Harvard Catalyst Profiles

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Rohit N. Kulkarni, PH.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK117639 (QI, LING) Dec 15, 2018 - Nov 30, 2023
    Interplay Between SERPINB1 and TLR2/TLR4 in Beta Cell Regeneration
    Role: Co-Principal Investigator
  2. R41DK115326 (PEMBERTON, PHILIP) Sep 17, 2018 - Aug 31, 2019
    Regulation of Autoimmune Type 1 Diabetes by Serpins B1 and A1 (Alpha 1-Antitrypsin)
    Role: Co-Principal Investigator
  3. UC4DK116278 (KULKARNI, ROHIT N.) Sep 20, 2017 - Aug 31, 2021
    Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
    Role: Principal Investigator
  4. UC4DK116255 (CHOUDHARY, AMIT) Sep 20, 2017 - Aug 31, 2020
    Development of small molecule-based methods for targeted cargo delivery to beta cells
    Role: Co-Principal Investigator
  5. UC4DK104167 (QIAN, WEI-JUN) Sep 20, 2014 - Aug 31, 2017
    Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A. ß-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity. Diabetes. 2019 Jun; 68(6):1121-1129. PMID: 31109941.
  2. Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic ß cells in diet-induced obesity. Nat Immunol. 2019 Jun; 20(6):677-686. PMID: 31110312.
  3. Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Human duct cells contribute to ß cell compensation in insulin resistance. JCI Insight. 2019 Apr 18; 4(8). PMID: 30996131.
  4. Yi L, Tsai CF, Dirice E, Swensen AC, Chen J, Shi T, Gritsenko MA, Chu RK, Piehowski PD, Smith RD, Rodland KD, Atkinson MA, Mathews CE, Kulkarni RN, Liu T, Qian WJ. Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells. Anal Chem. 2019 May 07; 91(9):5794-5801. PMID: 30843680.
  5. Jungtrakoon P, Shirakawa J, Buranasupkajorn P, Gupta MK, De Jesus DF, Pezzolesi MG, Panya A, Hastings T, Chanprasert C, Mendonca C, Kulkarni RN, Doria A. Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes. Diabetes. 2019 May; 68(5):1084-1093. PMID: 30833467.
  6. El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG. Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion. J Biol Chem. 2019 01 18; 294(3):1059-1069. PMID: 30459233.
    Citations:    Fields:    
  7. Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ. Attenuation of PKCd enhances metabolic activity and promotes expansion of blood progenitors. EMBO J. 2018 Dec 14; 37(24). PMID: 30446598.
    Citations:    Fields:    
  8. Iliopoulos-Tsoutsouvas C, Kulkarni RN, Makriyannis A, Nikas SP. Fluorescent probes for G-protein-coupled receptor drug discovery. Expert Opin Drug Discov. 2018 10; 13(10):933-947. PMID: 30249143.
    Citations:    Fields:    
  9. Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN. Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Mol Metab. 2018 12; 18:153-163. PMID: 30316806.
    Citations:    Fields:    
  10. Jeong DE, Heo S, Han JH, Lee EY, Kulkarni RN, Kim W. Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic ß Cells. Mol Cells. 2018 Oct 31; 41(10):909-916. PMID: 30165730.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Kim C, Jeong DE, Heo S, Ji E, Rho JG, Jung M, Ahn S, Kim YJ, Kim YS, Nam SW, Kulkarni RN, Lee KB, Lee EK, Kim W. Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis. J Pathol. 2018 Oct; 246(2):231-243. PMID: 30014466.
    Citations:    Fields:    
  12. Gannon M, Kulkarni RN, Tse HM, Mauvais-Jarvis F. Sex differences underlying pancreatic islet biology and its dysfunction. Mol Metab. 2018 09; 15:82-91. PMID: 29891438.
    Citations: 1     Fields:    
  13. Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y. Signaling between pancreatic ß cells and macrophages via S100 calcium-binding protein A8 exacerbates ß-cell apoptosis and islet inflammation. J Biol Chem. 2018 04 20; 293(16):5934-5946. PMID: 29496993.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Shin H, Han JH, Yoon J, Sim HJ, Park TJ, Yang S, Lee EK, Kulkarni RN, Egan JM, Kim W. Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells. J Cell Mol Med. 2018 Apr; 22(4):2337-2345. PMID: 29431265.
    Citations: 2     Fields:    
  15. Johansson BB, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, Ræder H, Kulkarni RN, Johansson S, Njølstad PR, Molven A. The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Pancreatology. 2018 Jan; 18(1):12-19. PMID: 29233499.
    Citations: 1     Fields:    Translation:HumansAnimals
  16. Srivaths LV, Zhang QC, Byams VR, Dietrich JE, James AH, Kouides PA, Kulkarni R. Differences in bleeding phenotype and provider interventions in postmenarchal adolescents when compared to adult women with bleeding disorders and heavy menstrual bleeding. Haemophilia. 2018 Jan; 24(1):63-69. PMID: 28873279.
    Citations:    Fields:    Translation:Humans
  17. Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. J Biol Chem. 2017 10 27; 292(43):17598-17608. PMID: 28860191.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Mol Cell Endocrinol. 2017 10 15; 454:146-157. PMID: 28648619.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Ghanem SS, Muturi HT, DeAngelis AM, Hu J, Kulkarni RN, Heinrich G, Najjar SM. Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. Diabetologia. 2017 Sep; 60(9):1751-1760. PMID: 28567513.
    Citations:    Fields:    Translation:Animals
  20. Kawamori D, Shirakawa J, Liew CW, Hu J, Morioka T, Duttaroy A, Burkey B, Kulkarni RN. GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in ßIRKO mice. Diabetologia. 2017 08; 60(8):1442-1453. PMID: 28526921.
    Citations: 1     Fields:    Translation:AnimalsCells
  21. Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RN. Heterogeneity of proliferative markers in pancreatic ß-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. Acta Diabetol. 2017 Aug; 54(8):737-747. PMID: 28512677.
    Citations:    Fields:    Translation:HumansCells
  22. Shirakawa J, De Jesus DF, Kulkarni RN. Exploring inter-organ crosstalk to uncover mechanisms that regulate ß-cell function and mass. Eur J Clin Nutr. 2017 07; 71(7):896-903. PMID: 28294170.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  23. Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic ß Cell Proliferation. Cell Metab. 2017 Apr 04; 25(4):868-882.e5. PMID: 28286049.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  24. Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metab. 2017 02 07; 25(2):448-462. PMID: 28065828.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Rasaily R, Ganguly KK, Roy M, Vani SN, Kharood N, Kulkarni R, Chauhan S, Swain S, Kanugo L. Community based kangaroo mother care for low birth weight babies: A pilot study. Indian J Med Res. 2017 Jan; 145(1):51-57. PMID: 28574014.
    Citations: 1     Fields:    Translation:Humans
  26. Viswanathan C, Kulkarni R, Bopardikar A, Ramdasi S. Significance of CD34 Negative Hematopoietic Stem Cells and CD34 Positive Mesenchymal Stem Cells - A Valuable Dimension to the Current Understanding. Curr Stem Cell Res Ther. 2017; 12(6):476-483. PMID: 28464788.
    Citations:    Fields:    Translation:HumansAnimalsCells
  27. Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. Corrigendum: IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep. 2016 10 10; 6:34969. PMID: 27721427.
    Citations:    Fields:    
  28. Aledort L, Recht M, Kulkarni R, Kobrinsky N. Adult, previously untreated patients remain a significant therapeutic challenge. J Thromb Haemost. 2016 10; 14(10):2075-2076. PMID: 27496600.
    Citations:    Fields:    Translation:Humans
  29. Shirakawa J, Kulkarni RN. Novel factors modulating human ß-cell proliferation. Diabetes Obes Metab. 2016 09; 18 Suppl 1:71-7. PMID: 27615134.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  30. Mezza T, Shirakawa J, Martinez R, Hu J, Giaccari A, Kulkarni RN. Nuclear Export of FoxO1 Is Associated with ERK Signaling in ß-Cells Lacking Insulin Receptors. J Biol Chem. 2016 Oct 07; 291(41):21485-21495. PMID: 27535223.
    Citations: 1     Fields:    Translation:AnimalsCells
  31. Kahraman S, Okawa ER, Kulkarni RN. Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes? Curr Diab Rep. 2016 08; 16(8):70. PMID: 27313072.
    Citations: 1     Fields:    Translation:HumansCells
  32. Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep. 2016 07 05; 6:28177. PMID: 27378176.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR. Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Diabetes. 2016 08; 65(8):2201-13. PMID: 27207537.
    Citations: 9     Fields:    Translation:AnimalsCells
  34. Shirakawa J, Kulkarni RN. ERR?-A New Player in ß Cell Maturation. Cell Metab. 2016 05 10; 23(5):765-7. PMID: 27166940.
    Citations:    Fields:    Translation:HumansAnimalsCells
  35. Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN. Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep. 2016 Apr 19; 15(3):460-470. PMID: 27068459.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Molven A, Hollister-Lock J, Hu J, Martinez R, Njølstad PR, Liew CW, Weir G, Kulkarni RN. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes. 2016 06; 65(6):1672-8. PMID: 26953163.
    Citations:    Fields:    Translation:AnimalsCells
  37. Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dancík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human ß-Cell Proliferation. Diabetes. 2016 06; 65(6):1660-71. PMID: 26953159.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  38. Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-ß Signaling Promotes Human Pancreatic ß-Cell Replication. Diabetes. 2016 05; 65(5):1208-18. PMID: 26936960.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS One. 2016; 11(2):e0148252. PMID: 26872145.
    Citations: 10     Fields:    Translation:AnimalsCells
  40. Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN. Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. Stem Cell Reports. 2016 Mar 08; 6(3):357-67. PMID: 26876668.
    Citations: 6     Fields:    Translation:HumansCells
  41. Dirice E, Kulkarni RN. Harnessing immune cells to enhance ß-cell mass in type 1 diabetes. J Investig Med. 2016 Jan; 64(1):14-20. PMID: 26755809.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  42. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic ß Cell Proliferation. Cell Metab. 2016 Jan 12; 23(1):194-205. PMID: 26701651.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  43. Mezza T, Sorice GP, Conte C, Sun VA, Cefalo CM, Moffa S, Pontecorvi A, Mari A, Kulkarni RN, Giaccari A. ß-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans. J Clin Endocrinol Metab. 2016 Feb; 101(2):470-5. PMID: 26649619.
    Citations: 1     Fields:    Translation:HumansCells
  44. Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, Kim JK, Giovannucci DR, Najjar SM. Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). J Biol Chem. 2016 Jan 08; 291(2):980-8. PMID: 26586918.
    Citations: 2     Fields:    Translation:Animals
  45. Felix JC, Lacey MJ, Miller JD, Lenhart GM, Kulkarni R. Clinical-Economic Modeling Analysis Of Human Papillomavirus (Hpv) Co-Testing With Genotyping Versus Primary Hpv Testing For Cervical Cancer Screening. Value Health. 2015 Nov; 18(7):A353. PMID: 26531999.
    Citations:    Fields:    
  46. Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP. Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015 Nov; 156(11):4047-58. PMID: 26295369.
    Citations:    Fields:    Translation:HumansAnimalsCells
  47. Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts. Stem Cells Transl Med. 2015 Oct; 4(10):1101-8. PMID: 26253715.
    Citations: 3     Fields:    Translation:HumansCells
  48. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 04; 22(2):239-52. PMID: 26244933.
    Citations: 9     Fields:    Translation:HumansCells
  49. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG, Smith RD, Qian WJ, Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015 Aug 07; 14(8):3111-3122. PMID: 26151086.
    Citations: 3     Fields:    Translation:AnimalsCells
  50. Teo AK, Gupta MK, Doria A, Kulkarni RN. Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab. 2015 Sep; 4(9):593-604. PMID: 26413465.
    Citations: 2     Fields:    
  51. Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Human ß-cell proliferation and intracellular signaling: part 3. Diabetes. 2015 Jun; 64(6):1872-85. PMID: 25999530.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  52. Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, Philbrick WM, Najjar SM. Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance. Diabetes. 2015 Aug; 64(8):2780-90. PMID: 25972571.
    Citations: 17     Fields:    Translation:Animals
  53. Young G, Mahlangu J, Kulkarni R, Nolan B, Liesner R, Pasi J, Barnes C, Neelakantan S, Gambino G, Cristiano LM, Pierce GF, Allen G. Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A. J Thromb Haemost. 2015 Jun; 13(6):967-77. PMID: 25912075.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  54. Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 May; 14(3):307-22. PMID: 25840412.
    Citations: 3     Fields:    Translation:AnimalsCells
  55. Valdez IA, Teo AK, Kulkarni RN. Cellular stress drives pancreatic plasticity. Sci Transl Med. 2015 Feb 04; 7(273):273ps2. PMID: 25653218.
    Citations: 5     Fields:    Translation:Humans
  56. Kulkarni RN, Stewart AF. Summary of the Keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research. Diabetes. 2014 Dec; 63(12):3979-81. PMID: 25414011.
    Citations: 4     Fields:    Translation:Humans
  57. Xi Y, Liu S, Bettaieb A, Matsuo K, Matsuo I, Hosein E, Chahed S, Wiede F, Zhang S, Zhang ZY, Kulkarni RN, Tiganis T, Haj FG. Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia. 2015 Jan; 58(1):122-31. PMID: 25338551.
    Citations: 2     Fields:    Translation:AnimalsCells
  58. Shapiro AD, Ragni MV, Kulkarni R, Oldenberg J, Srivastava A, Quon DV, Pasi KJ, Hanabusa H, Pabinger I, Mahlangu J, Fogarty P, Lillicrap D, Kulke S, Potts J, Neelakantan S, Nestorov I, Li S, Dumont JA, Jiang H, Brennan A, Pierce GF. Recombinant factor VIII Fc fusion protein: extended-interval dosing maintains low bleeding rates and correlates with von Willebrand factor levels. J Thromb Haemost. 2014 Nov; 12(11):1788-800. PMID: 25196897.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  59. Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15; 307(10):E906-18. PMID: 25249504.
    Citations: 3     Fields:    Translation:AnimalsCells
  60. De Jesus DF, Kulkarni RN. Epigenetic modifiers of islet function and mass. Trends Endocrinol Metab. 2014 Dec; 25(12):628-36. PMID: 25246382.
    Citations: 4     Fields:    Translation:HumansCells
  61. Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA. The Polycomb protein, Bmi1, regulates insulin sensitivity. Mol Metab. 2014 Nov; 3(8):794-802. PMID: 25379404.
    Citations: 2     Fields:    
  62. Liu S, Xi Y, Bettaieb A, Matsuo K, Matsuo I, Kulkarni RN, Haj FG. Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects ß-cell function. Endocrinology. 2014 Sep; 155(9):3329-38. PMID: 24956127.
    Citations: 3     Fields:    Translation:AnimalsCells
  63. Teo AK, Valdez IA, Dirice E, Kulkarni RN. Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum. Stem Cell Reports. 2014 Jul 08; 3(1):5-14. PMID: 25068117.
    Citations: 5     Fields:    Translation:HumansCells
  64. Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2319-28. PMID: 24843127.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  65. Hatanaka M, Maier B, Sims EK, Templin AT, Kulkarni RN, Evans-Molina C, Mirmira RG. Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway. Diabetes. 2014 Oct; 63(10):3404-15. PMID: 24834975.
    Citations: 9     Fields:    Translation:AnimalsCells
  66. Mezza T, Kulkarni RN. The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. Diabetologia. 2014 Jul; 57(7):1291-303. PMID: 24824733.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  67. Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A. Human ß-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes. 2014 Mar; 63(3):819-31. PMID: 24556859.
    Citations: 50     Fields:    Translation:HumansCells
  68. Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F. The islet estrogen receptor-a is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes. PLoS One. 2014; 9(2):e87941. PMID: 24498408.
    Citations: 14     Fields:    Translation:Animals
  69. Bakker AD, Kulkarni RN, Klein-Nulend J, Lems WF. IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts. J Dent Res. 2014 Apr; 93(4):394-9. PMID: 24492932.
    Citations: 7     Fields:    Translation:AnimalsCells
  70. Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85a deficiency protects ß-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1192-7. PMID: 24395790.
    Citations: 7     Fields:    Translation:AnimalsCells
  71. Haznedar J, Moreira S, Marbury T, Robson R, Smith W, Kulkarni R, Munson ML, Thommes JA, Lemenuel-Diot A, Washington C, Smith P, Chen YC. The effect of mild to moderate renal impairment on the pharmacokinetics of the nucleoside analog hepatitis C virus polymerase inhibitor mericitabine. Drug Dev Res. 2014 Mar; 75(2):107-13. PMID: 24648253.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  72. Gane EJ, Rouzier R, Wiercinska-Drapalo A, Larrey DG, Morcos PN, Brennan BJ, Le Pogam S, Nájera I, Petric R, Tran JQ, Kulkarni R, Zhang Y, Smith P, Yetzer ES, Shulman NS. Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders. Antimicrob Agents Chemother. 2014; 58(2):1136-45. PMID: 24295986.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  73. Mezza T, Muscogiuri G, Sorice GP, Clemente G, Hu J, Pontecorvi A, Holst JJ, Giaccari A, Kulkarni RN. Insulin resistance alters islet morphology in nondiabetic humans. Diabetes. 2014 Mar; 63(3):994-1007. PMID: 24215793.
    Citations: 34     Fields:    Translation:HumansCells
  74. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Soluble factors secreted by T cells promote ß-cell proliferation. Diabetes. 2014 Jan; 63(1):188-202. PMID: 24089508.
    Citations: 22     Fields:    Translation:AnimalsCells
  75. Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP, Kulkarni RN. Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes. 2014 Jan; 63(1):259-69. PMID: 24062244.
    Citations: 6     Fields:    Translation:HumansCells
  76. Teo AK, Wagers AJ, Kulkarni RN. New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab. 2013 Dec 03; 18(6):775-91. PMID: 24035588.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  77. Negahdar M, Aukrust I, Molnes J, Solheim MH, Johansson BB, Sagen JV, Dahl-Jørgensen K, Kulkarni RN, Søvik O, Flatmark T, Njølstad PR, Bjørkhaug L. GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation. Mol Cell Endocrinol. 2014 Jan 25; 382(1):55-65. PMID: 24001579.
    Citations: 1     Fields:    Translation:HumansCells
  78. Pockros PJ, Jensen D, Tsai N, Taylor R, Ramji A, Cooper C, Dickson R, Tice A, Kulkarni R, Vierling JM, Lou Munson M, Chen YC, Najera I, Thommes J. JUMP-C: a randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients. Hepatology. 2013 Aug; 58(2):514-23. PMID: 23359491.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  79. Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR, Kulkarni RN. Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). PLoS One. 2013; 8(4):e60229. PMID: 23565203.
    Citations: 6     Fields:    Translation:Animals
  80. Akiyama M, Liew CW, Lu S, Hu J, Martinez R, Hambro B, Kennedy RT, Kulkarni RN. X-box binding protein 1 is essential for insulin regulation of pancreatic a-cell function. Diabetes. 2013 Jul; 62(7):2439-49. PMID: 23493568.
    Citations: 14     Fields:    Translation:AnimalsCells
  81. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-derived systemic factors drive ß cell hyperplasia in insulin-resistant states. Cell Rep. 2013 Feb 21; 3(2):401-10. PMID: 23375376.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  82. Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN. Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 2013 Feb 22; 288(8):5353-6. PMID: 23306198.
    Citations: 24     Fields:    Translation:HumansCells
  83. Aukrust I, Bjørkhaug L, Negahdar M, Molnes J, Johansson BB, Müller Y, Haas W, Gygi SP, Søvik O, Flatmark T, Kulkarni RN, Njølstad PR. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. J Biol Chem. 2013 Feb 22; 288(8):5951-62. PMID: 23297408.
    Citations: 10     Fields:    Translation:AnimalsCells
  84. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  85. Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun. 2013; 4:1871. PMID: 23695665.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  86. Su D, Shukla AK, Chen B, Kim JS, Nakayasu E, Qu Y, Aryal U, Weitz K, Clauss TR, Monroe ME, Camp DG, Bigelow DJ, Smith RD, Kulkarni RN, Qian WJ. Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry. Free Radic Biol Med. 2013 Apr; 57:68-78. PMID: 23277143.
    Citations: 16     Fields:    Translation:AnimalsCells
  87. Goldfine AB, Kulkarni RN. Modulation of ß-cell function: a translational journey from the bench to the bedside. Diabetes Obes Metab. 2012 Oct; 14 Suppl 3:152-60. PMID: 22928576.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  88. Teo AK, Kulkarni RN. Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 2012 Oct 17; 31(20):3956-7. PMID: 22983555.
    Citations:    Fields:    Translation:Animals
  89. Kulkarni RN. Identifying biomarkers of subclinical diabetes. Diabetes. 2012 Aug; 61(8):1925-6. PMID: 22826312.
    Citations: 2     Fields:    Translation:AnimalsCells
  90. Negahdar M, Aukrust I, Johansson BB, Molnes J, Molven A, Matschinsky FM, Søvik O, Kulkarni RN, Flatmark T, Njølstad PR, Bjørkhaug L. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochim Biophys Acta. 2012 Nov; 1822(11):1705-15. PMID: 22820548.
    Citations: 1     Fields:    Translation:HumansCells
  91. Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM, Kulkarni RN. Rosiglitazone promotes PPAR?-dependent and -independent alterations in gene expression in mouse islets. Endocrinology. 2012 Oct; 153(10):4593-9. PMID: 22807489.
    Citations: 4     Fields:    Translation:Animals
  92. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human ß-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes. 2012 Sep; 61(9):2205-13. PMID: 22751699.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  93. Morioka T, Dishinger JF, Reid KR, Liew CW, Zhang T, Inaba M, Kennedy RT, Kulkarni RN. Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling. Mol Endocrinol. 2012 Jun; 26(6):967-76. PMID: 22474124.
    Citations: 3     Fields:    Translation:AnimalsCells
  94. Kim W, Lao Q, Shin YK, Carlson OD, Lee EK, Gorospe M, Kulkarni RN, Egan JM. Cannabinoids induce pancreatic ß-cell death by directly inhibiting insulin receptor activation. Sci Signal. 2012 Mar 20; 5(216):ra23. PMID: 22434934.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  95. Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M. RNA-binding protein HuD controls insulin translation. Mol Cell. 2012 Mar 30; 45(6):826-35. PMID: 22387028.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  96. Halperin F, Lopez X, Manning R, Kahn CR, Kulkarni RN, Goldfine AB. Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes. 2012 Feb; 61(2):301-9. PMID: 22275085.
    Citations: 11     Fields:    Translation:HumansCells
  97. Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V. Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2376-81. PMID: 22308370.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  98. Chu TW, Kulkarni R, Gane EJ, Roberts SK, Stedman C, Angus PW, Ritchie B, Lu XY, Ipe D, Lopatin U, Germer S, Iglesias VA, Elston R, Smith PF, Shulman NS. Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology. 2012 Apr; 142(4):790-5. PMID: 22248659.
    Citations: 30     Fields:    Translation:HumansCells
  99. Galkina EV, Butcher M, Keller SR, Goff M, Bruce A, Pei H, Sarembock IJ, Sanders JM, Nagelin MH, Srinivasan S, Kulkarni RN, Hedrick CC, Lattanzio FA, Dobrian AD, Nadler JL, Ley K. Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):247-56. PMID: 22199371.
    Citations: 14     Fields:    Translation:AnimalsCells
  100. Folli F, Okada T, Perego C, Gunton J, Liew CW, Akiyama M, D'Amico A, La Rosa S, Placidi C, Lupi R, Marchetti P, Sesti G, Hellerstein M, Perego L, Kulkarni RN. Altered insulin receptor signalling and ß-cell cycle dynamics in type 2 diabetes mellitus. PLoS One. 2011; 6(11):e28050. PMID: 22140505.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  101. Kawamori D, Akiyama M, Hu J, Hambro B, Kulkarni RN. Growth factor signalling in the regulation of a-cell fate. Diabetes Obes Metab. 2011 Oct; 13 Suppl 1:21-30. PMID: 21824253.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  102. Lopez X, Cypess A, Manning R, O'Shea S, Kulkarni RN, Goldfine AB. Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids. J Clin Endocrinol Metab. 2011 Dec; 96(12):3811-21. PMID: 21956413.
    Citations: 5     Fields:    Translation:HumansCells
  103. Rowland KJ, Trivedi S, Lee D, Wan K, Kulkarni RN, Holzenberger M, Brubaker PL. Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion. Gastroenterology. 2011 Dec; 141(6):2166-2175.e7. PMID: 21925122.
    Citations: 20     Fields:    Translation:AnimalsCells
  104. Zhou JY, Dann GP, Liew CW, Smith RD, Kulkarni RN, Qian WJ. Unraveling pancreatic islet biology by quantitative proteomics. Expert Rev Proteomics. 2011 Aug; 8(4):495-504. PMID: 21819304.
    Citations: 3     Fields:    Translation:HumansAnimals
  105. Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13379-86. PMID: 21788502.
    Citations: 47     Fields:    Translation:AnimalsCells
  106. Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R. Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12815-20. PMID: 21768367.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  107. Hinault C, Kawamori D, Liew CW, Maier B, Hu J, Keller SR, Mirmira RG, Scrable H, Kulkarni RN. ?40 Isoform of p53 controls ß-cell proliferation and glucose homeostasis in mice. Diabetes. 2011 Apr; 60(4):1210-22. PMID: 21357466.
    Citations: 12     Fields:    Translation:AnimalsCells
  108. Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Cannabinoids inhibit insulin receptor signaling in pancreatic ß-cells. Diabetes. 2011 Apr; 60(4):1198-209. PMID: 21346174.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  109. Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T. Class IA phosphatidylinositol 3-kinase in pancreatic ß cells controls insulin secretion by multiple mechanisms. Cell Metab. 2010 Dec 01; 12(6):619-32. PMID: 21109194.
    Citations: 18     Fields:    Translation:AnimalsCells
  110. Kulkarni RN. GIP: no longer the neglected incretin twin? Sci Transl Med. 2010 Sep 15; 2(49):49ps47. PMID: 20844284.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  111. Vesterhus M, Raeder H, Kurpad AJ, Kawamori D, Molven A, Kulkarni RN, Kahn CR, Njølstad PR. Pancreatic function in carboxyl-ester lipase knockout mice. Pancreatology. 2010; 10(4):467-76. PMID: 20720448.
    Citations: 11     Fields:    Translation:AnimalsCells
  112. Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R. Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem. 2010 Jul 21; 21(7):1362-8. PMID: 20583828.
    Citations: 20     Fields:    Translation:AnimalsCells
  113. Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010 Aug; 120(8):2876-88. PMID: 20592469.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  114. Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest. 2010 Jun; 120(6):2171-83. PMID: 20440072.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  115. Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4770-5. PMID: 20176932.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  116. Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B. Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J Biol Chem. 2010 Apr 02; 285(14):10538-45. PMID: 20145256.
    Citations: 20     Fields:    Translation:AnimalsCells
  117. Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96. PMID: 20103709.
    Citations: 24     Fields:    Translation:AnimalsCells
  118. Robertson S, Ishida-Takahashi R, Tawara I, Hu J, Patterson CM, Jones JC, Kulkarni RN, Myers MG. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes. 2010 Apr; 59(4):782-90. PMID: 20068132.
    Citations: 11     Fields:    Translation:AnimalsCells
  119. Kawamori D, Welters HJ, Kulkarni RN. Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol. 2010; 654:421-45. PMID: 20217508.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  120. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505. PMID: 20032314.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  121. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983. PMID: 19956695.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  122. Zhou JY, Petritis BO, Petritis K, Norbeck AD, Weitz KK, Moore RJ, Camp DG, Kulkarni RN, Smith RD, Qian WJ. Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome. J Proteome Res. 2009 Nov; 8(11):5387-95. PMID: 19722698.
    Citations: 10     Fields:    Translation:HumansAnimals
  123. Liew CW, Holman A, Kulkarni RN. The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:21-9. PMID: 19817785.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  124. Kawamori D, Kulkarni RN. Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion. Islets. 2009 Nov-Dec; 1(3):276-9. PMID: 21099284.
    Citations: 5     Fields:    Translation:AnimalsCells
  125. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5. PMID: 19667185.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  126. Kulkarni RN. Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 2009 Jul; 150(7):2994-6. PMID: 19549885.
    Citations: 1     Fields:    Translation:AnimalsCells
  127. Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 2009 Apr; 9(4):350-61. PMID: 19356716.
    Citations: 89     Fields:    Translation:AnimalsCells
  128. Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN. Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 2009 Jun; 29(11):3219-28. PMID: 19273608.
    Citations: 47     Fields:    Translation:AnimalsCells
  129. Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T. Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 2009 Mar; 58(3):682-92. PMID: 19073770.
    Citations: 7     Fields:    Translation:AnimalsCells
  130. Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I. Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 2009 Jan; 58(1):174-84. PMID: 18984736.
    Citations: 28     Fields:    Translation:AnimalsCells
  131. Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN. Differential expression of cell cycle proteins during ageing of pancreatic islet cells. Diabetes Obes Metab. 2008 Nov; 10 Suppl 4:136-46. PMID: 18834441.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  132. Welters HJ, Kulkarni RN. Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab. 2008 Dec; 19(10):349-55. PMID: 18926717.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  133. Assmann A, Hinault C, Kulkarni RN. Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes. 2009 Feb; 10(1):14-32. PMID: 18828795.
    Citations: 23     Fields:    Translation:HumansCells
  134. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Retraction. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2008 Sep; 22(9):2203. PMID: 18757780.
    Citations:    Fields:    
  135. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21; 454(7207):1000-4. PMID: 18719589.
    Citations: 311     Fields:    Translation:AnimalsCells
  136. Petyuk VA, Qian WJ, Hinault C, Gritsenko MA, Singhal M, Monroe ME, Camp DG, Kulkarni RN, Smith RD. Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res. 2008 Aug; 7(8):3114-26. PMID: 18570455.
    Citations: 16     Fields:    Translation:AnimalsCells
  137. DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 2008 Sep; 57(9):2296-303. PMID: 18544705.
    Citations: 35     Fields:    Translation:AnimalsCells
  138. Pawar A, Krishnan R, Davis K, Bosma K, Kulkarni R. Perceptions about quality of life in a school-based population of adolescents with menorrhagia: implications for adolescents with bleeding disorders. Haemophilia. 2008 May; 14(3):579-83. PMID: 18282153.
    Citations:    Fields:    Translation:Humans
  139. Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE. A patient with type B insulin resistance syndrome, responsive to immune therapy. Nat Clin Pract Endocrinol Metab. 2007 Dec; 3(12):835-40. PMID: 18026162.
    Citations: 7     Fields:    Translation:Humans
  140. Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 2007 Nov; 117(11):3463-74. PMID: 17932564.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  141. Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN. Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest. 2007 Oct; 117(10):2860-8. PMID: 17909627.
    Citations: 63     Fields:    Translation:AnimalsCells
  142. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep; 27(17):6026-37. PMID: 17576812.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  143. Kulkarni RN, Kahn CR. Ephs and ephrins keep pancreatic Beta cells connected. Cell. 2007 Apr 20; 129(2):241-3. PMID: 17448984.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  144. Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN. Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8977-82. PMID: 17416680.
    Citations: 82     Fields:    Translation:AnimalsCells
  145. Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb; 56(2):311-9. PMID: 17259374.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  146. Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 2006 Nov; 26(22):8217-27. PMID: 16966378.
    Citations: 85     Fields:    Translation:AnimalsCells
  147. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2006 Nov; 20(11):2671-81. PMID: 16803864.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  148. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 2006 Jun 23; 312(5781):1763-6. PMID: 16794074.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  149. Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet. 2006 May; 38(5):583-8. PMID: 16642022.
    Citations: 66     Fields:    Translation:HumansAnimals
  150. He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93. PMID: 16469952.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  151. Neubauer N, Kulkarni RN. Molecular approaches to study control of glucose homeostasis. ILAR J. 2006; 47(3):199-211. PMID: 16804195.
    Citations: 10     Fields:    Translation:HumansAnimals
  152. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49. PMID: 16096055.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  153. Kulkarni RN. New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord. 2005 Aug; 6(3):199-210. PMID: 16151624.
    Citations: 31     Fields:    Translation:AnimalsCells
  154. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. PMID: 15827066.
    Citations: 9     Fields:    Translation:AnimalsCells
  155. Bates SH, Kulkarni RN, Seifert M, Myers MG. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab. 2005 Mar; 1(3):169-78. PMID: 16054060.
    Citations: 49     Fields:    Translation:AnimalsCells
  156. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36. PMID: 15372107.
    Citations: 87     Fields:    Translation:Animals
  157. Kulkarni RN, Roper MG, Dahlgren G, Shih DQ, Kauri LM, Peters JL, Stoffel M, Kennedy RT. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes. 2004 Jun; 53(6):1517-25. PMID: 15161756.
    Citations: 15     Fields:    Translation:AnimalsCells
  158. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. PMID: 15107844.
    Citations: 180     Fields:    Translation:HumansAnimalsCells
  159. Goren HJ, Kulkarni RN, Kahn CR. Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology. 2004 Jul; 145(7):3307-23. PMID: 15044376.
    Citations: 46     Fields:    Translation:AnimalsCells
  160. Kulkarni RN. The islet beta-cell. Int J Biochem Cell Biol. 2004 Mar; 36(3):365-71. PMID: 14687913.
    Citations: 7     Fields:    Translation:Animals
  161. Kulkarni RN, Kahn CR. Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes. Science. 2004 Feb 27; 303(5662):1311-2. PMID: 14988544.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  162. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest. 2003 Nov; 112(10):1521-32. PMID: 14617753.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  163. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9. PMID: 14517292.
    Citations: 56     Fields:    Translation:Animals
  164. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E41-9. PMID: 14519599.
    Citations: 31     Fields:    Translation:AnimalsCells
  165. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. PMID: 12842910.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  166. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003 Jun 06; 300(5625):1574-7. PMID: 12791994.
    Citations: 269     Fields:    Translation:HumansAnimalsCells
  167. Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes. 2003 Jun; 52(6):1535-43. PMID: 12765967.
    Citations: 18     Fields:    Translation:Animals