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Lora Georgieva Bankova, M.D.

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Overview
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We are defining the epithelial cell pathways triggered by native allergens and the downstream activation of resident immune cells, and examining how these two events drive the transition of the immune response towards allergic inflammation.

Our long term goal is to determine how allergens and epithelial damage exhaust repair mechanisms in the airway mucosa, disrupting normal tissue healing and promoting the transition to epithelial and olfactory dysfunction.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21AI154345 (BANKOVA, LORA) Mar 2, 2021 - Feb 28, 2023
    NIH
    Brush cell sensing of aeroallergen-elicited stress signals promotes epithelial cell activation
    Role: Principal Investigator
  2. K08AI132723 (BANKOVA, LORA) Jul 1, 2017 - Jun 30, 2022
    NIH
    The Cysteinyl Leukotriene E4 Receptor, GPR99, Orchestrates Airway Epithelial Cell Differentiation and Type 2 Pulmonary Inflammation
    Role: Principal Investigator

Bibliographic
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Säfholm J, Abma W, Bankova LG, Boyce JA, Al-Ameri M, Orre AC, Wheelock CE, Dahlén SE, Adner M. Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor. Eur J Pharmacol. 2022 Nov 05; 934:175257. PMID: 36116518.
    Citations:    Fields:    Translation:HumansAnimals
  2. Ye Q, Bankova LG. Brush cells fine-tune neurogenic inflammation in the airways. J Clin Invest. 2022 07 01; 132(13). PMID: 35775485; PMCID: PMC9246375.
    Citations:    Fields:    Translation:HumansCells
  3. Ualiyeva S, Bankova LG. Isolation, Ex Vivo Culture, and Stimulation of Tracheal and Nasal Chemosensory Cells. Methods Mol Biol. 2022; 2506:151-165. PMID: 35771470.
    Citations:    Fields:    Translation:AnimalsCells
  4. Ualiyeva S, Lemire E, Aviles EC, Wong C, Boyd AA, Lai J, Liu T, Matsumoto I, Barrett NA, Boyce JA, Haber AL, Bankova LG. Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. Sci Immunol. 2021 Dec 24; 6(66):eabj0474. PMID: 34932383; PMCID: PMC8750919.
    Citations: 14     Fields:    Translation:AnimalsCells
  5. Ualiyeva S, Boyd AA, Barrett NA, Bankova LG. Isolation of Nasal Brush Cells for Single-cell Preparations. Bio Protoc. 2021 Sep 20; 11(18):e4163. PMID: 34692913; PMCID: PMC8481025.
    Citations: 1     
  6. Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). PMID: 33753496.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  7. Derakhshan T, Samuchiwal SK, Hallen N, Bankova LG, Boyce JA, Barrett NA, Austen KF, Dwyer DF. Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021 01 04; 218(1). PMID: 32946563.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 06; 145(6):1574-1584. PMID: 32199912; PMCID: PMC7282948.
    Citations: 23     Fields:    Translation:HumansCells
  9. Bankova LG, Barrett NA. Epithelial cell function and remodeling in nasal polyposis. Ann Allergy Asthma Immunol. 2020 04; 124(4):333-341. PMID: 32007569.
    Citations: 10     Fields:    Translation:Humans
  10. Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). PMID: 31953256; PMCID: PMC7176051.
    Citations: 34     Fields:    Translation:AnimalsCells
  11. Ualiyeva S, Yoshimoto E, Barrett NA, Bankova LG. Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas. J Vis Exp. 2019 06 12; (148). PMID: 31259891.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Sci Immunol. 2018 10 05; 3(28). PMID: 30291131; PMCID: PMC6599626.
    Citations: 60     Fields:    Translation:AnimalsCells
  13. Bankova LG, Boyce JA. A new spin on mast cells and cysteinyl leukotrienes: Leukotriene E4 activates mast cells in vivo. J Allergy Clin Immunol. 2018 10; 142(4):1056-1057. PMID: 30165055.
    Citations: 4     Fields:    Translation:HumansCells
  14. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938; PMCID: PMC4896673.
    Citations: 51     Fields:    Translation:AnimalsCells
  15. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 41     Fields:    Translation:Humans
  16. Castells MC, Bankova L. Reply. J Allergy Clin Immunol Pract. 2016 Jan-Feb; 4(1):190-1. PMID: 26772937.
    Citations:    Fields:    Translation:HumansPHPublic Health
  17. Cui Y, Dahlin JS, Feinstein R, Bankova LG, Xing W, Shin K, Gurish MF, Hallgren J. Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma. J Immunol. 2014 Nov 15; 193(10):4783-4789. PMID: 25320274; PMCID: PMC4225174.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Bankova LG, Dwyer DF, Liu AY, Austen KF, Gurish MF. Maturation of mast cell progenitors to mucosal mast cells during allergic pulmonary inflammation in mice. Mucosal Immunol. 2015 May; 8(3):596-606. PMID: 25291985; PMCID: PMC4390399.
    Citations: 33     Fields:    Translation:AnimalsCells
  19. Bankova LG, Lezcano C, Pejler G, Stevens RL, Murphy GF, Austen KF, Gurish MF. Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15; 192(6):2812-20. PMID: 24523504; PMCID: PMC3970423.
    Citations: 20     Fields:    Translation:AnimalsCells
  20. Liu AY, Dwyer DF, Jones TG, Bankova LG, Shen S, Katz HR, Austen KF, Gurish MF. Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6. J Immunol. 2013 Feb 15; 190(4):1758-66. PMID: 23319739; PMCID: PMC3563837.
    Citations: 9     Fields:    Translation:AnimalsCells
  21. Bankova LG, Walter JE, Iyengar SR, Lorenzo ME, Hornick JL, Castells MC. Generalized bullous eruption after routine vaccination in a child with diffuse cutaneous mastocytosis. J Allergy Clin Immunol Pract. 2013 Jan; 1(1):94-6. PMID: 24229828.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  22. Bavbek S, Ataman S, Bankova L, Castells M. Injection site reaction to adalimumab: Positive skin test and successful rapid desensitisation. Allergol Immunopathol (Madr). 2013 May-Jun; 41(3):204-6. PMID: 23063342.
    Citations: 6     Fields:    Translation:Humans
  23. Hong DI, Bankova L, Cahill KN, Kyin T, Castells MC. Allergy to monoclonal antibodies: cutting-edge desensitization methods for cutting-edge therapies. Expert Rev Clin Immunol. 2012 Jan; 8(1):43-52; quiz 53-4. PMID: 22149339.
    Citations: 15     Fields:    Translation:Humans
  24. Bundy KW, McGirt LY, Bankova LG, Wollenberg A, Beck LA, De Benedetto A. Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum. Dermatol Res Pract. 2011; 2011:769890. PMID: 22110485.
    Citations: 1     
  25. Juraschek SP, Bankova L, Falade O, Chow G, McKenzie R, Bhogal HK. An uncommon cause of portal hypertension: schistosomiasis. Am J Med. 2011 Feb; 124(2):e7-8. PMID: 21092928.
    Citations:    Fields:    Translation:HumansAnimals
  26. De Benedetto A, Agnihothri R, McGirt LY, Bankova LG, Beck LA. Atopic dermatitis: a disease caused by innate immune defects? J Invest Dermatol. 2009 Jan; 129(1):14-30. PMID: 19078985.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  27. Fluhr JW, Bankova L, Fuchs S, Kelterer D, Schliemann-Willers S, Norgauer J, Kleesz P, Grieshaber R, Elsner P. Fruit acids and sodium hydroxide in the food industry and their combined effect with sodium lauryl sulphate: controlled in vivo tandem irritation study. Br J Dermatol. 2004 Nov; 151(5):1039-48. PMID: 15541082.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  28. Kappes U, Schliemann-Willers S, Bankova L, Heinemann C, Fischer TW, Ziemer M, Schubert H, Norgauer J, Fluhr JW, Elsner P. The quality of human skin xenografts on SCID mice: a noninvasive bioengineering approach. Br J Dermatol. 2004 Nov; 151(5):971-6. PMID: 15541074.
    Citations: 1     Fields:    Translation:HumansAnimals
  29. Fuchs SM, Fluhr JW, Bankova L, Tittelbach J, Hoffmann G, Elsner P. Photodynamic therapy (PDT) and waterfiltered infrared A (wIRA) in patients with recalcitrant common hand and foot warts. Ger Med Sci. 2004 Oct 29; 2:Doc08. PMID: 19675691.
    Citations: 20     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.