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Last Name

profileJason George Homsy, M.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
75 Francis St
Boston MA 02115
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K08HL133448     (HOMSY, JASON GEORGE)May 15, 2017 - Apr 30, 2022
Discovery of Novel Genetic Variants in Congenital Heart Disease by Whole Genome Sequencing
Role: Principal Investigator

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  1. Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Nat Genet. 2017 Nov; 49(11):1593-1601. PMID: 28991257.
    View in: PubMed
  2. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. PMID: 27840107.
    View in: PubMed
  3. McKean DM, Homsy J, Wakimoto H, Patel N, Gorham J, DePalma SR, Ware JS, Zaidi S, Ma W, Patel N, Lifton RP, Chung WK, Kim R, Shen Y, Brueckner M, Goldmuntz E, Sharp AJ, Seidman CE, Gelb BD, Seidman JG. Loss of RNA expression and allele-specific expression associated with congenital heart disease. Nat Commun. 2016 Sep 27; 7:12824. PMID: 27670201.
    View in: PubMed
  4. Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science. 2015 Dec 04; 350(6265):1262-6. PMID: 26785492; PMCID: PMC4890146.
  5. Ware JS, Samocha KE, Homsy J, Daly MJ. Interpreting de novo Variation in Human Disease Using denovolyzeR. Curr Protoc Hum Genet. 2015 Oct 06; 87:7.25.1-15. PMID: 26439716; PMCID: PMC4606471 [Available on 10/06/16].
  6. Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, Linke WA, Chen CS, Seidman JG, Seidman CE. HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science. 2015 Aug 28; 349(6251):982-6. PMID: 26315439; PMCID: PMC4618316.
  7. Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J, Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507. PMID: 25425480; PMCID: PMC4352754.
  8. Glessner JT, Bick AG, Ito K, Homsy J, Rodriguez-Murillo L, Fromer M, Mazaika E, Vardarajan B, Italia M, Leipzig J, DePalma SR, Golhar R, Sanders SJ, Yamrom B, Ronemus M, Iossifov I, Willsey AJ, State MW, Kaltman JR, White PS, Shen Y, Warburton D, Brueckner M, Seidman C, Goldmuntz E, Gelb BD, Lifton R, Seidman J, Hakonarson H, Chung WK. Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data. Circ Res. 2014 Oct 24; 115(10):884-896. PMID: 25205790; PMCID: PMC4209190.
  9. Mazaika E, Homsy J. Digital Droplet PCR: CNV Analysis and Other Applications. Curr Protoc Hum Genet. 2014 Jul 14; 82:7.24.1-13. PMID: 25042719; PMCID: PMC4355013.
  10. Backenroth D, Homsy J, Murillo LR, Glessner J, Lin E, Brueckner M, Lifton R, Goldmuntz E, Chung WK, Shen Y. CANOES: detecting rare copy number variants from whole exome sequencing data. Nucleic Acids Res. 2014 Jul; 42(12):e97. PMID: 24771342; PMCID: PMC4081054.
  11. Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D. JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Dev Dyn. 2006 Feb; 235(2):427-34. PMID: 16317725.
    View in: PubMed
  12. Kockel L, Homsy JG, Bohmann D. Drosophila AP-1: lessons from an invertebrate. Oncogene. 2001 Apr 30; 20(19):2347-64. PMID: 11402332.
    View in: PubMed
  13. Morrow WJ, Homsy J, Eichberg JW, Krowka J, Pan LZ, Gaston I, Legg H, Lerche N, Thomas J, Levy JA. Long-term observation of baboons, rhesus monkeys, and chimpanzees inoculated with HIV and given periodic immunosuppressive treatment. AIDS Res Hum Retroviruses. 1989 Apr; 5(2):233-45. PMID: 2713168.
    View in: PubMed
  14. Homsy J, Thomson-Honnebier GA, Cheng-Mayer C, Levy JA. Detection of human immunodeficiency virus (HIV) in serum and body fluids by sequential competition ELISA. J Virol Methods. 1988 Jan; 19(1):43-56. PMID: 3280585.
    View in: PubMed
  15. Homsy J, Steimer K, Kaslow R. Towards an AIDS vaccine: challenges and prospects. Immunol Today. 1987; 8(7-8):193-6. PMID: 25290421.
    View in: PubMed
  16. Homsy J, Morrow WJ, Levy JA. Life span of MRL/lpr/lpr mice. Immunol Today. 1985 Apr; 6(4):120. PMID: 25289493.
    View in: PubMed
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