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Daniel Adam Mordes, M.D., Ph.D.

Title
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Department
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Biography
Duke UniversityBSE05/2003Biomedical Engineering
Vanderbilt UniversityPhD09/2008Biochemistry
Vanderbilt UniversityMD05/2010Medicine
2008
Leon W. Cunningham Graduate Biochemistry Award
2009
Alpha Omega Alpha
2010
John G. Coniglio Prize in Biochemistry
2010
Dean’s Award for Research
2014
AANP Travel Award
2015
ALS Association Investigator-Initiated Starter Award
2015
Cozzarelli Prize (paper of the year) in PNAS
2017 - 2018
Massachusetts Alzheimer’s Disease Research Center (ADRC) Pilot Project Award
2019 - 2024
NINDS Mentored Clinical Scientist Research Career Development Award (K08)

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08NS104270 (MORDES, DANIEL ADAM) Aug 15, 2019 - May 31, 2024
    NIH
    Novel pathways in C9ORF72-associated ALS and dementia
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mordes DA, Morrison BM, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang JY, Eggan K, Rothstein JD. Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice. Neuron. 2020 11 25; 108(4):775-783.e4. PMID: 33022228.
    Citations:    Fields:    Translation:AnimalsCells
  2. Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. Kinetics of a-synuclein prions preceding neuropathological inclusions in multiple system atrophy. PLoS Pathog. 2020 02; 16(2):e1008222. PMID: 32017806.
    Citations: 2     Fields:    Translation:HumansAnimals
  3. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Khleifat AA, Mordes DA, Ghosh S, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2020 Feb; 23(2):295. PMID: 31857710.
    Citations: 2     Fields:    
  4. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2019 12; 22(12):1966-1974. PMID: 31768050.
    Citations: 16     Fields:    Translation:Humans
  5. Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB. Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines. Acta Neuropathol. 2019 03; 137(3):437-454. PMID: 30690664.
    Citations: 18     Fields:    Translation:HumansAnimals
  6. Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. 2019 02; 22(2):167-179. PMID: 30643292.
    Citations: 45     Fields:    Translation:HumansCells
  7. Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018 07 04; 6(1):55. PMID: 29973287.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K. The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018 07 01; 32(13-14):929-943. PMID: 29950492.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  9. Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB. Familial Parkinson's point mutation abolishes multiple system atrophy prion replication. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):409-414. PMID: 29279394.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  10. Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB. MSA prions exhibit remarkable stability and resistance to inactivation. Acta Neuropathol. 2018 01; 135(1):49-63. PMID: 28849371.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  11. Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7701-E7709. PMID: 27849576.
    Citations: 44     Fields:    Translation:HumansCells
  12. Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K. Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nat Commun. 2016 10 31; 7:13283. PMID: 27796305.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  13. Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. PMID: 27412785.
    Citations: 73     Fields:    Translation:Animals
  14. LaBuzetta JN, Mordes D, Arrillaga I, Chi A, Dietrich J. A 34-Year-Old Male with An Intracranial Mass. Brain Pathol. 2016 Mar; 26(2):289-90. PMID: 27000488.
    Citations:    Fields:    Translation:Humans
  15. Agarwalla PK, Koch MJ, Mordes DA, Codd PJ, Coumans JV. Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology. Neurosurgery. 2016 Jan; 78(1):142-55. PMID: 26355366.
    Citations:    Fields:    Translation:HumansAnimals
  16. Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622. PMID: 26564777.
    Citations: 18     Fields:    Translation:HumansCells
  17. Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA. Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock. N Engl J Med. 2015 Sep 24; 373(13):1251-61. PMID: 26398074.
    Citations: 1     Fields:    Translation:Humans
  18. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. PMID: 26324905.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  19. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4949-58. PMID: 26286986.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  20. Lin TY, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA. Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia. N Engl J Med. 2015 Apr 16; 372(16):1550-62. PMID: 25875261.
    Citations:    Fields:    Translation:Humans
  21. Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP. VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations. Am J Clin Pathol. 2014 Jun; 141(6):811-5. PMID: 24838325.
    Citations: 9     Fields:    Translation:Humans
  22. Ginat DT, Walcott BP, Mordes D, Schaefer PW, Nahed B. Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. Clin Imaging. 2014 May-Jun; 38(3):322-5. PMID: 24456989.
    Citations: 1     Fields:    Translation:Humans
  23. Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS. Glioblastoma mimicking an arteriovenous malformation. Front Neurol. 2013; 4:144. PMID: 24137154.
    Citations: 5     
  24. Mordes DA, Brachtel EF. Cytopathology of subacute thyroiditis. Diagn Cytopathol. 2012 May; 40(5):433-4. PMID: 22045514.
    Citations: 3     Fields:    Translation:Humans
  25. Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS. A workshop on leadership for MD/PhD students. Med Educ Online. 2011; 16. PMID: 21841905.
    Citations: 4     Fields:    Translation:Humans
  26. DeCroos FC, Kondo Y, Mordes D, Lee MR, Ahmad S, Asrani S, Allingham RR, Olbrich KC, Klitzman B. In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene. Curr Eye Res. 2011 Feb; 36(2):112-7. PMID: 21281065.
    Citations: 4     Fields:    
  27. DeCroos FC, Ahmad S, Kondo Y, Chow J, Mordes D, Lee MR, Asrani S, Allingham RR, Olbrich KC, Klitzman B. Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve. Curr Eye Res. 2009 Jul; 34(7):562-7. PMID: 19899969.
    Citations: 7     Fields:    Translation:Animals
  28. Mordes DA, Nam EA, Cortez D. Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18730-4. PMID: 19028869.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  29. Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol. 2008 Dec; 28(24):7345-53. PMID: 18936170.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  30. Mordes DA, Cortez D. Activation of ATR and related PIKKs. . 2008 Sep 15; 7(18):2809-12. PMID: 18769153.
    Citations: 33     Translation:HumansAnimalsCells
  31. Mordes DA, Glick GG, Zhao R, Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008 Jun 01; 22(11):1478-89. PMID: 18519640.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  32. Mordes D, Yuan L, Xu L, Kawada M, Molday RS, Wu JY. Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa. Neurobiol Dis. 2007 May; 26(2):291-300. PMID: 17350276.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D. Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol. 2007 May; 27(9):3367-77. PMID: 17339343.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  34. Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P, Wu JY. Pre-mRNA splicing and retinitis pigmentosa. Mol Vis. 2006 Oct 26; 12:1259-71. PMID: 17110909.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.