Harvard Catalyst Profiles

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Jennifer Rose Gatchel, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23AG058805 (GATCHEL, JENNIFER ROSE) Apr 1, 2018 - Mar 31, 2023
    Depressive symptoms in the pathogenesis of preclinical Alzheimer's Disease
    Role: Principal Investigator
  2. F30MH072117 (GATCHEL, JENNIFER R) Sep 27, 2004 - Sep 26, 2008
    Studying the Mechanism of Neuronal Dysfunction in SCA7
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Capuano AW, Wilson RS, Honer WG, Petyuk VA, Leurgans SE, Yu L, Gatchel JR, Arnold S, Bennett DA, Arvanitakis Z. Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons. J Affect Disord. 2019 Mar 08; 250:313-318. PMID: 30875674.
  2. Hanseeuw BJ, Lopera F, Sperling RA, Norton DJ, Guzman-Velez E, Baena A, Pardilla-Delgado E, Schultz AP, Gatchel J, Jin D, Chen K, Reiman EM, Johnson KA, Quiroz YT. Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer's disease. Alzheimers Res Ther. 2019 Feb 04; 11(1):17. PMID: 30717814.
  3. Halawa OA, Gatchel JR, Amariglio RE, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease. Alzheimers Res Ther. 2019 Jan 31; 11(1):14. PMID: 30704519.
    Citations:    Fields:    
  4. Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019 Feb; 85(2):181-193. PMID: 30549303.
    Citations:    Fields:    
  5. Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Vascular Risk and ß-Amyloid Are Synergistically Associated with Cortical Tau. Ann Neurol. 2019 Feb; 85(2):272-279. PMID: 30565287.
    Citations:    Fields:    
  6. Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia. J Alzheimers Dis. 2019; 67(2):757-768. PMID: 30689584.
    Citations:    Fields:    
  7. Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT. Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred. J Prev Alzheimers Dis. 2019; 6(2):112-120. PMID: 30756118.
  8. Ismail Z, Gatchel J, Bateman DR, Barcelos-Ferreira R, Cantillon M, Jaeger J, Donovan NJ, Mortby ME. Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria - CORRIGENDUM. Int Psychogeriatr. 2019 Jan; 31(1):157. PMID: 30461372.
    Citations:    Fields:    
  9. Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. Am J Psychiatry. 2018 Jun 01; 175(6):530-537. PMID: 29325447.
    Citations: 2     Fields:    
  10. Ehrenberg AJ, Suemoto CK, França Resende EP, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT. Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease. J Alzheimers Dis. 2018; 66(1):115-126. PMID: 30223398.
    Citations:    Fields:    
  11. Rej S, Quayle W, Forester BP, Dols A, Gatchel J, Chen P, Gough S, Fox R, Sajatovic M, Strejilevich SA, Eyler LT. Measurement tools for assessment of older age bipolar disorder: A systematic review of the recent global literature. Bipolar Disord. 2018 06; 20(4):359-369. PMID: 29108106.
  12. Ismail Z, Gatchel J, Bateman DR, Barcelos-Ferreira R, Chantillon M, Jaeger J, Donovan NJ, Mortby ME. Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria. Int Psychogeriatr. 2018 02; 30(2):185-196. PMID: 28899446.
    Citations: 1     Fields:    Translation:Humans
  13. Wang S, Wu Y, Ungvari GS, Ng CH, Forester BP, Gatchel JR, Chiu HFK, Kou C, Fu Y, Qi Y, Yu Y, Li B, Xiang YT. Sleep duration and its association with demographics, lifestyle factors, poor mental health and chronic diseases in older Chinese adults. Psychiatry Res. 2017 11; 257:212-218. PMID: 28777953.
    Citations:    Fields:    Translation:Humans
  14. Gatchel JR, Forester BP. Editorial Comment: Running Out of Time: Clock Copying as a Psychometric to Predict Mortality in Vulnerable Older Adults? Am J Geriatr Psychiatry. 2017 Sep; 25(9):1017-1018. PMID: 28600125.
    Citations:    Fields:    
  15. Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid ß. Alzheimers Dement. 2017 Sep; 13(9):1004-1012. PMID: 28253478.
    Citations: 8     Fields:    Translation:Humans
  16. Gatchel JR, Donovan NJ, Locascio JJ, Becker JA, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease. Am J Geriatr Psychiatry. 2017 Jul; 25(7):683-693. PMID: 28410856.
    Citations: 2     Fields:    Translation:Humans
  17. Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. J Alzheimers Dis. 2017; 59(3):975-985. PMID: 28697559.
    Citations: 2     Fields:    Translation:Humans
  18. Gatchel JR. Positive Psychiatry: A Clinical Handbook, Edited by Dilip V. Jeste and Barton W. Palmer. Psychiatry. 2017; 80(2):203-205. PMID: 28767334.
  19. Lokko HN, Gatchel JR, Becker MA, Stern TA. The Art and Science of Learning, Teaching, and Delivering Feedback in Psychosomatic Medicine. Psychosomatics. 2016 Jan-Feb; 57(1):31-40. PMID: 26683348.
    Citations:    Fields:    Translation:Humans
  20. Gatchel J, Legesse B, Tayeb S, Murray E, Price B. Neurosyphilis in psychiatric practice: a case-based discussion of clinical evaluation and diagnosis. Gen Hosp Psychiatry. 2015 Sep-Oct; 37(5):459-63. PMID: 26022384.
    Citations:    Fields:    Translation:Humans
  21. Forester BP, Gatchel JR. Medical co-morbidity, brain disease, and the future of geriatric psychiatry. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1061-5. PMID: 25307312.
    Citations:    Fields:    Translation:Humans
  22. Perroud B, Jafar-Nejad P, Wikoff WR, Gatchel JR, Wang L, Barupal DK, Crespo-Barreto J, Fiehn O, Zoghbi HY, Kaddurah-Daouk R. Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects. PLoS One. 2013; 8(8):e70610. PMID: 23936457; PMCID: PMC3732229.
    Citations: 2     Fields:    Translation:Animals
  23. Chen YC, Gatchel JR, Lewis RW, Mao CA, Grant PA, Zoghbi HY, Dent SY. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet. 2012 Jan 15; 21(2):394-405. PMID: 22002997; PMCID: PMC3276287.
    Citations: 18     Fields:    Translation:AnimalsCells
  24. Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat Neurosci. 2008 Oct; 11(10):1137-9. PMID: 18758459; PMCID: PMC2574629.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  25. Gatchel JR, Watase K, Thaller C, Carson JP, Jafar-Nejad P, Shaw C, Zu T, Orr HT, Zoghbi HY. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1291-6. PMID: 18216249; PMCID: PMC2234131.
    Citations: 21     Fields:    Translation:AnimalsCells
  26. Watase K, Gatchel JR, Sun Y, Emamian E, Atkinson R, Richman R, Mizusawa H, Orr HT, Shaw C, Zoghbi HY. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med. 2007 May; 4(5):e182. PMID: 17535104; PMCID: PMC1880853.
    Citations: 57     Fields:    Translation:AnimalsCells
  27. Gatchel JR, Zoghbi HY. Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet. 2005 Oct; 6(10):743-55. PMID: 16205714.
    Citations: 258     Fields:    Translation:HumansCells
  28. Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. J Neurosci. 2004 Apr 07; 24(14):3643-54. PMID: 15071113.
    Citations: 53     Fields:    Translation:AnimalsCells
  29. Gazo BM, Murphy P, Gatchel JR, Browning KS. A novel interaction of Cap-binding protein complexes eukaryotic initiation factor (eIF) 4F and eIF(iso)4F with a region in the 3'-untranslated region of satellite tobacco necrosis virus. J Biol Chem. 2004 Apr 02; 279(14):13584-92. PMID: 14729906.
    Citations: 36     Fields:    Translation:Cells
  30. Bick RJ, Poindexter BJ, Tong S, Kalis NN, Van der Merwe P, Gatchel J, Young DC. Effects of IgM from rheumatic fever patients on intracellular calcium levels of neonatal rat cardiac myocytes. Life Sci. 2003 Sep 05; 73(16):2101-11. PMID: 12899933.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.