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Samuel A Frank, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Prakash N, Caspell-Garcia C, Coffey C, Siderowf A, Tanner CM, Kieburtz K, Mollenhauer B, Galasko D, Merchant K, Foroud T, Chahine LM, Weintraub D, Casaceli C, Dorsey R, Wilson R, Herzog M, Daegele N, Arnedo V, Frasier M, Sherer T, Marek K, Frank S, Jennings D, Simuni T. Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI). Parkinsonism Relat Disord. 2019 Jan 31. PMID: 30738748.
    Citations:    
  2. Richard A, Frank S. Deutetrabenazine in the treatment of Huntington's disease. Neurodegener Dis Manag. 2019 Feb; 9(1):31-37. PMID: 30624137.
    Citations:    Fields:    
  3. Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170. PMID: 30049650.
    Citations:    Fields:    
  4. Parikh SK, Frank SA. Author response: Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. Neurology. 2018 Jan 16; 90(3):146-147. PMID: 29335312.
    Citations:    Fields:    
  5. Goldman JG, Andrews H, Amara A, Naito A, Alcalay RN, Shaw LM, Taylor P, Xie T, Tuite P, Henchcliffe C, Hogarth P, Frank S, Saint-Hilaire MH, Frasier M, Arnedo V, Reimer AN, Sutherland M, Swanson-Fischer C, Gwinn K, Kang UJ. Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features. Mov Disord. 2018 02; 33(2):282-288. PMID: 29205509.
    Citations: 2     Fields:    
  6. Frank S, Stamler D, Kayson E, Claassen DO, Colcher A, Davis C, Duker A, Eberly S, Elmer L, Furr-Stimming E, Gudesblatt M, Hunter C, Jankovic J, Kostyk SK, Kumar R, Loy C, Mallonee W, Oakes D, Scott BL, Sung V, Goldstein J, Vaughan C, Testa CM. Safety of Converting From Tetrabenazine to Deutetrabenazine for the Treatment of Chorea. JAMA Neurol. 2017 08 01; 74(8):977-982. PMID: 28692723.
    Citations: 2     Fields:    Translation:Humans
  7. Carlozzi NE, Ready RE, Frank S, Cella D, Hahn EA, Goodnight SM, Schilling SG, Boileau NR, Dayalu P. Patient-reported outcomes in Huntington's disease: Quality of life in neurological disorders (Neuro-QoL) and Huntington's disease health-related quality of life (HDQLIFE) physical function measures. Mov Disord. 2017 Jul; 32(7):1096-1102. PMID: 28556412.
    Citations:    Fields:    Translation:Humans
  8. Parikh SK, Frank SA. Clinical Reasoning: Labyrinthine hemorrhage: An unusual etiology for peripheral vertigo. Neurology. 2017 01 10; 88(2):e14-e18. PMID: 28069982.
    Citations:    Fields:    Translation:Humans
  9. McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, Guttman M, Wojcieszek J, Kumar R, LeDoux MS, Jenkins M, Rosas HD, Nance M, Biglan K, Como P, Dubinsky RM, Shannon KM, O'Suilleabhain P, Chou K, Walker F, Martin W, Wheelock VL, McCusker E, Jankovic J, Singer C, Sanchez-Ramos J, Scott B, Suchowersky O, Factor SA, Higgins DS, Molho E, Revilla F, Caviness JN, Friedman JH, Perlmutter JS, Feigin A, Anderson K, Rodriguez R, McFarland NR, Margolis RL, Farbman ES, Raymond LA, Suski V, Kostyk S, Colcher A, Seeberger L, Epping E, Esmail S, Diaz N, Fung WL, Diamond A, Frank S, Hanna P, Hermanowicz N, Dure LS, Cudkowicz M. A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. Neurology. 2017 Jan 10; 88(2):152-159. PMID: 27913695.
    Citations: 9     Fields:    Translation:Humans
  10. Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, O'Neill C, Vaughan C, Goldstein J, Herzog M, Snively V, Whaley J, Wong C, Suter G, Jankovic J, Jimenez-Shahed J, Hunter C, Claassen DO, Roman OC, Sung V, Smith J, Janicki S, Clouse R, Saint-Hilaire M, Hohler A, Turpin D, James RC, Rodriguez R, Rizer K, Anderson KE, Heller H, Carlson A, Criswell S, Racette BA, Revilla FJ, Nucifora F, Margolis RL, Ong M, Mendis T, Mendis N, Singer C, Quesada M, Paulsen JS, Brashers-Krug T, Miller A, Kerr J, Dubinsky RM, Gray C, Factor SA, Sperin E, Molho E, Eglow M, Evans S, Kumar R, Reeves C, Samii A, Chouinard S, Beland M, Scott BL, Hickey PT, Esmail S, Fung WL, Gibbons C, Qi L, Colcher A, Hackmyer C, McGarry A, Klos K, Gudesblatt M, Fafard L, Graffitti L, Schneider DP, Dhall R, Wojcieszek JM, LaFaver K, Duker A, Neefus E, Wilson-Perez H, Shprecher D, Wall P, Blindauer KA, Wheeler L, Boyd JT, Houston E, Farbman ES, Agarwal P, Eberly SW, Watts A, Tariot PN, Feigin A, Evans S, Beck C, Orme C, Edicola J, Christopher E. Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. JAMA. 2016 Jul 05; 316(1):40-50. PMID: 27380342.
    Citations: 17     Fields:    Translation:Humans
  11. Kang UJ, Goldman JG, Alcalay RN, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Rudolph A, Casaceli C, Andrews H, Gwinn K, Sutherland M, Kopil C, Vincent L, Frasier M. The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort. Mov Disord. 2016 06; 31(6):924-32. PMID: 27113479.
    Citations: 4     Fields:    Translation:Humans
  12. Hoss AG, Lagomarsino VN, Frank S, Hadzi TC, Myers RH, Latourelle JC. Study of plasma-derived miRNAs mimic differences in Huntington's disease brain. Mov Disord. 2015 Dec; 30(14):1961-4. PMID: 26573701.
    Citations: 4     Fields:    Translation:Humans
  13. Zuzuárregui JR, Frank SA. Progressive Ataxia and Palatal Tremor. JAMA Neurol. 2015 Oct; 72(10):1195. PMID: 26258499.
    Citations: 1     Fields:    Translation:Humans
  14. Jain S, Himali J, Beiser A, Ton TG, Kelly-Hayes M, Biggs ML, Delaney JA, Rosano C, Seshadri S, Frank SA. Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria. Am J Epidemiol. 2015 Feb 01; 181(3):185-90. PMID: 25550359.
    Citations: 2     Fields:    Translation:Humans
  15. Shprecher DR, Rubenstein LA, Gannon K, Frank SA, Kurlan R. Temporal course of the tourette syndrome clinical triad. Tremor Other Hyperkinet Mov (N Y). 2014; 4:243. PMID: 25295223.
    Citations: 3     Fields:    
  16. Desalermos AP, Frank S, Farraye FA. Recurrent Bell's palsy in a patient with Crohn's disease on methotrexate. J Clin Gastroenterol. 2014 Aug; 48(7):651-2. PMID: 24492402.
    Citations: 2     Fields:    Translation:Humans
  17. Kim SY, De Vries R, Parnami S, Wilson R, Kim HM, Frank S, Holloway RG, Kieburtz K. Are therapeutic motivation and having one's own doctor as researcher sources of therapeutic misconception? J Med Ethics. 2015 May; 41(5):391-7. PMID: 24855070.
    Citations: 1     Fields:    Translation:Humans
  18. Victorson D, Carlozzi NE, Frank S, Beaumont JL, Cheng W, Gorin B, Duh MS, Samuelson D, Tulsky D, Gutierrez S, Nowinski CJ, Mueller A, Shen V, Sung V. Identifying Motor, Emotional-Behavioral, and Cognitive Deficits that Comprise the Triad of HD Symptoms from Patient, Caregiver, and Provider Perspectives. Tremor Other Hyperkinet Mov (N Y). 2014; 4:224. PMID: 24757585.
    Citations: 4     Fields:    
  19. Carlozzi NE, Victorson D, Sung V, Beaumont JL, Cheng W, Gorin B, Duh MS, Samuelson D, Tulsky D, Gutierrez S, Nowinski CJ, Mueller A, Shen V, Frank S. HD-PRO-TRIAD™ Validation: A Patient-reported Instrument for the Symptom Triad of Huntington's Disease. Tremor Other Hyperkinet Mov (N Y). 2014; 4:223. PMID: 24761312.
    Citations: 7     Fields:    
  20. Frank S. Treatment of Huntington's disease. Neurotherapeutics. 2014 Jan; 11(1):153-60. PMID: 24366610.
    Citations: 15     Fields:    Translation:Humans
  21. Kleinman M, Frank S. Epidemiology and Clinical Diagnosis of Parkinson Disease. PET Clin. 2013 Oct; 8(4):447-58. PMID: 27156472.
    Citations:    Fields:    
  22. Kim SY, de Vries R, Wilson R, Parnami S, Frank S, Kieburtz K, Holloway RG. Research participants' "irrational" expectations: common or commonly mismeasured? IRB. 2013 Jan-Feb; 35(1):1-9. PMID: 23424820.
    Citations: 7     Fields:    Translation:Humans
  23. Wilkenfeld AJ, Frank SA, McCarthy DC. Botulinum toxin for painful spasms from focal seizures: theoretical considerations and case report. Neurologist. 2013 Jan; 19(1):15-6. PMID: 23269101.
    Citations: 1     Fields:    Translation:Humans
  24. Kim SY, De Vries R, Holloway RG, Wilson R, Parnami S, Kim HM, Frank S, Kieburtz K. Sham surgery controls in Parkinson's disease clinical trials: views of participants. Mov Disord. 2012 Sep 15; 27(11):1461-5. PMID: 22927064.
    Citations: 3     Fields:    Translation:Humans
  25. Ramos EM, Latourelle JC, Lee JH, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Population stratification may bias analysis of PGC-1a as a modifier of age at Huntington disease motor onset. Hum Genet. 2012 Dec; 131(12):1833-40. PMID: 22825315.
    Citations: 10     Fields:    Translation:HumansCells
  26. Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB, Shoulson I, Myers RH, MacDonald ME, Gusella JF. TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. Biochem Biophys Res Commun. 2012 Aug 03; 424(3):404-8. PMID: 22771793.
    Citations: 4     Fields:    Translation:HumansCells
  27. Lee JM, Gillis T, Mysore JS, Ramos EM, Myers RH, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Griguoli A, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, MacDonald ME, Gusella JF. Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. Am J Hum Genet. 2012 Mar 09; 90(3):434-44. PMID: 22387017.
    Citations: 20     Fields:    Translation:HumansCells
  28. Perloff MD, Zuzuárregui JR, Frank SA. Writing from the wards: advice for residents. Neurologist. 2012 Mar; 18(2):96-8. PMID: 22367840.
    Citations: 1     Fields:    Translation:Humans
  29. Kim SY, Wilson RM, Kim HM, Holloway RG, De Vries RG, Frank SA, Kieburtz K. Comparison of enrollees and decliners of Parkinson disease sham surgery trials. Mov Disord. 2012 Apr; 27(4):506-11. PMID: 22314796.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  30. Dorsey R, Biglan K, Eberly S, Auinger P, Brocht A, Umeh CC, Oakes D, Clarence-Smith K, Marshall F, Shoulson I, Frank S. Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study. PLoS Curr. 2011 Nov 13; 3:RRN1283. PMID: 22139861.
    Citations: 1     
  31. Frank SA. Prepublication process. Neurology. 2011 Oct 11; 77(15):1500; author reply 1500-1. PMID: 21987643.
    Citations:    Fields:    
  32. Frank S. Seize the day: Quantitative EEG as a biomarker for dementia in Parkinson disease. Neurology. 2011 Jul 12; 77(2):94-5. PMID: 21633129.
    Citations:    Fields:    Translation:Humans
  33. Frank S. Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease. Neuropsychiatr Dis Treat. 2010 Oct 05; 6:657-65. PMID: 20957126.
    Citations: 17     
  34. Frank S, Jankovic J. Advances in the pharmacological management of Huntington's disease. Drugs. 2010 Mar 26; 70(5):561-71. PMID: 20329804.
    Citations: 12     Fields:    Translation:HumansAnimals
  35. Frank S. Tetrabenazine as anti-chorea therapy in Huntington disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators. BMC Neurol. 2009 Dec 18; 9:62. PMID: 20021666.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  36. Kim SY, Schrock L, Wilson RM, Frank SA, Holloway RG, Kieburtz K, de Vries RG. An approach to evaluating the therapeutic misconception. IRB. 2009 Sep-Oct; 31(5):7-14. PMID: 19873836.
    Citations: 15     Fields:    Translation:Humans
  37. Frank S. Financing graduate medical education. Nat Clin Pract Neurol. 2009 Jan; 5(1):58-9. PMID: 18981999.
    Citations: 1     Fields:    
  38. Kim SY, Holloway RG, Frank S, Wilson R, Kieburtz K. Trust in early phase research: therapeutic optimism and protective pessimism. Med Health Care Philos. 2008 Dec; 11(4):393-401. PMID: 18629609.
    Citations: 3     Fields:    Translation:Humans
  39. Frank S, Ondo W, Fahn S, Hunter C, Oakes D, Plumb S, Marshall F, Shoulson I, Eberly S, Walker F, Factor S, Hunt V, Shinaman A, Jankovic J. A study of chorea after tetrabenazine withdrawal in patients with Huntington disease. Clin Neuropharmacol. 2008 May-Jun; 31(3):127-33. PMID: 18520979.
    Citations: 17     Fields:    Translation:Humans
  40. Frank SA, Wilson R, Holloway RG, Zimmerman C, Peterson DR, Kieburtz K, Kim SY. Ethics of sham surgery: perspective of patients. Mov Disord. 2008 Jan; 23(1):63-8. PMID: 17960809.
    Citations: 7     Fields:    Translation:Humans
  41. Frank S, Biglan K. Long-term fetal cell transplant in Huntington disease: stayin' alive. Neurology. 2007 Jun 12; 68(24):2055-6. PMID: 17562824.
    Citations: 2     Fields:    Translation:HumansCells
  42. Frank S. Teaching residents to be teachers. Nat Clin Pract Neurol. 2007 Apr; 3(4):236-7. PMID: 17410111.
    Citations:    Fields:    Translation:Humans
  43. Frank S, Barbano R. Trauma-induced spinal vascular event producing hemipseudoathetosis. Mov Disord. 2005 Oct; 20(10):1378-80. PMID: 16007625.
    Citations:    Fields:    Translation:Humans
  44. Kim SY, Frank S, Holloway R, Zimmerman C, Wilson R, Kieburtz K. Science and ethics of sham surgery: a survey of Parkinson disease clinical researchers. Arch Neurol. 2005 Sep; 62(9):1357-60. PMID: 16157742.
    Citations: 14     Fields:    Translation:Humans
  45. Richard IH, Frank S, LaDonna KA, Wang H, McDermott MP, Kurlan R. Mood fluctuations in Parkinson's disease: a pilot study comparing the effects of intravenous and oral levodopa administration. Neuropsychiatr Dis Treat. 2005 Sep; 1(3):261-8. PMID: 18568104.
    Citations: 2     
  46. Frank S, Kieburtz K, Holloway R, Kim SY. What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports. Neurology. 2005 Oct 11; 65(7):1101-3. PMID: 16033990.
    Citations: 4     Fields:    Translation:Humans
  47. Richard IH, Frank S, McDermott MP, Wang H, Justus AW, LaDonna KA, Kurlan R. The ups and downs of Parkinson disease: a prospective study of mood and anxiety fluctuations. Cogn Behav Neurol. 2004 Dec; 17(4):201-7. PMID: 15622015.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  48. Gill DJ, Frank SA. The neurology resident as teacher: evaluating and improving our role. Neurology. 2004 Oct 12; 63(7):1334-8. PMID: 15477573.
    Citations:    Fields:    
  49. Frank SA, Józefowicz RF. The challenges of residents teaching neurology. Neurologist. 2004 Jul; 10(4):216-20. PMID: 15245587.
    Citations: 2     Fields:    Translation:Humans
  50. Frank S, Holloway R. Medical errors on an inpatient neurology service. Neurology. 2003 Jul 22; 61(2):254-7. PMID: 12874413.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.