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profileAmit Vikram Khera, M.D.

TitleInstructor in Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Grb 804
55 Fruit St
Boston MA 02114
Phone617/726-2677
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Emdin CA, Khera AV, Klarin D, Natarajan P, Zekavat SM, Nomura A, Haas ME, Aragam K, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gormley P, Palotie A, Stitziel N, Gupta N, Danesh JN, Saleheen D, Gabriel SB, Kathiresan S. Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling. Circulation. 2017 Oct 05. PMID: 28982690.
    View in: PubMed
  2. Lam CSP, Barry K, Khera A. Medical Podcasting and Circulation on the Run: Why, How, and What Now. Circulation. 2017 Aug 08; 136(6):513-515. PMID: 28784821.
    View in: PubMed
  3. Gupta RM, Hadaya J, Trehan A, Zekavat SM, Roselli C, Klarin D, Emdin CA, Hilvering CRE, Bianchi V, Mueller C, Khera AV, Ryan RJH, Engreitz JM, Issner R, Shoresh N, Epstein CB, de Laat W, Brown JD, Schnabel RB, Bernstein BE, Kathiresan S. A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression. Cell. 2017 Jul 27; 170(3):522-533.e15. PMID: 28753427.
    View in: PubMed
  4. Klarin D, Zhu QM, Emdin CA, Chaffin M, Horner S, McMillan BJ, Leed A, Weale ME, Spencer CCA, Aguet F, Segrè AV, Ardlie KG, Khera AV, Kaushik VK, Natarajan P, Kathiresan S. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 2017 Sep; 49(9):1392-1397. PMID: 28714974.
    View in: PubMed
  5. Ren HY, Khera A, de Lemos JA, Ayers CR, Rohatgi A. Soluble endothelial cell-selective adhesion molecule and incident cardiovascular events in a multiethnic population. Am Heart J. 2017 Sep; 191:55-61. PMID: 28888270.
    View in: PubMed
  6. Emdin CA, Khera AV, Kathiresan S. Genetic Predisposition to Abdominal Obesity and Cardiometabolic Risk-Reply. JAMA. 2017 06 13; 317(22):2334-2335. PMID: 28609529.
    View in: PubMed
  7. Khine HW, Teiber JF, Haley RW, Khera A, Ayers CR, Rohatgi A. Association of the serum myeloperoxidase/high-density lipoprotein particle ratio and incident cardiovascular events in a multi-ethnic population: Observations from the Dallas Heart Study. Atherosclerosis. 2017 Aug; 263:156-162. PMID: 28645072.
    View in: PubMed
  8. Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017 Jun 23; 121(1):81-88. PMID: 28506971.
    View in: PubMed
  9. Prasad A, Clopton P, Ayers C, Khera A, de Lemos JA, Witztum JL, Tsimikas S. Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1213-1221. PMID: 28473443.
    View in: PubMed
  10. Khera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20; 135(25):2494-2504. PMID: 28450350.
    View in: PubMed
  11. Emdin CA, Klarin D, Natarajan P, Florez JC, Kathiresan S, Khera AV. Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease. Diabetes. 2017 Aug; 66(8):2310-2315. PMID: 28411266.
    View in: PubMed
  12. Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, Shah SH, Yu B, Boerwinkle E, Rader DJ, Gupta N, Frossard PM, Rasheed A, Danesh J, Lander ES, Gabriel S, Saleheen D, Musunuru K, Kathiresan S. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017 Apr 25; 69(16):2054-2063. PMID: 28385496.
    View in: PubMed
  13. de Lemos JA, Ayers CR, Levine B, deFilippi CR, Wang TJ, Hundley WG, Berry JD, Seliger SL, McGuire DK, Ouyang P, Drazner MH, Budoff M, Greenland P, Ballantyne CM, Khera A. Multimodality Strategy for Cardiovascular Risk Assessment: Performance in 2 Population-Based Cohorts. Circulation. 2017 May 30; 135(22):2119-2132. PMID: 28360032.
    View in: PubMed
  14. Khera AV, Emdin CA, Kathiresan S. Genetic Risk, Lifestyle, and Coronary Artery Disease. N Engl J Med. 2017 03 23; 376(12):1194-5. PMID: 28328341.
    View in: PubMed
  15. Konstam MA, Hill JA, Kovacs RJ, Harrington RA, Arrighi JA, Khera A. The Academic Medical System: Reinvention to Survive the Revolution in Health Care. J Am Coll Cardiol. 2017 Mar 14; 69(10):1305-1312. PMID: 28279297.
    View in: PubMed
  16. Khera AV, Kathiresan S. Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine. Circulation. 2017 Mar 14; 135(11):1005-1007. PMID: 28289003.
    View in: PubMed
  17. Khera AV, Kathiresan S. Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet. 2017 Jun; 18(6):331-344. PMID: 28286336.
    View in: PubMed
  18. Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 03 07; 317(9):937-946. PMID: 28267856.
    View in: PubMed
  19. Emdin CA, Khera AV, Natarajan P, Klarin D, Zekavat SM, Hsiao AJ, Kathiresan S. Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease. JAMA. 2017 02 14; 317(6):626-634. PMID: 28196256.
    View in: PubMed
  20. Khera AV, Kathiresan S. Reply: Familial Hypercholesterolemia: Independent Malignity and LDLR Variant Databases. J Am Coll Cardiol. 2017 Feb 14; 69(6):755. PMID: 28183517.
    View in: PubMed
  21. Lew J, Sanghavi M, Ayers CR, McGuire DK, Omland T, Atzler D, Gore MO, Neeland I, Berry JD, Khera A, Rohatgi A, de Lemos JA. Sex-Based Differences in Cardiometabolic Biomarkers. Circulation. 2017 Feb 07; 135(6):544-555. PMID: 28153991.
    View in: PubMed
  22. Khera AV, Kathiresan S. Child-Parent Familial Hypercholesterolemia Screening in Primary Care. N Engl J Med. 2017 02 02; 376(5):498-9. PMID: 28150925.
    View in: PubMed
  23. Khera A, Joshi P. What's a Malignant Family History?: You'll Know It When You See It. JACC Cardiovasc Imaging. 2017 Oct; 10(10 Pt A):1136-1138. PMID: 28109931.
    View in: PubMed
  24. Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol. 2016 Dec 27; 68(25):2761-2772. PMID: 28007139.
    View in: PubMed
  25. Emdin CA, Khera AV, Natarajan P, Klarin D, Baber U, Mehran R, Rader DJ, Fuster V, Kathiresan S. Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. Am J Cardiol. 2017 Mar 15; 119(6):881-885. PMID: 28061997.
    View in: PubMed
  26. Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 12 15; 375(24):2349-2358. PMID: 27959714.
    View in: PubMed
  27. Khera AV, Ridker PM. Demystifying HDL Cholesterol-A "Human Knockout" to the Rescue? Clin Chem. 2017 Jan; 63(1):33-36. PMID: 27881451.
    View in: PubMed
  28. Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 Jun 07; 67(22):2578-89. PMID: 27050191.
    View in: PubMed
  29. Khera AV, Natarajan P, Kathiresan S. The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism? Eur J Prev Cardiol. 2016 Jul; 23(10):1062-4. PMID: 26268264.
    View in: PubMed
  30. Khera AV, Millar JS, Ruotolo G, Wang MD, Rader DJ. Potent peroxisome proliferator-activated receptor-a agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14; 36(43):3020-2. PMID: 26112886; PMCID: PMC4644252 [Available on 11/14/16].
  31. Qamar A, Khetarpal SA, Khera AV, Qasim A, Rader DJ, Reilly MP. Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):1880-8. PMID: 26069232; PMCID: PMC4556282.
  32. Khera AV, Qamar A, Murphy SA, Cannon CP, Sabatine MS, Rader DJ. On-Statin Resistin, Leptin, and Risk of Recurrent Coronary Events After Hospitalization for an Acute Coronary Syndrome (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Study). Am J Cardiol. 2015 Sep 01; 116(5):694-8. PMID: 26119654.
    View in: PubMed
  33. Khera AV, Mehta NN. Single-cell transcriptomics: an emerging tool in the study of cardiometabolic disease. J Transl Med. 2014 Nov 06; 12:312. PMID: 25377125; PMCID: PMC4228185.
  34. Khera AV, Qamar A, Reilly MP, Dunbar RL, Rader DJ. Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia. Am J Cardiol. 2015 Jan 15; 115(2):178-82. PMID: 25432415.
    View in: PubMed
  35. Khera AV, Everett BM, Caulfield MP, Hantash FM, Wohlgemuth J, Ridker PM, Mora S. Response to letter regarding article, "lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER trial (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin)". Circulation. 2014 Oct 21; 130(17):e152. PMID: 25332285.
    View in: PubMed
  36. Khera AV, Everett BM, Caulfield MP, Hantash FM, Wohlgemuth J, Ridker PM, Mora S. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). Circulation. 2014 Feb 11; 129(6):635-42. PMID: 24243886; PMCID: PMC3946056.
  37. Khera AV, Patel PJ, Reilly MP, Rader DJ. The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality. J Am Coll Cardiol. 2013 Nov 12; 62(20):1909-10. PMID: 23933538.
    View in: PubMed
  38. Khera AV, Plutzky J. Management of low levels of high-density lipoprotein-cholesterol. Circulation. 2013 Jul 02; 128(1):72-8. PMID: 23817482; PMCID: PMC4231714.
  39. Khera AV, Rader DJ. Cholesterol efflux capacity: full steam ahead or a bump in the road? Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1449-51. PMID: 23766382.
    View in: PubMed
  40. Patel PJ, Khera AV, Wilensky RL, Rader DJ. Anti-oxidative and cholesterol efflux capacities of high-density lipoprotein are reduced in ischaemic cardiomyopathy. Eur J Heart Fail. 2013 Nov; 15(11):1215-9. PMID: 23709232; PMCID: PMC3888304.
  41. Khera AV, Mora S. Fasting for lipid testing: is it worth the trouble?: comment on "fasting time and lipid levels in a community-based population". Arch Intern Med. 2012 Dec 10; 172(22):1710-1. PMID: 23403645.
    View in: PubMed
  42. Khera AV, Mora S. Fasting for lipid testing: Is it worth the trouble? Arch Intern Med. 2012 Dec 10; 172(22):1710-2. PMID: 23405395.
    View in: PubMed
  43. Patel PJ, Khera AV, Jafri K, Wilensky RL, Rader DJ. The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease. J Am Coll Cardiol. 2011 Nov 08; 58(20):2068-75. PMID: 22051328.
    View in: PubMed
  44. Mehta NN, Li M, William D, Khera AV, DerOhannessian S, Qu L, Ferguson JF, McLaughlin C, Shaikh LH, Shah R, Patel PN, Bradfield JP, He J, Stylianou IM, Hakonarson H, Rader DJ, Reilly MP. The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur Heart J. 2011 Apr; 32(8):963-71. PMID: 21415067; PMCID: PMC3076669.
  45. Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Döring A, Thorand B, Li M, Reilly MP, Koenig W, Samani NJ, Rader DJ. Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circ Cardiovasc Genet. 2011 Apr; 4(2):145-55. PMID: 21303902; PMCID: PMC3319351.
  46. Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, Rader DJ. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. 2011 Jan 13; 364(2):127-35. PMID: 21226578; PMCID: PMC3030449.
  47. Khera AV, Wolfe ML, Cannon CP, Qin J, Rader DJ. On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study). Am J Cardiol. 2010 Aug 15; 106(4):451-6. PMID: 20691300.
    View in: PubMed
  48. Burke MF, Khera AV, Rader DJ. Polyphenols and cholesterol efflux: is coffee the next red wine? Circ Res. 2010 Mar 05; 106(4):627-9. PMID: 20203311; PMCID: PMC3137435.
  49. Testani JM, St John Sutton MG, Wiegers SE, Khera AV, Shannon RP, Kirkpatrick JN. Accuracy of noninvasively determined pulmonary artery systolic pressure. Am J Cardiol. 2010 Apr 15; 105(8):1192-7. PMID: 20381676; PMCID: PMC2994808.
  50. Testani JM, Khera AV, St John Sutton MG, Keane MG, Wiegers SE, Shannon RP, Kirkpatrick JN. Effect of right ventricular function and venous congestion on cardiorenal interactions during the treatment of decompensated heart failure. Am J Cardiol. 2010 Feb 15; 105(4):511-6. PMID: 20152246; PMCID: PMC2995805.
  51. Khera AV, Rader DJ. Future therapeutic directions in reverse cholesterol transport. Curr Atheroscler Rep. 2010 Jan; 12(1):73-81. PMID: 20425274; PMCID: PMC3315100.
  52. Khera AV, Rader DJ. Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics. Trends Cardiovasc Med. 2009 Aug; 19(6):195-201. PMID: 20211435; PMCID: PMC3328807.
  53. Khera AV. My most famous patient. (Second-place essay at the Francis A. Velay Humanism in Medicine Essay Contest presented by the Arnold P. Gold Foundation). Acad Med. 2008 Dec; 83(12):1170-1. PMID: 19202493.
    View in: PubMed
  54. Deaner RO, Khera AV, Platt ML. Monkeys pay per view: adaptive valuation of social images by rhesus macaques. Curr Biol. 2005 Mar 29; 15(6):543-8. PMID: 15797023.
    View in: PubMed
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