Harvard Catalyst Profiles

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Elliot L. Chaikof, Ph.D., M.D.

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Biography
1976
Ann Shepard Biology Award, University College, University of Toronto
1977
Ann Shepard Zoology Award, University College, University of Toronto
1979
Phi Beta Kappa, Johns Hopkins University
1982
Alpha Omega Alpha, Johns Hopkins School of Medicine
1988
Sigma Xi, MIT
1996
E.J. Wylie Fellowship, Society for Vascular Surgery
1999
Distinguished Fellow, Society for Vascular Surgery
2002
Woodruff Fund Teaching Award, Emory University
2003
Harvard-Longwood Visiting Professor
2004
Member, Southern Surgical Association
2005
Fellow, American Institute of Medical and Biological Engineering
2006
Member, American Surgical Association
2008
John Mannick Visiting Professor, Brigham and Women's Hospital
2008 - 2010
President, International Society of Applied Cardiovascular Biology
2010
Milton F. Bryant Lecture, University of Michigan
2011
Inaugural Brandi Rutherford Lecture, Johns Hopkins School of Medicine
2011
Emile Holman Lecture, Stanford University
2012
Charles B. Huggins Lecture, University of Chicago
2012
Robert B. Smith, III Lecture, Emory University
2013
Robert O. Gregg Lecture, SUNY-Upstate
2013
Paul D. Abramson Lecture, Louisiana State University
2013
Clemson Award for Applied Research, Society for Biomaterials
2014
Wiliam H. Baker Lecture, Loyola University
2014
Institute of Medicine, National Academy of Medicine
2014
Ori Rotstein Lecture, University of Toronto
2014
Visiting Professor, Chinese PLA Medical School, Beijing, China
2016
John Mannick Visiting Professor in Surgery, Brigham and Women’s Hospital
2016
Edelstone-Bendix Visiting Professor, Northwestern University
2017
Fraser Gurd Visiting Professor, McGill University

Overview
Dr. Chaikof was born and raised in Toronto and earned BA and MD degrees at the Johns Hopkins University in Baltimore. He completed a residency in general surgery at the Massachusetts General Hospital and while a surgical resident, received a PhD in Chemical Engineering at the Massachusetts Institute of Technology with a focus on artificial organs and the design of biomaterials for reconstructive surgery. Following his surgical training in Boston, he completed additional training in Vascular Surgery at the Emory University School of Medicine where he joined the surgical faculty, most recently holding the John E. Skandalakis Chair of Surgery at Emory University, serving as Chief of Vascular Surgery and Director of the Residency in Vascular Surgery. While at Emory University, Dr. Chaikof held secondary appointments as an Adjunct Professor in the School of Chemical and Biomolecular Engineering at the Georgia Institute of Technology and was a member of the faculty in the Department of Biomedical Engineering.

In 2010, Dr. Chaikof was appointed as the Johnson and Johnson Professor of Surgery at Harvard Medical School and Chairman of the Department of Surgery and Surgeon-in-Chief of the Beth Israel Deaconess Medical Center. A surgeon and biomedical engineer, he is a member of the Wyss Institute of Biological Inspired Engineering and the Harvard Stem Cell Institute. He is internationally recognized for his many original and innovative contributions to vascular surgery through his basic science, clinical, and translational studies. He has changed the way in which patient with aortic aneurysms are evaluated and treated. His work in biomedical engineering and materials science has lead to the development of an advance generation of cardiovascular materials, devices, cell based therapies and pharmacotherapeutics based upon the principles of biomimetics, molecular and tissue engineering, as well as micro- and nanofabrication technologies. In 2013, he was the recipient of the Clemson Award for Applied Research from the Society for Biomaterials. Dr. Chaikof is the Editor of the Atlas of Vascular Surgery and Endovascular Therapy: Anatomy and Technique, published by Elsevier in English, Portuguese, and Mandarin editions. In 2014, Dr. Chaikof was elected to the Institute of Medicine of the National Academies.

Lab web site: http://chaikoflab.org/

Mentoring
Available: 09/01/11, Expires: 08/28/21

The control of blood clot formation on molecularly engineered surfaces remains a hurdle in the development of a small diameter arterial prosthesis critical to the fields of cardiac, plastic, and vascular surgery, as well as to the development of a permanently implantable artificial kidney, liver, or lung. We postulate that a clinically durable blood contacting surface can achieved by incorporating onto or within the material actively anti-thrombogenic mechanisms that are operative under a range of hemodynamic conditions. Ongoing research in our lab is directed at (i) engineering molecularly defined surfaces that prevent blood clotting in vitro and in vivo; and (ii) development of computational FEM models using MatchCad and Comsol programs that describe surface induced coagulation events under flow as a design tool for this effort.

Available: 09/01/11, Expires: 08/28/21

At the beginning of the twenty-first century, we are witnessing a remarkable convergence of our synthetic and physical technologies with the world of molecular biology, which will provide unprecedented opportunities for the creation of novel, functional biomolecules using biosynthetic and chemical strategies. Our group is involved in the design of living artificial organs. Most applications are directed at the fabrication of cardiovascular organs (e.g. tissue engineered blood vessels).

Engineering collagen-based arterial substitutes that recapitulate native vessel structural and functional properties
Soma Weiss, 04/01/22 - 12/28/18

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UG3AI150551 (CHAIKOF, ELLIOT) Aug 22, 2019 - Jul 31, 2022
    NIH
    Delivery Technologies for In Vivo Genome Editing
    Role: Principal Investigator
  2. R01HL147855 (CHAIKOF, ELLIOT) Aug 1, 2019 - Jul 31, 2023
    NIH
    Clot-Targeted Antithrombotics for Venous Thromboprophylaxis
    Role: Principal Investigator
  3. U01HL143365 (ZWICKER, JEFFREY) Aug 1, 2018 - Jul 31, 2023
    NIH
    Biomarkers and mechanisms in cancer associated thrombosis
    Role: Co-Principal Investigator
  4. K12HL141953 (SACKSTEIN, ROBERT) Jul 1, 2018 - Jun 30, 2023
    NIH
    Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education
    Role: Co-Principal Investigator
  5. R01DK107405 (CHAIKOF, ELLIOT) Mar 1, 2016 - Feb 29, 2020
    NIH
    A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J. The NIH Somatic Cell Genome Editing program. Nature. 2021 Apr; 592(7853):195-204. PMID: 33828315.
    Citations:    Fields:    
  2. Tarabanis C, Miranda-Nieves D, Ferrante T, Haller CA, Chaikof EL. Standardized User-Independent Confocal Microscopy Image Acquisition and Analysis for Thickness Measurements of Microscale Collagen Scaffolds. Microsc Microanal. 2021 Mar 31; 1-6. PMID: 33785078.
    Citations:    Fields:    
  3. Chung JJ, Qiu JM, Chaikof EL, Naples JG. Multidisciplinary care initiative: A paradigm shift in the pre-clinical curriculum. Med Educ. 2021 Mar 15. PMID: 33723862.
    Citations:    Fields:    
  4. Rokosh RS, Mastracci TM, Chaikof EL. Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: Screening for an abdominal aortic aneurysm. J Vasc Surg. 2021 Apr; 73(4):1126-1127. PMID: 33610680.
    Citations:    Fields:    
  5. Rokosh RS, Starnes BW, Chaikof EL. Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: Repair of an abdominal aortic aneurysm. J Vasc Surg. 2021 Feb 04. PMID: 33548428.
    Citations:    Fields:    
  6. Wong DJ, Miranda-Nieves D, Nandivada P, Patel MS, Hashimoto DA, Kent DO, Gómez-Márquez J, Lin SJ, Feldman HJ, Chaikof EL. The Surgical Program in Innovation (SPIN): A Design and Prototyping Curriculum for Surgical Trainees. Acad Med. 2021 Feb 02. PMID: 33538475.
    Citations:    Fields:    
  7. Park DD, Chen J, Kudelka MR, Jia N, Haller CA, Kosaraju R, Premji AM, Galizzi M, Nairn AV, Moremen KW, Cummings RD, Chaikof EL. Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins. Cell Chem Biol. 2020 Dec 29. PMID: 33378651.
    Citations:    Fields:    
  8. Matsumoto Y, Kudelka MR, Hanes MS, Lehoux S, Dutta S, Jones MB, Stackhouse KA, Cervoni GE, Heimburg-Molinaro J, Smith DF, Ju T, Chaikof EL, Cummings RD. Erratum to: Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. Glycobiology. 2020 Dec 09; 30(12):1015. PMID: 32415964.
    Citations:    Fields:    
  9. Bienvenu LA, Maluenda A, McFadyen JD, Searle AK, Yu E, Haller C, Chaikof EL, Peter K, Wang X. Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury. Circ Res. 2020 Oct 09; 127(9):1211-1213. PMID: 32806996.
    Citations: 1     Fields:    
  10. Wong DJ, Chaikof EL. Inferring causality. J Vasc Surg. 2020 08; 72(2):387-388. PMID: 32711903.
    Citations:    Fields:    Translation:Humans
  11. Wong DJ, Chaikof EL. The ESSEA Trial: A Clear Image of a Fuzzy Problem. Circ Cardiovasc Imaging. 2020 06; 13(6):e010990. PMID: 32507021.
    Citations:    Fields:    Translation:Humans
  12. Wong DJ, Chaikof EL. Safety in numbers as administrative data supports the use of endovascular aneurysm repair in ruptured abdominal aortic aneurysms. J Vasc Surg. 2020 06; 71(6):1879-1880. PMID: 32446506.
    Citations:    Fields:    Translation:Humans
  13. Malladi S, Miranda-Nieves D, Leng L, Grainger SJ, Tarabanis C, Nesmith AP, Kosaraju R, Haller CA, Parker KK, Chaikof EL, Günther A. Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. ACS Biomater Sci Eng. 2020 07 13; 6(7):4236-4246. PMID: 32685675.
    Citations:    
  14. Matsumoto Y, Kudelka MR, Hanes MS, Lehoux S, Dutta S, Jones MB, Stackhouse KA, Cervoni GE, Heimburg-Molinaro J, Smith DF, Ju T, Chaikof EL, Cummings RD. Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. Glycobiology. 2020 04 20; 30(5):282-300. PMID: 31742337.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. McNamara SL, Brudno Y, Miller AB, Ham HO, Aizenberg M, Chaikof EL, Mooney DJ. Regenerating Antithrombotic Surfaces through Nucleic Acid Displacement. ACS Biomater Sci Eng. 2020 04 13; 6(4):2159-2166. PMID: 33455325.
    Citations:    
  16. Eldrup-Jorgensen J, Kraiss LW, Chaikof EL, Neal D, Forbes TL. Vascular Quality Initiative assessment of compliance with Society for Vascular Surgery clinical practice guidelines on the care of patients with abdominal aortic aneurysm. J Vasc Surg. 2020 09; 72(3):874-885. PMID: 31973949.
    Citations: 1     Fields:    Translation:Humans
  17. Chen J, Haller CA, Jernigan FE, Koerner SK, Wong DJ, Wang Y, Cheong JE, Kosaraju R, Kwan J, Park DD, Thomas B, Bhasin S, De La Rosa RC, Premji AM, Liu L, Park E, Moss AC, Emili A, Bhasin M, Sun L, Chaikof EL. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Sci Adv. 2020 01; 6(3):eaay8230. PMID: 31998845.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Castillo-Angeles M, Calvillo-Ortiz R, Barrows C, Chaikof EL, Kent TS. The Learning Environment in Surgery Clerkship: What are Faculty Perceptions? J Surg Educ. 2020 Jan - Feb; 77(1):61-68. PMID: 31375466.
    Citations:    Fields:    
  19. Lagoo J, Berry WR, Miller K, Neal BJ, Sato L, Lillemoe KD, Doherty GM, Kasser JR, Chaikof EL, Gawande AA, Haynes AB. Multisource Evaluation of Surgeon Behavior Is Associated With Malpractice Claims. Ann Surg. 2019 07; 270(1):84-90. PMID: 29578910.
    Citations: 2     Fields:    Translation:Humans
  20. Maitz MF, Martins MCL, Grabow N, Matschegewski C, Huang N, Chaikof EL, Barbosa MA, Werner C, Sperling C. The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions. Acta Biomater. 2019 08; 94:33-43. PMID: 31226481.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Tsikis S, Fleishman A, Chaikof EL, Rodrigue JR. Design and Implementation of an Infrastructure Program to Support Clinical Research in Surgery. J Surg Res. 2019 09; 241:264-270. PMID: 31035141.
    Citations:    Fields:    Translation:Humans
  22. Chaikof EL. Reply. J Vasc Surg. 2019 03; 69(3):975-976. PMID: 30798849.
    Citations:    Fields:    Translation:Humans
  23. McCallum JC, Wyers MC, Soden PA, Eidt JF, Guzman RJ, Schermerhorn ML, Chaikof EL, Hamdan AD. Vascular fellow and resident experience performing infrapopliteal revascularization with endovascular procedures and vein bypass during training. J Vasc Surg. 2018 11; 68(5):1533-1537. PMID: 30360842.
    Citations: 1     Fields:    Translation:Humans
  24. Cauley R, Wu WW, Doval A, Chaikof E, Ho KKL, Iorio ML. Identifying Complications and Optimizing Consultations following Transradial Arterial Access for Cardiac Procedures. Ann Vasc Surg. 2019 Apr; 56:87-96. PMID: 30342206.
    Citations: 3     Fields:    Translation:Humans
  25. Hanjaya-Putra D, Haller C, Wang X, Dai E, Lim B, Liu L, Jaminet P, Yao J, Searle A, Bonnard T, Hagemeyer CE, Peter K, Chaikof EL. Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis. JCI Insight. 2018 08 09; 3(15). PMID: 30089712.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Sardar MYR, Mandhapati AR, Park S, Wever WJ, Cummings RD, Chaikof EL. Convergent Synthesis of Sialyl LewisX- O-Core-1 Threonine. J Org Chem. 2018 05 04; 83(9):4963-4972. PMID: 29638128.
    Citations: 1     Fields:    
  27. Kudelka MR, Nairn AV, Sardar MY, Sun X, Chaikof EL, Ju T, Moremen KW, Cummings RD. Isotopic labeling with cellular O-glycome reporter/amplification (ICORA) for comparative O-glycomics of cultured cells. Glycobiology. 2018 04 01; 28(4):214-222. PMID: 29390058.
    Citations: 2     Fields:    Translation:HumansCells
  28. Patel MS, Tomich D, Kent TS, Chaikof EL, Rodrigue JR. A Program for Promoting Clinical Scholarship in General Surgery. J Surg Educ. 2018 Jul - Aug; 75(4):854-860. PMID: 29398630.
    Citations: 1     Fields:    Translation:Humans
  29. Chaikof EL, Dalman RL, Eskandari MK, Jackson BM, Lee WA, Mansour MA, Mastracci TM, Mell M, Murad MH, Nguyen LL, Oderich GS, Patel MS, Schermerhorn ML, Starnes BW. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018 01; 67(1):2-77.e2. PMID: 29268916.
    Citations: 120     Fields:    Translation:Humans
  30. Ayala P, Dai E, Hawes M, Liu L, Chaudhuri O, Haller CA, Mooney DJ, Chaikof EL. Evaluation of a bioengineered construct for tissue engineering applications. . 2018 08; 106(6):2345-2354. PMID: 29130596.
    Citations: 3     Translation:Animals
  31. Sardar MYR, Krishnamurthy VR, Park S, Mandhapati AR, Wever WJ, Park D, Cummings RD, Chaikof EL. Synthesis of LewisX-O-Core-1 threonine: A building block for O-linked LewisX glycopeptides. Carbohydr Res. 2017 Nov 27; 452:47-53. PMID: 29065342.
    Citations: 1     Fields:    Translation:Cells
  32. Morikis VA, Chase S, Wun T, Chaikof EL, Magnani JL, Simon SI. Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. Blood. 2017 11 09; 130(19):2101-2110. PMID: 28811304.
    Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
  33. Zaiem F, Almasri J, Tello M, Prokop LJ, Chaikof EL, Murad MH. A systematic review of surveillance after endovascular aortic repair. J Vasc Surg. 2018 01; 67(1):320-331.e37. PMID: 28662928.
    Citations: 6     Fields:    Translation:Humans
  34. Patel MS, Chaikof EL. Ruptured aneurysm systems of care: A national imperative to improve clinical outcomes. J Vasc Surg. 2017 03; 65(3):589-590. PMID: 28236911.
    Citations:    Fields:    Translation:Humans
  35. Patel MS, Miranda-Nieves D, Chen J, Haller CA, Chaikof EL. Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome. Transl Res. 2017 05; 183:1-13. PMID: 28034759.
    Citations: 8     Fields:    Translation:Humans
  36. Patel MS, Chaikof EL. Disclosing Industry Relationships-A Patient-Centered Approach. JAMA Surg. 2016 10 01; 151(10):895-896. PMID: 27366991.
    Citations:    Fields:    Translation:Humans
  37. Chen J, Haller CA, Chaikof EL. Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1. Transl Cancer Res. 2016 Oct; 5(Suppl 4):S668-S671. PMID: 30613475.
    Citations: 1     
  38. Chen J, Howell C, Haller CA, Patel MS, Ayala P, Moravec KA, Dai E, Liu L, Sotiri I, Aizenberg M, Aizenberg J, Chaikof EL. An immobilized liquid interface prevents device associated bacterial infection in vivo. Biomaterials. 2017 01; 113:80-92. PMID: 27810644.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Miranda-Nieves D, Chaikof EL. Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues. ACS Biomater Sci Eng. 2017 May 08; 3(5):694-711. PMID: 33440491.
    Citations: 3     
  40. Patel MS, Chaikof EL. Promoting Creativity and Innovation in a Structured Learning Environment. Ann Surg. 2016 Jul; 264(1):39-40. PMID: 26835984.
    Citations:    Fields:    Translation:Humans
  41. Angsana J, Chen J, Liu L, Haller CA, Chaikof EL. Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization. Eur J Immunol. 2016 07; 46(7):1592-9. PMID: 27139187.
    Citations: 9     Fields:    Translation:AnimalsCells
  42. Ham HO, Qu Z, Haller CA, Dorr BM, Dai E, Kim W, Liu DR, Chaikof EL. In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A. Nat Commun. 2016 Apr 13; 7:11140. PMID: 27073027.
    Citations: 7     Fields: