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Christian Badr, Ph.D.

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Biography
Vrije University , Amsterdam, The NetherlandsPhD2010Molecular biology
Henri Poincare University, Nancy, FranceMSc2004Cell engineering
Henri Poincare University, Nancy, FranceBSc2003Cell biology and animal physiology
Lebanese University, Beirut, LebanonBSc2002Animal biology
2018
Innovation Discovery Award
2017
Innovation Discovery Award
2016
SAC Poster of Distinction Award
2015
Transition Career Development Award
2015
Partners in Excellence Award: Outstanding Community Contributions
2015
Partners in Excellence Award: Leadership and Innovation
2011
Post-Doctoral Fellowship Award
2011
Best Abstract Presentation
2011
Young investigator travel award
2010
MGH ECOR Fund for Medical Discovery Fellowship Award
2010
SwitchGear Pathways Grant Program Award

Overview

Mentoring
Available: 01/10/22, Expires: 03/01/24

We are seeking Research Interns to join our group at the Massachusetts General Hospital. The lab, which is part of the Neurology Department, is in Charlestown, MA (149 13th Street, Charlestown, MA 02129). Our primary disease focus is brain cancer and particularly Glioblastoma (GBM), a highly aggressive and incurable tumor. Our research is centered on studying molecular and metabolic aspects governing self-renewal and tumor initiation in brain tumor initiating cells (glioma stem cells). We are also studying tumor plasticity, particularly the genetic and metabolic switches allowing glioma stem cells to adapt to environmental stress and therapeutic insults. Our long-term goal is to develop effective, targeted therapeutics for brain tumors. The incumbent of this position will work on a project involving the role of fatty acid (lipid) metabolism in brain tumors. The student researcher will study gene regulation and the molecular biology of brain tumors, particularly in the context of lipid and fatty acid metabolism. He/She will receive daily mentorship, will be encouraged to attend local conferences, and participate in lab meetings, journal clubs etc. Previous experience in molecular biology techniques is desired but not required. Some of the key techniques involved in this research include: 1. Mammalian tissue culture, including maintenance and propagation of primary patient-derived cancer (stem) cells as well as common laboratory cell lines 2. RNA or protein isolation from cells. Quantitative RT-PCR on RNA or western blots on proteins. 3. Cell based assays such as cell viability, flow cytometry and measurement of bioluminescence or fluorescence 4. Implantation of tumor cells in mice, optical imaging of tumors and testing of new therapeutics in these mouse models. For more information about the lab, please check our Twitter account or visit our webpage. Interested individuals should email a Resume and a brief description of research interest to Dr. Christian E. Badr (badr.christian@mgh.harvard.edu).


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS119959 (BADR, CHRISTIAN ELIAS) Aug 1, 2021 - Jan 31, 2023
    NIH
    Translocon-regulated ER proteostasis in glioblastoma
    Role: Principal Investigator
  2. R01NS113822 (BADR, CHRISTIAN ELIAS) Sep 15, 2020 - Jul 31, 2025
    NIH
    Role of ER stress and fatty acid metabolism in glioma stem cells
    Role: Principal Investigator
  3. R61NS117554 (TANNOUS, BAKHOS A) Sep 15, 2020 - Jul 31, 2021
    NIH
    Screening for DNA damage response modulators in glioblastoma stem cells
    Role: Co-Principal Investigator
  4. W81XWH-20-1-0397 (BADR, CHRISTIAN ELIAS) May 15, 2020 - May 14, 2023
    Department of Defense
    The role of ER stress in gliomagenesis and tumor progression
    Role: PI
  5. (BADR, CHRISTIAN ELIAS) Jan 1, 2019 - Dec 31, 2019
    American Brain Tumor Association
    Therapeutic targeting of Endoplasmic Reticulum proteostasis in GBM
    Role: PI

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.