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Ana Paula Arruda, Ph.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS. Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity. bioRxiv. 2023 Feb 22. PMID: 36865319; PMCID: PMC9980148.
    Citations:    
  2. Arruda AP, Parlakgül G. Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease. Cold Spring Harb Perspect Biol. 2023 Feb 01; 15(2). PMID: 35940911; PMCID: PMC9899651.
    Citations:    Fields:    Translation:HumansCells
  3. Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L. Integration of ER protein quality control mechanisms defines ß cell function and ER architecture. J Clin Invest. 2023 01 03; 133(1). PMID: 36346671; PMCID: PMC9797341.
    Citations:    Fields:    Translation:AnimalsCells
  4. Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 03; 603(7902):736-742. PMID: 35264794; PMCID: PMC9014868.
    Citations: 11     Fields:    Translation:AnimalsCells
  5. Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Sci Signal. 2021 Dec 14; 14(713):eabf2059. PMID: 34905386.
    Citations:    Fields:    Translation:HumansCells
  6. Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metab. 2021 Aug 03; 33(8):1716. PMID: 34348100.
    Citations: 2     Fields:    
  7. Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metab. 2021 02 02; 33(2):319-333.e6. PMID: 33340456; PMCID: PMC7858244.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  8. Arruda APN, Zhang Y, Gomaa H, Bergamaschi CC, Guimaraes CC, Righesso LAR, Paglia MDG, Barberato-Filho S, Lopes LC, Ayala Melendez AP, de Oliveira LD, Paula-Ramos L, Johnston B, El Dib R. Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2019 05 24; 9(5):e023729. PMID: 31129571; PMCID: PMC6538060.
    Citations: 3     Fields:    Translation:Humans
  9. Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 03; 24(3):292-303. PMID: 29400713; PMCID: PMC5839993.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  10. Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity. Elife. 2017 12 15; 6. PMID: 29243589.
    Citations: 15     Fields:    Translation:AnimalsCells
  11. Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS. NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 2017 Nov 16; 171(5):1094-1109.e15. PMID: 29149604.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  12. Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep. 2017 Oct 10; 21(2):393-402. PMID: 29020626.
    Citations: 16     Fields:    Translation:Animals
  13. Arruda APN, Ayala AP, Lopes LC, Bergamaschi CC, Guimarães C, Grossi MD, Righesso LAR, Agarwal A, El Dib R. Herbal medications for surgical patients: a systematic review protocol. BMJ Open. 2017 07 26; 7(7):e014290. PMID: 28751485.
    Citations: 2     Fields:    Translation:Humans
  14. Coope A, Milanski M, Arruda AP, Ignacio-Souza LM, Saad MJ, Anhê GF, Velloso LA. Chaperone insufficiency links TLR4 signaling to endoplasmic reticulum stress. J Biol Chem. 2016 12 23; 291(52):26936. PMID: 28011878; PMCID: PMC5207200.
    Citations:    Fields:    
  15. Romanatto T, Roman EA, Arruda AP, Denis RG, Solon C, Milanski M, Moraes JC, Bonfleur ML, Degasperi GR, Picardi PK, Hirabara S, Boschero AC, Curi R, Velloso LA. Deletion of tumor necrosis factor-a receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem. 2016 12 23; 291(52):26934. PMID: 28011876; PMCID: PMC5207198.
    Citations: 1     Fields:    
  16. Arruda AP, Hotamisligil GS. Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metab. 2015 Sep 01; 22(3):381-97. PMID: 26190652; PMCID: PMC4558313.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  17. Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17; 7(292):292ra98. PMID: 26084805.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  18. Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014 Dec; 20(12):1427-35. PMID: 25419710.
    Citations: 232     Fields:    Translation:AnimalsCells
  19. Ignacio-Souza LM, Bombassaro B, Pascoal LB, Portovedo MA, Razolli DS, Coope A, Victorio SC, de Moura RF, Nascimento LF, Arruda AP, Anhe GF, Milanski M, Velloso LA. Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology. 2014 Aug; 155(8):2831-44. PMID: 24892821.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  20. Milanski M, Arruda AP, Coope A, Ignacio-Souza LM, Nunez CE, Roman EA, Romanatto T, Pascoal LB, Caricilli AM, Torsoni MA, Prada PO, Saad MJ, Velloso LA. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes. 2012 Jun; 61(6):1455-62. PMID: 22522614; PMCID: PMC3357298.
    Citations: 88     Fields:    Translation:AnimalsCells
  21. Coope A, Milanski M, Arruda AP, Ignacio-Souza LM, Saad MJ, Anhê GF, Velloso LA. Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress. J Biol Chem. 2012 May 04; 287(19):15580-9. PMID: 22427667; PMCID: PMC3346100.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Solon CS, Franci D, Ignacio-Souza LM, Romanatto T, Roman EA, Arruda AP, Morari J, Torsoni AS, Carneiro EM, Velloso LA. Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino Acids. 2012 Jun; 42(6):2403-10. PMID: 21818562.
    Citations: 11     Fields:    Translation:AnimalsCells
  23. Arruda AP, Milanski M, Velloso LA. Hypothalamic inflammation and thermogenesis: the brown adipose tissue connection. J Bioenerg Biomembr. 2011 Feb; 43(1):53-8. PMID: 21271281.
    Citations: 6     Fields:    Translation:Humans
  24. Arruda AP, Milanski M, Coope A, Torsoni AS, Ropelle E, Carvalho DP, Carvalheira JB, Velloso LA. Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology. 2011 Apr; 152(4):1314-26. PMID: 21266511.
    Citations: 81     Fields:    Translation:AnimalsCells
  25. Breder I, Coope A, Arruda AP, Razolli D, Milanski M, Dorighello Gde G, de Oliveira HC, Velloso LA. Reduction of endoplasmic reticulum stress--a novel mechanism of action of statins in the protection against atherosclerosis. Atherosclerosis. 2010 Sep; 212(1):30-1. PMID: 20537647.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  26. Arruda AP, Milanski M, Romanatto T, Solon C, Coope A, Alberici LC, Festuccia WT, Hirabara SM, Ropelle E, Curi R, Carvalheira JB, Vercesi AE, Velloso LA. Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology. 2010 Feb; 151(2):683-94. PMID: 19996183.
    Citations: 38     Fields:    Translation:Animals
  27. Romanatto T, Roman EA, Arruda AP, Denis RG, Solon C, Milanski M, Moraes JC, Bonfleur ML, Degasperi GR, Picardi PK, Hirabara S, Boschero AC, Curi R, Velloso LA. Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem. 2009 Dec 25; 284(52):36213-36222. PMID: 19858212.
    Citations: 68     Fields:    Translation:Animals
  28. Ketzer LA, Arruda AP, Carvalho DP, de Meis L. Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H556-63. PMID: 19525379.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Nigro M, Arruda AP, de Meis L. Ca2+ transport and heat production in vesicles derived from the sarcoplasmic reticulum terminal cisternae: regulation by K+. Biochim Biophys Acta. 2009 Jul; 1788(7):1517-22. PMID: 19376087.
    Citations:    Fields:    Translation:AnimalsCells
  30. Arruda AP, Ketzer LA, Nigro M, Galina A, Carvalho DP, de Meis L. Cold tolerance in hypothyroid rabbits: role of skeletal muscle mitochondria and sarcoplasmic reticulum Ca2+ ATPase isoform 1 heat production. Endocrinology. 2008 Dec; 149(12):6262-71. PMID: 18703625.
    Citations: 27     Fields:    Translation:AnimalsCells
  31. de Meis L, Arruda AP, Guimarães J. The impact of science in Brazil. IUBMB Life. 2007 Apr-May; 59(4-5):227-34. PMID: 17505957.
    Citations: 4     Fields:    Translation:Humans
  32. Arruda AP, Nigro M, Oliveira GM, de Meis L. Thermogenic activity of Ca2+-ATPase from skeletal muscle heavy sarcoplasmic reticulum: the role of ryanodine Ca2+ channel. Biochim Biophys Acta. 2007 Jun; 1768(6):1498-505. PMID: 17466935.
    Citations: 16     Fields:    Translation:AnimalsCells
  33. Pimentel WA, Martinez EE, Ambrose JA, Mathias W, Arruda A, Horta PE, Ribeiro EE, Esteves A, Lemos PA, Ramires JA. Human myocardium preconditioning during successive balloon inflations: irrelevant influence of both collateral recruitment and clinical pre-intervention interference. EuroIntervention. 2006 Nov; 2(3):345-50. PMID: 19755311.
    Citations: 1     Fields:    
  34. de Meis L, Arruda AP, da Costa RM, Benchimol M. Identification of a Ca2+-ATPase in brown adipose tissue mitochondria: regulation of thermogenesis by ATP and Ca2+. J Biol Chem. 2006 Jun 16; 281(24):16384-90. PMID: 16608844.
    Citations: 18     Fields:    Translation:AnimalsCells
  35. Arruda AP, Oliveira GM, Carvalho DP, De Meis L. Thyroid hormones differentially regulate the distribution of rabbit skeletal muscle Ca(2+)-ATPase (SERCA) isoforms in light and heavy sarcoplasmic reticulum. Mol Membr Biol. 2005 Nov-Dec; 22(6):529-37. PMID: 16373324.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. de Meis L, Arruda AP, Carvalho DP. Role of sarco/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis. Biosci Rep. 2005 Jun-Aug; 25(3-4):181-90. PMID: 16283552.
    Citations: 34     Fields:    Translation:AnimalsCells
  37. de Meis L, Oliveira GM, Arruda AP, Santos R, Costa RM, Benchimol M. The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase. IUBMB Life. 2005 Apr-May; 57(4-5):337-45. PMID: 16036618.
    Citations: 14     Fields:    Translation:AnimalsCells
  38. Arruda AP, Marques W, Foss NT, Garbino JA, Virmond M, Barreira AA. Near nerve potential of sural nerve in leprosy. Arq Neuropsiquiatr. 2004 Sep; 62(3A):571-4. PMID: 15334210.
    Citations: 1     Fields:    Translation:HumansCells
  39. Arruda AP, Da-Silva WS, Carvalho DP, De Meis L. Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase. Biochem J. 2003 Nov 01; 375(Pt 3):753-60. PMID: 12887329; PMCID: PMC1223713.
    Citations: 11     Fields:    Translation:AnimalsCells
  40. Marques W, Foss NT, Arruda AP, Barreira AA. Near-nerve potential in lepromatous leprosy. Muscle Nerve. 2003 Oct; 28(4):460-3. PMID: 14506718.
    Citations: 2     Fields:    Translation:HumansCells
  41. de Meis L, Arruda AP, da-Silva WS, Reis M, Carvalho DP. The thermogenic function of the sarcoplasmic reticulum Ca2+-ATPase of normal and hyperthyroid rabbit. Ann N Y Acad Sci. 2003 Apr; 986:481-8. PMID: 12763868.
    Citations: 1     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.