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profileJames Moon, Ph.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Ctr for Immunology & Inflammatory Disease
149 13th Street
Charlestown MA 02129
Phone617/726-4161
Fax617/726-5651
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AI124143     (MOON, JAMES J)Dec 15, 2016 - Nov 30, 2018
NIH/NIAID
CD4+ T cell Tolerance to Enteric Commensal Bacteria
Role: Principal Investigator

R01AI107020     (MOON, JAMES J)Dec 1, 2013 - Nov 30, 2018
NIH/NIAID
Self Antigen Specific CD4 Positive T cells
Role: Principal Investigator

U19AI095261     (LUSTER, ANDREW D)Aug 5, 2011 - Jul 31, 2016
NIH/NIAID
T cell effector and regulatory mechanisms in asthma and food allergy
Role: Co-Principal Investigator

F32AI063793     (MOON, JAMES J)Feb 1, 2006 - Jan 31, 2008
NIH/NIAID
Role of Cytokines in Naive CD4+ T cell Activation
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD. Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. 2016 Oct 05; 8(359):359ra132. PMID: 27708065.
    View in: PubMed
  2. Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AW, Rezk T, Fontana M, Palladini G, Milani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation. 2016 Jun 14; 133(24):2404-12. PMID: 27143678.
    View in: PubMed
  3. Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ. CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity. 2015 Nov 17; 43(5):896-908. PMID: 26572061; PMCID: PMC4654997 [Available on 11/17/16].
  4. Moon JJ, Jenkins MK. The human T-cell repertoire grows up. Immunol Cell Biol. 2015 Aug; 93(7):601-2. PMID: 25939281.
    View in: PubMed
  5. Nelson RW, Beisang D, Tubo NJ, Dileepan T, Wiesner DL, Nielsen K, Wüthrich M, Klein BS, Kotov DI, Spanier JA, Fife BT, Moon JJ, Jenkins MK. T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity. 2015 Jan 20; 42(1):95-107. PMID: 25601203; PMCID: PMC4355167.
  6. Pauken KE, Linehan JL, Spanier JA, Sahli NL, Kalekar LA, Binstadt BA, Moon JJ, Mueller DL, Jenkins MK, Fife BT. Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice. J Immunol. 2013 Nov 15; 191(10):4913-7. PMID: 24123682; PMCID: PMC3987747.
  7. Jenkins MK, Moon JJ. Response to comment on “The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude”. J Immunol. 2013 Mar 01; 190(5):1896. PMID: 23544199.
    View in: PubMed
  8. Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 2012 Dec 14; 37(6):1091-103. PMID: 23123063; PMCID: PMC3525757.
  9. Legoux FP, Moon JJ. Peptide:MHC tetramer-based enrichment of epitope-specific T cells. J Vis Exp. 2012 Oct 22; (68). PMID: 23117190; PMCID: PMC3490303.
  10. Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7847-52. PMID: 22552229; PMCID: PMC3356674.
  11. Jenkins MK, Moon JJ. The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J Immunol. 2012 May 01; 188(9):4135-40. PMID: 22517866; PMCID: PMC3334329.
  12. Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD. CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. J Immunol. 2011 Dec 15; 187(12):6197-207. PMID: 22075698; PMCID: PMC3237896.
  13. Dileepan T, Linehan JL, Moon JJ, Pepper M, Jenkins MK, Cleary PP. Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog. 2011 Sep; 7(9):e1002252. PMID: 21966268; PMCID: PMC3178561.
  14. Moon JJ, Dash P, Oguin TH, McClaren JL, Chu HH, Thomas PG, Jenkins MK. Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14602-7. PMID: 21873213; PMCID: PMC3167500.
  15. Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, Irvine DJ. Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. J Control Release. 2012 Feb 10; 157(3):354-65. PMID: 21820024; PMCID: PMC3811132.
  16. Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Khant H, Goodwin JT, Ramos J, Chiu W, Irvine DJ. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater. 2011 Mar; 10(3):243-51. PMID: 21336265; PMCID: PMC3077947.
  17. Reiley WW, Shafiani S, Wittmer ST, Tucker-Heard G, Moon JJ, Jenkins MK, Urdahl KB, Winslow GM, Woodland DL. Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19408-13. PMID: 20962277; PMCID: PMC2984157.
  18. Chu HH, Moon JJ, Kruse AC, Pepper M, Jenkins MK. Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations. J Immunol. 2010 Oct 15; 185(8):4705-13. PMID: 20861357; PMCID: PMC3510669.
  19. Winstead CJ, Reilly CS, Moon JJ, Jenkins MK, Hamilton SE, Jameson SC, Way SS, Khoruts A. CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol. 2010 May 01; 184(9):4749-60. PMID: 20357265; PMCID: PMC3813316.
  20. Jenkins MK, Chu HH, McLachlan JB, Moon JJ. On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands. Annu Rev Immunol. 2010; 28:275-94. PMID: 20307209.
    View in: PubMed
  21. Chu HH, Moon JJ, Takada K, Pepper M, Molitor JA, Schacker TW, Hogquist KA, Jameson SC, Jenkins MK. Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11241-5. PMID: 19541603; PMCID: PMC2708705.
  22. Hu Y, Atukorale PU, Lu JJ, Moon JJ, Um SH, Cho EC, Wang Y, Chen J, Irvine DJ. Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles. Biomacromolecules. 2009 Apr 13; 10(4):756-65. PMID: 19239276; PMCID: PMC2769516.
  23. McLachlan JB, Catron DM, Moon JJ, Jenkins MK. Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity. 2009 Feb 20; 30(2):277-88. PMID: 19200757; PMCID: PMC2770245.
  24. Moon JJ, Chu HH, Hataye J, Pagán AJ, Pepper M, McLachlan JB, Zell T, Jenkins MK. Tracking epitope-specific T cells. Nat Protoc. 2009; 4(4):565-81. PMID: 19373228; PMCID: PMC3517879.
  25. Moon JJ, McSorley SJ. Tracking the dynamics of salmonella specific T cell responses. Curr Top Microbiol Immunol. 2009; 334:179-98. PMID: 19521686; PMCID: PMC2732114.
  26. Jusforgues-Saklani H, Uhl M, Blachère N, Lemaître F, Lantz O, Bousso P, Braun D, Moon JJ, Albert ML. Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming. J Immunol. 2008 Sep 01; 181(5):3067-76. PMID: 18713977.
    View in: PubMed
  27. Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity. 2008 Jan; 28(1):112-21. PMID: 18199418; PMCID: PMC2430111.
  28. Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity. 2007 Aug; 27(2):203-13. PMID: 17707129; PMCID: PMC2200089.
  29. Medeiros RB, Burbach BJ, Mueller KL, Srivastava R, Moon JJ, Highfill S, Peterson EJ, Shimizu Y. Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. Science. 2007 May 04; 316(5825):754-8. PMID: 17478723.
    View in: PubMed
  30. Hataye J, Moon JJ, Khoruts A, Reilly C, Jenkins MK. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science. 2006 Apr 07; 312(5770):114-6. PMID: 16513943.
    View in: PubMed
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