Harvard Catalyst Profiles

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Kathleen Mary Buchheit, M.D.


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  1. K23AI139352 (BUCHHEIT, KATHLEEN MARY) Jun 19, 2019 - Mar 31, 2024
    The Role of IL-5 and Local Nasal Polyp Immunoglobulin Production in Aspirin-Exacerbated Respiratory Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen CC, Buchheit KM. Endotyping Chronic Rhinosinusitis with Nasal Polyps: Understanding Inflammation Beyond Phenotypes. Am J Rhinol Allergy. 2023 Mar; 37(2):132-139. PMID: 36848270.
    Citations:    Fields:    
  2. Wang X, Hallen NR, Lee M, Samuchiwal S, Ye Q, Buchheit KM, Maxfield AZ, Roditi RE, Bergmark RW, Bhattacharyya N, Ryan T, Gakpo D, Raychaudhuri S, Dwyer D, Laidlaw TM, Boyce JA, Gutierrez-Arcelus M, Barrett NA. Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling. J Allergy Clin Immunol. 2023 Feb 16. PMID: 36804595.
    Citations:    Fields:    
  3. Li L, Bensko J, Baloh CH, Bibbo C, Buchheit KM. Two-step nonsteroidal anti-inflammatory drug challenges during pregnancy: A case series. J Allergy Clin Immunol Pract. 2023 Feb; 11(2):652-654. PMID: 36566780; PMCID: PMC9911358.
    Citations:    Fields:    Translation:Humans
  4. Hopkins C, Buchheit KM, Heffler E, Cohen NA, Olze H, Khan AH, Msihid J, Siddiqui S, Nash S, Jacob-Nara JA, Rowe PJ, Deniz Y. Improvement in Health-Related Quality of Life with Dupilumab in Patients with Moderate-to-Severe Asthma with Comorbid Chronic Rhinosinusitis with/without Nasal Polyps: An Analysis of the QUEST Study. J Asthma Allergy. 2022; 15:767-773. PMID: 35698581; PMCID: PMC9188334.
  5. Tchekmedyian R, Lundberg M, Buchheit KM, Maurer R, Gakpo D, Mullur J, Bensko JC, Laidlaw TM. Loss of smell in patients with aspirin-exacerbated respiratory disease impacts mental health and quality of life. Clin Exp Allergy. 2022 12; 52(12):1414-1421. PMID: 35506180; PMCID: PMC9630163.
    Citations:    Fields:    
  6. Morris J, Olonisakin TF, Moore JA, Phan B, Parker DM, Uribe BA, Barel SJ, Bowers EMR, Buchheit KM, Laidlaw TM, Lee SE. Inhibiting the type 2 inflammatory pathway with dupilumab is associated with an increase in interleukin-4 and interleukin-18 production. Int Forum Allergy Rhinol. 2022 10; 12(10):1313-1316. PMID: 35394682.
    Citations:    Fields:    
  7. Buchheit KM, Sohail A, Hacker J, Maurer R, Gakpo D, Bensko JC, Taliaferro F, Ordovas-Montanes J, Laidlaw TM. Rapid and sustained effect of dupilumab on clinical and mechanistic outcomes in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2022 08; 150(2):415-424. PMID: 35460728; PMCID: PMC9378638.
    Citations:    Fields:    
  8. Mullol J, Azar A, Buchheit KM, Hopkins C, Bernstein JA. Chronic Rhinosinusitis With Nasal Polyps: Quality of Life in the Biologics Era. J Allergy Clin Immunol Pract. 2022 06; 10(6):1434-1453.e9. PMID: 35306180.
    Citations:    Fields:    Translation:Humans
  9. Mullur J, Steger CM, Gakpo D, Bensko JC, Maurer R, Laidlaw TM, Buchheit KM. Aspirin desensitization and biologics in aspirin-exacerbated respiratory disease: Efficacy, tolerability, and patient experience. Ann Allergy Asthma Immunol. 2022 05; 128(5):575-582. PMID: 35131410; PMCID: PMC9058196.
    Citations:    Fields:    Translation:Humans
  10. Miss Ozuna L, Ryan T, Bensko JC, Laidlaw TM, Buchheit KM. Dupilumab-associated arthralgia in patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2022 04; 128(4):469-472. PMID: 35124224; PMCID: PMC8977235.
    Citations: 1     Fields:    Translation:Humans
  11. Patel P, Bensko JC, Bhattacharyya N, Laidlaw TM, Buchheit KM. Dupilumab as an adjunct to surgery in patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2022 03; 128(3):326-328. PMID: 34863953; PMCID: PMC8882131.
    Citations:    Fields:    Translation:Humans
  12. Li L, Bensko J, Buchheit K, Saff RR, Laidlaw TM. Safety, Outcomes, and Recommendations for Two-Step Outpatient Nonsteroidal Anti-Inflammatory Drug Challenges. J Allergy Clin Immunol Pract. 2022 05; 10(5):1286-1292.e2. PMID: 34800703; PMCID: PMC9086081.
    Citations:    Fields:    Translation:Humans
  13. Buchheit KM, Laidlaw TM, Levy JM. Immunology-based recommendations for available and upcoming biologics in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2021 08; 148(2):348-350. PMID: 34174296; PMCID: PMC9022378.
    Citations: 2     Fields:    Translation:Humans
  14. Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM. Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2021 08; 148(2):574-584. PMID: 34144111; PMCID: PMC9096876.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  15. Buchheit KM, Hacker JJ, Gakpo DH, Mullur J, Sohail A, Laidlaw TM. Influence of daily aspirin therapy on ACE2 expression and function-implications for SARS-CoV-2 and patients with aspirin-exacerbated respiratory disease. Clin Exp Allergy. 2021 07; 51(7):968-971. PMID: 33987897.
    Citations: 2     Fields:    Translation:HumansCells
  16. Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK, Barrett NA, Boyce JA. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021 02 26; 6(56). PMID: 33637594; PMCID: PMC8362933.
    Citations: 15     Fields:    Translation:HumansCells
  17. Bavaro N, Gakpo D, Mittal A, Bensko JC, Laidlaw TM, Buchheit KM. Efficacy of dupilumab in patients with aspirin-exacerbated respiratory disease and previous inadequate response to anti-IL-5 or anti-IL-5Ra in a real-world setting. J Allergy Clin Immunol Pract. 2021 07; 9(7):2910-2912.e1. PMID: 33631410; PMCID: PMC8277677.
    Citations: 4     Fields:    Translation:Humans
  18. Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA. The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2021 03; 147(3):827-844. PMID: 33307116; PMCID: PMC7980229.
    Citations: 15     Fields:    Translation:HumansAnimals
  19. Bergmark RW, Palumbo M, Rahman S, Maurer R, Dominas C, Roditi R, Bhattacharyya N, Maxfield A, Buchheit KM, Laidlaw TM. Aspirin-Exacerbated Respiratory Disease: Association Between Patient-Reported Sinus and Asthma Morbidity. J Allergy Clin Immunol Pract. 2021 04; 9(4):1604-1611. PMID: 33307278.
    Citations: 1     Fields:    Translation:Humans
  20. Gruye LE, McCunney RJ, Buchheit KM, Goldminz AM. Allergic contact dermatitis in a wastewater treatment worker: The role of sodium hypochlorite. Contact Dermatitis. 2020 Dec; 83(6):533-535. PMID: 32965031.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  21. Buchheit KM, Hulse KE. Local immunoglobulin production in nasal tissues: A key to pathogenesis in chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2021 02; 126(2):127-134. PMID: 33065294; PMCID: PMC8210467.
    Citations: 3     Fields:    Translation:HumansCells
  22. Broyles AD, Banerji A, Barmettler S, Biggs CM, Blumenthal K, Brennan PJ, Breslow RG, Brockow K, Buchheit KM, Cahill KN, Cernadas J, Chiriac AM, Crestani E, Demoly P, Dewachter P, Dilley M, Farmer JR, Foer D, Fried AJ, Garon SL, Giannetti MP, Hepner DL, Hong DI, Hsu JT, Kothari PH, Kyin T, Lax T, Lee MJ, Lee-Sarwar K, Liu A, Logsdon S, Louisias M, MacGinnitie A, Maciag M, Minnicozzi S, Norton AE, Otani IM, Park M, Patil S, Phillips EJ, Picard M, Platt CD, Rachid R, Rodriguez T, Romano A, Stone CA, Torres MJ, Verdú M, Wang AL, Wickner P, Wolfson AR, Wong JT, Yee C, Zhou J, Castells M. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. J Allergy Clin Immunol Pract. 2020 10; 8(9S):S16-S116. PMID: 33039007.
    Citations: 28     Fields:    Translation:Humans
  23. Buchheit K, Bensko JC, Lewis E, Gakpo D, Laidlaw TM. The importance of timely diagnosis of aspirin-exacerbated respiratory disease for patient health and safety. World J Otorhinolaryngol Head Neck Surg. 2020 Dec; 6(4):203-206. PMID: 33336174; PMCID: PMC7729250.
    Citations: 1     
  24. Foer D, Tran LK, Wickner P, Castells M, Marquis KA, Buchheit KM. Challenges in skin testing for progestogen hypersensitivity. Ann Allergy Asthma Immunol. 2021 01; 126(1):100-102. PMID: 32911056.
    Citations:    Fields:    Translation:Humans
  25. Laidlaw TM, Gakpo DH, Bensko JC, Buchheit K. Leukotriene-Associated Rash in Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2020 10; 8(9):3170-3171. PMID: 32739465.
    Citations:    Fields:    Translation:Humans
  26. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 05 28; 181(5):1016-1035.e19. PMID: 32413319; PMCID: PMC7252096.
    Citations: 986     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  27. Chen YS, Bensko JC, Laidlaw TM, Buchheit KM. A retrospective analysis of bronchiectasis in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2020 09; 8(8):2799-2801. PMID: 32330669.
    Citations:    Fields:    Translation:Humans
  28. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 06; 145(6):1574-1584. PMID: 32199912; PMCID: PMC7282948.
    Citations: 15     Fields:    Translation:HumansCells
  29. Laidlaw TM, Buchheit KM. Biologics in chronic rhinosinusitis with nasal polyposis. Ann Allergy Asthma Immunol. 2020 04; 124(4):326-332. PMID: 31830587.
    Citations: 13     Fields:    Translation:Humans
  30. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709; PMCID: PMC6462243.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  31. Foer D, Buchheit KM. Presentation and natural history of progestogen hypersensitivity. Ann Allergy Asthma Immunol. 2019 02; 122(2):156-159. PMID: 30712576; PMCID: PMC6497082.
    Citations:    Fields:    Translation:Humans
  32. Eid RC, Palumbo ML, Laidlaw TM, Buchheit KM, Cahill KN. A retrospective analysis of esophageal eosinophilia in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2019 04; 7(4):1338-1340. PMID: 30261317; PMCID: PMC6433551.
    Citations: 4     Fields:    Translation:Humans
  33. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654. PMID: 30135581.
    Citations: 116     Fields:    Translation:HumansCells
  34. Pan D, Buchheit KM, Samuchiwal SK, Liu T, Cirka H, Raff H, Boyce JA. COX-1 mediates IL-33-induced extracellular signal-regulated kinase activation in mast cells: Implications for aspirin sensitivity. J Allergy Clin Immunol. 2019 03; 143(3):1047-1057.e8. PMID: 30017554; PMCID: PMC6330164.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Tuttle KL, Buchheit KM, Laidlaw TM, Cahill KN. A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):1045-1047. PMID: 29501519.
    Citations: 24     Fields:    Translation:Humans
  36. Li RC, Buchheit KM, Bernstein JA. Progestogen Hypersensitivity. Curr Allergy Asthma Rep. 2018 01 19; 18(1):1. PMID: 29349660.
    Citations: 2     Fields:    Translation:Humans
  37. Foer D, Buchheit KM. Progestogen Hypersensitivity: An Evidence-Based Approach to Diagnosis and Management in Clinical Practice. Immunol Allergy Clin North Am. 2017 11; 37(4):773-784. PMID: 28965640.
    Citations: 3     Fields:    Translation:Humans
  38. Buchheit KM, Bernstein JA. Progestogen Hypersensitivity: Heterogeneous Manifestations with a Common Trigger. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):566-574. PMID: 28483311.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  39. Buchheit KM, Laidlaw TM. Update on the Management of Aspirin-Exacerbated Respiratory Disease. Allergy Asthma Immunol Res. 2016 Jul; 8(4):298-304. PMID: 27126722; PMCID: PMC4853506.
    Citations: 11     
  40. Foer D, Buchheit KM, Gargiulo AR, Lynch DM, Castells M, Wickner PG. Progestogen Hypersensitivity in 24 Cases: Diagnosis, Management, and Proposed Renaming and Classification. J Allergy Clin Immunol Pract. 2016 Jul-Aug; 4(4):723-9. PMID: 27090357.
    Citations: 21     Fields:    Translation:Humans
  41. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435; PMCID: PMC4860132.
    Citations: 58     Fields:    Translation:HumansCells
  42. Stevens W, Buchheit K, Cahill KN. Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis. Curr Allergy Asthma Rep. 2015 Dec; 15(12):69. PMID: 26475526.
    Citations: 6     Fields:    Translation:HumansAnimals
  43. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029; PMCID: PMC4592820.
    Citations: 47     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.