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David Michael Miller, M.D.,Ph.D.

Other Positions

Food and Drug Administration, Silver Spring, Maryland10/2018Regulatory Medicine
University of Massachusetts Medical School, Worcester, MAMD/PhD05/2010Medicine/Biomedical Science
Brigham and Women's Hospital, Boston, MA6/2015Internal Medicine
Columbia University Medical Center, New York, New York6/2014Dermatology
Beth Israel Deaconess Medical Center, Boston, MA12/2018Hematology/Oncology

David Michael Miller MD, PhD, FAAD is a Board-Certified Dermatologist and Medical Oncologist at Massachusetts General Hospital and investigator in the Massachusetts General Hospital Cancer Center. The Miller Lab’s long-term goal is to identify and develop novel therapeutics for advanced skin cancer and to understand the mechanism of response and resistance to those therapies.

Dr. Miller is one of the very few clinicians in the country who is board certified in Internal Medicine, Dermatology and Medical Oncology. He currently practices both Dermatology and Medical Oncology in the Massachusetts General Hospital Cancer Center and at Massachusetts Eye and Ear Infirmary, where he co-directs multidiscliplinary clinics in advanced skin cancer, including the Merkel Cell Carcinoma Treatment Program.

The Miller Lab’s research portfolio consists of clinical and translational projects in Merkel Cell carcinoma, cutaneous Squamous Cell Carcinoma and Melanoma. Dr. Miller has received support for his research from the NIH in the form of a loan repayment award, a Research Grant from the American Skin Association, the Paul Carbone, MD fellowship award from ECOG-ACRIN, and the Mentoring Award in Oncology, Advanced Analytics and Regulatory Science from Project Data Sphere.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Paul Carbone, MD Fellowship Award (David Miller) Jul 1, 2018 - Jun 30, 2019
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Saqlain F, Shalhout SZ, Miller DM. Tutorial Series on the Instruments of the Merkel Cell Carcinoma Patient Registry: Presentation and Initial Staging. 2020. View Publication.
  2. Hoang MP, Donizy P, Wu CL, Kopczynski J, Pieniazek M, Miller DM, Rys J. TdT Expression Is a Marker of Better Survival in Merkel Cell Carcinoma, and Expression of B-Cell Markers Is Associated With Merkel Cell Polyomavirus. Am J Clin Pathol. 2020 06 08; 154(1):38-47. PMID: 32134459.
  3. Shalhout SZ, Miller DM. Visualizing Tumor Response using Waterfall Charts with R. 2020. View Publication.
  4. Saqlain F, Shalhout SZ, Miller DM. Optimizing Real World Data Collection: Retrospective Record Routine Maintenance. 2020. View Publication.
  5. Saqlain F, Shalhout SZ, Miller DM. Optimizing Real World Data Collection: Prospective Records Flagging for REDCap. 2020. View Publication.
  6. Saqlain F, Shalhout SZ, Miller DM. Optimizing Real World Data Collection: Retrospective Record Monitoring for REDCap. 2020. View Publication.
  7. Saqlain F, Shalhout SZ, Miller DM. Optimizing Real World Data Collection: In-Instrument Quality Control in REDCap. 2020. 2020. View Publication.
  8. Saqlain F, Shalhout SZ, Miller DM. Optimizing Real World Data Collection: Improving the UX/UI of REDCap via Branching Logic. 2020. View Publication.
  9. Saqlain F, Shalhout SZ, Miller DM. Optimizing Real World Data Collection: Enhancing the UX/UI of REDCap via Field Formatting. 2020. View Publication.
  10. Shalhout SZ, Miller DM. . Visualizing Real World Data Timelines in R. 2020. View Publication.
  11. Shalhout SZ, Bloom R, Drake L, Miller DM. Evaluation of the fragility of pivotal trials used to support US Food and Drug Administration approval for plaque psoriasis. J Am Acad Dermatol. 2020 Apr 19. PMID: 32320767.
  12. Miller DM, Shalhout SZ. Survival Analysis in R. 2020. View Publication.
  13. Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S. Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy. Oncologist. 2020 05; 25(5):366-368. PMID: 32073194.
  14. Shalhout SZ, Nahas MR, Drews RE, Miller DM. Generalized Acquired Cutis Laxa Associated with Monoclonal Gammopathy of Dermatological Significance. Case Rep Dermatol Med. 2020; 2020:7480607. PMID: 32099688.
  15. Shalhout SZ, Miller DM. Graphical Representation of Survival - Swimmer Plots for Clinical Trials in Clinical Oncology. 2020. View Publication.
  16. Miller DM, Shalhout SZ. Create Interactive Data Visualization with Plotly in R. 2020. View Publication.
  17. Miller DM, Shalhout SZ. Showcasing Clinical and Translational Research Presentations with Hugo Academic. 2020. View Publication.
  18. Miller DM, Shalhout SZ. FlexDashboards for Clinical and Translational Research. 2020. View Publication.
  19. Melms JC, Vallabhaneni S, Mills CE, Yapp C, Chen JY, Morelli E, Waszyk P, Kumar S, Deming D, Moret N, Rodriguez S, Subramanian K, Rogava M, Cartwright ANR, Luoma A, Mei S, Brinker TJ, Miller DM, Spektor A, Schadendorf D, Riggi N, Wucherpfennig KW, Sorger PK, Izar B. Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity. Cancer Res. 2020 02 15; 80(4):798-810. PMID: 31882401.
  20. Shalhout SZ, Miller DM. Communicating CT Research via Website Development with R. 2019. View Publication.
  21. Miller DM, Trowbridge RM, Desai A, Drews RE. Kaposi's varicelliform eruption in a patient with metastatic melanoma and primary cutaneous anaplastic large cell lymphoma treated with talimogene laherparepvec and nivolumab. J Immunother Cancer. 2018 11 19; 6(1):122. PMID: 30454071.
    Citations:    Fields:    
  22. Klebanov N, Gunasekera NS, Lin WM, Hawryluk EB, Miller DM, Reddy BY, Christman MP, Beaulieu D, Rajadurai S, Duncan LM, Sober AJ, Tsao H. Clinical spectrum of cutaneous melanoma morphology. J Am Acad Dermatol. 2019 Jan; 80(1):178-188.e3. PMID: 30165162.
    Citations:    Fields:    
  23. Eliades P, Abraham BJ, Ji Z, Miller DM, Christensen CL, Kwiatkowski N, Kumar R, Njauw CN, Taylor M, Miao B, Zhang T, Wong KK, Gray NS, Young RA, Tsao H. High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma. J Invest Dermatol. 2018 07; 138(7):1582-1590. PMID: 29408204.
    Citations: 1     Fields:    
  24. Miller DM, Faulkner-Jones BE, Stone JR, Drews RE. Complete pathologic response of metastatic cutaneous squamous cell carcinoma and allograft rejection after treatment with combination immune checkpoint blockade. JAAD Case Rep. 2017 Sep; 3(5):412-415. PMID: 28932782.
    Citations: 3     
  25. Reddy BY, Miller DM, Tsao H. Somatic driver mutations in melanoma. Cancer. 2017 06 01; 123(S11):2104-2117. PMID: 28543693.
    Citations: 3     Fields:    Translation:Humans
  26. Eliades P, Miller DM, Miao B, Kumar R, Taylor M, Buch S, Srinivasa SP, Flaherty KT, Tsao H. A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors. . 2016 07 02; 17(7):778-84. PMID: 26810603.
    Citations:    Fields:    Translation:HumansCells
  27. Miller DM, Flaherty KT, Tsao H. Current status and future directions of molecularly targeted therapies and immunotherapies for melanoma. Semin Cutan Med Surg. 2014 Jun; 33(2):60-7. PMID: 25085663.
    Citations: 5     Fields:    Translation:Humans
  28. Miller DM, Flaherty KT, Tsao H. Commentary: Molecular testing in melanoma. J Am Acad Dermatol. 2014 May; 70(5):863-70. PMID: 24534656.
    Citations: 1     Fields:    Translation:Humans
  29. Miller DM, Flaherty KT. Cyclin-dependent kinases as therapeutic targets in melanoma. Pigment Cell Melanoma Res. 2014 May; 27(3):351-65. PMID: 24405945.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  30. Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol. 2010 Apr; 135(1):84-98. PMID: 20096637.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  31. Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL. TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade. J Immunol. 2009 May 01; 182(9):5547-59. PMID: 19380803.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL. TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance. Ann N Y Acad Sci. 2008 Dec; 1150:149-51. PMID: 19120285.
    Citations: 2     Fields:    Translation:AnimalsCells
  33. Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol. 2008 Nov; 154(2):270-84. PMID: 18785974.
    Citations: 53     Fields:    Translation:HumansAnimals
  34. Miller DM, Thornley TB, Greiner DL, Rossini AA. Viral infection: a potent barrier to transplantation tolerance. Clin Dev Immunol. 2008; 2008:742810. PMID: 18815618.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  35. Miller DM, Rossini AA, Greiner DL. Role of innate immunity in transplantation tolerance. Crit Rev Immunol. 2008; 28(5):403-39. PMID: 19166387.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  36. Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Am J Transplant. 2007 Jul; 7(7):1710-21. PMID: 17564635.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Cole EB, Miller D, Rometo D, Greenberg RM, Brömme D, Cataltepe S, Pak SC, Mills DR, Silverman GA, Luke CJ. Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Biochemistry. 2004 Sep 21; 43(37):11750-9. PMID: 15362859.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  38. Al-Khunaizi M, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S, Miller D, Mills DR, Tsu C, Brömme D, Irving JA, Whisstock JC, Silverman GA. The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry. 2002 Mar 05; 41(9):3189-99. PMID: 11863458.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.