Rachel Amy Ross, M.D.,Ph.D.
Instructor in Psychiatry
Neurobiology of Fear Lab
115 Mill St - Mailstop 339
Belmont MA 02478
Available: 01/07/19, Expires: 12/31/20
Understanding the signaling and circuitry involved in homeostatically driven food intake and its interplay with reward, stress, and attention related pathways is essential in developing appropriate treatments for the spectrum of eating disorders (from obesity to anorexia). We use mouse models, and also human samples, to study the underlying neural circuitry, hormone changes and behavior related to feeding and metabolism in the setting of stress in order to understand how these processes may lead to disease. For this project we are specifically investigating the role of diet-based motivation on cognitive behavior.
Students can choose from a variety of potential projects. Those interested in animal research will learn to model simple and complex animal behavior, and process tissues to understand the role individual neurons or neuromodulators play in that behavior. Specifically students will assay feeding behavior and cognitive flexibility, in the setting of different perturbations to neural circuitry and neural hormones known to be involved in metabolism and stress response using optogenetics, chemogenetics, and conditional knockout models. Students may also learn basic neuroscience techniques, including animal perfusion and brain slice mounting. Students who are interested in clinical research, or are less interested in hands on animal work, can participate in ongoing projects by performing literature reviews and data analysis relevant to ongoing projects, currently related to diet and stress effects on cognitive behavior.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
(ROSS, RACHEL A)
Feb 28, 2019 - Dec 31, 2022
Dissecting a novel prefrontal cortical pathway regulating feeding behavior
Role: Principal Investigator
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