Harvard Catalyst Profiles

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Shahrokh Charles Khani, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY013600 (KHANI, SHAHROKH C) Aug 1, 2003 - Jul 31, 2009
    Transcriptional Regulation of Rhodopsin Kinase Gene
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pawlyk BS, Bulgakov OV, Sun X, Adamian M, Shu X, Smith AJ, Berson EL, Ali RR, Khani S, Wright AF, Sandberg MA, Li T. Photoreceptor rescue by an abbreviated human RPGR gene in a murine model of X-linked retinitis pigmentosa. Gene Ther. 2016 Feb; 23(2):196-204. PMID: 26348595.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  2. Sakurai K, Chen J, Khani SC, Kefalov VJ. Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase. J Biol Chem. 2015 Apr 03; 290(14):9239-50. PMID: 25673692.
    Citations: 18     Fields:    Translation:AnimalsCells
  3. Sakurai K, Young JE, Kefalov VJ, Khani SC. Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug 29; 52(9):6793-800. PMID: 21474765.
    Citations: 10     Fields:    Translation:AnimalsCells
  4. Pawlyk BS, Bulgakov OV, Liu X, Xu X, Adamian M, Sun X, Khani SC, Berson EL, Sandberg MA, Li T. Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis. Hum Gene Ther. 2010 Aug; 21(8):993-1004. PMID: 20384479.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  5. Semple-Rowland SL, Coggin WE, Geesey M, Eccles KS, Abraham L, Pachigar K, Ludlow R, Khani SC, Smith WC. Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and Müller cells. Mol Vis. 2010 May 27; 16:916-34. PMID: 20517486.
    Citations: 10     Fields:    Translation:AnimalsCells
  6. Whitcomb T, Sakurai K, Brown BM, Young JE, Sheflin L, Dlugos C, Craft CM, Kefalov VJ, Khani SC. Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1728-37. PMID: 19834036.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  7. Sun X, Pawlyk B, Xu X, Liu X, Bulgakov OV, Adamian M, Sandberg MA, Khani SC, Tan MH, Smith AJ, Ali RR, Li T. Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations. Gene Ther. 2010 Jan; 17(1):117-31. PMID: 19710705.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  8. Khani SC, Pawlyk BS, Bulgakov OV, Kasperek E, Young JE, Adamian M, Sun X, Smith AJ, Ali RR, Li T. AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):3954-61. PMID: 17724172.
    Citations: 64     Fields:    Translation:AnimalsCells
  9. Young JE, Kasperek EM, Vogt TM, Lis A, Khani SC. Conserved interactions of a compact highly active enhancer/promoter upstream of the rhodopsin kinase (GRK1) gene. Genomics. 2007 Aug; 90(2):236-48. PMID: 17524610.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Young JE, Gross KW, Khani SC. Conserved structure and spatiotemporal function of the compact rhodopsin kinase (GRK1) enhancer/promoter. Mol Vis. 2005 Dec 07; 11:1041-51. PMID: 16357827.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Young JE, Vogt T, Gross KW, Khani SC. A short, highly active photoreceptor-specific enhancer/promoter region upstream of the human rhodopsin kinase gene. Invest Ophthalmol Vis Sci. 2003 Sep; 44(9):4076-85. PMID: 12939331.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  12. Khani SC, Karoukis AJ, Young JE, Ambasudhan R, Burch T, Stockton R, Lewis RA, Sullivan LS, Daiger SP, Reichel E, Ayyagari R. Late-onset autosomal dominant macular dystrophy with choroidal neovascularization and nonexudative maculopathy associated with mutation in the RDS gene. Invest Ophthalmol Vis Sci. 2003 Aug; 44(8):3570-7. PMID: 12882809.
    Citations: 10     Fields:    Translation:HumansCells
  13. Gonzalez-Fernandez F, Kurz D, Bao Y, Newman S, Conway BP, Young JE, Han DP, Khani SC. 11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus. Mol Vis. 1999 Dec 30; 5:41. PMID: 10617778.
  14. Khani SC, Nielsen L, Vogt TM. Biochemical evidence for pathogenicity of rhodopsin kinase mutations correlated with the oguchi form of congenital stationary night blindness. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2824-7. PMID: 9501174.
  15. Zhao X, Huang J, Khani SC, Palczewski K. Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem. 1998 Feb 27; 273(9):5124-31. PMID: 9478965.
  16. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A. 1998 Jan 06; 95(1):328-33. PMID: 9419375.
  17. Yamamoto S, Khani SC, Berson EL, Dryja TP. Evaluation of the rhodopsin kinase gene in patients with retinitis pigmentosa. Exp Eye Res. 1997 Aug; 65(2):249-53. PMID: 9268593.
    Citations: 6     Fields:    Translation:Humans
  18. Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP. Characterization and chromosomal localization of the gene for human rhodopsin kinase. Genomics. 1996 Aug 01; 35(3):571-6. PMID: 8812493.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Porter TD, Khani SC, Coon MJ. Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes. Mol Pharmacol. 1989 Jul; 36(1):61-5. PMID: 2747631.
  20. Khani SC, Porter TD, Fujita VS, Coon MJ. Organization and differential expression of two highly similar genes in the rabbit alcohol-inducible cytochrome P-450 subfamily. J Biol Chem. 1988 May 25; 263(15):7170-5. PMID: 3366772.
  21. Khani SC, Porter TD, Coon MJ. Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene. Biochem Biophys Res Commun. 1988 Jan 15; 150(1):10-7. PMID: 2827660.
  22. Khani SC, Zaphiropoulos PG, Fujita VS, Porter TD, Koop DR, Coon MJ. cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC). Proc Natl Acad Sci U S A. 1987 Feb; 84(3):638-42. PMID: 3027695.
  23. Sumner J, Jencks DA, Khani S, Matthews RG. Photoaffinity labeling of methylenetetrahydrofolate reductase with 8-azido-S-adenosylmethionine. J Biol Chem. 1986 Jun 15; 261(17):7697-700. PMID: 3754872.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.