Harvard Catalyst Profiles

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James Moon, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01DK126910 (MOON, JAMES J) Jun 9, 2021 - Apr 30, 2025
    NIH
    T cell Tolerance to Enteric Commensal Bacteria
    Role: Principal Investigator
  2. R21AI124143 (MOON, JAMES J) Dec 15, 2016 - Nov 30, 2018
    NIH
    CD4+ T cell Tolerance to Enteric Commensal Bacteria
    Role: Principal Investigator
  3. R01AI107020 (MOON, JAMES J) Dec 1, 2013 - Nov 30, 2018
    NIH
    Self Antigen Specific CD4 Positive T cells
    Role: Principal Investigator
  4. U19AI095261 (LUSTER, ANDREW D) Aug 5, 2011 - Jul 31, 2016
    NIH
    T cell effector and regulatory mechanisms in asthma and food allergy
    Role: Co-Principal Investigator
  5. F32AI063793 (MOON, JAMES J) Feb 1, 2006 - Jan 31, 2008
    NIH
    Role of Cytokines in Naive CD4+ T cell Activation
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shin DS, Ratnapriya S, Cashin CN, Kuhn LF, Rahimi RA, Anthony RM, Moon JJ. Lung injury induces a polarized immune response by self antigen-specific Foxp3 + regulatory T cells. bioRxiv. 2023 Feb 10. PMID: 36798259; PMCID: PMC9934659.
    Citations:    
  2. Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM. A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo. Cell Rep Med. 2022 10 18; 3(10):100774. PMID: 36195094; PMCID: PMC9519379.
    Citations: 2     Fields:    Translation:HumansCells
  3. Li H, Adamopoulos IE, Moulton VR, Stillman IE, Herbert Z, Moon JJ, Sharabi A, Krishfield S, Tsokos MG, Tsokos GC. Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells. Nat Commun. 2020 06 05; 11(1):2859. PMID: 32503973.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  4. Zhang Z, Legoux FP, Vaughan SW, Moon JJ. Opposing peripheral fates of tissue-restricted self antigen-specific conventional and regulatory CD4+ T cells. Eur J Immunol. 2020 01; 50(1):63-72. PMID: 31580477.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT. Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science. 2018 09 14; 361(6407). PMID: 30213884.
    Citations: 81     Fields:    Translation:AnimalsCells
  6. Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD. Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. 2016 10 05; 8(359):359ra132. PMID: 27708065; PMCID: PMC5399547.
    Citations: 22     Fields:    Translation:HumansCells
  7. Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AW, Rezk T, Fontana M, Palladini G, Milani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation. 2016 Jun 14; 133(24):2404-12. PMID: 27143678.
    Citations: 453     Fields:    Translation:Humans
  8. Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17; 43(5):1011-21. PMID: 26588783.
    Citations: 202     Fields:    Translation:AnimalsCells
  9. Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ. CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity. 2015 Nov 17; 43(5):896-908. PMID: 26572061.
    Citations: 108     Fields:    Translation:AnimalsCells
  10. Moon JJ, Jenkins MK. The human T-cell repertoire grows up. Immunol Cell Biol. 2015 Aug; 93(7):601-2. PMID: 25939281.
    Citations: 2     Fields:    Translation:HumansCells
  11. Nelson RW, Beisang D, Tubo NJ, Dileepan T, Wiesner DL, Nielsen K, Wüthrich M, Klein BS, Kotov DI, Spanier JA, Fife BT, Moon JJ, Jenkins MK. T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity. 2015 Jan 20; 42(1):95-107. PMID: 25601203; PMCID: PMC4355167.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  12. Pauken KE, Linehan JL, Spanier JA, Sahli NL, Kalekar LA, Binstadt BA, Moon JJ, Mueller DL, Jenkins MK, Fife BT. Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice. J Immunol. 2013 Nov 15; 191(10):4913-7. PMID: 24123682; PMCID: PMC3987747.
    Citations: 36     Fields:    Translation:AnimalsCells
  13. Jenkins MK, Moon JJ. Response to comment on “The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude”. J Immunol. 2013 Mar 01; 190(5):1896. PMID: 23544199.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 2012 Dec 14; 37(6):1091-103. PMID: 23123063.
    Citations: 195     Fields:    Translation:AnimalsCells
  15. Legoux FP, Moon JJ. Peptide:MHC tetramer-based enrichment of epitope-specific T cells. J Vis Exp. 2012 Oct 22; (68). PMID: 23117190.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7847-52. PMID: 22552229.
    Citations: 66     Fields:    Translation:AnimalsCellsPHPublic Health
  17. Jenkins MK, Moon JJ. The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J Immunol. 2012 May 01; 188(9):4135-40. PMID: 22517866; PMCID: PMC3334329.
    Citations: 159     Fields:    Translation:HumansAnimalsCells
  18. Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD. CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. J Immunol. 2011 Dec 15; 187(12):6197-207. PMID: 22075698; PMCID: PMC3237896.
    Citations: 10     Fields:    Translation:AnimalsCells
  19. Dileepan T, Linehan JL, Moon JJ, Pepper M, Jenkins MK, Cleary PP. Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog. 2011 Sep; 7(9):e1002252. PMID: 21966268.
    Citations: 46     Fields:    Translation:AnimalsCells
  20. Moon JJ, Dash P, Oguin TH, McClaren JL, Chu HH, Thomas PG, Jenkins MK. Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14602-7. PMID: 21873213.
    Citations: 71     Fields:    Translation:AnimalsCells
  21. Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, Irvine DJ. Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. J Control Release. 2012 Feb 10; 157(3):354-65. PMID: 21820024; PMCID: PMC3811132.
    Citations: 41     Fields:    Translation:AnimalsCells
  22. Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Khant H, Goodwin JT, Ramos J, Chiu W, Irvine DJ. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater. 2011 Mar; 10(3):243-51. PMID: 21336265; PMCID: PMC3077947.
    Citations: 181     Fields:    Translation:Animals
  23. Reiley WW, Shafiani S, Wittmer ST, Tucker-Heard G, Moon JJ, Jenkins MK, Urdahl KB, Winslow GM, Woodland DL. Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19408-13. PMID: 20962277.
    Citations: 107     Fields:    Translation:AnimalsCells
  24. Chu HH, Moon JJ, Kruse AC, Pepper M, Jenkins MK. Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations. J Immunol. 2010 Oct 15; 185(8):4705-13. PMID: 20861357; PMCID: PMC3510669.
    Citations: 30     Fields:    Translation:AnimalsCells
  25. Winstead CJ, Reilly CS, Moon JJ, Jenkins MK, Hamilton SE, Jameson SC, Way SS, Khoruts A. CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol. 2010 May 01; 184(9):4749-60. PMID: 20357265; PMCID: PMC3813316.
    Citations: 11     Fields:    Translation:AnimalsCells
  26. Jenkins MK, Chu HH, McLachlan JB, Moon JJ. On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands. Annu Rev Immunol. 2010; 28:275-94. PMID: 20307209.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  27. Chu HH, Moon JJ, Takada K, Pepper M, Molitor JA, Schacker TW, Hogquist KA, Jameson SC, Jenkins MK. Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11241-5. PMID: 19541603.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  28. Hu Y, Atukorale PU, Lu JJ, Moon JJ, Um SH, Cho EC, Wang Y, Chen J, Irvine DJ. Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles. Biomacromolecules. 2009 Apr 13; 10(4):756-65. PMID: 19239276; PMCID: PMC2769516.
    Citations: 25     Fields:    Translation:AnimalsCells
  29. McLachlan JB, Catron DM, Moon JJ, Jenkins MK. Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity. 2009 Feb 20; 30(2):277-88. PMID: 19200757.
    Citations: 88     Fields:    Translation:AnimalsCells
  30. Moon JJ, Chu HH, Hataye J, Pagán AJ, Pepper M, McLachlan JB, Zell T, Jenkins MK. Tracking epitope-specific T cells. Nat Protoc. 2009; 4(4):565-81. PMID: 19373228.
    Citations: 187     Fields:    Translation:AnimalsCells
  31. Moon JJ, McSorley SJ. Tracking the dynamics of salmonella specific T cell responses. Curr Top Microbiol Immunol. 2009; 334:179-98. PMID: 19521686.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  32. Jusforgues-Saklani H, Uhl M, Blachère N, Lemaître F, Lantz O, Bousso P, Braun D, Moon JJ, Albert ML. Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming. J Immunol. 2008 Sep 01; 181(5):3067-76. PMID: 18713977.
    Citations: 20     Fields:    Translation:AnimalsCells
  33. Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity. 2008 Jan; 28(1):112-21. PMID: 18199418.
    Citations: 215     Fields:    Translation:AnimalsCells
  34. Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity. 2007 Aug; 27(2):203-13. PMID: 17707129.
    Citations: 527     Fields:    Translation:AnimalsCellsPHPublic Health
  35. Medeiros RB, Burbach BJ, Mueller KL, Srivastava R, Moon JJ, Highfill S, Peterson EJ, Shimizu Y. Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. Science. 2007 May 04; 316(5825):754-8. PMID: 17478723.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  36. Hataye J, Moon JJ, Khoruts A, Reilly C, Jenkins MK. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science. 2006 Apr 07; 312(5770):114-6. PMID: 16513943.
    Citations: 197     Fields:    Translation:AnimalsCells
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.