Harvard Catalyst Profiles

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Ana Carrizosa Anderson, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA229400 (ANDERSON, ANA C) Jul 1, 2018 - Jun 30, 2023
    NIH/NCI
    Steroid hormone regulation of immune responses
    Role: Principal Investigator
  2. R01CA187975 (ANDERSON, ANA C) Mar 1, 2015 - Feb 29, 2020
    NIH/NCI
    Role of Tim-3 in determining T cell immunity
    Role: Principal Investigator
  3. K01NS054096 (ANDERSON, ANA C) Feb 3, 2006 - Jan 31, 2011
    NIH/NINDS
    Genetic Elements that Influence Susceptibility to CNS Autoimmunity
    Role: Principal Investigator
  4. F32AI050415 (ANDERSON, ANA C) Jul 1, 2001
    NIH/NIAID
    The Role of Numb in Lymphocyte Development
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Singer M, Anderson AC. Revolutionizing Cancer Immunology: The Power of Next-Generation Sequencing Technologies. Cancer Immunol Res. 2019 Feb; 7(2):168-173. PMID: 30709909.
    Citations:    Fields:    
  2. Kurtulus S, Madi A, Escobar G, Klapholz M, Nyman J, Christian E, Pawlak M, Dionne D, Xia J, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells. Immunity. 2019 Jan 15; 50(1):181-194.e6. PMID: 30635236.
    Citations:    Fields:    
  3. Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018 06; 558(7710):454-459. PMID: 29899446.
    Citations:    Fields:    Translation:AnimalsCells
  4. Nakashima H, Nguyen T, Kasai K, Passaro C, Ito H, Goins WF, Shaikh I, Erdelyi R, Nishihara R, Nakano I, Reardon DA, Anderson AC, Kuchroo V, Chiocca EA. Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 Jun 01; 24(11):2574-2584. PMID: 29511029.
    Citations: 1     Fields:    
  5. Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N. Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. J Immunol. 2018 Apr 15; 200(8):3000-3007. PMID: 29500245.
    Citations: 2     Fields:    
  6. Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2017 11 16; 171(5):1221-1223. PMID: 29149608.
    Citations: 1     Fields:    
  7. Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC. Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy. Oncoimmunology. 2018; 7(2):e1385690. PMID: 29308307.
    Citations: 2     
  8. Wang C, Singer M, Anderson AC. Molecular Dissection of CD8+ T-Cell Dysfunction. Trends Immunol. 2017 08; 38(8):567-576. PMID: 28662970.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Dougall WC, Kurtulus S, Smyth MJ, Anderson AC. TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy. Immunol Rev. 2017 03; 276(1):112-120. PMID: 28258695.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  10. Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2016 Sep 08; 166(6):1500-1511.e9. PMID: 27610572; PMCID: PMC5019125.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  11. Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Immunity. 2016 05 17; 44(5):989-1004. PMID: 27192565; PMCID: PMC4942846.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  12. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 08 18; 536(7616):359. PMID: 26982724.
    Citations: 7     Fields:    
  13. Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC, Kuchroo VK, Behar SM. TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection. PLoS Pathog. 2016 Mar; 12(3):e1005490. PMID: 26967901.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  14. Ignatius Arokia Doss PM, Roy AP, Wang A, Anderson AC, Rangachari M. The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple Sclerosis. Front Immunol. 2015; 6:541. PMID: 26557120; PMCID: PMC4617102.
    Citations: 3     
  15. Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest. 2015 Nov 02; 125(11):4053-62. PMID: 26413872; PMCID: PMC4639980.
    Citations: 38     Fields:    Translation:AnimalsCells
  16. Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015 Jul 08; 6:7657. PMID: 26153760.
    Citations: 2     Fields:    
  17. Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK. A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation. J Autoimmun. 2015 May; 59:38-42. PMID: 25725581; PMCID: PMC4414806.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC. Consensus nomenclature for CD8+ T cell phenotypes in cancer. Oncoimmunology. 2015 Apr; 4(4):e998538. PMID: 26137416.
    Citations: 26     
  19. Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015 Jan 23; 6:6072. PMID: 25614966.
    Citations: 27     Fields:    Translation:AnimalsCells
  20. Ascierto PA, Grimaldi AM, Anderson AC, Bifulco C, Cochran A, Garbe C, Eggermont AM, Faries M, Ferrone S, Gershenwald JE, Gajewski TF, Halaban R, Hodi FS, Kefford R, Kirkwood JM, Larkin J, Leachman S, Maio M, Marais R, Masucci G, Melero I, Palmieri G, Puzanov I, Ribas A, Saenger Y, Schilling B, Seliger B, Stroncek D, Sullivan R, Testori A, Wang E, Ciliberto G, Mozzillo N, Marincola FM, Thurin M. Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013. J Transl Med. 2014 Oct 28; 12:277. PMID: 25348889; PMCID: PMC4232645.
    Citations: 5     Fields:    Translation:Humans
  21. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 01 15; 517(7534):386-90. PMID: 25363763; PMCID: PMC4297519.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  22. Kuchroo VK, Anderson AC, Petrovas C. Coinhibitory receptors and CD8 T cell exhaustion in chronic infections. Curr Opin HIV AIDS. 2014 Sep; 9(5):439-45. PMID: 25010894.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  23. Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, Kuchroo VK. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity. 2014 Aug 21; 41(2):270-82. PMID: 25065622; PMCID: PMC4219323.
    Citations: 40     Fields:    Translation:AnimalsCells
  24. Kuchroo VK, Anderson AC, Freeman GJ. Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection". J Immunol. 2014 Jul 15; 193(2):467. PMID: 24994907.
    Citations: 3     Fields:    Translation:AnimalsCells
  25. Anderson AC. Tim-3: an emerging target in the cancer immunotherapy landscape. Cancer Immunol Res. 2014 May; 2(5):393-8. PMID: 24795351.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  26. da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunol Res. 2014 May; 2(5):410-22. PMID: 24795354; PMCID: PMC4046278.
    Citations: 52     Fields:    Translation:HumansCells
  27. Fourcade J, Sun Z, Pagliano O, Chauvin JM, Sander C, Janjic B, Tarhini AA, Tawbi HA, Kirkwood JM, Moschos S, Wang H, Guillaume P, Luescher IF, Krieg A, Anderson AC, Kuchroo VK, Zarour HM. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8? T cells induced by melanoma vaccines. Cancer Res. 2014 Feb 15; 74(4):1045-55. PMID: 24343228; PMCID: PMC3952491.
    Citations: 53     Fields:    Translation:HumansCellsCTClinical Trials
  28. Sakuishi K, Ngiow SF, Sullivan JM, Teng MW, Kuchroo VK, Smyth MJ, Anderson AC. TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer. Oncoimmunology. 2013 Apr 01; 2(4):e23849. PMID: 23734331.
    Citations: 50     
  29. Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM. IL-1ß promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol. 2013 Apr 15; 190(8):4196-204. PMID: 23487424; PMCID: PMC3622150.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  30. Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med. 2012 Sep; 18(9):1394-400. PMID: 22863785; PMCID: PMC3491118.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  31. Joller N, Peters A, Anderson AC, Kuchroo VK. Immune checkpoints in central nervous system autoimmunity. Immunol Rev. 2012 Jul; 248(1):122-39. PMID: 22725958; PMCID: PMC3674871.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  32. Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012 Jul 19; 120(3):682-90. PMID: 22677125; PMCID: PMC3401220.
    Citations: 19     Fields:    Translation:AnimalsCells
  33. Anderson AC. Editorial: Tim-3 puts on the brakes. J Leukoc Biol. 2012 Feb; 91(2):183-5. PMID: 22293940.
    Citations: 1     Fields:    Translation:HumansCells
  34. Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK. A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells. J Immunol. 2012 Mar 01; 188(5):2084-92. PMID: 22279107; PMCID: PMC3288950.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  35. Anderson AC. Tim-3, a negative regulator of anti-tumor immunity. Curr Opin Immunol. 2012 Apr; 24(2):213-6. PMID: 22226204.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  36. Liu SM, Lee DH, Sullivan JM, Chung D, Jäger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov; 121(11):4303-10. PMID: 22019586; PMCID: PMC3204832.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  37. Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011 Aug; 32(8):345-9. PMID: 21697013; PMCID: PMC3164311.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  38. Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011 Apr 28; 117(17):4501-10. PMID: 21385853; PMCID: PMC3099570.
    Citations: 148     Fields:    Translation:AnimalsCells
  39. Zhu C, Anderson AC, Kuchroo VK. TIM-3 and its regulatory role in immune responses. Curr Top Microbiol Immunol. 2011; 350:1-15. PMID: 20700701.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  40. Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med. 2010 Oct 25; 207(11):2343-54. PMID: 20937702; PMCID: PMC2964580.
    Citations: 63     Fields:    Translation:AnimalsCells
  41. Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 2010 Sep 27; 207(10):2187-94. PMID: 20819927; PMCID: PMC2947065.
    Citations: 415     Fields:    Translation:AnimalsCells
  42. Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14733-8. PMID: 20679213; PMCID: PMC2930455.
    Citations: 259     Fields:    Translation:AnimalsCells
  43. Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol. 2010 Aug 01; 185(3):1383-92. PMID: 20574007; PMCID: PMC2925247.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  44. Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8706-11. PMID: 20368430; PMCID: PMC2889349.
    Citations: 74     Fields:    Translation:AnimalsCells
  45. Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK. T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol. 2010 Mar; 40(3):859-66. PMID: 20049876; PMCID: PMC2837127.
    Citations: 35     Fields:    Translation:AnimalsCells
  46. Anderson AC, Chandwaskar R, Lee DH, Kuchroo VK. Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC. J Immunol. 2008 Dec 01; 181(11):7449-52. PMID: 19017931; PMCID: PMC2614216.
    Citations: 12     Fields:    Translation:AnimalsCells
  47. Kuchroo VK, Dardalhon V, Xiao S, Anderson AC. New roles for TIM family members in immune regulation. Nat Rev Immunol. 2008 08; 8(8):577-80. PMID: 18617884.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  48. Dardalhon V, Korn T, Kuchroo VK, Anderson AC. Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun. 2008 Nov; 31(3):252-6. PMID: 18502610; PMCID: PMC3178062.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  49. Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 01; 180(7):4706-13. PMID: 18354194; PMCID: PMC2948965.
    Citations: 44     Fields:    Translation:AnimalsCells
  50. Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 2007 Nov 16; 318(5853):1141-3. PMID: 18006747.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  51. Zhu B, Bando Y, Xiao S, Yang K, Anderson AC, Kuchroo VK, Khoury SJ. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol. 2007 Oct 15; 179(8):5228-37. PMID: 17911608.
    Citations: 140     Fields:    Translation:AnimalsCells
  52. Korn T, Anderson AC, Bettelli E, Oukka M. The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis. J Neuroimmunol. 2007 Nov; 191(1-2):51-60. PMID: 17916388; PMCID: PMC2289998.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  53. Illés Z, Waldner H, Reddy J, Anderson AC, Sobel RA, Kuchroo VK. Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background. Int Immunol. 2007 Oct; 19(10):1235-48. PMID: 17804690.
    Citations: 5     Fields:    Translation:AnimalsCells
  54. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 09; 204(7):1691-702. PMID: 17606630; PMCID: PMC2118637.
    Citations: 56     Fields:    Translation:AnimalsCells
  55. Kostianovsky AM, Maier LM, Baecher-Allan C, Anderson AC, Anderson DE. Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. J Immunol. 2007 May 15; 178(10):6158-63. PMID: 17475842.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  56. Anderson AC, Xiao S, Kuchroo VK. Tim protein structures reveal a unique face for ligand binding. Immunity. 2007 Mar; 26(3):273-5. PMID: 17376389.
    Citations: 6     Fields:    Translation:AnimalsCells
  57. Anderson AC, Anderson DE. TIM-3 in autoimmunity. Curr Opin Immunol. 2006 Dec; 18(6):665-9. PMID: 17011764.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  58. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005 Dec; 6(12):1245-52. PMID: 16286920.
    Citations: 417     Fields:    Translation:AnimalsCells
  59. Manilay JO, Anderson AC, Kang C, Robey EA. Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1. J Immunol. 2005 Jun 01; 174(11):6732-41. PMID: 15905513.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  60. Anderson AC, Kitchens EA, Chan SW, St Hill C, Jan YN, Zhong W, Robey EA. The Notch regulator Numb links the Notch and TCR signaling pathways. J Immunol. 2005 Jan 15; 174(2):890-7. PMID: 15634911.
    Citations: 18     Fields:    Translation:AnimalsCells
  61. Anderson AC, Reddy J, Nazareno R, Sobel RA, Nicholson LB, Kuchroo VK. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol. 2004 Jul 15; 173(2):828-34. PMID: 15240669.
    Citations: 16     Fields:    Translation:Animals
  62. Anderson AC, Kuchroo VK. Expression of self-antigen in the thymus: a little goes a long way. J Exp Med. 2003 Dec 01; 198(11):1627-9. PMID: 14657216; PMCID: PMC2194139.
    Citations: 9     Fields:    Translation:AnimalsCells
  63. Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol. 2002; 20:101-23. PMID: 11861599.
    Citations: 103     Fields:    Translation:AnimalsCells
  64. Anderson AC, Robey EA, Huang YH. Notch signaling in lymphocyte development. Curr Opin Genet Dev. 2001 Oct; 11(5):554-60. PMID: 11532398.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  65. Anderson AC, Nicholson LB, Kuchroo VK. The origin and regulation of autopathogenic T cells. J Clin Immunol. 2001 Mar; 21(2):74-80. PMID: 11332656.
    Citations:    Fields:    Translation:HumansAnimalsCells
  66. Anderson AC, Waldner H, Turchin V, Jabs C, Prabhu Das M, Kuchroo VK, Nicholson LB. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. Cell Immunol. 2000 Jun 15; 202(2):88-96. PMID: 10896768.
    Citations: 1     Fields:    Translation:AnimalsCells
  67. Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med. 2000 Mar 06; 191(5):761-70. PMID: 10704458; PMCID: PMC2195861.
    Citations: 65     Fields:    Translation:AnimalsCells
  68. Nicholson LB, Anderson AC, Kuchroo VK. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. Int Immunol. 2000 Feb; 12(2):205-13. PMID: 10653856.
    Citations: 10     Fields:    Translation:AnimalsCells
  69. Flajnik MF, Ohta Y, Greenberg AS, Salter-Cid L, Carrizosa A, Du Pasquier L, Kasahara M. Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC. J Immunol. 1999 Oct 01; 163(7):3826-33. PMID: 10490981.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  70. Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol. 1998 Nov 02; 91(1-2):1-9. PMID: 9846813.
    Citations: 13     Fields:    Translation:HumansCells
  71. Carrizosa AM, Nicholson LB, Farzan M, Southwood S, Sette A, Sobel RA, Kuchroo VK. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol. 1998 Oct 01; 161(7):3307-14. PMID: 9759846.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  72. Nicholson LB, Waldner H, Carrizosa AM, Sette A, Collins M, Kuchroo VK. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc Natl Acad Sci U S A. 1998 Jan 06; 95(1):264-9. PMID: 9419364; PMCID: PMC18196.
    Citations: 10     Fields:    Translation:AnimalsCells
  73. Miller SD, Vanderlugt CL, Begolka WS, Pao W, Yauch RL, Neville KL, Katz-Levy Y, Carrizosa A, Kim BS. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med. 1997 Oct; 3(10):1133-6. PMID: 9334726.
    Citations: 139     Fields:    Translation:AnimalsCells
  74. Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol. 1996 Aug 01; 157(3):1127-31. PMID: 8757617.
    Citations: 28     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.