Harvard Catalyst Profiles

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Silvia Giannini, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL134829 (GIANNINI, SILVIA) Jan 10, 2017 - Dec 31, 2021
    The role of glycans in thrombopoiesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fischer K, Ohori S, Meral FC, Uehara M, Giannini S, Ichimura T, Smith RN, Jolesz FA, Guleria I, Zhang Y, White PJ, McDannold NJ, Hoffmeister K, Givertz MM, Abdi R. Testing the Efficacy of Contrast-Enhanced Ultrasound in Detecting Transplant Rejection Using a Murine Model of Heart Transplantation. Am J Transplant. 2017 Jul; 17(7):1791-1801. PMID: 28009476.
    Citations:    Fields:    Translation:Animals
  2. Elf S, Abdelfattah NS, Chen E, Perales-Patón J, Rosen EA, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan EA, Tothova Z, Losman JA, Schneider RK, Al-Shahrour F, Mullally A. Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation. Cancer Discov. 2016 Apr; 6(4):368-81. PMID: 26951227; PMCID: PMC4851866.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  3. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Novel mechanisms of platelet clearance and thrombopoietin regulation. Curr Opin Hematol. 2015 Sep; 22(5):445-51. PMID: 26154508.
    Citations: 2     Fields:    Translation:HumansCells
  4. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Regulating billions of blood platelets: glycans and beyond. Blood. 2015 Oct 15; 126(16):1877-84. PMID: 26330242; PMCID: PMC4608239.
    Citations: 15     Fields:    Translation:HumansCells
  5. Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015 Jul 02; 126(1):80-8. PMID: 25838348; PMCID: PMC4492198.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  6. Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood. 2015 Feb 05; 125(6):1014-24. PMID: 25468568; PMCID: PMC4319232.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Falcinelli E, Francisci D, Belfiori B, Petito E, Guglielmini G, Malincarne L, Mezzasoma A, Sebastiano M, Conti V, Giannini S, Bonora S, Baldelli F, Gresele P. In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients. Thromb Haemost. 2013 Aug; 110(2):349-57. PMID: 23703656.
    Citations: 12     Fields:    Translation:HumansCells
  8. Giannini S, Falcinelli E, Bury L, Guglielmini G, Rossi R, Momi S, Gresele P. Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake. Am J Physiol Heart Circ Physiol. 2011 Jun; 300(6):H2072-9. PMID: 21378140.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  9. Giannini S, Solimando M, Fierro T, Baronciani L, Federici AB, Gresele P. Acquired von Willebrand syndrome type 2A in a JAK2-positive essential thrombocythaemia-affected member of a large von Willebrand disease family with a novel autosomal dominant A1716P mutation. Thromb Haemost. 2011 May; 105(5):921-4. PMID: 21359411.
    Citations: 2     Fields:    Translation:Humans
  10. Gresele P, Marzotti S, Guglielmini G, Momi S, Giannini S, Minuz P, Lucidi P, Bolli GB. Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agent. Diabetes Care. 2010 Jun; 33(6):1262-8. PMID: 20299485; PMCID: PMC2875435.
    Citations: 8     Fields:    Translation:Humans
  11. Giannini S, Cecchetti L, Mezzasoma AM, Gresele P. Diagnosis of platelet-type von Willebrand disease by flow cytometry. Haematologica. 2010 Jun; 95(6):1021-4. PMID: 19951970; PMCID: PMC2878803.
    Citations: 1     Fields:    Translation:HumansCells
  12. Momi S, Falcinelli E, Giannini S, Ruggeri L, Cecchetti L, Corazzi T, Libert C, Gresele P. Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo. J Exp Med. 2009 Oct 26; 206(11):2365-79. PMID: 19808257; PMCID: PMC2768852.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Gresele P, Falcinelli E, Giannini S, D'Adamo P, D'Eustacchio A, Corazzi T, Mezzasoma AM, Di Bari F, Guglielmini G, Cecchetti L, Noris P, Balduini CL, Savoia A. Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families. Haematologica. 2009 May; 94(5):663-9. PMID: 19336737; PMCID: PMC2675678.
    Citations: 15     Fields:    Translation:HumansCells
  14. Francisci D, Giannini S, Baldelli F, Leone M, Belfiori B, Guglielmini G, Malincarne L, Gresele P. HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS. 2009 Mar 13; 23(5):589-96. PMID: 19177019.
    Citations: 36     Fields:    Translation:HumansCells
  15. Giannini S, Mezzasoma AM, Guglielmini G, Rossi R, Falcinelli E, Gresele P. A new case of acquired Glanzmann's thrombasthenia: diagnostic value of flow cytometry. Cytometry B Clin Cytom. 2008 May; 74(3):194-9. PMID: 18200593.
    Citations: 5     Fields:    Translation:HumansCells
  16. Pitchford SC, Momi S, Baglioni S, Casali L, Giannini S, Rossi R, Page CP, Gresele P. Allergen induces the migration of platelets to lung tissue in allergic asthma. Am J Respir Crit Care Med. 2008 Mar 15; 177(6):604-12. PMID: 18096710.
    Citations: 25     Fields:    Translation:AnimalsCells
  17. Giannini S, Mezzasoma AM, Leone M, Gresele P. Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand's disease by flow cytometry. Haematologica. 2007 Dec; 92(12):1647-54. PMID: 18055988.
    Citations: 5     Fields:    Translation:HumansCells
  18. Falcinelli E, Giannini S, Boschetti E, Gresele P. Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirin. Br J Haematol. 2007 Jul; 138(2):221-30. PMID: 17593030.
    Citations: 9     Fields:    Translation:HumansCells
  19. Buratta M, Piccotti L, Giannini S, Gresele P, Roberti R, Corazzi L. Selective cytochrome c displacement by phosphate and Ca(2+) in brain mitochondria. J Membr Biol. 2006; 212(3):199-210. PMID: 17334837.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Pitchford SC, Momi S, Giannini S, Casali L, Spina D, Page CP, Gresele P. Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood. 2005 Mar 01; 105(5):2074-81. PMID: 15528309.
    Citations: 48     Fields:    Translation:AnimalsCells
  21. Pitchford SC, Yano H, Lever R, Riffo-Vasquez Y, Ciferri S, Rose MJ, Giannini S, Momi S, Spina D, O'connor B, Gresele P, Page CP. Platelets are essential for leukocyte recruitment in allergic inflammation. J Allergy Clin Immunol. 2003 Jul; 112(1):109-18. PMID: 12847487.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.