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Christian Badr, Ph.D.

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Biography
Vrije University , Amsterdam, The NetherlandsPhD2010Molecular biology
Henri Poincare University, Nancy, FranceMSc2004Cell engineering
Henri Poincare University, Nancy, FranceBSc2003Cell biology and animal physiology
Lebanese University, Beirut, LebanonBSc2002Animal biology
2018
Innovation Discovery Award
2017
Innovation Discovery Award
2016
SAC Poster of Distinction Award
2015
Transition Career Development Award
2015
Partners in Excellence Award: Outstanding Community Contributions
2015
Partners in Excellence Award: Leadership and Innovation
2011
Post-Doctoral Fellowship Award
2011
Best Abstract Presentation
2011
Young investigator travel award
2010
MGH ECOR Fund for Medical Discovery Fellowship Award
2010
SwitchGear Pathways Grant Program Award

Overview

Mentoring
Available: 12/02/19, Expires: 11/30/20

We are seeking volunteer-based Research Assistants to join our group focused on brain tumor research at Massachusetts General Hospital. Our lab is focused on studying molecular aspects governing self-renewal and tumor initiation in brain tumor initiating cells and using this knowledge to develop targeted therapies for brain tumors.

We are seeking highly motivated students looking to gain hands-on experience in molecular biology, cell biology and cancer genetics. The incumbent of this position will receive daily mentorship, will be encouraged to attend local conferences, and participate in lab meetings, journal clubs etc. The student researcher will work on studying gene regulation and the molecular biology of brain tumors, particularly in the context of lipid and fatty acid metabolism. Previous experience in molecular biology techniques is desired but not required. Part-time candidates should be able to commit to a minimum of 20 hours/week.

Some of the key techniques involved in this research include:

  1. Mammalian tissue culture, including maintenance and propagation of primary patient-derived cancer (stem) cells as well as common laboratory cell lines
  2. RNA or protein isolation from cells. Quantitative RT-PCR on RNA or western blots on proteins
  3. Cell based assays such as cell viability, flow cytometry and measurement of bioluminescence or fluorescence
  4. Implantation of tumor cells in mice, optical imaging of tumors and testing of new therapeutics in these mouse models.

Interested individuals should email a resume and a brief description of research interest and career goals to Dr. Christian E. Badr (badr.christian@mgh.harvard.edu).


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. W81XWH-20-1-0397 (BADR, CHRISTIAN ELIAS) May 15, 2020 - May 14, 2023
    Department of Defense
    The role of ER stress in gliomagenesis and tumor progression
    Role: PI
  2. (BADR, CHRISTIAN ELIAS) Jan 1, 2019 - Dec 31, 2019
    American Brain Tumor Association
    Therapeutic targeting of Endoplasmic Reticulum proteostasis in GBM
    Role: PI
  3. K22CA197053 (BADR, CHRISTIAN ELIAS) Sep 30, 2015 - Sep 29, 2018
    NIH/NCI
    Identifying vulnerabilities and therapeutic targets in Glioma Stem Cells
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Badr CE, Silver DJ, Siebzehnrubl FA, Deleyrolle LP. Metabolic heterogeneity and adaptability in brain tumors. Cell Mol Life Sci. 2020 Jun 06. PMID: 32506168.
    Citations:    
  2. Badr CE, da Hora CC, Kirov AB, Tabet E, Amante R, Maksoud S, Nibbs AE, Fitzsimons E, Boukhali M, Chen JW, Chiu NHL, Nakano I, Haas W, Mazitschek R, Tannous BA. Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation. ACS Chem Biol. 2020 Jun 19; 15(6):1445-1454. PMID: 32338864.
    Citations:    
  3. Tannous BA, Badr CE. An allosteric inhibitor of SHP2 effectively targets PDGFRa-driven glioblastoma. Neuro Oncol. 2019 11 04; 21(11):1348-1349. PMID: 31616943.
    Citations:    
  4. da Hora CC, Pinkham K, Carvalho L, Zinter M, Tabet E, Nakano I, Tannous BA, Badr CE. Erratum: Author Correction: Sustained NF-?B-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition. Cell Death Discov. 2019; 5:103. PMID: 31240130.
    Citations:    
  5. Pinkham K, Park DJ, Hashemiaghdam A, Kirov AB, Adam I, Rosiak K, da Hora CC, Teng J, Cheah PS, Carvalho L, Ganguli-Indra G, Kelly A, Indra AK, Badr CE. Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells. Stem Cell Reports. 2019 04 09; 12(4):712-727. PMID: 30930246.
    Citations:    
  6. Tannous BA, Badr CE. A TNF-NF-?B-STAT3 loop triggers resistance of glioma-stem-like cells to Smac mimetics while sensitizing to EZH2 inhibitors. Cell Death Dis. 2019 03 19; 10(4):268. PMID: 30890700.
    Citations:    
  7. da Hora CC, Pinkham K, Carvalho L, Zinter M, Tabet E, Nakano I, Tannous BA, Badr CE. Sustained NF-?B-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition. Cell Death Discov. 2019; 5:72. PMID: 30854231.
    Citations:    
  8. Volak A, LeRoy SG, Natasan JS, Park DJ, Cheah PS, Maus A, Fitzpatrick Z, Hudry E, Pinkham K, Gandhi S, Hyman BT, Mu D, GuhaSarkar D, Stemmer-Rachamimov AO, Sena-Esteves M, Badr CE, Maguire CA. Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery. J Neurooncol. 2018 Sep; 139(2):293-305. PMID: 29767307.
    Citations:    Fields:    
  9. Teng J, da Hora CC, Kantar RS, Nakano I, Wakimoto H, Batchelor TT, Chiocca EA, Badr CE, Tannous BA. Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 06 01; 19(6):820-832. PMID: 28062830.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Crommentuijn MH, Kantar R, Noske DP, Vandertop WP, Badr CE, Würdinger T, Maguire CA, Tannous BA. Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model. Mol Ther Oncolytics. 2016; 3:16017. PMID: 27382645.
    Citations: 3     
  11. Crommentuijn MH, Maguire CA, Niers JM, Vandertop WP, Badr CE, Würdinger T, Tannous BA. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2016 Apr; 10(4):625-34. PMID: 26708508.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO. Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 2015 May 13; 6:7029. PMID: 25967391.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  13. Teng J, Hejazi S, Badr CE, Tannous BA. Systemic anticancer neural stem cells in combination with a cardiac glycoside for glioblastoma therapy. Stem Cells. 2014 Aug; 32(8):2021-32. PMID: 24801379.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Badr CE. Bioluminescence imaging: basics and practical limitations. Methods Mol Biol. 2014; 1098:1-18. PMID: 24166364.
    Citations: 8     Fields:    Translation:HumansAnimals
  15. Amante RJ, Badr CE. Cell-based bioluminescence screening assays. Methods Mol Biol. 2014; 1098:185-95. PMID: 24166378.
    Citations:    Fields:    Translation:HumansCells
  16. Maguire CA, Bovenberg MS, Crommentuijn MH, Niers JM, Kerami M, Teng J, Sena-Esteves M, Badr CE, Tannous BA. Triple bioluminescence imaging for in vivo monitoring of cellular processes. Mol Ther Nucleic Acids. 2013 Jun 18; 2:e99. PMID: 23778500.
    Citations: 20     
  17. Badr CE, Van Hoppe S, Dumbuya H, Tjon-Kon-Fat LA, Tannous BA. Targeting cancer cells with the natural compound obtusaquinone. J Natl Cancer Inst. 2013 May 01; 105(9):643-53. PMID: 23479453.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  18. Badr CE, Tannous BA. Bioluminescence imaging: progress and applications. Trends Biotechnol. 2011 Dec; 29(12):624-33. PMID: 21788092.
    Citations: 52     Fields:    Translation:Humans
  19. Badr CE, Wurdinger T, Nilsson J, Niers JM, Whalen M, Degterev A, Tannous BA. Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway. Neuro Oncol. 2011 Nov; 13(11):1213-24. PMID: 21757445.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  20. Badr CE, Wurdinger T, Tannous BA. Functional drug screening assay reveals potential glioma therapeutics. Assay Drug Dev Technol. 2011 Jun; 9(3):281-9. PMID: 21184646.
    Citations: 14     Fields:    Translation:HumansCells
  21. Badr CE, Niers JM, Morse D, Koelen JA, Vandertop P, Noske D, Wurdinger T, Zalloua PA, Tannous BA. Suicidal gene therapy in an NF-?B-controlled tumor environment as monitored by a secreted blood reporter. Gene Ther. 2011 May; 18(5):445-51. PMID: 21150937.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Badr CE, Niers JM, Tjon-Kon-Fat LA, Noske DP, Wurdinger T, Tannous BA. Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models. Mol Imaging. 2009 Sep-Oct; 8(5):278-90. PMID: 19796605.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  23. Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA. A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods. 2008 Feb; 5(2):171-3. PMID: 18204457.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  24. Badr CE, Hewett JW, Breakefield XO, Tannous BA. A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One. 2007 Jun 27; 2(6):e571. PMID: 17593970.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.