK, Orlandi RR, Becker M, Dorminy CA, Becker SD, Blasetti M, Becker DG. Postoperative Opioid Use in Sinonasal Surgery. Otolaryngol Head Neck Surg. 2019 Mar; 160(3):402-408. PMID: 30324849.
    Citations:    Fields:    
  14. Wu D, Gray ST, Holbrook EH, BuSaba NY, Bleier BS. SNOT-22 score patterns strongly negatively predict chronic rhinosinusitis in patients with headache. Int Forum Allergy Rhinol. 2019 Jan; 9(1):9-15. PMID: 30281928.
    Citations:    Fields:    
  15. Bleier BS. A Shift in the Orbit: Immediate Endoscopic Reconstruction After Transnasal Orbital Tumors Resection: Response. J Craniofac Surg. 2018 09; 29(6):1674-1675. PMID: 30067523.
    Citations:    Fields:    
  16. Mueller SK, Nocera AL, Dillon ST, Wu D, Libermann TA, Bleier BS. Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2018 12; 8(12):1438-1444. PMID: 30091854.
    Citations:    Fields:    
  17. Wu D, Bleier BS, Wei Y. Temporary olfactory improvement in chronic rhinosinusitis with nasal polyps after treatment. Eur Arch Otorhinolaryngol. 2018 Sep; 275(9):2193-2202. PMID: 30027441.
    Citations:    Fields:    Translation:Humans
  18. Wu D, Mueller SK, Nocera AL, Finn K, Libermann TA, Bleier BS. TREM-1 Neutrophil Activation Pathway Is Suppressed in Eosinophilic Nasal Polyps. Am J Rhinol Allergy. 2018 Sep; 32(5):359-368. PMID: 29961347.
    Citations:    Fields:    Translation:HumansCells
  19. Wu D, Mueller SK, Nocera AL, Finn K, Libermann TA, Bleier BS. Axonal Guidance Signaling Pathway Is Suppressed in Human Nasal Polyps. Am J Rhinol Allergy. 2018 Jul; 32(4):208-216. PMID: 29754498.
    Citations:    Fields:    Translation:HumansCells
  20. Mueller SK, Freitag SK, Bleier BS. Morphometric Analysis of the Orbital Process of the Palatine Bone and its Relationship to Endoscopic Orbital Apex Surgery. Ophthalmic Plast Reconstr Surg. 2018 May/Jun; 34(3):254-257. PMID: 28658180.
    Citations: 1     Translation:Humans
  21. Bleier BS. A "golden age" in skull base and rhinology research. Int Forum Allergy Rhinol. 2018 05; 8(5):561-562. PMID: 29694736.
    Citations:    Fields:    
  22. Mueller SK, Freitag SK, Lefebvre DR, Lee NG, Bleier BS. Revision eDCR using a superior pedicled mucosal flap. Orbit. 2019 Feb; 38(1):1-6. PMID: 29517401.
    Citations:    Fields:    
  23. Wu D, Wei Y, Bleier BS. Emerging Role of Proteases in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps. Front Cell Infect Microbiol. 2017; 7:538. PMID: 29376037.
    Citations:    Fields:    Translation:HumansCells
  24. Mueller SK, Bleier BS. Osteologic analysis of ethnic differences in supernumerary ethmoidal foramina: implications for endoscopic sinus and orbit surgery. Int Forum Allergy Rhinol. 2018 05; 8(5):655-658. PMID: 29278458.
    Citations:    Fields:    
  25. Hoggard M, Nocera A, Biswas K, Taylor MW, Douglas RG, Bleier BS. The sinonasal microbiota, neural signaling, and depression in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018 03; 8(3):394-405. PMID: 29278464.
    Citations: 1     Fields:    
  26. Gregorio LL, Busaba NY, Miyake MM, Freitag SK, Bleier BS. Expanding the limits of endoscopic intraorbital tumor resection using 3-dimensional reconstruction. Braz J Otorhinolaryngol. 2019 Mar - Apr; 85(2):157-161. PMID: 29337012.
    Citations:    Fields:    
  27. Mueller SK, Scangas G, Amiji MM, Bleier BS. Prospective transfrontal sheep model of skull-base reconstruction using vascularized mucosa. Int Forum Allergy Rhinol. 2018 05; 8(5):614-619. PMID: 29227037.
    Citations:    Fields:    
  28. Bleier BS. Case of the month. Int Forum Allergy Rhinol. 2017 12; 7(12):1119-1120. PMID: 29149548.
    Citations:    Fields:    Translation:Humans
  29. Mueller SK, Nocera AL, Bleier BS. Exosome function in aerodigestive mucosa. Nanomedicine. 2018 02; 14(2):269-277. PMID: 29127037.
    Citations:    Fields:    Translation:HumansAnimalsCells
  30. Wu D, Bleier BS, Li L, Zhan X, Zhang L, Lv Q, Wang J, Wei Y. Clinical Phenotypes of Nasal Polyps and Comorbid Asthma Based on Cluster Analysis of Disease History. J Allergy Clin Immunol Pract. 2018 Jul - Aug; 6(4):1297-1305.e1. PMID: 29100865.
    Citations: 2     Fields:    
  31. Levy JM, Smith SS, Varshney R, Chang EH, Ramakrishnan VR, Ting JY, Bleier BS. Trends in sinusitis research: a systematic review of extramural funding. Int Forum Allergy Rhinol. 2017 11; 7(11):1104-1107. PMID: 28985031.
    Citations:    Fields:    Translation:Humans
  32. Mueller SK, Miyake MM, Lefebvre DR, Freitag SK, Bleier BS. Long-term impact of endoscopic orbital decompression on sinonasal-specific quality of life. Laryngoscope. 2018 04; 128(4):785-788. PMID: 28944477.
    Citations:    Fields:    Translation:Humans
  33. Maxfield AZ, Brook CD, Miyake MM, Bleier BS. Compartmental Endoscopic Surgical Anatomy of the Inferior Intraconal Orbital Space. J Neurol Surg B Skull Base. 2018 Apr; 79(2):189-192. PMID: 29868326.
    Citations:    
  34. Finn AP, Bleier B, Cestari DM, Kazlas MA, Dagi LR, Lefebvre DR, Yoon MK, Freitag SK. A Retrospective Review of Orbital Decompression for Thyroid Orbitopathy with Endoscopic Preservation of the Inferomedial Orbital Bone Strut. Ophthalmic Plast Reconstr Surg. 2017 Sep/Oct; 33(5):334-339. PMID: 27608287.
    Citations: 1     Translation:Humans
  35. Mueller SK, Freitag SK, Lefebvre DR, Bleier BS. Endoscopic DCR using bipedicled interlacing mucosal flaps. Laryngoscope. 2018 04; 128(4):794-797. PMID: 28786234.
    Citations:    Fields:    Translation:Humans
  36. Scangas GA, Remenschneider AK, Bleier BS, Holbrook EH, Gray ST, Metson RB. Does the Timing of Middle Turbinate Resection Influence Quality-of-Life Outcomes for Patients with Chronic Rhinosinusitis? Otolaryngol Head Neck Surg. 2017 11; 157(5):874-879. PMID: 28508726.
    Citations: 1     Fields:    Translation:Humans
  37. Nocera AL, Miyake MM, Seifert P, Han X, Bleier BS. Exosomes mediate interepithelial transfer of functional P-glycoprotein in chronic rhinosinusitis with nasal polyps. Laryngoscope. 2017 09; 127(9):E295-E300. PMID: 28485529.
    Citations: 1     Fields:    Translation:HumansCells
  38. Miyake MM, Nocera A, Levesque P, Guo R, Finn CA, Goldfarb J, Gray S, Holbrook E, Busaba N, Dolci JEL, Bleier BS. Double-blind placebo-controlled randomized clinical trial of verapamil for chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2017 07; 140(1):271-273. PMID: 28126245.
    Citations: 1     Fields:    
  39. Scangas GA, Bleier BS. Anosmia: Differential diagnosis, evaluation, and management. Am J Rhinol Allergy. 2017 Jan 01; 31(1):3-7. PMID: 28234141.
    Citations:    Fields:    Translation:Humans
  40. Günel C, Bleier BS, Bozkurt G, Eliyatkin N. Microarray analysis of the genes associated with osteitis in chronic rhinosinusitis. Laryngoscope. 2017 03; 127(3):E85-E90. PMID: 27888647.
    Citations:    Fields:    Translation:HumansCells
  41. Günel C, Bleier BS, Meteoglu I. Antibiotics in eosinophilic chronic rhinosinusitis: Rethinking maximal antimicrobial medical therapy. Laryngoscope. 2017 04; 127(4):794-796. PMID: 27888519.
    Citations: 1     Fields:    Translation:Humans
  42. Chen X, Bleier BS, Lefebvre DR, Lee NG. Pseudomonas Aeruginosa: A Masquerader in Sino-Orbital Infections. Ophthalmic Plast Reconstr Surg. 2016 Sep-Oct; 32(5):374-7. PMID: 26398244.
    Citations:    Translation:HumansCells
  43. Miyake MM, Gregorio LL, Freitag SK, Lefebvre DR, Gray ST, Holbrook EH, Bleier BS. Impact of endoscopic dacryocystorhinostomy on sinonasal quality of life. Am J Rhinol Allergy. 2016 Sep; 30(5):189-91. PMID: 27657894.
    Citations: 1     Fields:    Translation:Humans
  44. Nocera AL, Meurer AT, Miyake MM, Sadow PM, Han X, Bleier BS. Secreted P-glycoprotein is a noninvasive biomarker of chronic rhinosinusitis. Laryngoscope. 2017 01; 127(1):E1-E4. PMID: 27577924.
    Citations: 1     Fields:    Translation:Humans
  45. Maxfield AZ, Korkmaz H, Gregorio LL, Busaba NY, Gray ST, Holbrook EH, Guo R, Bleier BS. General antibiotic exposure is associated with increased risk of developing chronic rhinosinusitis. Laryngoscope. 2017 02; 127(2):296-302. PMID: 27549904.
    Citations: 1     Fields:    Translation:Humans
  46. Cheng YS, Bleier BS. Influence of P-Glycoprotein Function on Chronic Rhinosinusitis/Nasal Polyps Pathophysiology. Adv Otorhinolaryngol. 2016; 79:38-47. PMID: 27466845.
    Citations: 2     Fields:    Translation:Humans
  47. Jacobs J, Bleier BS, Hopkins C, Hwang P, Poetker D, Schlosser R, Stewart M, Varshney R. Response to: The "RACE" national database for recurrent acute rhinosinusitis may need a relook. Int Forum Allergy Rhinol. 2016 10; 6(10):1100. PMID: 27383827.
    Citations:    Fields:    Translation:Humans
  48. Korkmaz H, Yao W, Korkmaz M, Bleier BS. Benefit of Preoperative Oral Steroids during Sinus Surgery when Utilizing Concentrated Topical Epinephrine. ORL J Otorhinolaryngol Relat Spec. 2016; 78(4):216-22. PMID: 27383647.
    Citations:    Fields:    Translation:Humans
  49. Nocera AL, Meurer AT, Singleton A, Simons C, BuSaba J, Tara Gass N, Han X, Bleier BS. Intact soluble P-glycoprotein is secreted by sinonasal epithelial cells. Am J Rhinol Allergy. 2016 Jul; 30(4):246-9. PMID: 27456593.
    Citations:    Fields:    Translation:HumansCells
  50. Lin G, Bleier B. Surgical Management of Severe Epistaxis. Otolaryngol Clin North Am. 2016 Jun; 49(3):627-37. PMID: 27267015.
    Citations: 2     Fields:    Translation:Humans
  51. Lin GC, Freitag SK, Kocharyan A, Yoon MK, Lefebvre DR, Bleier BS. Comparative techniques of medial rectus muscle retraction for endoscopic exposure of the medial intraconal space. Am J Rhinol Allergy. 2016 May; 30(3):226-9. PMID: 27216355.
    Citations: 1     Fields:    Translation:Humans
  52. Naunheim MR, Goyal N, Dedmon MM, Chambers KJ, Sedaghat AR, Bleier BS, Holbrook EH, Curry WT, Gray ST, Lin DT. An Algorithm for Surgical Approach to the Anterior Skull Base. J Neurol Surg B Skull Base. 2016 Aug; 77(4):364-70. PMID: 27441163.
    Citations:    
  53. Bleier BS, Kohman RE, Guerra K, Nocera AL, Ramanlal S, Kocharyan AH, Curry WT, Han X. Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier. Neurosurgery. 2016 Mar; 78(3):448-57; discussion 457. PMID: 26352099.
    Citations: 1     Fields:    Translation:Animals
  54. Teo L, Bleier B, Lim L, Freitag S. Use of a retinal sponge for silicone tube fixation after bicanalicular lacrimal intubation or dacryocystorhinostomy. Orbit. 2016; 35(2):97. PMID: 26891427.
    Citations:    Fields:    Translation:Humans
  55. Yao WC, Bleier BS. Endoscopic management of orbital tumors. Curr Opin Otolaryngol Head Neck Surg. 2016 Feb; 24(1):57-62. PMID: 26575515.
    Citations:    Fields:    Translation:Humans
  56. Bleier BS, Castelnuovo P, Battaglia P, Turri-Zanoni M, Dallan I, Metson R, Sedaghat AR, Stefko ST, Gardner PA, Snyderman CH, Nogueira JF, Ramakrishnan VR, Muscatello L, Lenzi R, Freitag S. Endoscopic endonasal orbital cavernous hemangioma resection: global experience in techniques and outcomes. Int Forum Allergy Rhinol. 2016 Feb; 6(2):156-61. PMID: 26623968.
    Citations: 3     Fields:    Translation:HumansCells
  57. Bleier BS, Singleton A, Nocera AL, Kocharyan A, Petkova V, Han X. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. Int Forum Allergy Rhinol. 2016 Feb; 6(2):169-77. PMID: 26625351.
    Citations:    Fields:    Translation:HumansCells
  58. Miyake MM, Bleier BS. Bypassing the blood-brian barrier using established skull base reconstruction techniques. World J Otorhinolaryngol Head Neck Surg. 2015 Sep; 1(1):11-16. PMID: 29204535.
    Citations:    
  59. Lenzi R, Bleier BS, Felisati G, Muscatello L. Purely endoscopic trans-nasal management of orbital intraconal cavernous haemangiomas: a systematic review of the literature. Eur Arch Otorhinolaryngol. 2016 Sep; 273(9):2319-22. PMID: 26210157.
    Citations: 2     Fields:    Translation:Humans
  60. Korkmaz H, Yao WC, Korkmaz M, Bleier BS. Safety and efficacy of concentrated topical epinephrine use in endoscopic endonasal surgery. Int Forum Allergy Rhinol. 2015 Dec; 5(12):1118-23. PMID: 26152362.
    Citations:    Fields:    Translation:Humans
  61. Trief D, Gray ST, Jakobiec FA, Durand ML, Fay A, Freitag SK, Lee NG, Lefebvre DR, Holbrook E, Bleier B, Sadow P, Rashid A, Chhabra N, Yoon MK. Invasive fungal disease of the sinus and orbit: a comparison between mucormycosis and Aspergillus. Br J Ophthalmol. 2016 Feb; 100(2):184-8. PMID: 26112869.
    Citations: 3     Fields:    Translation:HumansAnimals
  62. Naunheim MR, Sedaghat AR, Lin DT, Bleier BS, Holbrook EH, Curry WT, Gray ST. Immediate and Delayed Complications Following Endoscopic Skull Base Surgery. J Neurol Surg B Skull Base. 2015 Sep; 76(5):390-6. PMID: 26401482.
    Citations: 2     
  63. Lin GC, Sedaghat AR, Bleier BS, Holbrook EH, Busaba NY, Yoon MK, Gray ST. Volumetric analysis of chronic maxillary atelectasis. Am J Rhinol Allergy. 2015 May-Jun; 29(3):166-9. PMID: 25975247.
    Citations: 4     Fields:    Translation:Humans
  64. Yao WC, Bleier BS. Centrifugal frontal sinus dissection technique: addressing anterior and posterior frontoethmoidal air cells. Int Forum Allergy Rhinol. 2015 Aug; 5(8):761-3. PMID: 25914121.
    Citations:    Fields:    Translation:Humans
  65. Lam A, Hoang JD, Singleton A, Han X, Bleier BS. Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. Int Forum Allergy Rhinol. 2015 Jun; 5(6):477-80. PMID: 25907295.
    Citations: 1     Fields:    Translation:HumansCells
  66. Yao WC, Bleier BS. A simple, single stage technique to harvest optimal ethmoid bone grafts for caudal septal deflections. Int Forum Allergy Rhinol. 2015 Jul; 5(7):622-5. PMID: 25885185.
    Citations:    Fields:    Translation:Humans
  67. Miyake MM, Bleier BS. The blood-brain barrier and nasal drug delivery to the central nervous system. Am J Rhinol Allergy. 2015 Mar-Apr; 29(2):124-7. PMID: 25785753.
    Citations: 11     Fields:    Translation:HumansAnimals
  68. Günel C, Basak HS, Bleier BS. Oral steroids and intraoperative bleeding during endoscopic sinus surgery. B-ENT. 2015; 11(2):123-8. PMID: 26563012.
    Citations:    Fields:    Translation:Humans
  69. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3. PMID: 25330767.
    Citations: 1     Fields:    Translation:HumansCells
  70. Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8. PMID: 25145685.
    Citations:    Fields:    Translation:HumansCells
  71. Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014 Jul 16; (89). PMID: 25077554.
    Citations:    Fields:    Translation:Animals
  72. Chhabra N, Healy DY, Freitag SK, Bleier BS. The nasoseptal flap for reconstruction of the medial and inferior orbit. Int Forum Allergy Rhinol. 2014 Sep; 4(9):763-6. PMID: 25044694.
    Citations: 1     Fields:    Translation:Humans
  73. Bleier B. Editorial: Blending medical and surgical therapies to optimize patient outcomes in chronic rhinosinusitis and allergic rhinitis. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):279-80. PMID: 25197912.
    Citations: 1     Fields:    Translation:Humans
  74. Healy DY, Lee NG, Freitag SK, Bleier BS. Endoscopic bimanual approach to an intraconal cavernous hemangioma of the orbital apex with vascularized flap reconstruction. Ophthalmic Plast Reconstr Surg. 2014 Jul-Aug; 30(4):e104-6. PMID: 24833438.
    Citations: 3     Translation:Humans
  75. Bleier BS, Healy DY, Chhabra N, Freitag S. Compartmental endoscopic surgical anatomy of the medial intraconal orbital space. Int Forum Allergy Rhinol. 2014 Jul; 4(7):587-91. PMID: 24687956.
    Citations: 3     Fields:    Translation:Humans
  76. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94. PMID: 24599606.
    Citations:    Fields:    Translation:HumansCells
  77. Günel C, Feldman RE, Bleier BS. Osteitis is associated with P-glycoprotein overexpression in patients with chronic sinusitis without nasal polyps. Am J Rhinol Allergy. 2014 Mar-Apr; 28(2):99-102. PMID: 24717943.
    Citations: 2     Fields:    Translation:HumansCells
  78. Bleier BS, Lefebvre DR, Freitag SK. Endoscopic orbital floor decompression with preservation of the inferomedial strut. Int Forum Allergy Rhinol. 2014 Jan; 4(1):82-4. PMID: 24124099.
    Citations: 4     Fields:    Translation:Humans
  79. Shargorodsky J, Bleier BS, Holbrook EH, Cohen JM, Busaba N, Metson R, Gray ST. Outcomes analysis in epistaxis management: development of a therapeutic algorithm. Otolaryngol Head Neck Surg. 2013 Sep; 149(3):390-8. PMID: 23764960.
    Citations: 3     Fields:    Translation:Humans
  80. Feldman RE, Lam AC, Sadow PM, Bleier BS. P-glycoprotein is a marker of tissue eosinophilia and radiographic inflammation in chronic rhinosinusitis without nasal polyps. Int Forum Allergy Rhinol. 2013 Aug; 3(8):684-7. PMID: 23677641.
    Citations: 3     Fields:    Translation:HumansCells
  81. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694. PMID: 23637885.
    Citations: 7     Fields:    Translation:AnimalsCells
  82. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8. PMID: 23520057.
    Citations: 1     Fields:    Translation:HumansCells
  83. Bleier BS, Palmer JN, Cohen NA. Evaluation of a polysaccharide gel for laser-assisted skull base repair. Am J Rhinol Allergy. 2013 Mar-Apr; 27(2):148-50. PMID: 23562206.
    Citations:    Fields:    Translation:HumansAnimals
  84. Meier JC, Bleier BS. Novel techniques and the future of skull base reconstruction. Adv Otorhinolaryngol. 2013; 74:174-83. PMID: 23257563.
    Citations: 1     Fields:    Translation:Humans
  85. Meier JC, Bleier BS. Anteriorly based pedicled flaps for skull base reconstruction. Adv Otorhinolaryngol. 2013; 74:64-70. PMID: 23257553.
    Citations:    Fields:    Translation:Humans
  86. Bleier BS, Feldman R, Sadow PM, Wu A, Ting J, Metson R. The accessory posterolateral nerve: an immunohistological analysis. Am J Rhinol Allergy. 2012 Jul-Aug; 26(4):271-3. PMID: 22801012.
    Citations: 3     Fields:    Translation:Humans
  87. Bleier BS, Preena D, Schlosser RJ, Harvey RJ. Dose quantification of topical drug delivery to the paranasal sinuses by fluorescein luminosity calculation. Int Forum Allergy Rhinol. 2012 Jul-Aug; 2(4):316-20. PMID: 22411746.
    Citations: 3     Fields:    Translation:Humans
  88. Bleier BS. Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis. Int Forum Allergy Rhinol. 2012 Mar-Apr; 2(2):122-5. PMID: 22223515.
    Citations: 1     Fields:    Translation:HumansCells
  89. Bleier BS, Mulligan RM, Schlosser RJ. Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis. J Pharm Pharmacol. 2012 Mar; 64(3):449-56. PMID: 22309277.
    Citations: 6     Fields:    Translation:HumansCells
  90. Bloom JD, Bleier BS, Goldstein SA, Carniol PJ, Palmer JN, Cohen NA. Laser facial nerve welding in a rabbit model. Arch Facial Plast Surg. 2012 Jan-Feb; 14(1):52-8. PMID: 21844481.
    Citations: 1     Fields:    Translation:Animals
  91. Bleier BS, Debnath I, Harvey RJ, Schlosser RJ. Temporospatial quantification of fluorescein-labeled sinonasal irrigation delivery. Int Forum Allergy Rhinol. 2011 Sep-Oct; 1(5):361-5. PMID: 22287467.
    Citations: 2     Fields:    Translation:Humans
  92. Bleier BS, Curry WT, Wang EW, Schlosser RJ. The bipedicled anterior septal flap: a radioanatomic and cadaveric study. Laryngoscope. 2011 Jul; 121(7):1367-71. PMID: 21671235.
    Citations: 2     Fields:    Translation:Humans
  93. Bleier BS, Wang EW, Vandergrift WA, Schlosser RJ. Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps. Am J Rhinol Allergy. 2011 May-Jun; 25(3):186-7. PMID: 21679531.
    Citations: 7     Fields:    Translation:Humans
  94. Ayers CM, Schlosser RJ, O'Connell BP, Atkinson C, Mulligan RM, Casey SE, Bleier BS, Wang EW, Sansoni ER, Kuhlen JL, Mulligan JK. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Int Forum Allergy Rhinol. 2011 Jul-Aug; 1(4):296-302. PMID: 22287435.
    Citations: 10     Fields:    Translation:HumansCells
  95. Mulligan JK, Bleier BS, O'Connell B, Mulligan RM, Wagner C, Schlosser RJ. Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol. 2011 Jun; 164(3):312-20. PMID: 21401575.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  96. Bleier BS, Schlosser RJ. Endoscopic anatomy of the postganglionic pterygopalatine innervation of the posterolateral nasal mucosa. Int Forum Allergy Rhinol. 2011 Mar-Apr; 1(2):113-7. PMID: 22287329.
    Citations: 4     Fields:    Translation:Humans
  97. Bleier BS, Debnath I, O'Connell BP, Vandergrift WA, Palmer JN, Schlosser RJ. Preliminary study on the stability of beta-2 transferrin in extracorporeal cerebrospinal fluid. Otolaryngol Head Neck Surg. 2011 Jan; 144(1):101-3. PMID: 21493396.
    Citations:    Fields:    Translation:Humans
  98. Bloom JD, Bleier BS, Mirza N, Chalian AA, Thaler ER. Factors predicting endoscopic exposure of Zenker's diverticulum. Ann Otol Rhinol Laryngol. 2010 Nov; 119(11):736-41. PMID: 21140632.
    Citations: 12     Fields:    Translation:Humans
  99. Virgin FW, Bleier BS, Woodworth BA. Evolving materials and techniques for endoscopic sinus surgery. Otolaryngol Clin North Am. 2010 Jun; 43(3):653-72, xi. PMID: 20525517.
    Citations: 2     Fields:    Translation:Humans
  100. Bleier BS. Novel topical therapeutics. Otolaryngol Clin North Am. 2010 Jun; 43(3):539-49, viii-ix. PMID: 20525509.
    Citations:    Fields:    Translation:Humans
  101. Bleier BS, Schlosser RJ. Prevention and management of medial rectus injury. Otolaryngol Clin North Am. 2010 Aug; 43(4):801-7. PMID: 20599084.
    Citations: 2     Fields:    Translation:Humans
  102. Bleier BS, Cohen NA, Chiu AG, O'Malley BW, Doghramji L, Palmer JN. Endonasal laser tissue welding: first human experience. Am J Rhinol Allergy. 2010 May-Jun; 24(3):244-6. PMID: 20537294.
    Citations:    Fields:    Translation:Humans
  103. Bleier BS, Cohen NM, Bloom JD, Palmer JN, Cohen NA. Laser tissue welding in lung and tracheobronchial repair: an animal model. Chest. 2010 Aug; 138(2):345-9. PMID: 20299627.
    Citations: 1     Fields:    Translation:Animals
  104. Bleier BS, Kofonow JM, Hashmi N, Chennupati SK, Cohen NA. Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model. Am J Rhinol Allergy. 2010 Mar-Apr; 24(2):129-32. PMID: 20338111.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  105. Harvey RJ, Debnath N, Srubiski A, Bleier B, Schlosser RJ. Fluid residuals and drug exposure in nasal irrigation. Otolaryngol Head Neck Surg. 2009 Dec; 141(6):757-61. PMID: 19932850.
    Citations: 3     Fields:    Translation:Humans
  106. Bleier BS, Palmer JN. Cranial-base repair using endoscopic laser welding. Otolaryngol Clin North Am. 2009 Oct; 42(5):901-6, xi. PMID: 19909868.
    Citations: 2     Fields:    Translation:Humans
  107. Bloom JD, Kaplan SE, Bleier BS, Goldstein SA. Septoplasty complications: avoidance and management. Otolaryngol Clin North Am. 2009 Jun; 42(3):463-81. PMID: 19486742.
    Citations: 8     Fields:    Translation:Humans
  108. Bleier BS, Kennedy DW, Palmer JN, Chiu AG, Bloom JD, O'Malley BW. Current management of juvenile nasopharyngeal angiofibroma: a tertiary center experience 1999-2007. Am J Rhinol Allergy. 2009 May-Jun; 23(3):328-30. PMID: 19490810.
    Citations: 3     Fields:    Translation:Humans
  109. Bleier BS, Paulson DP, O'Malley BW, Li D, Palmer JN, Chiu AG, Cohen NA. Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent. Am J Rhinol Allergy. 2009 Jan-Feb; 23(1):76-9. PMID: 19379617.
    Citations: 5     Fields:    Translation:Animals
  110. Chennupati SK, Chiu AG, Tamashiro E, Banks CA, Cohen MB, Bleier BS, Kofonow JM, Tam E, Cohen NA. Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis. Am J Rhinol Allergy. 2009 Jan-Feb; 23(1):46-51. PMID: 19379612.
    Citations: 16     Fields:    Translation:AnimalsCells
  111. Bleier BS, Palmer JN. Otolaryngologic Clinics of North America. Cranial Base Repair Using Endoscopic Laser Welding (ELW). 2009; 5(42):901-906.
  112. Bloom JD, Kaplan SE, Bleier BS, Goldstein SE. Otolaryngologic Clinics of North America. Septoplasty Complications: Avoidance and Management. 2009; 3(42):463-481.
  113. Bleier BS, Gratton MA, Leibowitz JM, Palmer JN, Newman JG, Cohen NA. Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model. Otolaryngol Head Neck Surg. 2008 Nov; 139(5):713-7. PMID: 18984269.
    Citations: 2     Fields:    Translation:Animals
  114. Bleier BS, Palmer JN, Gratton MA, Cohen NA. In vivo laser tissue welding in the rabbit maxillary sinus. Am J Rhinol. 2008 Nov-Dec; 22(6):625-8. PMID: 19178803.
    Citations: 1     Fields:    Translation:Animals
  115. Bleier BS, Gawthrop CS, Thaler ER, Sewell DA, Montone KT, Marvel DM, Chiu AG. Diffuse intranasal papillomatosis and its association with human papillomavirus. Arch Otolaryngol Head Neck Surg. 2008 Jul; 134(7):778-80. PMID: 18645131.
    Citations:    Fields:    Translation:HumansCells
  116. Bleier BS, Palmer JN, Woodworth BA. Revision Sinus Surgery. Recurrent Mucoceles. 2008.
  117. Bleier BS. Rhinosinusitis: A Guide to Diagnosis and Management. Complications of Sinusitis. 2008.
  118. Bleier BS, Palmer JN, Sparano AM, Cohen NA. Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility. Otolaryngol Head Neck Surg. 2007 Nov; 137(5):810-4. PMID: 17967651.
    Citations: 4     Fields:    Translation:Animals
  119. Bleier BS, Levine MS, Mick R, Rubesin SE, Sack SZ, McKinney K, Mirza N. Dysphagia after chemoradiation: analysis by modified barium swallow. Ann Otol Rhinol Laryngol. 2007 Nov; 116(11):837-41. PMID: 18074669.
    Citations: 10     Fields:    Translation:Humans
  120. Bleier BS, Govindaraj S, Palmer JN. Rhinologic and Sleep Apnea Surgical Techniques. Paranasal Sinus Mucoceles. 2007.
  121. Bleier BS, Mirza N. Image guided transoral approach to the pterygopalatine fossa. Laryngoscope. 2006 Oct; 116(10):1927-9. PMID: 17003698.
    Citations:    Fields:    Translation:Humans
  122. Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS. Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas. Arch Otolaryngol Head Neck Surg. 2006 Jul; 132(7):779-82. PMID: 16847189.
    Citations: 7     Fields:    Translation:HumansCells
  123. Bleier BS, Govindaraj S, Palmer JN. Operative Techniques in Otolaryngology Head and Neck Surgery. State of the Art Cerebrospinal Fluid Leak and Encephalocele Repair. 2006; 1(17):49-57.
  124. Bleier BS, Newman JG, Quon H, Feldman MD, Kent KK, Weinstein GS. Eccrine porocarcinoma of the nose: case report and review of world literature. Arch Otolaryngol Head Neck Surg. 2006 Feb; 132(2):215-8. PMID: 16490882.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.