Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Elliot L. Chaikof, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture
Other Positions
Title
Institution
Department

Biography
1976
Ann Shepard Biology Award, University College, University of Toronto
1977
Ann Shepard Zoology Award, University College, University of Toronto
1979
Phi Beta Kappa, Johns Hopkins University
1982
Alpha Omega Alpha, Johns Hopkins School of Medicine
1988
Sigma Xi, MIT
1996
E.J. Wylie Fellowship, Society for Vascular Surgery
1999
Distinguished Fellow, Society for Vascular Surgery
2002
Woodruff Fund Teaching Award, Emory University
2003
Harvard-Longwood Visiting Professor
2004
Member, Southern Surgical Association
2005
Fellow, American Institute of Medical and Biological Engineering
2006
Member, American Surgical Association
2008
John Mannick Visiting Professor, Brigham and Women's Hospital
2008 - 2010
President, International Society of Applied Cardiovascular Biology
2010
Milton F. Bryant Lecture, University of Michigan
2011
Inaugural Brandi Rutherford Lecture, Johns Hopkins School of Medicine
2011
Emile Holman Lecture, Stanford University
2012
Charles B. Huggins Lecture, University of Chicago
2012
Robert B. Smith, III Lecture, Emory University
2013
Robert O. Gregg Lecture, SUNY-Upstate
2013
Paul D. Abramson Lecture, Louisiana State University
2013
Clemson Award for Applied Research, Society for Biomaterials
2014
Wiliam H. Baker Lecture, Loyola University
2014
Institute of Medicine, National Academy of Medicine
2014
Ori Rotstein Lecture, University of Toronto
2014
Visiting Professor, Chinese PLA Medical School, Beijing, China
2016
John Mannick Visiting Professor in Surgery, Brigham and Women’s Hospital
2016
Edelstone-Bendix Visiting Professor, Northwestern University
2017
Fraser Gurd Visiting Professor, McGill University

Overview
Dr. Chaikof was born and raised in Toronto and earned BA and MD degrees at the Johns Hopkins University in Baltimore. He completed a residency in general surgery at the Massachusetts General Hospital and while a surgical resident, received a PhD in Chemical Engineering at the Massachusetts Institute of Technology with a focus on artificial organs and the design of biomaterials for reconstructive surgery. Following his surgical training in Boston, he completed additional training in Vascular Surgery at the Emory University School of Medicine where he joined the surgical faculty, most recently holding the John E. Skandalakis Chair of Surgery at Emory University, serving as Chief of Vascular Surgery and Director of the Residency in Vascular Surgery. While at Emory University, Dr. Chaikof held secondary appointments as an Adjunct Professor in the School of Chemical and Biomolecular Engineering at the Georgia Institute of Technology and was a member of the faculty in the Department of Biomedical Engineering.

In 2010, Dr. Chaikof was appointed as the Johnson and Johnson Professor of Surgery at Harvard Medical School and Chairman of the Department of Surgery and Surgeon-in-Chief of the Beth Israel Deaconess Medical Center. A surgeon and biomedical engineer, he is a member of the Wyss Institute of Biological Inspired Engineering and the Harvard Stem Cell Institute. He is internationally recognized for his many original and innovative contributions to vascular surgery through his basic science, clinical, and translational studies. He has changed the way in which patient with aortic aneurysms are evaluated and treated. His work in biomedical engineering and materials science has lead to the development of an advance generation of cardiovascular materials, devices, cell based therapies and pharmacotherapeutics based upon the principles of biomimetics, molecular and tissue engineering, as well as micro- and nanofabrication technologies. In 2013, he was the recipient of the Clemson Award for Applied Research from the Society for Biomaterials. Dr. Chaikof is the Editor of the Atlas of Vascular Surgery and Endovascular Therapy: Anatomy and Technique, published by Elsevier in English, Portuguese, and Mandarin editions. In 2014, Dr. Chaikof was elected to the Institute of Medicine of the National Academies.

Lab web site: http://chaikoflab.org/

Mentoring
Available: 09/01/11, Expires: 08/28/21

The control of blood clot formation on molecularly engineered surfaces remains a hurdle in the development of a small diameter arterial prosthesis critical to the fields of cardiac, plastic, and vascular surgery, as well as to the development of a permanently implantable artificial kidney, liver, or lung. We postulate that a clinically durable blood contacting surface can achieved by incorporating onto or within the material actively anti-thrombogenic mechanisms that are operative under a range of hemodynamic conditions. Ongoing research in our lab is directed at (i) engineering molecularly defined surfaces that prevent blood clotting in vitro and in vivo; and (ii) development of computational FEM models using MatchCad and Comsol programs that describe surface induced coagulation events under flow as a design tool for this effort.

Available: 09/01/11, Expires: 08/28/21

At the beginning of the twenty-first century, we are witnessing a remarkable convergence of our synthetic and physical technologies with the world of molecular biology, which will provide unprecedented opportunities for the creation of novel, functional biomolecules using biosynthetic and chemical strategies. Our group is involved in the design of living artificial organs. Most applications are directed at the fabrication of cardiovascular organs (e.g. tissue engineered blood vessels).

Engineering collagen-based arterial substitutes that recapitulate native vessel structural and functional properties
Soma Weiss, 04/01/22 - 12/28/18

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UG3AI150551 (CHAIKOF, ELLIOT) Aug 22, 2019 - Jul 31, 2022
    NIH
    Delivery Technologies for In Vivo Genome Editing
    Role: Principal Investigator
  2. R01HL147855 (CHAIKOF, ELLIOT) Aug 1, 2019 - Jul 31, 2023
    NIH
    Clot-Targeted Antithrombotics for Venous Thromboprophylaxis
    Role: Principal Investigator
  3. U01HL143365 (ZWICKER, JEFFREY) Aug 1, 2018 - Jul 31, 2023
    NIH
    Biomarkers and mechanisms in cancer associated thrombosis
    Role: Co-Principal Investigator
  4. K12HL141953 (SACKSTEIN, ROBERT) Jul 1, 2018 - Jun 30, 2023
    NIH
    Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education
    Role: Co-Principal Investigator
  5. R01DK107405 (CHAIKOF, ELLIOT) Mar 1, 2016 - Feb 28, 2021
    NIH
    A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rokosh RS, Wu WW, Schermerhorn M, Chaikof EL. Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: Postoperative surveillance after abdominal aortic aneurysm repair. J Vasc Surg. 2021 May 20. PMID: 34022379.
    Citations:    Fields:    
  2. Rokosh RS, Wu WW, Dalman RL, Chaikof EL. Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: endoleak management. J Vasc Surg. 2021 May 19. PMID: 34022378.
    Citations:    Fields:    
  3. Rokosh RS, Wu WW, Eskandari MK, Chaikof EL. Society for Vascular Surgery implementation of guidelines in abdominal aortic aneurysms: preoperative surveillance and threshold for repair. J Vasc Surg. 2021 May 19. PMID: 34022377.
    Citations:    Fields:    
  4. Wong DJ, Park DD, Park S, Haller CA, Chen J, Dai E, Liu L, Mandhapati AR, Eradi P, Dhakal B, Wever W, Hanes M, Sun L, Cummings RD, Chaikof EL. A PSGL-1 Glycomimetic Reduces Thrombus Burden Without Affecting Hemostasis. Blood. 2021 05 04. PMID: 33945603.
    Citations:    Fields:    
  5. Panthofer AM, Olson SL, Rademacher BL, Grudzinski JK, Chaikof EL, Matsumura JS. Anatomic eligibility for endovascular aneurysm repair preserved over 2 years of surveillance. J Vasc Surg. 2021 May 04. PMID: 33957227.
    Citations:    Fields:    
  6. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J. The NIH Somatic Cell Genome Editing program. Nature. 2021 Apr; 592(7853):195-204. PMID: 33828315.
    Citations: 2     Fields:    
  7. Tarabanis C, Miranda-Nieves D, Ferrante T, Haller CA, Chaikof EL. Standardized User-Independent Confocal Microscopy Image Acquisition and Analysis for Thickness Measurements of Microscale Collagen Scaffolds. Microsc Microanal. 2021 Mar 31; 1-6. PMID: 33785078.
    Citations:    Fields:    
  8. Chung JJ, Qiu JM, Chaikof EL, Naples JG. Multidisciplinary care initiative: A paradigm shift in the pre-clinical curriculum. Med Educ. 2021 05; 55(5):644. PMID: 33723862.
    Citations:    Fields:    Translation:Humans
  9. Rokosh RS, Mastracci TM, Chaikof EL. Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: Screening for an abdominal aortic aneurysm. J Vasc Surg. 2021 Apr; 73(4):1126-1127. PMID: 33610680.
    Citations:    Fields:    
  10. Rokosh RS, Starnes BW, Chaikof EL. Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: Repair of an abdominal aortic aneurysm. J Vasc Surg. 2021 May; 73(5):1485-1487. PMID: 33548428.
    Citations:    Fields:    
  11. Wong DJ, Miranda-Nieves D, Nandivada P, Patel MS, Hashimoto DA, Kent DO, Gómez-Márquez J, Lin SJ, Feldman HJ, Chaikof EL. The Surgical Program in Innovation (SPIN): A Design and Prototyping Curriculum for Surgical Trainees. Acad Med. 2021 Feb 02. PMID: 33538475.
    Citations:    Fields:    
  12. Park DD, Chen J, Kudelka MR, Jia N, Haller CA, Kosaraju R, Premji AM, Galizzi M, Nairn AV, Moremen KW, Cummings RD, Chaikof EL. Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins. Cell Chem Biol. 2021 04 15; 28(4):567-582.e4. PMID: 33378651.
    Citations:    Fields:    
  13. Matsumoto Y, Kudelka MR, Hanes MS, Lehoux S, Dutta S, Jones MB, Stackhouse KA, Cervoni GE, Heimburg-Molinaro J, Smith DF, Ju T, Chaikof EL, Cummings RD. Erratum to: Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies. Glycobiology. 2020 12 09; 30(12):1015. PMID: 32415964.
    Citations:    Fields:    
  14. Bienvenu LA, Maluenda A, McFadyen JD, Searle AK, Yu E, Haller C, Chaikof EL, Peter K, Wang X. Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury. Circ Res. 2020 10 09; 127(9):1211-1213. PMID: 32806996.
    Citations: 2     Fields:    Translation:HumansAnimals
  15. Wong DJ, Chaikof EL. Inferring causality. J Vasc Surg. 2020 08; 72(2):387-388. PMID: 32711903.
    Citations:    Fields:    Translation:Humans
  16. Wong DJ, Chaikof EL. The ESSEA Trial: A Clear Image of a Fuzzy Problem. Circ Cardiovasc Imaging. 2020 06; 13(6):e010990. PMID: 32507021.
    Citations:    Fields:    Translation:Humans
  17. Wong DJ, Chaikof EL. Safety in numbers as administrative data supports the use of endovascular aneurysm repair in ruptured abdominal aortic aneurysms. J Vasc Surg. 2020 06; 71(6):1879-1880. PMID: 32446506.
    Citations:    Fields:    Translation:Humans
  18. Malladi S, Miranda-Nieves D, Leng L, Grainger SJ, Tarabanis C, Nesmith AP, Kosaraju R, Haller CA, Parker KK, Chaikof EL, Günther A. Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. ACS Biomater Sci Eng. 2020 07 13; 6(7):4236-4246. PMID: 32685675.
    Citations:    Translation:Cells
  19. Matsumoto Y, Kudelka MR,