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Last Name

profileRohit N. Kulkarni, PH.D., M.D.

TitleProfessor of Medicine
InstitutionJoslin Diabetes Center
AddressJoslin Diabetes Center
One Joslin Place - Rm 602
Research 6th Floor
Boston MA 02215
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
UC4DK116278     (KULKARNI, ROHIT N.)Sep 20, 2017 - Aug 31, 2021
Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Role: Principal Investigator

UC4DK116255     (CHOUDHARY, AMIT)Sep 20, 2017 - Aug 31, 2020
Development of small molecule-based methods for targeted cargo delivery to beta cells
Role: Co-Principal Investigator

UC4DK104167     (QIAN, WEI-JUN)Sep 20, 2014 - Aug 31, 2017
Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
Role: Principal Investigator

R01DK103215     (KULKARNI, ROHIT N.)Sep 1, 2014 - Aug 31, 2019
Role of SerpinB1 in beta cell growth
Role: Principal Investigator

R21RR024905     (KULKARNI, ROHIT N.)May 15, 2009 - Apr 30, 2012
Characterization of the inducible-beta-cell-specific p53 knockout mice
Role: Principal Investigator
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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Srivaths LV, Zhang QC, Byams VR, Dietrich JE, James AH, Kouides PA, Kulkarni R. Differences in bleeding phenotype and provider interventions in postmenarchal adolescents when compared to adult women with bleeding disorders and heavy menstrual bleeding. Haemophilia. 2017 Sep 05. PMID: 28873279.
    View in: PubMed
  2. Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. J Biol Chem. 2017 Oct 27; 292(43):17598-17608. PMID: 28860191.
    View in: PubMed
  3. Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Mol Cell Endocrinol. 2017 Oct 15; 454:146-157. PMID: 28648619.
    View in: PubMed
  4. Ghanem SS, Muturi HT, DeAngelis AM, Hu J, Kulkarni RN, Heinrich G, Najjar SM. Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. Diabetologia. 2017 Sep; 60(9):1751-1760. PMID: 28567513.
    View in: PubMed
  5. Kawamori D, Shirakawa J, Liew CW, Hu J, Morioka T, Duttaroy A, Burkey B, Kulkarni RN. GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in ßIRKO mice. Diabetologia. 2017 Aug; 60(8):1442-1453. PMID: 28526921.
    View in: PubMed
  6. Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RN. Heterogeneity of proliferative markers in pancreatic ß-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. Acta Diabetol. 2017 Aug; 54(8):737-747. PMID: 28512677.
    View in: PubMed
  7. Shirakawa J, De Jesus DF, Kulkarni RN. Exploring inter-organ crosstalk to uncover mechanisms that regulate ß-cell function and mass. Eur J Clin Nutr. 2017 Jul; 71(7):896-903. PMID: 28294170.
    View in: PubMed
  8. Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic ß Cell Proliferation. Cell Metab. 2017 Apr 04; 25(4):868-882.e5. PMID: 28286049.
    View in: PubMed
  9. Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metab. 2017 Feb 07; 25(2):448-462. PMID: 28065828.
    View in: PubMed
  10. Rasaily R, Ganguly KK, Roy M, Vani SN, Kharood N, Kulkarni R, Chauhan S, Swain S, Kanugo L. Community based kangaroo mother care for low birth weight babies: A pilot study. Indian J Med Res. 2017 Jan; 145(1):51-57. PMID: 28574014.
    View in: PubMed
  11. Viswanathan C, Kulkarni R, Bopardikar A, Ramdasi S. Significance of CD34 Negative Hematopoietic Stem Cells and CD34 Positive Mesenchymal Stem Cells - A Valuable Dimension to the Current Understanding. Curr Stem Cell Res Ther. 2017; 12(6):476-483. PMID: 28464788.
    View in: PubMed
  12. Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. Corrigendum: IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep. 2016 Oct 10; 6:34969. PMID: 27721427.
    View in: PubMed
  13. Aledort L, Recht M, Kulkarni R, Kobrinsky N. Adult, previously untreated patients remain a significant therapeutic challenge. J Thromb Haemost. 2016 Oct; 14(10):2075-2076. PMID: 27496600.
    View in: PubMed
  14. Shirakawa J, Kulkarni RN. Novel factors modulating human ß-cell proliferation. Diabetes Obes Metab. 2016 Sep; 18 Suppl 1:71-7. PMID: 27615134; PMCID: PMC5021183 [Available on 09/01/17].
  15. Mezza T, Shirakawa J, Martinez R, Hu J, Giaccari A, Kulkarni RN. Nuclear Export of FoxO1 Is Associated with ERK Signaling in ß-Cells Lacking Insulin Receptors. J Biol Chem. 2016 Oct 07; 291(41):21485-21495. PMID: 27535223.
    View in: PubMed
  16. Kahraman S, Okawa ER, Kulkarni RN. Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes? Curr Diab Rep. 2016 Aug; 16(8):70. PMID: 27313072.
    View in: PubMed
  17. Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep. 2016 Jul 05; 6:28177. PMID: 27378176; PMCID: PMC4932502.
  18. Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR. Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Diabetes. 2016 Aug; 65(8):2201-13. PMID: 27207537; PMCID: PMC4955980 [Available on 08/01/17].
  19. Shirakawa J, Kulkarni RN. ERR?-A New Player in ß Cell Maturation. Cell Metab. 2016 May 10; 23(5):765-7. PMID: 27166940.
    View in: PubMed
  20. Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN. Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep. 2016 Apr 19; 15(3):460-470. PMID: 27068459; PMCID: PMC4838491.
  21. Molven A, Hollister-Lock J, Hu J, Martinez R, Njølstad PR, Liew CW, Weir G, Kulkarni RN. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes. 2016 Jun; 65(6):1672-8. PMID: 26953163; PMCID: PMC4878426 [Available on 06/01/17].
  22. Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dancík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human ß-Cell Proliferation. Diabetes. 2016 Jun; 65(6):1660-71. PMID: 26953159; PMCID: PMC4878416 [Available on 06/01/17].
  23. Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-ß Signaling Promotes Human Pancreatic ß-Cell Replication. Diabetes. 2016 May; 65(5):1208-18. PMID: 26936960; PMCID: PMC4839200 [Available on 05/01/17].
  24. Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS One. 2016; 11(2):e0148252. PMID: 26872145; PMCID: PMC4752212.
  25. Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN. Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. Stem Cell Reports. 2016 Mar 08; 6(3):357-67. PMID: 26876668; PMCID: PMC4788763.
  26. Dirice E, Kulkarni RN. Harnessing immune cells to enhance ß-cell mass in type 1 diabetes. J Investig Med. 2016 Jan; 64(1):14-20. PMID: 26755809.
    View in: PubMed
  27. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic ß Cell Proliferation. Cell Metab. 2016 Jan 12; 23(1):194-205. PMID: 26701651; PMCID: PMC4715773 [Available on 01/12/17].
  28. Mezza T, Sorice GP, Conte C, Sun VA, Cefalo CM, Moffa S, Pontecorvi A, Mari A, Kulkarni RN, Giaccari A. ß-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans. J Clin Endocrinol Metab. 2016 Feb; 101(2):470-5. PMID: 26649619; PMCID: PMC4880124 [Available on 02/01/17].
  29. Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, Kim JK, Giovannucci DR, Najjar SM. Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). J Biol Chem. 2016 Jan 08; 291(2):980-8. PMID: 26586918; PMCID: PMC4705415 [Available on 01/08/17].
  30. Felix JC, Lacey MJ, Miller JD, Lenhart GM, Kulkarni R. Clinical-Economic Modeling Analysis Of Human Papillomavirus (Hpv) Co-Testing With Genotyping Versus Primary Hpv Testing For Cervical Cancer Screening. Value Health. 2015 Nov; 18(7):A353. PMID: 26531999.
    View in: PubMed
  31. Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP. Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015 Nov; 156(11):4047-58. PMID: 26295369; PMCID: PMC4606759 [Available on 11/01/16].
  32. Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts. Stem Cells Transl Med. 2015 Oct; 4(10):1101-8. PMID: 26253715; PMCID: PMC4572895.
  33. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 04; 22(2):239-52. PMID: 26244933; PMCID: PMC4589213.
  34. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG, Smith RD, Qian WJ, Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015 Aug 07; 14(8):3111-3122. PMID: 26151086; PMCID: PMC4615688.
  35. Teo AK, Gupta MK, Doria A, Kulkarni RN. Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab. 2015 Sep; 4(9):593-604. PMID: 26413465; PMCID: PMC4563028.
  36. Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Human ß-cell proliferation and intracellular signaling: part 3. Diabetes. 2015 Jun; 64(6):1872-85. PMID: 25999530; PMCID: PMC4439562.
  37. Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, Philbrick WM, Najjar SM. Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance. Diabetes. 2015 Aug; 64(8):2780-90. PMID: 25972571; PMCID: PMC4512217.
  38. Young G, Mahlangu J, Kulkarni R, Nolan B, Liesner R, Pasi J, Barnes C, Neelakantan S, Gambino G, Cristiano LM, Pierce GF, Allen G. Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A. J Thromb Haemost. 2015 Jun; 13(6):967-77. PMID: 25912075.
    View in: PubMed
  39. Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 May; 14(3):307-22. PMID: 25840412; PMCID: PMC4439311.
  40. Valdez IA, Teo AK, Kulkarni RN. Cellular stress drives pancreatic plasticity. Sci Transl Med. 2015 Feb 04; 7(273):273ps2. PMID: 25653218.
    View in: PubMed
  41. Kulkarni RN, Stewart AF. Summary of the Keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research. Diabetes. 2014 Dec; 63(12):3979-81. PMID: 25414011; PMCID: PMC4238004 [Available on 12/01/15].
  42. Xi Y, Liu S, Bettaieb A, Matsuo K, Matsuo I, Hosein E, Chahed S, Wiede F, Zhang S, Zhang ZY, Kulkarni RN, Tiganis T, Haj FG. Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia. 2015 Jan; 58(1):122-31. PMID: 25338551; PMCID: PMC4258175.
  43. Shapiro AD, Ragni MV, Kulkarni R, Oldenberg J, Srivastava A, Quon DV, Pasi KJ, Hanabusa H, Pabinger I, Mahlangu J, Fogarty P, Lillicrap D, Kulke S, Potts J, Neelakantan S, Nestorov I, Li S, Dumont JA, Jiang H, Brennan A, Pierce GF. Recombinant factor VIII Fc fusion protein: extended-interval dosing maintains low bleeding rates and correlates with von Willebrand factor levels. J Thromb Haemost. 2014 Nov; 12(11):1788-800. PMID: 25196897.
    View in: PubMed
  44. Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15; 307(10):E906-18. PMID: 25249504; PMCID: PMC4233258.
  45. De Jesus DF, Kulkarni RN. Epigenetic modifiers of islet function and mass. Trends Endocrinol Metab. 2014 Dec; 25(12):628-36. PMID: 25246382.
    View in: PubMed
  46. Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA. The Polycomb protein, Bmi1, regulates insulin sensitivity. Mol Metab. 2014 Nov; 3(8):794-802. PMID: 25379404; PMCID: PMC4216405.
  47. Liu S, Xi Y, Bettaieb A, Matsuo K, Matsuo I, Kulkarni RN, Haj FG. Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects ß-cell function. Endocrinology. 2014 Sep; 155(9):3329-38. PMID: 24956127; PMCID: PMC4138572.
  48. Teo AK, Valdez IA, Dirice E, Kulkarni RN. Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum. Stem Cell Reports. 2014 Jul 08; 3(1):5-14. PMID: 25068117; PMCID: PMC4110751.
  49. Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2319-28. PMID: 24843127; PMCID: PMC4050564.
  50. Hatanaka M, Maier B, Sims EK, Templin AT, Kulkarni RN, Evans-Molina C, Mirmira RG. Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway. Diabetes. 2014 Oct; 63(10):3404-15. PMID: 24834975; PMCID: PMC4171659.
  51. Mezza T, Kulkarni RN. The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. Diabetologia. 2014 Jul; 57(7):1291-303. PMID: 24824733.
    View in: PubMed
  52. Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A. Human ß-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes. 2014 Mar; 63(3):819-31. PMID: 24556859; PMCID: PMC3931400.
  53. Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F. The islet estrogen receptor-a is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes. PLoS One. 2014; 9(2):e87941. PMID: 24498408; PMCID: PMC3912162.
  54. Bakker AD, Kulkarni RN, Klein-Nulend J, Lems WF. IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts. J Dent Res. 2014 Apr; 93(4):394-9. PMID: 24492932.
    View in: PubMed
  55. Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85a deficiency protects ß-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1192-7. PMID: 24395790; PMCID: PMC3903202.
  56. Haznedar J, Moreira S, Marbury T, Robson R, Smith W, Kulkarni R, Munson ML, Thommes JA, Lemenuel-Diot A, Washington C, Smith P, Chen YC. The effect of mild to moderate renal impairment on the pharmacokinetics of the nucleoside analog hepatitis C virus polymerase inhibitor mericitabine. Drug Dev Res. 2014 Mar; 75(2):107-13. PMID: 24648253.
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  57. Gane EJ, Rouzier R, Wiercinska-Drapalo A, Larrey DG, Morcos PN, Brennan BJ, Le Pogam S, Nájera I, Petric R, Tran JQ, Kulkarni R, Zhang Y, Smith P, Yetzer ES, Shulman NS. Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders. Antimicrob Agents Chemother. 2014; 58(2):1136-45. PMID: 24295986; PMCID: PMC3910820.
  58. Mezza T, Muscogiuri G, Sorice GP, Clemente G, Hu J, Pontecorvi A, Holst JJ, Giaccari A, Kulkarni RN. Insulin resistance alters islet morphology in nondiabetic humans. Diabetes. 2014 Mar; 63(3):994-1007. PMID: 24215793; PMCID: PMC3931397.
  59. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Soluble factors secreted by T cells promote ß-cell proliferation. Diabetes. 2014 Jan; 63(1):188-202. PMID: 24089508; PMCID: PMC3868047.
  60. Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP, Kulkarni RN. Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes. 2014 Jan; 63(1):259-69. PMID: 24062244; PMCID: PMC3868055.
  61. Teo AK, Wagers AJ, Kulkarni RN. New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab. 2013 Dec 03; 18(6):775-91. PMID: 24035588; PMCID: PMC3858409.
  62. Negahdar M, Aukrust I, Molnes J, Solheim MH, Johansson BB, Sagen JV, Dahl-Jørgensen K, Kulkarni RN, Søvik O, Flatmark T, Njølstad PR, Bjørkhaug L. GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation. Mol Cell Endocrinol. 2014 Jan 25; 382(1):55-65. PMID: 24001579.
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  63. Pockros PJ, Jensen D, Tsai N, Taylor R, Ramji A, Cooper C, Dickson R, Tice A, Kulkarni R, Vierling JM, Lou Munson M, Chen YC, Najera I, Thommes J. JUMP-C: a randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients. Hepatology. 2013 Aug; 58(2):514-23. PMID: 23359491.
    View in: PubMed
  64. Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR, Kulkarni RN. Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). PLoS One. 2013; 8(4):e60229. PMID: 23565203; PMCID: PMC3615023.
  65. Akiyama M, Liew CW, Lu S, Hu J, Martinez R, Hambro B, Kennedy RT, Kulkarni RN. X-box binding protein 1 is essential for insulin regulation of pancreatic a-cell function. Diabetes. 2013 Jul; 62(7):2439-49. PMID: 23493568; PMCID: PMC3712068.
  66. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-derived systemic factors drive ß cell hyperplasia in insulin-resistant states. Cell Rep. 2013 Feb 21; 3(2):401-10. PMID: 23375376; PMCID: PMC3655439.
  67. Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN. Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 2013 Feb 22; 288(8):5353-6. PMID: 23306198; PMCID: PMC3581399.
  68. Aukrust I, Bjørkhaug L, Negahdar M, Molnes J, Johansson BB, Müller Y, Haas W, Gygi SP, Søvik O, Flatmark T, Kulkarni RN, Njølstad PR. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. J Biol Chem. 2013 Feb 22; 288(8):5951-62. PMID: 23297408; PMCID: PMC3581398.
  69. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629; PMCID: PMC3567215.
  70. Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun. 2013; 4:1871. PMID: 23695665; PMCID: PMC3707125.
  71. Su D, Shukla AK, Chen B, Kim JS, Nakayasu E, Qu Y, Aryal U, Weitz K, Clauss TR, Monroe ME, Camp DG, Bigelow DJ, Smith RD, Kulkarni RN, Qian WJ. Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry. Free Radic Biol Med. 2013 Apr; 57:68-78. PMID: 23277143; PMCID: PMC3771501.
  72. Goldfine AB, Kulkarni RN. Modulation of ß-cell function: a translational journey from the bench to the bedside. Diabetes Obes Metab. 2012 Oct; 14 Suppl 3:152-60. PMID: 22928576.
    View in: PubMed
  73. Teo AK, Kulkarni RN. Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 2012 Oct 17; 31(20):3956-7. PMID: 22983555; PMCID: PMC3474931.
  74. Kulkarni RN. Identifying biomarkers of subclinical diabetes. Diabetes. 2012 Aug; 61(8):1925-6. PMID: 22826312; PMCID: PMC3402306.
  75. Negahdar M, Aukrust I, Johansson BB, Molnes J, Molven A, Matschinsky FM, Søvik O, Kulkarni RN, Flatmark T, Njølstad PR, Bjørkhaug L. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochim Biophys Acta. 2012 Nov; 1822(11):1705-15. PMID: 22820548; PMCID: PMC3444650.
  76. Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM, Kulkarni RN. Rosiglitazone promotes PPAR?-dependent and -independent alterations in gene expression in mouse islets. Endocrinology. 2012 Oct; 153(10):4593-9. PMID: 22807489; PMCID: PMC3512010.
  77. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human ß-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes. 2012 Sep; 61(9):2205-13. PMID: 22751699; PMCID: PMC3425429.
  78. Morioka T, Dishinger JF, Reid KR, Liew CW, Zhang T, Inaba M, Kennedy RT, Kulkarni RN. Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling. Mol Endocrinol. 2012 Jun; 26(6):967-76. PMID: 22474124; PMCID: PMC3355538.
  79. Kim W, Lao Q, Shin YK, Carlson OD, Lee EK, Gorospe M, Kulkarni RN, Egan JM. Cannabinoids induce pancreatic ß-cell death by directly inhibiting insulin receptor activation. Sci Signal. 2012 Mar 20; 5(216):ra23. PMID: 22434934; PMCID: PMC3524575.
  80. Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M. RNA-binding protein HuD controls insulin translation. Mol Cell. 2012 Mar 30; 45(6):826-35. PMID: 22387028; PMCID: PMC3319250.
  81. Halperin F, Lopez X, Manning R, Kahn CR, Kulkarni RN, Goldfine AB. Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes. 2012 Feb; 61(2):301-9. PMID: 22275085; PMCID: PMC3266415.
  82. Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V. Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2376-81. PMID: 22308370; PMCID: PMC3289358.
  83. Chu TW, Kulkarni R, Gane EJ, Roberts SK, Stedman C, Angus PW, Ritchie B, Lu XY, Ipe D, Lopatin U, Germer S, Iglesias VA, Elston R, Smith PF, Shulman NS. Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology. 2012 Apr; 142(4):790-5. PMID: 22248659.
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  84. Galkina EV, Butcher M, Keller SR, Goff M, Bruce A, Pei H, Sarembock IJ, Sanders JM, Nagelin MH, Srinivasan S, Kulkarni RN, Hedrick CC, Lattanzio FA, Dobrian AD, Nadler JL, Ley K. Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):247-56. PMID: 22199371; PMCID: PMC3676303.
  85. Folli F, Okada T, Perego C, Gunton J, Liew CW, Akiyama M, D'Amico A, La Rosa S, Placidi C, Lupi R, Marchetti P, Sesti G, Hellerstein M, Perego L, Kulkarni RN. Altered insulin receptor signalling and ß-cell cycle dynamics in type 2 diabetes mellitus. PLoS One. 2011; 6(11):e28050. PMID: 22140505; PMCID: PMC3227614.
  86. Kawamori D, Akiyama M, Hu J, Hambro B, Kulkarni RN. Growth factor signalling in the regulation of a-cell fate. Diabetes Obes Metab. 2011 Oct; 13 Suppl 1:21-30. PMID: 21824253.
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  87. Lopez X, Cypess A, Manning R, O'Shea S, Kulkarni RN, Goldfine AB. Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids. J Clin Endocrinol Metab. 2011 Dec; 96(12):3811-21. PMID: 21956413; PMCID: PMC3232618.
  88. Rowland KJ, Trivedi S, Lee D, Wan K, Kulkarni RN, Holzenberger M, Brubaker PL. Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion. Gastroenterology. 2011 Dec; 141(6):2166-2175.e7. PMID: 21925122.
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  89. Zhou JY, Dann GP, Liew CW, Smith RD, Kulkarni RN, Qian WJ. Unraveling pancreatic islet biology by quantitative proteomics. Expert Rev Proteomics. 2011 Aug; 8(4):495-504. PMID: 21819304; PMCID: PMC3160816.
  90. Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13379-86. PMID: 21788502; PMCID: PMC3158206.
  91. Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R. Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12815-20. PMID: 21768367; PMCID: PMC3150928.
  92. Hinault C, Kawamori D, Liew CW, Maier B, Hu J, Keller SR, Mirmira RG, Scrable H, Kulkarni RN. ?40 Isoform of p53 controls ß-cell proliferation and glucose homeostasis in mice. Diabetes. 2011 Apr; 60(4):1210-22. PMID: 21357466; PMCID: PMC3064094.
  93. Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Cannabinoids inhibit insulin receptor signaling in pancreatic ß-cells. Diabetes. 2011 Apr; 60(4):1198-209. PMID: 21346174; PMCID: PMC3064093.
  94. Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T. Class IA phosphatidylinositol 3-kinase in pancreatic ß cells controls insulin secretion by multiple mechanisms. Cell Metab. 2010 Dec 01; 12(6):619-32. PMID: 21109194; PMCID: PMC3736578.
  95. Kulkarni RN. GIP: no longer the neglected incretin twin? Sci Transl Med. 2010 Sep 15; 2(49):49ps47. PMID: 20844284.
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  96. Vesterhus M, Raeder H, Kurpad AJ, Kawamori D, Molven A, Kulkarni RN, Kahn CR, Njølstad PR. Pancreatic function in carboxyl-ester lipase knockout mice. Pancreatology. 2010; 10(4):467-76. PMID: 20720448; PMCID: PMC2968766.
  97. Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R. Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem. 2010 Jul 21; 21(7):1362-8. PMID: 20583828; PMCID: PMC2912453.
  98. Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010 Aug; 120(8):2876-88. PMID: 20592469; PMCID: PMC2912176.
  99. Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest. 2010 Jun; 120(6):2171-83. PMID: 20440072; PMCID: PMC2877560.
  100. Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4770-5. PMID: 20176932; PMCID: PMC2842068.
  101. Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B. Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J Biol Chem. 2010 Apr 02; 285(14):10538-45. PMID: 20145256; PMCID: PMC2856261.
  102. Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96. PMID: 20103709; PMCID: PMC2844846.
  103. Robertson S, Ishida-Takahashi R, Tawara I, Hu J, Patterson CM, Jones JC, Kulkarni RN, Myers MG. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes. 2010 Apr; 59(4):782-90. PMID: 20068132; PMCID: PMC2844825.
  104. Kawamori D, Welters HJ, Kulkarni RN. Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol. 2010; 654:421-45. PMID: 20217508.
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  105. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505. PMID: 20032314; PMCID: PMC2879949.
  106. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983. PMID: 19956695; PMCID: PMC2776992.
  107. Zhou JY, Petritis BO, Petritis K, Norbeck AD, Weitz KK, Moore RJ, Camp DG, Kulkarni RN, Smith RD, Qian WJ. Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome. J Proteome Res. 2009 Nov; 8(11):5387-95. PMID: 19722698; PMCID: PMC2783519.
  108. Liew CW, Holman A, Kulkarni RN. The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:21-9. PMID: 19817785.
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  109. Kawamori D, Kulkarni RN. Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion. Islets. 2009 Nov-Dec; 1(3):276-9. PMID: 21099284.
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  110. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5. PMID: 19667185; PMCID: PMC2732833.
  111. Kulkarni RN. Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 2009 Jul; 150(7):2994-6. PMID: 19549885; PMCID: PMC2703513.
  112. Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 2009 Apr; 9(4):350-61. PMID: 19356716; PMCID: PMC2694613.
  113. Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN. Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 2009 Jun; 29(11):3219-28. PMID: 19273608; PMCID: PMC2682019.
  114. Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T. Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 2009 Mar; 58(3):682-92. PMID: 19073770; PMCID: PMC2646067.
  115. Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I. Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 2009 Jan; 58(1):174-84. PMID: 18984736; PMCID: PMC2606868.
  116. Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN. Differential expression of cell cycle proteins during ageing of pancreatic islet cells. Diabetes Obes Metab. 2008 Nov; 10 Suppl 4:136-46. PMID: 18834441.
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  117. Welters HJ, Kulkarni RN. Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab. 2008 Dec; 19(10):349-55. PMID: 18926717.
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  119. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Retraction. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2008 Sep; 22(9):2203. PMID: 18757780.
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  120. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21; 454(7207):1000-4. PMID: 18719589; PMCID: PMC2745972.
  121. Petyuk VA, Qian WJ, Hinault C, Gritsenko MA, Singhal M, Monroe ME, Camp DG, Kulkarni RN, Smith RD. Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res. 2008 Aug; 7(8):3114-26. PMID: 18570455; PMCID: PMC2749725.
  122. DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 2008 Sep; 57(9):2296-303. PMID: 18544705; PMCID: PMC2518480.
  123. Pawar A, Krishnan R, Davis K, Bosma K, Kulkarni R. Perceptions about quality of life in a school-based population of adolescents with menorrhagia: implications for adolescents with bleeding disorders. Haemophilia. 2008 May; 14(3):579-83. PMID: 18282153.
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  124. Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE. A patient with type B insulin resistance syndrome, responsive to immune therapy. Nat Clin Pract Endocrinol Metab. 2007 Dec; 3(12):835-40. PMID: 18026162.
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  126. Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN. Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest. 2007 Oct; 117(10):2860-8. PMID: 17909627; PMCID: PMC1994606.
  127. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep; 27(17):6026-37. PMID: 17576812; PMCID: PMC1952143.
  128. Kulkarni RN, Kahn CR. Ephs and ephrins keep pancreatic Beta cells connected. Cell. 2007 Apr 20; 129(2):241-3. PMID: 17448984.
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  129. Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN. Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8977-82. PMID: 17416680; PMCID: PMC1885613.
  130. Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb; 56(2):311-9. PMID: 17259374.
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  132. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2006 Nov; 20(11):2671-81. PMID: 16803864.
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  133. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 2006 Jun 23; 312(5781):1763-6. PMID: 16794074.
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  135. He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93. PMID: 16469952.
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  148. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9. PMID: 14517292; PMCID: PMC230305.
  149. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E41-9. PMID: 14519599.
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  150. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. PMID: 12842910; PMCID: PMC196130.
  151. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003 Jun 06; 300(5625):1574-7. PMID: 12791994.
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  152. Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes. 2003 Jun; 52(6):1535-43. PMID: 12765967.
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  154. Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71. PMID: 12775712.
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  155. Kulkarni RN, Zisman A. Lessons for human diabetes from experimental mouse models. Curr Diab Rep. 2003 Apr; 3(2):168-75. PMID: 12728643.
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  156. Laustsen PG, Michael MD, Crute BE, Cohen SE, Ueki K, Kulkarni RN, Keller SR, Lienhard GE, Kahn CR. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev. 2002 Dec 15; 16(24):3213-22. PMID: 12502742; PMCID: PMC187498.
  157. Kulkarni RN, Okada T. Tissue-specific targeting of the insulin receptor gene. Endocrine. 2002 Dec; 19(3):257-66. PMID: 12624425.
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  158. Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf). 2002 Jul; 57(1):1-9. PMID: 12100063.
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  159. Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet. 2002 May; 31(1):111-5. PMID: 11923875.
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  160. Kulkarni RN. Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans. 2002 Apr; 30(2):317-22. PMID: 12023872.
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  161. Roper MG, Qian WJ, Zhang BB, Kulkarni RN, Kahn CR, Kennedy RT. Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes. 2002 Feb; 51 Suppl 1:S43-9. PMID: 11815457.
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  162. Flier SN, Kulkarni RN, Kahn CR. Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7475-80. PMID: 11404474; PMCID: PMC34693.
  163. Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren PO. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell. 2001 Mar; 7(3):559-70. PMID: 11463381.
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  164. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001 Feb; 107(3):379-86. PMID: 11160162; PMCID: PMC199192.
  165. Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes. 2000 Dec; 49(12):2126-34. PMID: 11118016.
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  166. Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, Kennedy RT. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. J Biol Chem. 2000 Jul 21; 275(29):22331-8. PMID: 10764813.
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  167. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell. 2000 Jul; 6(1):87-97. PMID: 10949030.
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  168. Kulkarni RN, Wang ZL, Wang RM, Smith DM, Ghatei MA, Bloom SR. Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells. J Endocrinol. 2000 May; 165(2):509-18. PMID: 10810315.
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  169. Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus. J Pediatr Endocrinol Metab. 2000; 13 Suppl 6:1377-84. PMID: 11202213.
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  170. Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest. 1999 Dec; 104(12):R69-75. PMID: 10606633; PMCID: PMC409887.
  171. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 1999 Feb 05; 96(3):329-39. PMID: 10025399.
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  172. Morgan DG, Kulkarni RN, Hurley JD, Wang ZL, Wang RM, Ghatei MA, Karlsen AE, Bloom SR, Smith DM. Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells. Diabetologia. 1998 Dec; 41(12):1482-91. PMID: 9867216.
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  173. Vaz M, Kulkarni RN, Shetty PS. Metabolic responses to repeated infusions of identical doses of norepinephrine in chronically energy deficient human subjects. Indian J Med Res. 1998 Feb; 107:103-8. PMID: 9540286.
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  174. Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, Bloom SR. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest. 1997 Dec 01; 100(11):2729-36. PMID: 9389736; PMCID: PMC508476.
  175. Wang ZL, Kulkarni RN, Wang RM, Smith DM, Ghatei MA, Byfield PG, Bennet WM, Bloom SR. Possible evidence for endogenous production of a novel galanin-like peptide. J Clin Invest. 1997 Jul 01; 100(1):189-96. PMID: 9202071; PMCID: PMC508179.
  176. Kulkarni RN, Smith DM, Ghatei MA, Jones PM, Bloom SR. Investigation of the effects of antisense oligodeoxynucleotides to islet amyloid polypeptide mRNA on insulin release, content and expression. J Endocrinol. 1996 Dec; 151(3):341-8. PMID: 8994379.
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  177. Kulkarni RN, Wang ZL, Akinsanya KO, Bennet WM, Wang RM, Smith DM, Ghatei MA, Byfield PG, Bloom SR. Pyroglutamyl-phenylalanyl-proline amide attenuates thyrotropin-releasing hormone-stimulated insulin secretion in perifused rat islets and insulin-secreting clonal beta-cell lines. Endocrinology. 1995 Nov; 136(11):5155-64. PMID: 7588254.
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  178. Kulkarni RN, Smith DM, Ghatei MA, Bloom SR. A 67 kDa protein mediates pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated insulin secretion in a hamster clonal beta-cell line. J Endocrinol. 1995 Oct; 147(1):121-30. PMID: 7490525.
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  179. Olmos G, Kulkarni RN, Haque M, MacDermot J. Imidazolines stimulate release of insulin from RIN-5AH cells independently from I1- and I2-imidazoline receptors. Ann N Y Acad Sci. 1995 Jul 12; 763:374-6. PMID: 7677349.
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  180. Piers LS, Soares MJ, Kulkarni RN, Shetty PS. Thermic effect of a meal. 3. Effect of dietary supplementation in chronically undernourished human subjects. Br J Nutr. 1992 Mar; 67(2):187-94. PMID: 1596494.
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