Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Samuel A Frank, M.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture

Biography
Boston University, Boston, MAMD06/1998Medicine
University of Rochester, Rochester, NY06/2002Neurology Residency
University of Rochester, Rochester, NY06/2004Experimental Therapeutics Fellowship
2019
Excellence in Care Award
2017
Excellence in Teaching Award
2011
Alpha Omega Alpha Medical Honor Society, Alumni
2001
Humanism and Excellence in Teaching Award

Overview

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Carlozzi NE, Schilling SG, Boileau NR, Chou KL, Perlmutter JS, Frank S, McCormack MK, Stout JC, Paulsen JS, Lai JS, Dayalu P. How different aspects of motor dysfunction influence day-to-day function in huntington's disease. Mov Disord. 2019 12; 34(12):1910-1914. PMID: 31609508.
    Citations:    
  2. Frank S, Berk S, Hernandez L, Hogarth P, Shill HA, Siddiqi B, Simon DK. Transportation innovation to aid Parkinson disease trial recruitment. Contemp Clin Trials Commun. 2019 Dec; 16:100449. PMID: 31650070.
    Citations:    
  3. Luo L, Andrews H, Alcalay RN, Poyraz FC, Boehme AK, Goldman JG, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Sutherland M, Kopil C, Naito A, Kang UJ. Motor phenotype classification in moderate to advanced PD in BioFIND study. Parkinsonism Relat Disord. 2019 08; 65:178-183. PMID: 31255537.
    Citations:    
  4. Prakash N, Caspell-Garcia C, Coffey C, Siderowf A, Tanner CM, Kieburtz K, Mollenhauer B, Galasko D, Merchant K, Foroud T, Chahine LM, Weintraub D, Casaceli C, Dorsey R, Wilson R, Herzog M, Daegele N, Arnedo V, Frasier M, Sherer T, Marek K, Frank S, Jennings D, Simuni T. Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI). Parkinsonism Relat Disord. 2019 05; 62:201-209. PMID: 30738748.
    Citations:    
  5. Richard A, Frank S. Deutetrabenazine in the treatment of Huntington's disease. Neurodegener Dis Manag. 2019 Feb; 9(1):31-37. PMID: 30624137.
    Citations:    Fields:    
  6. Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 09; 14(9):1159-1170. PMID: 30049650.
    Citations:    Fields:    
  7. Parikh SK, Frank SA. Author response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. Neurology. 2018 01 16; 90(3):146-147. PMID: 29335312.
    Citations:    Fields:    
  8. Goldman JG, Andrews H, Amara A, Naito A, Alcalay RN, Shaw LM, Taylor P, Xie T, Tuite P, Henchcliffe C, Hogarth P, Frank S, Saint-Hilaire MH, Frasier M, Arnedo V, Reimer AN, Sutherland M, Swanson-Fischer C, Gwinn K, Kang UJ. Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features. Mov Disord. 2018 02; 33(2):282-288. PMID: 29205509.
    Citations: 2     Fields:    
  9. Frank S, Stamler D, Kayson E, Claassen DO, Colcher A, Davis C, Duker A, Eberly S, Elmer L, Furr-Stimming E, Gudesblatt M, Hunter C, Jankovic J, Kostyk SK, Kumar R, Loy C, Mallonee W, Oakes D, Scott BL, Sung V, Goldstein J, Vaughan C, Testa CM. Safety of Converting From Tetrabenazine to Deutetrabenazine for the Treatment of Chorea. JAMA Neurol. 2017 08 01; 74(8):977-982. PMID: 28692723.
    Citations: 2     Fields:    Translation:Humans
  10. Carlozzi NE, Ready RE, Frank S, Cella D, Hahn EA, Goodnight SM, Schilling SG, Boileau NR, Dayalu P. Patient-reported outcomes in Huntington's disease: Quality of life in neurological disorders (Neuro-QoL) and Huntington's disease health-related quality of life (HDQLIFE) physical function measures. Mov Disord. 2017 Jul; 32(7):1096-1102. PMID: 28556412.
    Citations:    Fields:    Translation:Humans
  11. Parikh SK, Frank SA. Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. Neurology. 2017 01 10; 88(2):e14-e18. PMID: 28069982.
    Citations:    Fields:    Translation:Humans
  12. McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, Guttman M, Wojcieszek J, Kumar R, LeDoux MS, Jenkins M, Rosas HD, Nance M, Biglan K, Como P, Dubinsky RM, Shannon KM, O'Suilleabhain P, Chou K, Walker F, Martin W, Wheelock VL, McCusker E, Jankovic J, Singer C, Sanchez-Ramos J, Scott B, Suchowersky O, Factor SA, Higgins DS, Molho E, Revilla F, Caviness JN, Friedman JH, Perlmutter JS, Feigin A, Anderson K, Rodriguez R, McFarland NR, Margolis RL, Farbman ES, Raymond LA, Suski V, Kostyk S, Colcher A, Seeberger L, Epping E, Esmail S, Diaz N, Fung WL, Diamond A, Frank S, Hanna P, Hermanowicz N, Dure LS, Cudkowicz M. A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. Neurology. 2017 Jan 10; 88(2):152-159. PMID: 27913695.
    Citations: 9     Fields:    Translation:Humans
  13. Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, O'Neill C, Vaughan C, Goldstein J, Herzog M, Snively V, Whaley J, Wong C, Suter G, Jankovic J, Jimenez-Shahed J, Hunter C, Claassen DO, Roman OC, Sung V, Smith J, Janicki S, Clouse R, Saint-Hilaire M, Hohler A, Turpin D, James RC, Rodriguez R, Rizer K, Anderson KE, Heller H, Carlson A, Criswell S, Racette BA, Revilla FJ, Nucifora F, Margolis RL, Ong M, Mendis T, Mendis N, Singer C, Quesada M, Paulsen JS, Brashers-Krug T, Miller A, Kerr J, Dubinsky RM, Gray C, Factor SA, Sperin E, Molho E, Eglow M, Evans S, Kumar R, Reeves C, Samii A, Chouinard S, Beland M, Scott BL, Hickey PT, Esmail S, Fung WL, Gibbons C, Qi L, Colcher A, Hackmyer C, McGarry A, Klos K, Gudesblatt M, Fafard L, Graffitti L, Schneider DP, Dhall R, Wojcieszek JM, LaFaver K, Duker A, Neefus E, Wilson-Perez H, Shprecher D, Wall P, Blindauer KA, Wheeler L, Boyd JT, Houston E, Farbman ES, Agarwal P, Eberly SW, Watts A, Tariot PN, Feigin A, Evans S, Beck C, Orme C, Edicola J, Christopher E. Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. JAMA. 2016 Jul 05; 316(1):40-50. PMID: 27380342.
    Citations: 17     Fields:    Translation:Humans
  14. Kang UJ, Goldman JG, Alcalay RN, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Rudolph A, Casaceli C, Andrews H, Gwinn K, Sutherland M, Kopil C, Vincent L, Frasier M. The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort. Mov Disord. 2016 06; 31(6):924-32. PMID: 27113479.
    Citations: 4     Fields:    Translation:Humans
  15. Hoss AG, Lagomarsino VN, Frank S, Hadzi TC, Myers RH, Latourelle JC. Study of plasma-derived miRNAs mimic differences in Huntington's disease brain. Mov Disord. 2015 Dec; 30(14):1961-4. PMID: 26573701.
    Citations: 4     Fields:    Translation:Humans
  16. Zuzuárregui JR, Frank SA. Progressive Ataxia and Palatal Tremor. JAMA Neurol. 2015 Oct; 72(10):1195. PMID: 26258499.
    Citations: 1     Fields:    Translation:Humans
  17. Jain S, Himali J, Beiser A, Ton TG, Kelly-Hayes M, Biggs ML, Delaney JA, Rosano C, Seshadri S, Frank SA. Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria. Am J Epidemiol. 2015 Feb 01; 181(3):185-90. PMID: 25550359.
    Citations: 2     Fields:    Translation:Humans
  18. Shprecher DR, Rubenstein LA, Gannon K, Frank SA, Kurlan R. Temporal course of the tourette syndrome clinical triad. Tremor Other Hyperkinet Mov (N Y). 2014; 4:243. PMID: 25295223.
    Citations: 3     Fields:    
  19. Desalermos AP, Frank S, Farraye FA. Recurrent Bell's palsy in a patient with Crohn's disease on methotrexate. J Clin Gastroenterol. 2014 Aug; 48(7):651-2. PMID: 24492402.
    Citations: 2     Fields:    Translation:Humans
  20. Kim SY, De Vries R, Parnami S, Wilson R, Kim HM, Frank S, Holloway RG, Kieburtz K. Are therapeutic motivation and having one's own doctor as researcher sources of therapeutic misconception? J Med Ethics. 2015 May; 41(5):391-7. PMID: 24855070.
    Citations: 1     Fields:    Translation:Humans
  21. Carlozzi NE, Victorson D, Sung V, Beaumont JL, Cheng W, Gorin B, Duh MS, Samuelson D, Tulsky D, Gutierrez S, Nowinski CJ, Mueller A, Shen V, Frank S. HD-PRO-TRIAD™ Validation: A Patient-reported Instrument for the Symptom Triad of Huntington's Disease. Tremor Other Hyperkinet Mov (N Y). 2014; 4:223. PMID: 24761312.
    Citations: 7     Fields:    
  22. Victorson D, Carlozzi NE, Frank S, Beaumont JL, Cheng W, Gorin B, Duh MS, Samuelson D, Tulsky D, Gutierrez S, Nowinski CJ, Mueller A, Shen V, Sung V. Identifying Motor, Emotional-Behavioral, and Cognitive Deficits that Comprise the Triad of HD Symptoms from Patient, Caregiver, and Provider Perspectives. Tremor Other Hyperkinet Mov (N Y). 2014; 4:224. PMID: 24757585.
    Citations: 4     Fields:    
  23. Frank S. Treatment of Huntington's disease. Neurotherapeutics. 2014 Jan; 11(1):153-60. PMID: 24366610.
    Citations: 15     Fields:    Translation:Humans
  24. Kleinman M, Frank S. Epidemiology and Clinical Diagnosis of Parkinson Disease. PET Clin. 2013 Oct; 8(4):447-58. PMID: 27156472.
    Citations:    Fields:    
  25. Kim SY, de Vries R, Wilson R, Parnami S, Frank S, Kieburtz K, Holloway RG. Research participants' "irrational" expectations: common or commonly mismeasured? IRB. 2013 Jan-Feb; 35(1):1-9. PMID: 23424820.
    Citations: 7     Fields:    Translation:Humans
  26. Wilkenfeld AJ, Frank SA, McCarthy DC. Botulinum toxin for painful spasms from focal seizures: theoretical considerations and case report. Neurologist. 2013 Jan; 19(1):15-6. PMID: 23269101.
    Citations: 1     Fields:    Translation:Humans
  27. Kim SY, De Vries R, Holloway RG, Wilson R, Parnami S, Kim HM, Frank S, Kieburtz K. Sham surgery controls in Parkinson's disease clinical trials: views of participants. Mov Disord. 2012 Sep 15; 27(11):1461-5. PMID: 22927064.
    Citations: 3     Fields:    Translation:Humans
  28. Ramos EM, Latourelle JC, Lee JH, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Population stratification may bias analysis of PGC-1a as a modifier of age at Huntington disease motor onset. Hum Genet. 2012 Dec; 131(12):1833-40. PMID: 22825315.
    Citations: 10     Fields:    Translation:HumansCells
  29. Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB, Shoulson I, Myers RH, MacDonald ME, Gusella JF. TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. Biochem Biophys Res Commun. 2012 Aug 03; 424(3):404-8. PMID: 22771793.
    Citations: 4     Fields:    Translation:HumansCells
  30. Lee JM, Gillis T, Mysore JS, Ramos EM, Myers RH, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Griguoli A, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, MacDonald ME, Gusella JF. Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. Am J Hum Genet. 2012 Mar 09; 90(3):434-44. PMID: 22387017.
    Citations: 20     Fields:    Translation:HumansCells
  31. Perloff MD, Zuzuárregui JR, Frank SA. Writing from the wards: advice for residents. Neurologist. 2012 Mar; 18(2):96-8. PMID: 22367840.
    Citations: 1     Fields:    Translation:Humans
  32. Kim SY, Wilson RM, Kim HM, Holloway RG, De Vries RG, Frank SA, Kieburtz K. Comparison of enrollees and decliners of Parkinson disease sham surgery trials. Mov Disord. 2012 Apr; 27(4):506-11. PMID: 22314796.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  33. Dorsey R, Biglan K, Eberly S, Auinger P, Brocht A, Umeh CC, Oakes D, Clarence-Smith K, Marshall F, Shoulson I, Frank S. Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study. PLoS Curr. 2011 Nov 13; 3:RRN1283. PMID: 22139861.
    Citations: 1     
  34. Frank SA. Prepublication process. Neurology. 2011 Oct 11; 77(15):1500; author reply 1500-1. PMID: 21987643.
    Citations:    Fields:    
  35. Frank S. Seize the day: Quantitative EEG as a biomarker for dementia in Parkinson disease. Neurology. 2011 Jul 12; 77(2):94-5. PMID: 21633129.
    Citations:    Fields:    Translation:Humans
  36. Frank S. Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease. Neuropsychiatr Dis Treat. 2010 Oct 05; 6:657-65. PMID: 20957126.
    Citations: 17     
  37. Frank S, Jankovic J. Advances in the pharmacological management of Huntington's disease. Drugs. 2010 Mar 26; 70(5):561-71. PMID: 20329804.
    Citations: 12     Fields:    Translation:HumansAnimals
  38. Frank S. Tetrabenazine as anti-chorea therapy in Huntington disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators. BMC Neurol. 2009 Dec 18; 9:62. PMID: 20021666.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  39. Kim SY, Schrock L, Wilson RM, Frank SA, Holloway RG, Kieburtz K, de Vries RG. An approach to evaluating the therapeutic misconception. IRB. 2009 Sep-Oct; 31(5):7-14. PMID: 19873836.
    Citations: 15     Fields:    Translation:Humans
  40. Frank S. Financing graduate medical education. Nat Clin Pract Neurol. 2009 Jan; 5(1):58-9. PMID: 18981999.
    Citations: 1     Fields:    
  41. Kim SY, Holloway RG, Frank S, Wilson R, Kieburtz K. Trust in early phase research: therapeutic optimism and protective pessimism. Med Health Care Philos. 2008 Dec; 11(4):393-401. PMID: 18629609.
    Citations: 3     Fields:    Translation:Humans
  42. Frank S, Ondo W, Fahn S, Hunter C, Oakes D, Plumb S, Marshall F, Shoulson I, Eberly S, Walker F, Factor S, Hunt V, Shinaman A, Jankovic J. A study of chorea after tetrabenazine withdrawal in patients with Huntington disease. Clin Neuropharmacol. 2008 May-Jun; 31(3):127-33. PMID: 18520979.
    Citations: 17     Fields:    Translation:Humans
  43. Frank SA, Wilson R, Holloway RG, Zimmerman C, Peterson DR, Kieburtz K, Kim SY. Ethics of sham surgery: perspective of patients. Mov Disord. 2008 Jan; 23(1):63-8. PMID: 17960809.
    Citations: 7     Fields:    Translation:Humans
  44. Frank S, Biglan K. Long-term fetal cell transplant in Huntington disease: stayin' alive. Neurology. 2007 Jun 12; 68(24):2055-6. PMID: 17562824.
    Citations: 2     Fields:    Translation:HumansCells
  45. Frank S. Teaching residents to be teachers. Nat Clin Pract Neurol. 2007 Apr; 3(4):236-7. PMID: 17410111.
    Citations:    Fields:    Translation:Humans
  46. Frank S, Barbano R. Trauma-induced spinal vascular event producing hemipseudoathetosis. Mov Disord. 2005 Oct; 20(10):1378-80. PMID: 16007625.
    Citations:    Fields:    Translation:Humans
  47. Kim SY, Frank S, Holloway R, Zimmerman C, Wilson R, Kieburtz K. Science and ethics of sham surgery: a survey of Parkinson disease clinical researchers. Arch Neurol. 2005 Sep; 62(9):1357-60. PMID: 16157742.
    Citations: 14     Fields:    Translation:Humans
  48. Richard IH, Frank S, LaDonna KA, Wang H, McDermott MP, Kurlan R. Mood fluctuations in Parkinson's disease: a pilot study comparing the effects of intravenous and oral levodopa administration. Neuropsychiatr Dis Treat. 2005 Sep; 1(3):261-8. PMID: 18568104.
    Citations: 2     
  49. Frank S, Kieburtz K, Holloway R, Kim SY. What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports. Neurology. 2005 Oct 11; 65(7):1101-3. PMID: 16033990.
    Citations: 4     Fields:    Translation:Humans
  50. Richard IH, Frank S, McDermott MP, Wang H, Justus AW, LaDonna KA, Kurlan R. The ups and downs of Parkinson disease: a prospective study of mood and anxiety fluctuations. Cogn Behav Neurol. 2004 Dec; 17(4):201-7. PMID: 15622015.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  51. Gill DJ, Frank SA. The neurology resident as teacher: evaluating and improving our role. Neurology. 2004 Oct 12; 63(7):1334-8. PMID: 15477573.
    Citations:    Fields:    
  52. Frank SA, Józefowicz RF. The challenges of residents teaching neurology. Neurologist. 2004 Jul; 10(4):216-20. PMID: 15245587.
    Citations: 2     Fields:    Translation:Humans
  53. Frank S, Holloway R. Medical errors on an inpatient neurology service. Neurology. 2003 Jul 22; 61(2):254-7. PMID: 12874413.
    Citations:    Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Frank's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (189)
Explore
_
Co-Authors (11)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.