Harvard Catalyst Profiles

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Robert Joseph Thomas, M.D.

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Mentoring
Available: 05/31/17, Expires: 05/31/20

There is an opportunity to join and contribute to a long-range effort in a new approach to sleep physiology and pathology, called "sleep effectiveness". This approach to sleep is totally different from the conventional stages, yet is complementary. The base signal is the electrocardiogram (ECG), from which mapping of coupled oscillations during sleep provides a unique biological map. The technique is being applied to large (> 10000) and small datasets across the age spectrum, including epidemiological studies such as the Framingham Heart Study and the Korean Genome and Epidemiology study. The student will have a choice from a wide variety of options, based on interest, prior background and time. The student will learn significant amounts of sleep science across the basic, clinical and laboratory spectrum. Specific student type project include: 1. The genetic determinants of effective sleep. 2. Hemodynamics of sleep states. 3. Sleep effectiveness as a driver of sleep apnea pathology 4. Long range dynamics of sleep effectiveness in healthy and diseased populations.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HL097061 (THOMAS, ROBERT JOSEPH) Aug 14, 2011 - Jun 30, 2014
    NIH/NHLBI
    Neuroanatomical and functional outcomes of pediatric obstructive sleep apnea
    Role: Principal Investigator
  2. RC1HL099749 (THOMAS, ROBERT JOSEPH) Sep 30, 2009 - Aug 31, 2012
    NIH/NHLBI
    ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Role: Principal Investigator
  3. R21HL079248 (THOMAS, ROBERT J) May 5, 2005 - Apr 30, 2008
    NIH/NHLBI
    ECG-derived estimators of sleep physiology
    Role: Principal Investigator
  4. K23HL004457 (THOMAS, ROBERT J) Sep 30, 2002 - Jul 31, 2008
    NIH/NHLBI
    WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim TJ, Yoon JE, Park JA, Lee SK, Chu MK, Yang KI, Kim WJ, Park SH, Thomas RJ, Shin C, Yun CH. Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population. Neuroepidemiology. 2019; 52(3-4):193-204. PMID: 30763945.
    Citations:    
  2. Johnson KG, Johnson DC, Thomas RJ, Feldmann E, Lindenauer PK, Visintainer P, Kryger MH. Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography. Sleep Med. 2018 Nov 30. PMID: 30583916.
    Citations:    Fields:    
  3. Sun H, Paixao L, Oliva JT, Goparaju B, Carvalho DZ, van Leeuwen KG, Akeju O, Thomas RJ, Cash SS, Bianchi MT, Westover MB. Brain age from the electroencephalogram of sleep. Neurobiol Aging. 2019 Feb; 74:112-120. PMID: 30448611.
    Citations:    Fields:    
  4. Gunn S, Naik S, Bianchi MT, Thomas RJ. Estimation of adaptive ventilation success and failure using polysomnogram and outpatient therapy biomarkers. Sleep. 2018 Sep 01; 41(9). PMID: 29471442.
    Citations:    Fields:    
  5. Baik I, Lee S, Thomas RJ, Shin C. Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness. Int J Dermatol. 2019 Jan; 58(1):67-74. PMID: 30144036.
    Citations:    Fields:    
  6. Kim RE, Yun CH, Thomas RJ, Oh JH, Johnson HJ, Kim S, Lee S, Seo HS, Shin C. Lifestyle-dependent brain change: a longitudinal cohort MRI study. Neurobiol Aging. 2018 09; 69:48-57. PMID: 29852410.
    Citations:    Fields:    
  7. Mano T, Thomas RJ. Anatomo-functional basis of restless legs syndrome. Neurology. 2018 May 22; 90(21):945-946. PMID: 29695591.
    Citations:    Fields:    
  8. Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Author response: Sleep architecture and the risk of incident dementia in the community. Neurology. 2018 Mar 06; 90(10):487. PMID: 29507137.
    Citations:    Fields:    
  9. Koo DL, Nam H, Thomas RJ, Yun CH. Sleep Disturbances as a Risk Factor for Stroke. J Stroke. 2018 Jan; 20(1):12-32. PMID: 29402071.
    Citations: 2     
  10. Thomas RJ, Wood C, Bianchi MT. Cardiopulmonary coupling spectrogram as an ambulatory clinical biomarker of sleep stability and quality in health, sleep apnea and insomnia. Sleep. 2017 Dec 09. PMID: 29237080.
    Citations:    Fields:    
  11. Anter E, Di Biase L, Contreras-Valdes FM, Gianni C, Mohanty S, Tschabrunn CM, Viles-Gonzalez JF, Leshem E, Buxton AE, Kulbak G, Halaby RN, Zimetbaum PJ, Waks JW, Thomas RJ, Natale A, Josephson ME. Atrial Substrate and Triggers of Paroxysmal Atrial Fibrillation in Patients With Obstructive Sleep Apnea. Circ Arrhythm Electrophysiol. 2017 Nov; 10(11). PMID: 29133380.
    Citations: 3     Fields:    Translation:Humans
  12. Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Sleep architecture and the risk of incident dementia in the community. Neurology. 2017 Sep 19; 89(12):1244-1250. PMID: 28835407.
    Citations: 4     Fields:    Translation:Humans
  13. Bianchi MT, Thomas RJ, Westover MB. Response. Sleep Med. 2017 10; 38:160-161. PMID: 28843388.
    Citations:    Fields:    
  14. Kim H, Au R, Thomas RJ, Yun CH, Lee SK, Han C, Shin C. Cognitive performance norms from the Korean genome and epidemiology study (KoGES). Int Psychogeriatr. 2017 11; 29(11):1909-1924. PMID: 28703093.
    Citations:    Fields:    Translation:Humans
  15. Choi KM, Thomas RJ, Kim J, Lee SK, Yoon DW, Shin C. Overlap syndrome of COPD and OSA in Koreans. Medicine (Baltimore). 2017 Jul; 96(27):e7241. PMID: 28682873.
    Citations:    Fields:    Translation:Humans
  16. Im HJ, Baek SH, Chu MK, Yang KI, Kim WJ, Park SH, Thomas RJ, Yun CH. Association Between Weekend Catch-up Sleep and Lower Body Mass: Population-Based Study. Sleep. 2017 07 01; 40(7). PMID: 28525634.
    Citations: 1     Fields:    Translation:Humans
  17. Thomas RJ, Bianchi MT. Urgent Need to Improve PAP Management: The Devil Is in Two (Fixable) Details. J Clin Sleep Med. 2017 05 15; 13(5):657-664. PMID: 28095974.
    Citations: 2     Fields:    
  18. Kim H, Thomas RJ, Yun CH, Au R, Lee SK, Lee S, Shin C. Association of Mild Obstructive Sleep Apnea With Cognitive Performance, Excessive Daytime Sleepiness, and Quality of Life in the General Population: The Korean Genome and Epidemiology Study (KoGES). Sleep. 2017 05 01; 40(5). PMID: 28329071.
    Citations: 1     Fields:    Translation:Humans
  19. Ma Y, Sun S, Peng CK, Fang Y, Thomas RJ. Ambulatory Blood Pressure Monitoring in Chinese Patients with Obstructive Sleep Apnea. J Clin Sleep Med. 2017 Mar 15; 13(3):433-439. PMID: 27855748.
    Citations: 5     Fields:    Translation:Humans
  20. Bianchi MT, Thomas RJ, Westover MB. An open request to epidemiologists: please stop querying self-reported sleep duration. Sleep Med. 2017 07; 35:92-93. PMID: 28284821.
    Citations: 1     Fields:    
  21. Yun CH, Lee HY, Lee SK, Kim H, Seo HS, Bang SA, Kim SE, Greve DN, Au R, Shin C, Thomas RJ. Amyloid Burden in Obstructive Sleep Apnea. J Alzheimers Dis. 2017; 59(1):21-29. PMID: 28550245.
    Citations: 2     Fields:    Translation:Humans
  22. Choi KM, Thomas RJ, Yoon DW, Lee SK, Baik I, Shin C. Interaction between Obstructive Sleep Apnea and Shortened Telomere Length on Brain White Matter Abnormality. Sleep. 2016 Sep 01; 39(9):1639-45. PMID: 27397571.
    Citations: 2     Fields:    Translation:HumansCells
  23. Reiter J, Zleik B, Bazalakova M, Mehta P, Thomas RJ. Residual Events during Use of CPAP: Prevalence, Predictors, and Detection Accuracy. J Clin Sleep Med. 2016 08 15; 12(8):1153-8. PMID: 27166303.
    Citations: 2     Fields:    Translation:Humans
  24. Mariani S, Borges AF, Henriques T, Thomas RJ, Leistedt SJ, Linkowski P, Lanquart JP, Goldberger AL, Costa MD, Mariani S, Borges AF, Henriques T, Thomas RJ, Leistedt SJ, Linkowski P, Lanquart JP, Goldberger AL, Costa MD, Henriques T, Thomas RJ, Costa MD, Leistedt SJ, Linkowski P, Goldberger AL, Lanquart JP, Mariani S, Borges AF. Analysis of the sleep EEG in the complexity domain. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug; 2016:6429-6432. PMID: 28227982.
    Citations:    
  25. Mariani S, Borges AF, Henriques T, Thomas RJ, Leistedt SJ, Linkowski P, Lanquart JP, Goldberger AL, Costa MD. Analysis of the sleep EEG in the complexity domain. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:6429-6432. PMID: 28269718.
    Citations:    Fields:    Translation:Humans
  26. Thomas RJ, Wang D, Yee BJ, Grunstein RR. Response to Brugniaux, Foster, and Beaudin. J Appl Physiol (1985). 2016 07 01; 121(1):363. PMID: 27451281.
    Citations:    Fields:    
  27. Wang D, Thomas RJ, Yee BJ, Grunstein RR. Last Word on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing. J Appl Physiol (1985). 2016 06 15; 120(12):1489. PMID: 27306843.
    Citations:    Fields:    Translation:Humans
  28. Maski MR, Thomas RJ, Karumanchi SA, Parikh SM. Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea. PLoS One. 2016; 11(5):e0154503. PMID: 27149121.
    Citations:    Fields:    Translation:Humans
  29. Thomas RJ. Sleepiness and Driving: Multidimensional Legal, Social, Technological, and Biological Challenges. Sleep. 2016 05 01; 39(5):961-2. PMID: 27091521.
    Citations: 1     Fields:    Translation:Humans
  30. Wang D, Thomas RJ, Yee BJ, Grunstein RR. Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing. J Appl Physiol (1985). 2016 06 15; 120(12):1484. PMID: 26869712.
    Citations: 2     Fields:    Translation:Humans
  31. Thomas RJ. Positive pressure therapy induced harm - non-linear, adaptive and maladaptive responses. Sleep Med. 2015 Dec; 16(12):1582-3. PMID: 26323646.
    Citations: 1     Fields:    Translation:Humans
  32. Choi JH, Thomas RJ, Suh SY, Park IH, Kim TH, Lee SH, Lee HM, Yun CH, Lee SH. Sleep quality change after upper airway surgery in obstructive sleep apnea: Electrocardiogram-based cardiopulmonary coupling analysis. Laryngoscope. 2015 Jul; 125(7):1737-42. PMID: 25646936.
    Citations: 3     Fields:    Translation:Humans
  33. Kwon AM, Baik I, Thomas RJ, Shin C. The association between leukocyte telomere lengths and sleep instability based on cardiopulmonary coupling analysis. Sleep Breath. 2015 Sep; 19(3):963-8. PMID: 25628010.
    Citations: 2     Fields:    Translation:HumansCells
  34. Lee AH, Mojica J, Thomas RJ, Bianchi MT. Dissociation of EEG and autonomic sleep physiology. Sleep Med. 2015 Feb; 16(2):308-9. PMID: 25620197.
    Citations:    Fields:    Translation:Humans
  35. Thomas RJ, Guilleminault C, Ayappa I, Rapoport DM. Scoring respiratory events in sleep medicine: who is the driver--biology or medical insurance? J Clin Sleep Med. 2014 Nov 15; 10(11):1245-7. PMID: 25325601.
    Citations: 4     Fields:    Translation:Humans
  36. Yun CH, Kim H, Lee SK, Suh S, Lee SH, Park SH, Thomas RJ, Au R, Shin C. Daytime sleepiness associated with poor sustained attention in middle and late adulthood. Sleep Med. 2015 Jan; 16(1):143-51. PMID: 25534582.
    Citations: 2     Fields:    Translation:Humans
  37. Lee S, Thomas RJ, Kim H, Seo HS, Baik I, Yoon DW, Kim SJ, Lee SK, Shin C. Association between high nocturnal blood pressure and white matter change and its interaction by obstructive sleep apnoea among normotensive adults. J Hypertens. 2014 Oct; 32(10):2005-12; discussion 2012. PMID: 25023151.
    Citations: 3     Fields:    Translation:Humans
  38. Thomas RJ. Carbon dioxide in sleep medicine: the next frontier for measurement, manipulation, and research. J Clin Sleep Med. 2014 May 15; 10(5):523-6. PMID: 24910554.
    Citations:    Fields:    Translation:Humans
  39. Thomas RJ. Alternative approaches to treatment of Central Sleep Apnea. Sleep Med Clin. 2014 Mar 01; 9(1):87-104. PMID: 24772053.
    Citations: 3     Fields:    
  40. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997.
    Citations: 1     Fields:    Translation:Humans
  41. Soares FA, Chandra A, Thomas RJ, Pedersen RA, Vallier L, Williams DJ. Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions. J Biotechnol. 2014 Mar 10; 173:53-8. PMID: 24440272.
    Citations: 3     Fields:    Translation:HumansCells
  42. Rao H, Thomas RJ. Complex sleep apnea. Curr Treat Options Neurol. 2013 Dec; 15(6):677-91. PMID: 24136715.
    Citations: 1     
  43. Thomas RJ, Mietus JE, Peng CK, Guo D, Gozal D, Montgomery-Downs H, Gottlieb DJ, Wang CY, Goldberger AL. Relationship between delta power and the electrocardiogram-derived cardiopulmonary spectrogram: possible implications for assessing the effectiveness of sleep. Sleep Med. 2014 Jan; 15(1):125-31. PMID: 24269134.
    Citations: 12     Fields:    Translation:Humans
  44. Thomas RJ, Bianchi MT. Changing the direction of sleep medicine: business can boom, but it is not as usual. J Clin Sleep Med. 2013 Sep 15; 9(9):977-9. PMID: 23997714.
    Citations: 3     Fields:    Translation:Humans
  45. Kim H, Suh S, Cho ER, Yang HC, Yun CH, Thomas RJ, Lee SK, Shin C. Longitudinal course of insomnia: age-related differences in subjective sleepiness and vigilance performance in a population-based sample. J Psychosom Res. 2013 Dec; 75(6):532-8. PMID: 24290042.
    Citations:    Fields:    Translation:Humans
  46. Kim H, Yun CH, Thomas RJ, Lee SH, Seo HS, Cho ER, Lee SK, Yoon DW, Suh S, Shin C. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep. 2013 May 01; 36(5):709-715B. PMID: 23633753.
    Citations: 35     Fields:    Translation:Humans
  47. Ratcliffe E, Hourd P, Guijarro-Leach J, Rayment E, Williams DJ, Thomas RJ. Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture. Regen Med. 2013 Jan; 8(1):39-48. PMID: 23259804.
    Citations: 3     Fields:    Translation:HumansCells
  48. Bianchi MT, Thomas RJ. Technical advances in the characterization of the complexity of sleep and sleep disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 01; 45:277-86. PMID: 23174482.
    Citations: 6     Fields:    Translation:Humans
  49. Thomas RJ. Multimodality therapy for sleep apnea syndromes. J Clin Sleep Med. 2012 Oct 15; 8(5):565-7. PMID: 23066369.
    Citations:    Fields:    Translation:Humans
  50. Thomas RJ. Single vs. multi-modality treatment of central apnea syndromes. Sleep. 2012 Sep 01; 35(9):1197-8; author reply 1199. PMID: 22942496.
    Citations:    Fields:    Translation:Humans
  51. Bianchi MT, Thomas RJ, Ellenbogen JM. Hypnotics and mortality risk. J Clin Sleep Med. 2012 Aug 15; 8(4):351-2. PMID: 22893762.
    Citations: 2     Fields:    
  52. Lee SH, Choi JH, Park IH, Lee SH, Kim TH, Lee HM, Park HK, Thomas RJ, Shin C, Yun CH. Measuring sleep quality after adenotonsillectomy in pediatric sleep apnea. Laryngoscope. 2012 Sep; 122(9):2115-21. PMID: 22740041.
    Citations: 3     Fields:    Translation:Humans
  53. Schramm PJ, Thomas RJ. Assessment of therapeutic options for mild obstructive sleep apnea using cardiopulmonary coupling measures. J Clin Sleep Med. 2012 Jun 15; 8(3):315-20. PMID: 22701390.
    Citations: 2     Fields:    Translation:Humans
  54. Kim SJ, Lee SK, Kim SH, Yun CH, Kim JH, Thomas RJ, Shin C. Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study. Circ J. 2012; 76(4):907-13. PMID: 22322875.
    Citations: 15     Fields:    Translation:Humans
  55. Thomas RJ. Seeking useful biomarkers for the quality and effectiveness of sleep. Sleep. 2012 Feb 01; 35(2):173-4. PMID: 22294805.
    Citations:    Fields:    Translation:Humans
  56. Pogach MS, Punjabi NM, Thomas N, Thomas RJ. Electrocardiogram-based sleep spectrogram measures of sleep stability and glucose disposal in sleep disordered breathing. Sleep. 2012 Jan 01; 35(1):139-48. PMID: 22215928.
    Citations: 4     Fields:    Translation:Humans
  57. Thomas RJ. Sleep as a window into the world of fibromyalgia syndrome. J Rheumatol. 2011 Dec; 38(12):2499-500. PMID: 22134792.
    Citations:    Fields:    Translation:Humans
  58. Bianchi MT, Eiseman NA, Cash SS, Mietus J, Peng CK, Thomas RJ. Probabilistic sleep architecture models in patients with and without sleep apnea. J Sleep Res. 2012 Jun; 21(3):330-41. PMID: 21955148.
    Citations: 8     Fields:    Translation:Humans
  59. Eiseman NA, Westover MB, Mietus JE, Thomas RJ, Bianchi MT. Classification algorithms for predicting sleepiness and sleep apnea severity. J Sleep Res. 2012 Feb; 21(1):101-12. PMID: 21752133.
    Citations: 12     Fields:    Translation:Humans
  60. Thomas RJ. The chemoreflex and sleep-disordered breathing: man and machine vs. the beast. Sleep Med. 2011 Jun; 12(6):533-5. PMID: 21570343.
    Citations: 2     Fields:    Translation:Humans
  61. Guo D, Peng CK, Wu HL, Mietus JE, Liu Y, Sun RS, Thomas RJ. ECG-derived cardiopulmonary analysis of pediatric sleep-disordered breathing. Sleep Med. 2011 Apr; 12(4):384-9. PMID: 21396891.
    Citations: 6     Fields:    Translation:Humans
  62. Yang AC, Yang CH, Hong CJ, Tsai SJ, Kuo CH, Peng CK, Mietus JE, Goldberger AL, Thomas RJ. Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis. Psychophysiology. 2011 Feb; 48(2):285-91. PMID: 20624250.
    Citations: 15     Fields:    Translation:Humans
  63. Brettingham-Moore KH, Duong CP, Greenawalt DM, Heriot AG, Ellul J, Dow CA, Murray WK, Hicks RJ, Tjandra J, Chao M, Bui A, Joon DL, Thomas RJ, Phillips WA. Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma. Clin Cancer Res. 2011 May 01; 17(9):3039-47. PMID: 21224373.
    Citations: 11     Fields:    Translation:Humans
  64. Thomas RJ, Mietus JE. Mapping sleep using coupled biological oscillations. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1479-82. PMID: 22254599.
    Citations: 2     Fields:    Translation:Humans
  65. Gilmartin G, McGeehan B, Vigneault K, Daly RW, Manento M, Weiss JW, Thomas RJ. Treatment of positive airway pressure treatment-associated respiratory instability with enhanced expiratory rebreathing space (EERS). J Clin Sleep Med. 2010 Dec 15; 6(6):529-38. PMID: 21206741.
    Citations: 14     Fields:    Translation:Humans
  66. Ibrahim LH, Jacono FJ, Patel SR, Thomas RJ, Larkin EK, Mietus JE, Peng CK, Goldberger AL, Redline S. Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique. Sleep. 2010 May; 33(5):643-6. PMID: 20469806.
    Citations: 8     Fields:    Translation:Humans
  67. Thomas RJ, Mietus JE, Peng CK, Goldberger AL, Crofford LJ, Chervin RD. Impaired sleep quality in fibromyalgia: Detection and quantification with ECG-based cardiopulmonary coupling spectrograms. Sleep Med. 2010 May; 11(5):497-8. PMID: 20015685.
    Citations: 14     Fields:    Translation:Humans
  68. Thomas RJ, Weiss MD, Mietus JE, Peng CK, Goldberger AL, Gottlieb DJ. Prevalent hypertension and stroke in the Sleep Heart Health Study: association with an ECG-derived spectrographic marker of cardiopulmonary coupling. Sleep. 2009 Jul; 32(7):897-904. PMID: 19639752.
    Citations: 18     Fields:    Translation:Humans
  69. Thomas RJ. Strong chemoreflex modulation of sleep-breathing: some answers but even more questions. J Clin Sleep Med. 2009 Jun 15; 5(3):212-4. PMID: 19960640.
    Citations: 1     Fields:    Translation:Humans
  70. Weiss MD, Tamisier R, Boucher J, Lynch M, Gilmartin G, Weiss JW, Thomas RJ. A pilot study of sleep, cognition, and respiration under 4 weeks of intermittent nocturnal hypoxia in adult humans. Sleep Med. 2009 Aug; 10(7):739-45. PMID: 19282237.
    Citations: 5     Fields:    Translation:Humans
  71. Joseph E. Mietus Chung-Kang Peng Robert J. Thomas Ary L. Goldberger. Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling. 2008.
  72. Thomas RJ, Mietus JE, Peng CK, Gilmartin G, Daly RW, Goldberger AL, Gottlieb DJ. Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method. Sleep. 2007 Dec; 30(12):1756-69. PMID: 18246985.
    Citations: 35     Fields:    Translation:Humans
  73. Thomas RJ, Tamisier R, Boucher J, Kotlar Y, Vigneault K, Weiss JW, Gilmartin G. Nocturnal hypoxia exposure with simulated altitude for 14 days does not significantly alter working memory or vigilance in humans. Sleep. 2007 Sep; 30(9):1195-203. PMID: 17910391.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  74. Yeh GY, Mietus JE, Peng CK, Phillips RS, Davis RB, Wayne PM, Goldberger AL, Thomas RJ. Enhancement of sleep stability with Tai Chi exercise in chronic heart failure: preliminary findings using an ECG-based spectrogram method. Sleep Med. 2008 Jul; 9(5):527-36. PMID: 17689142.
    Citations: 23     Fields:    Translation:Humans
  75. Thomas RJ. Cyclic alternating pattern in the electroencephalogram: what is its clinical utility? Sleep. 2007 May; 30(5):553-5. PMID: 17552369.
    Citations: 6     Fields:    Translation:Humans
  76. Thomas RJ, Kwong K. Modafinil activates cortical and subcortical sites in the sleep-deprived state. Sleep. 2006 Nov; 29(11):1471-81. PMID: 17162995.
    Citations: 10     Fields:    Translation:Humans
  77. Thomas RJ. Sleep fragmentation and arousals from sleep-time scales, associations, and implications. Clin Neurophysiol. 2006 Apr; 117(4):707-11. PMID: 16500146.
    Citations: 6     Fields:    Translation:Humans
  78. Surman CB, Thomas RJ, Aleardi M, Pagano C, Biederman J. Adults with ADHD and sleep complaints: a pilot study identifying sleep-disordered breathing using polysomnography and sleep quality assessment. J Atten Disord. 2006 Feb; 9(3):550-5. PMID: 16481672.
    Citations: 6     Fields:    Translation:Humans
  79. Deldin PJ, Phillips LK, Thomas RJ. A preliminary study of sleep-disordered breathing in major depressive disorder. Sleep Med. 2006 Mar; 7(2):131-9. PMID: 16260180.
    Citations: 14     Fields:    Translation:Humans
  80. Gilmartin GS, Daly RW, Thomas RJ. Recognition and management of complex sleep-disordered breathing. Curr Opin Pulm Med. 2005 Nov; 11(6):485-93. PMID: 16217173.
    Citations: 41     Fields:    Translation:Humans
  81. Thomas RJ. Fatigue in the executive cortical network demonstrated in narcoleptics using functional magnetic resonance imaging--a preliminary study. Sleep Med. 2005 Sep; 6(5):399-406. PMID: 15996898.
    Citations: 10     Fields:    Translation:Humans
  82. Thomas RJ, Mietus JE, Peng CK, Goldberger AL. An electrocardiogram-based technique to assess cardiopulmonary coupling during sleep. Sleep. 2005 Sep; 28(9):1151-61. PMID: 16268385.
    Citations: 48     Fields:    Translation:Humans
  83. Parrino L, Thomas RJ, Smerieri A, Spaggiari MC, Del Felice A, Terzano MG. Reorganization of sleep patterns in severe OSAS under prolonged CPAP treatment. Clin Neurophysiol. 2005 Sep; 116(9):2228-39. PMID: 16040272.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  84. Thomas RJ, Rosen BR, Stern CE, Weiss JW, Kwong KK. Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol (1985). 2005 Jun; 98(6):2226-34. PMID: 15677733.
    Citations: 61     Fields:    Translation:HumansCTClinical Trials
  85. Thomas RJ. Effect of added dead space to positive airway pressure for treatment of complex sleep-disordered breathing. Sleep Med. 2005 Mar; 6(2):177-8. PMID: 15716223.
    Citations: 7     Fields:    Translation:Humans
  86. Thomas RJ, Daly RW, Weiss JW. Low-concentration carbon dioxide is an effective adjunct to positive airway pressure in the treatment of refractory mixed central and obstructive sleep-disordered breathing. Sleep. 2005 Jan; 28(1):69-77. PMID: 15700722.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  87. Gilmartin GS, Thomas RJ. Mechanisms of arousal from sleep and their consequences. Curr Opin Pulm Med. 2004 Nov; 10(6):468-74. PMID: 15510052.
    Citations: 2     Fields:    Translation:Humans
  88. Thomas RJ, Terzano MG, Parrino L, Weiss JW. Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern--a recognizable polysomnographic variant with practical clinical implications. Sleep. 2004 Mar 15; 27(2):229-34. PMID: 15124715.
    Citations: 25     Fields:    Translation:Humans
  89. Thomas RJ. Arousals in sleep-disordered breathing: patterns and implications. Sleep. 2003 Dec 15; 26(8):1042-7. PMID: 14746388.
    Citations: 15     Fields:    Translation:Humans
  90. Thomas RJ, Kwong K. Computational neuroanatomy in sleep-disordered breathing and related disorders. Sleep Med. 2003 Sep; 4(5):379-80. PMID: 14592277.
    Citations:    Fields:    Translation:Humans
  91. Thomas RJ. Cyclic alternating pattern and positive airway pressure titration. Sleep Med. 2002 Jul; 3(4):315-22. PMID: 14592193.
    Citations: 6     Fields:    
  92. Thomas RJ. Seizures and epilepsy in the elderly. Arch Intern Med. 1997 Mar 24; 157(6):605-17. PMID: 9080915.
    Citations: 8     Fields:    Translation:Humans
  93. Thomas RJ, Reagan DR. Association of a Tourette-like syndrome with ofloxacin. Ann Pharmacother. 1996 Feb; 30(2):138-41. PMID: 8835045.
    Citations: 10     Fields:    Translation:Humans
  94. Thomas RJ. Excitatory amino acids in health and disease. J Am Geriatr Soc. 1995 Nov; 43(11):1279-89. PMID: 7594165.
    Citations: 9     Fields:    Translation:HumansAnimals
  95. Thomas RJ. Neurotoxicity of antibacterial therapy. South Med J. 1994 Sep; 87(9):869-74. PMID: 8091248.
    Citations: 2     Fields:    Translation:HumansAnimals
  96. Thomas RJ. Blinking and the release reflexes: are they clinically useful? J Am Geriatr Soc. 1994 Jun; 42(6):609-13. PMID: 8201145.
    Citations: 2     Fields:    Translation:Humans
  97. Bambery P, Thomas RJ, Malhotra HS, Kaur U, Bhusnurmath SR, Deodhar SD. Adult onset Still's disease: clinical experience with 18 patients over 15 years in northern India. Ann Rheum Dis. 1992 Apr; 51(4):529-32. PMID: 1586255.
    Citations: 7     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.