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Ranjna Sharma, M.D.

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Biography
1994 - 1998
Ohio Academic Scholarship
1997
Psi Chi International Honor Society in Psychology
1997
Golden Key International Honor Society
1998
Alpha Phi Leadership Scholarship
2000 - 2002
College of Medicine Scholarship
2005
Resident Research Competition, 3rd place

Overview
My clinical research interests include oncoplastic reconstruction of partial mastectomy defects, evaluating clinical outcomes in the octogenarian patient population diagnosed with invasive carcinoma, and identifying radiologic and pathologic features that contribute to an upgrade of common breast atypias to carcinoma. Our Group has developed a protocol to retrospectively study prospectively collected patient data examining the oncoplastic reconstruction of partial mastectomy defects. To date, approximately 10 patients have undergone oncoplastic reconstruction following lumpectomy under the direction of our Plastic Surgery colleagues. Our Group is developing a protocol to retrospectively study the treatment decisions and clinical outcomes in the octogenarian patient population, as compared to younger patients, diagnosed with early breast cancer. Our Group has also developed a Database to retrospectively review the upgrade rate from atypia to carcinoma in patients with atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), and lobular carcinoma in situ (LCIS).

My translational research interests include breast cancer stem cell identification to elucidate diagnostic and therapeutic strategies, novel techniques to more accurately evaluate margins of surgical resection specimens, and evaluating the clinical efficacy of a breast cancer targeted vaccine.

I am also active in the education of surgical residents in the Department of Surgery at Beth Israel Deaconess Medical Center and Harvard Medical School students rotating on our surgical service as part of their third-year clerkship experience. I provide didactic lectures on the diagnosis and treatment of breast cancer. I have also developed our Service’s rotation-specific skills simulation curriculum and model, utilizing a gelatin breast model to teach principles of surgical resection during a wire-localized partial mastectomy.

Clinically, my practice involves the care of patients with benign and malignant breast disease. After completing a Fellowship in breast surgical oncology, this is my area of expertise. I perform advanced breast surgical oncology procedures to offer leading-edge care to our patient population.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mamtani A, Gonzalez JJ, Neo DT, Friedman RS, Recht A, Hacker MR, Sharma R. Treatment Strategies in Octogenarians with Early-Stage, High-Risk Breast Cancer. Ann Surg Oncol. 2018 Jun; 25(6):1495-1501. PMID: 29427213.
    View in: PubMed
  2. Linsk A, Mehta TS, Dialani V, Brook A, Chadashvili T, Houlihan MJ, Sharma R. Surgical upgrade rate of breast atypia to malignancy: An academic center's experience and validation of a predictive model. Breast J. 2018 Mar; 24(2):115-119. PMID: 28833923.
    View in: PubMed
  3. Chattha A, Bucknor A, Kamali P, Van Veldhuisen CL, Flecha-Hirsch R, Sharma R, Tobias AM, Lee BT, Lin SJ. Comparison of risk factors and complications in patients by stratified mastectomy weight: An institutional review of 1041 consecutive cases. J Surg Oncol. 2017 Dec; 116(7):811-818. PMID: 28833196.
    View in: PubMed
  4. Sharma R, Shulman LN, James T. The Future of Quality Improvement in Breast Cancer: Patient-Reported Outcomes. Am J Med Qual. 2017 Sep/Oct; 32(5):469-471. PMID: 28766360.
    View in: PubMed
  5. van Paridon MW, Kamali P, Paul MA, Wu W, Ibrahim AMS, Kansal KJ, Houlihan MJ, Morris DJ, Lee BT, Lin SJ, Sharma R. Oncoplastic breast surgery: Achieving oncological and aesthetic outcomes. J Surg Oncol. 2017 Aug; 116(2):195-202. PMID: 28464217.
    View in: PubMed
  6. Mele A, Mehta P, Slanetz PJ, Brook A, Recht A, Sharma R. Breast-Conserving Surgery Alone for Ductal Carcinoma In Situ: Factors Associated with Increased Risk of Local Recurrence. Ann Surg Oncol. 2017 May; 24(5):1221-1226. PMID: 27900632.
    View in: PubMed
  7. Manders JB, Kuerer HM, Smith BD, McCluskey C, Farrar WB, Frazier TG, Li L, Leonard CE, Carter DL, Chawla S, Medeiros LE, Guenther JM, Castellini LE, Buchholz DJ, Mamounas EP, Wapnir IL, Horst KC, Chagpar A, Evans SB, Riker AI, Vali FS, Solin LJ, Jablon L, Recht A, Sharma R, Lu R, Sing AP, Hwang ES, White J. Clinical Utility of the 12-Gene DCIS Score Assay: Impact on Radiotherapy Recommendations for Patients with Ductal Carcinoma In Situ. Ann Surg Oncol. 2017 Mar; 24(3):660-668. PMID: 27704370.
    View in: PubMed
  8. Mamtani A, Gonzalez JJ, Neo D, Slanetz PJ, Houlihan MJ, Herold CI, Recht A, Hacker MR, Sharma R. Early-Stage Breast Cancer in the Octogenarian: Tumor Characteristics, Treatment Choices, and Clinical Outcomes. Ann Surg Oncol. 2016 10; 23(10):3371-8. PMID: 27364507.
    View in: PubMed
  9. de Blacam C, Ogunleye AA, Momoh AO, Colakoglu S, Tobias AM, Sharma R, Houlihan MJ, Lee BT. High body mass index and smoking predict morbidity in breast cancer surgery: a multivariate analysis of 26,988 patients from the national surgical quality improvement program database. Ann Surg. 2012 Mar; 255(3):551-5. PMID: 22330036.
    View in: PubMed
  10. Sharma R, Rourke LL, Kronowitz SJ, Oh JL, Lucci A, Litton JK, Robb GL, Babiera GV, Mittendorf EA, Hunt KK, Kuerer HM. Management of local-regional recurrence following immediate breast reconstruction in patients with early breast cancer treated without postmastectomy radiotherapy. Plast Reconstr Surg. 2011 May; 127(5):1763-72. PMID: 21532405.
    View in: PubMed
  11. Sharma R, Wagner JL, Hwang RF. Ablative therapies of the breast. Surg Oncol Clin N Am. 2011 Apr; 20(2):317-39, viii. PMID: 21377586.
    View in: PubMed
  12. Hanna G, Lin SJ, Wertheimer MD, Sharma R. Unresolved, atraumatic breast hematoma: post-irradiation or secondary breast angiosarcoma. Breast Dis. 2011; 33(3):139-42. PMID: 22377611.
    View in: PubMed
  13. Saied A, Bhati C, Sharma R, Garrean S, Salti G. Small bowel obstruction from breast cancer metastasis: a case report and review of the literature. Breast Dis. 2011-2012; 33(4):183-8. PMID: 21778579.
    View in: PubMed
  14. Sharma R, Bedrosian I, Lucci A, Hwang RF, Rourke LL, Qiao W, Buchholz TA, Kronowitz SJ, Krishnamurthy S, Babiera GV, Gonzalez-Angulo AM, Meric-Bernstam F, Mittendorf EA, Hunt KK, Kuerer HM. Present-day locoregional control in patients with t1 or t2 breast cancer with 0 and 1 to 3 positive lymph nodes after mastectomy without radiotherapy. Ann Surg Oncol. 2010 Nov; 17(11):2899-908. PMID: 20443145; PMCID: PMC4324592.
  15. Sharma R, Dietz J, Wright H, Crowe J, DiNunzio A, Woletz J, Kim J. Comparative analysis of minimally invasive microductectomy versus major duct excision in patients with pathologic nipple discharge. Surgery. 2005 Oct; 138(4):591-6; discussion 596-7. PMID: 16269286.
    View in: PubMed
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