Harvard Catalyst Profiles

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Matthew Frederick Rose, M.D.,Ph.D.

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Institution
Department
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Biography
awards and honors
1995
Research Science Institute Fellow, Center for Excellence in Education, MIT
1996
First Place, College/Graduate Student Paper Competition, Tennessee Academy of Science
1996 - 2000
Echols Scholar, University of Virginia
1998 - 2000
Barry M. Goldwater National Scholar
2000 - 2009
Medical Scientist Training Program Fellow, NIGMS, Baylor College of Medicine (BCM)
2002 - 2008
BRASS Scholar, BCM
2003
Neurobiology Course Fellow, Marine Biological Laboratory (MBL), Woods Hole
2004 - 2007
Predoctoral National Research Service Award, NINDS, NIH (F31-NS051046)
2005
Milton Gregory Poster Award, BCM
2006
First Place, Genetics Department Paper Competition, BCM
2014 - 2016
Harvard Genetics Training Program T32 Selectee (NIGMS, 5-T32-GM007748)
2016
Poster of Distinction for Outstanding Achievement in Research, Brigham & Women’s (BWH) Dept. of Path
2016
BWH Pathology Training Program T32 Selectee (NHLBI, T32-HL007627)
2016 - Pres
K08 Career Development Award (NINDS, K08-NS099502)
2018
Poster of Distinction for Outstanding Achievement In Research, Harvard Medical Sch, Dept. of Path.
2018
AANP Travel Award, for the Best Abstract in Basic Science or Clinical Neuropathology
2018
Weil Award, for Best Paper in Experimental Neuropathology, American Association of Neuropathologists

Overview
overview
Research topics include: brainstem motor neuron development and disease, neurodevelopmental gene expression patterns, axon targeting, congenital cranial dysinnervation disorders (CCDDs), amyotrophic lateral sclerosis (ALS)

Instructor in Pathology, Harvard Medical School

Associate Pathologist, Dept. of Pathology, Brigham and Women's Hospital

Engle Laboratory, Dept. of Pathology, FM Kirby Neurobiology Center, and Dept. of Neurology, Boston Children's Hospital

Associated Scientist, Broad Institute of MIT and Harvard

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. K08NS099502 (ROSE, MATTHEW F) Dec 1, 2016 - Nov 30, 2021
    NIH/NINDS
    Mapping Brainstem Motor Neuron Subtypes and Genetic Pathways Involved in their Differential Susceptibility to Disease
    Role: Principal Investigator
  2. F31NS051046 (ROSE, MATTHEW F) Sep 30, 2004 - Sep 29, 2007
    NIH/NINDS
    Role of Math1 in brain stem &cerebellar development
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. An D, Fujiki R, Iannitelli DE, Smerdon JW, Maity S, Rose MF, Gelber A, Wanaselja EK, Yagudayeva I, Lee JY, Vogel C, Wichterle H, Engle EC, Mazzoni EO. Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. Elife. 2019 06 03; 8. PMID: 31157617.
    Citations:    
  2. Di Gioia SA, Connors S, Matsunami N, Cannavino J, Rose MF, Gilette NM, Artoni P, de Macena Sobreira NL, Chan WM, Webb BD, Robson CD, Cheng L, Van Ryzin C, Ramirez-Martinez A, Mohassel P, Leppert M, Scholand MB, Grunseich C, Ferreira CR, Hartman T, Hayes IM, Morgan T, Markie DM, Fagiolini M, Swift A, Chines PS, Speck-Martins CE, Collins FS, Jabs EW, Bönnemann CG, Olson EN, Carey JC, Robertson SP, Manoli I, Engle EC. A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. Nat Commun. 2017 07 06; 8:16077. PMID: 28681861.
    Citations:    
  3. Abedalthagafi MS, Bi WL, Merrill PH, Gibson WJ, Rose MF, Du Z, Francis JM, Du R, Dunn IF, Ligon AH, Beroukhim R, Santagata S. ARID1A and TERT promoter mutations in dedifferentiated meningioma. Cancer Genet. 2015 Jun; 208(6):345-50. PMID: 25963524.
    Citations: 11     Fields:    Translation:HumansCells
  4. Jakobiec FA, Rose MF, Trief D, Stagner AM, Kim I, Gragoudas ES. Immunohistochemical investigations of adult intraocular medulloepitheliomas. Clin Exp Ophthalmol. 2015 May-Jun; 43(4):379-85. PMID: 25251824.
    Citations: 1     Fields:    Translation:Humans
  5. Berkowitz AL, Rose MF, Daffner KR, Prasad S. Clinical Reasoning: a 75-year-old man with 3 years of visual difficulties. Neurology. 2014 Oct 21; 83(17):e160-5. PMID: 25332451.
    Citations:    Fields:    Translation:Humans
  6. Jakobiec FA, Trief D, Rashid A, Rose MF, Minckler D, Vanderveen D, Mukai S. New insights into the development of infantile intraocular medulloepithelioma. Am J Ophthalmol. 2014 Dec; 158(6):1275-1296.e1. PMID: 25174896.
    Citations: 2     Fields:    Translation:Humans
  7. Rose MF, Zimmerman EE, Hsu L, Golby AJ, Saleh E, Folkerth RD, Santagata SS, Milner DA, Ramkissoon SH. Atypical presentation of cerebral schistosomiasis four years after exposure to Schistosoma mansoni. Epilepsy Behav Case Rep. 2014; 2:80-5. PMID: 25667876.
    Citations: 3     
  8. Deaver P, Rose MF. Case of Thanatophoric Dysplasia. American Institute for Radiologic Pathology. 2014.
  9. Kaufmann WE, Rose MF. In MJ Aminoff and RB Daroff (Ed.), Encyclopedia of the Neurological Sciences. Cortical Histogenesis. 2014; 872-878.
  10. Berkowitz AL, Sheu SH, Rose MF, Delalle I, Folkerth RD. Bilirubin labeling of borderzone and anterior cerebral artery territory infarction. Neurology. 2013 Oct 01; 81(14):1272-3. PMID: 24081962.
    Citations:    Fields:    Translation:Humans
  11. Driver EC, Sillers L, Coate TM, Rose MF, Kelley MW. The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. Dev Biol. 2013 Apr 01; 376(1):86-98. PMID: 23318633.
    Citations: 36     Fields:    Translation:AnimalsCells
  12. Rose MF, Ahmad KA, Thaller C, Zoghbi HY. Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22462-7. PMID: 20080794.
    Citations: 49     Fields:    Translation:AnimalsCells
  13. Rose MF, Ren J, Ahmad KA, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12; 64(3):341-54. PMID: 19914183.
    Citations: 53     Fields:    Translation:AnimalsCells
  14. Englund C, Kowalczyk T, Daza RA, Dagan A, Lau C, Rose MF, Hevner RF. Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter. J Neurosci. 2006 Sep 06; 26(36):9184-95. PMID: 16957075.
    Citations: 61     Fields:    Translation:AnimalsCells
  15. Chizhikov VV, Lindgren AG, Currle DS, Rose MF, Monuki ES, Millen KJ. The roof plate regulates cerebellar cell-type specification and proliferation. Development. 2006 Aug; 133(15):2793-804. PMID: 16790481.
    Citations: 62     Fields:    Translation:Animals
  16. Young JI, Hong EP, Castle JC, Crespo-Barreto J, Bowman AB, Rose MF, Kang D, Richman R, Johnson JM, Berget S, Zoghbi HY. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17551-8. PMID: 16251272.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  17. Wang VY, Rose MF, Zoghbi HY. Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron. 2005 Oct 06; 48(1):31-43. PMID: 16202707.
    Citations: 146     Fields:    Translation:AnimalsCells
  18. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44. PMID: 16122429.
    Citations: 78     Fields:    Translation:AnimalsCells
  19. Frankfort BJ, Pepple KL, Mamlouk M, Rose MF, Mardon G. Senseless is required for pupal retinal development in Drosophila. Genesis. 2004 Apr; 38(4):182-94. PMID: 15083519.
    Citations: 7     Fields:    Translation:AnimalsCells
  20. Rose MF, Rose SR. Melatonin accelerates metamorphosis in Xenopus laevis. J Pineal Res. 1998 Mar; 24(2):90-5. PMID: 9510433.
    Citations:    Fields:    Translation:Animals
  21. Rose MF. R-cognin and melatonin effects on embryonic chick retinal cell aggregation. Handbook and Proceedings of the Tennessee Junior Academy of Science. Johnson City, Tennessee. 1996; 27-43.
  22. Rose MF. Circadian and hormonal regulation of growth and metamorphosis in Xenopus laevis: Phases IV, V, & VI. In Jack Rhoton (ed): Handbook and Proceedings of the Tennessee Junior Academy of Science. Johnson City, Tennessee. 1995; 22-48.
  23. Rose MF. Phase III: Circadian and hormonal regulation of growth and metamorphosis in Xenopus Laevis. In Jack Rhoton (ed): Handbook and Proceedings of the Tennessee Junior Academy of Science. Johnson City, Tennessee. 1994; 13-32.
  24. Rose MF. Regional differences in pH in rain, surface and tap water: Phase II. In Jack Rhoton (ed): Handbook and Proceedings of the Tennessee Junior Academy of Science. Johnson City, Tennessee. 1993; 46-61.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.