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Jennifer Rose Gatchel, M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23AG058805 (GATCHEL, JENNIFER ROSE) Apr 1, 2018 - Mar 31, 2023
    NIH/NIA
    Depressive symptoms in the pathogenesis of preclinical Alzheimer's Disease
    Role: Principal Investigator
  2. F30MH072117 (GATCHEL, JENNIFER R) Sep 27, 2004 - Sep 26, 2008
    NIH/NIMH
    Studying the Mechanism of Neuronal Dysfunction in SCA7
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ismail Z, Gatchel J, Bateman DR, Barcelos-Ferreira R, Cantillon M, Jaeger J, Donovan NJ, Mortby ME. Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria - CORRIGENDUM. Int Psychogeriatr. 2018 Nov 21; 1. PMID: 30461372.
    View in: PubMed
  2. Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. Am J Psychiatry. 2018 Jun 01; 175(6):530-537. PMID: 29325447.
    View in: PubMed
  3. Ehrenberg AJ, Suemoto CK, França Resende EP, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT. Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease. J Alzheimers Dis. 2018; 66(1):115-126. PMID: 30223398.
    View in: PubMed
  4. Rej S, Quayle W, Forester BP, Dols A, Gatchel J, Chen P, Gough S, Fox R, Sajatovic M, Strejilevich SA, Eyler LT. Measurement tools for assessment of older age bipolar disorder: A systematic review of the recent global literature. Bipolar Disord. 2018 Jun; 20(4):359-369. PMID: 29108106.
    View in: PubMed
  5. Ismail Z, Gatchel J, Bateman DR, Barcelos-Ferreira R, Chantillon M, Jaeger J, Donovan NJ, Mortby ME. Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria. Int Psychogeriatr. 2018 02; 30(2):185-196. PMID: 28899446.
    View in: PubMed
  6. Wang S, Wu Y, Ungvari GS, Ng CH, Forester BP, Gatchel JR, Chiu HFK, Kou C, Fu Y, Qi Y, Yu Y, Li B, Xiang YT. Sleep duration and its association with demographics, lifestyle factors, poor mental health and chronic diseases in older Chinese adults. Psychiatry Res. 2017 11; 257:212-218. PMID: 28777953.
    View in: PubMed
  7. Gatchel JR, Forester BP. Editorial Comment: Running Out of Time: Clock Copying as a Psychometric to Predict Mortality in Vulnerable Older Adults? Am J Geriatr Psychiatry. 2017 Sep; 25(9):1017-1018. PMID: 28600125.
    View in: PubMed
  8. Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid ß. Alzheimers Dement. 2017 Sep; 13(9):1004-1012. PMID: 28253478.
    View in: PubMed
  9. Gatchel JR, Donovan NJ, Locascio JJ, Becker JA, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease. Am J Geriatr Psychiatry. 2017 Jul; 25(7):683-693. PMID: 28410856.
    View in: PubMed
  10. Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. J Alzheimers Dis. 2017; 59(3):975-985. PMID: 28697559.
    View in: PubMed
  11. Gatchel JR. Positive Psychiatry: A Clinical Handbook, Edited by Dilip V. Jeste and Barton W. Palmer. Psychiatry. 2017; 80(2):203-205. PMID: 28767334.
    View in: PubMed
  12. Lokko HN, Gatchel JR, Becker MA, Stern TA. The Art and Science of Learning, Teaching, and Delivering Feedback in Psychosomatic Medicine. Psychosomatics. 2016 Jan-Feb; 57(1):31-40. PMID: 26683348.
    View in: PubMed
  13. Gatchel J, Legesse B, Tayeb S, Murray E, Price B. Neurosyphilis in psychiatric practice: a case-based discussion of clinical evaluation and diagnosis. Gen Hosp Psychiatry. 2015 Sep-Oct; 37(5):459-63. PMID: 26022384.
    View in: PubMed
  14. Forester BP, Gatchel JR. Medical co-morbidity, brain disease, and the future of geriatric psychiatry. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1061-5. PMID: 25307312.
    View in: PubMed
  15. Perroud B, Jafar-Nejad P, Wikoff WR, Gatchel JR, Wang L, Barupal DK, Crespo-Barreto J, Fiehn O, Zoghbi HY, Kaddurah-Daouk R. Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects. PLoS One. 2013; 8(8):e70610. PMID: 23936457; PMCID: PMC3732229.
  16. Chen YC, Gatchel JR, Lewis RW, Mao CA, Grant PA, Zoghbi HY, Dent SY. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet. 2012 Jan 15; 21(2):394-405. PMID: 22002997; PMCID: PMC3276287.
  17. Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat Neurosci. 2008 Oct; 11(10):1137-9. PMID: 18758459; PMCID: PMC2574629.
  18. Gatchel JR, Watase K, Thaller C, Carson JP, Jafar-Nejad P, Shaw C, Zu T, Orr HT, Zoghbi HY. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1291-6. PMID: 18216249; PMCID: PMC2234131.
  19. Watase K, Gatchel JR, Sun Y, Emamian E, Atkinson R, Richman R, Mizusawa H, Orr HT, Shaw C, Zoghbi HY. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med. 2007 May; 4(5):e182. PMID: 17535104; PMCID: PMC1880853.
  20. Gatchel JR, Zoghbi HY. Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet. 2005 Oct; 6(10):743-55. PMID: 16205714.
    View in: PubMed
  21. Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. J Neurosci. 2004 Apr 07; 24(14):3643-54. PMID: 15071113.
    View in: PubMed
  22. Gazo BM, Murphy P, Gatchel JR, Browning KS. A novel interaction of Cap-binding protein complexes eukaryotic initiation factor (eIF) 4F and eIF(iso)4F with a region in the 3'-untranslated region of satellite tobacco necrosis virus. J Biol Chem. 2004 Apr 02; 279(14):13584-92. PMID: 14729906.
    View in: PubMed
  23. Bick RJ, Poindexter BJ, Tong S, Kalis NN, Van der Merwe P, Gatchel J, Young DC. Effects of IgM from rheumatic fever patients on intracellular calcium levels of neonatal rat cardiac myocytes. Life Sci. 2003 Sep 05; 73(16):2101-11. PMID: 12899933.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.