Harvard Catalyst Profiles

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Da-Zhi Wang, Ph.D.

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Basil O’Connor Scholar
Established Investigator Award
Elected Fellow

Our lab is interested in the molecular events that control gene expression during animal development. Using muscle (cardiac, skeletal and smooth) as model systems, we study transcriptional, epigenetic and microRNA (miRNA)-mediated post-transcriptional regulation of gene expression. We apply a variety of developmental, molecular, cellular, biochemical, genetic and physiological approaches, including transgenic and knockout mouse models in our lab.

The heart is the “heart” of life. Heart disease is the number one cause of mortality and morbidity world wide. Congenital heart disease occurs in one of every one hundred live births and is the most common human birth defect. Discovery of the genetic control and molecular mechanisms of heart development is an important prerequisite to develop novel therapies for human cardiovascular disease.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL141853 (CHEN, HONG) Jan 15, 2020 - Dec 31, 2023
    CD45-mediated endothelial-to-mesenchymal transition in cardiovascular disease
    Role: Co-Principal Investigator
  2. R01HL149401 (WANG, DA-ZHI) Aug 1, 2019 - May 31, 2023
    Role: Principal Investigator
  3. R01HL138757 (WANG, DA-ZHI) Jul 15, 2017 - Jun 30, 2021
    MicroRNAs, cardiac function and cardiomyopathy
    Role: Principal Investigator
  4. R01HL125925 (WANG, DA-ZHI) Jan 1, 2016 - Dec 31, 2020
    Therapeutic applications of miRNAs in myocardial and cardiac regeneration
    Role: Principal Investigator
  5. R01HL116919 (WANG, DA-ZHI) Jul 1, 2013 - Jun 30, 2018
    Molecular Mechanisms of Dilated Cardiomyopathy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. He X, Liu J, Gu F, Chen J, Lu YW, Ding J, Guo H, Nie M, Kataoka M, Lin Z, Hu X, Chen H, Liao X, Dong Y, Min W, Deng ZL, Pu WT, Huang ZP, Wang DZ. Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2022 02 02; 30(2):898-914. PMID: 34400329; PMCID: PMC8822131.
    Citations: 2     Fields:    Translation:HumansAnimals
  2. Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J. LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Res Cardiol. 2021 08 11; 116(1):48. PMID: 34379189; PMCID: PMC8357683.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  3. Kong LF, He YB, Xie ZX, Luo X, Zhang H, Yi SH, Lin ZL, Zhang SF, Yan KQ, Xu HK, Jin T, Lin L, Qin W, Chen F, Liu SQ, Wang DZ. Illuminating Key Microbial Players and Metabolic Processes Involved in the Remineralization of Particulate Organic Carbon in the Ocean's Twilight Zone by Metaproteomics. Appl Environ Microbiol. 2021 09 28; 87(20):e0098621. PMID: 34319792; PMCID: PMC8478463.
    Citations: 1     Fields:    Translation:Cells
  4. Wang Y, Chen J, Cowan DB, Wang DZ. Non-coding RNAs in cardiac regeneration: Mechanism of action and therapeutic potential. Semin Cell Dev Biol. 2021 10; 118:150-162. PMID: 34284952; PMCID: PMC8434979.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Seok H, Deng R, Cowan DB, Wang DZ. Application of CRISPR-Cas9 gene editing for congenital heart disease. Clin Exp Pediatr. 2021 Jun; 64(6):269-279. PMID: 33677855.
    Citations: 2     
  6. Lima VM, Liu J, Brandão BB, Lino CA, Balbino Silva CS, Ribeiro MAC, Oliveira TE, Real CC, de Paula Faria D, Cederquist C, Huang ZP, Hu X, Barreto-Chaves ML, Ferreira JCB, Festuccia WT, Mori MA, Kahn CR, Wang DZ, Diniz GP. miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation. Metabolism. 2021 04; 117:154723. PMID: 33549579; PMCID: PMC8935324.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. de Oliveira Silva T, Lino CA, Buzatto VC, Asprino PF, Lu YW, Lima VM, Fonseca RIB, Jensen L, Murata GM, Filho SV, Ribeiro MAC, Donato JJ, Ferreira JCB, Rodrigues AC, Irigoyen MC, Barreto-Chaves MLM, Huang ZP, Galante PAF, Wang DZ, Diniz GP. Deletion of miRNA-22 Induces Cardiac Hypertrophy in Females but Attenuates Obesogenic Diet-Mediated Metabolic Disorders. Cell Physiol Biochem. 2020 Dec 01; 54(6):1199-1217. PMID: 33252886.
    Citations: 1     Fields:    Translation:Animals
  8. Liang T, Gao F, Jiang J, Lu YW, Zhang F, Wang Y, Liu N, Fu X, Dong X, Pei J, Cowan DB, Hu X, Wang J, Wang DZ, Chen J. Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. Circulation. 2020 12; 142(22):2196-2199. PMID: 33253002; PMCID: PMC7853321.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Zhang F, Fu X, Kataoka M, Liu N, Wang Y, Gao F, Liang T, Dong X, Pei J, Hu X, Zhu W, Yu H, Cowan DB, Hu X, Huang ZP, Wang J, Wang DZ, Chen J. Long noncoding RNA Cfast regulates cardiac fibrosis. Mol Ther Nucleic Acids. 2021 Mar 05; 23:377-392. PMID: 33473324; PMCID: PMC7787992.
    Citations: 16     
  10. Singh GB, Cowan DB, Wang DZ. Tiny Regulators of Massive Tissue: MicroRNAs in Skeletal Muscle Development, Myopathies, and Cancer Cachexia. Front Oncol. 2020; 10:598964. PMID: 33330096; PMCID: PMC7719840.
    Citations: 9     
  11. Yan H, Wang H, Zhu X, Huang J, Li Y, Zhou K, Hua Y, Yan F, Wang DZ, Luo Y. Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha. Mol Ther Nucleic Acids. 2021 Mar 05; 23:406-417. PMID: 33473326; PMCID: PMC7787996.
    Citations: 7     
  12. Cao J, Cowan DB, Wang DZ. tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy. Front Pharmacol. 2020; 11:572941. PMID: 33041815; PMCID: PMC7527594.
    Citations: 11     
  13. Guo H, Lu YW, Lin Z, Huang ZP, Liu J, Wang Y, Seok HY, Hu X, Ma Q, Li K, Kyselovic J, Wang Q, Lin JL, Lin JJ, Cowan DB, Naya F, Chen Y, Pu WT, Wang DZ. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. PMID: 32938943; PMCID: PMC7494909.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Dong Y, Lee Y, Cui K, He M, Wang B, Bhattacharjee S, Zhu B, Yago T, Zhang K, Deng L, Ouyang K, Wen A, Cowan DB, Song K, Yu L, Brophy ML, Liu X, Wylie-Sears J, Wu H, Wong S, Cui G, Kawashima Y, Matsumoto H, Kodera Y, Wojcikiewicz RJH, Srivastava S, Bischoff J, Wang DZ, Ley K, Chen H. Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nat Commun. 2020 08 07; 11(1):3984. PMID: 32770009.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Bektik E, Cowan DB, Wang DZ. Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System. Int J Mol Sci. 2020 Jul 30; 21(15). PMID: 32751460.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Liu J, Huang ZP, Nie M, Wang G, Silva WJ, Yang Q, Freire PP, Hu X, Chen H, Deng Z, Pu WT, Wang DZ. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265. PMID: 32719146; PMCID: PMC7430979.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  17. Salazar-Roa M, Trakala M, Álvarez-Fernández M, Valdés-Mora F, Zhong C, Muñoz J, Yu Y, Peters TJ, Graña-Castro O, Serrano R, Zapatero-Solana E, Abad M, Bueno MJ, Gómez de Cedrón M, Fernández-Piqueras J, Serrano M, Blasco MA, Wang DZ, Clark SJ, Izpisua-Belmonte JC, Ortega S, Malumbres M. Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells. EMBO J. 2020 08 17; 39(16):e104324. PMID: 32614092; PMCID: PMC7429746.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Chen J, Ma Q, King JS, Sun Y, Xu B, Zhang X, Zohrabian S, Guo H, Cai W, Li G, Bruno I, Cooke JP, Wang C, Kontaridis M, Wang DZ, Luo H, Pu WT, Lin Z. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1). PMID: 31843959; PMCID: PMC6918510.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Li C, Hu Z, Zhang W, Yu J, Yang Y, Xu Z, Luo H, Liu X, Liu Y, Chen C, Cai Y, Xia X, Zhang X, Wang DZ, Wu G, Zeng C. Regulation of Cholesterol Homeostasis by a Novel Long Non-coding RNA LASER. Sci Rep. 2019 05 22; 9(1):7693. PMID: 31118464.
    Citations: 10     Fields:    Translation:HumansCells
  20. Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J, Chen J, Wang DZ. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802. PMID: 30996254; PMCID: PMC6470165.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  21. Zhou Q, Yu B, Anderson C, Huang ZP, Hanus J, Zhang W, Han Y, Bhattacharjee PS, Srinivasan S, Zhang K, Wang DZ, Wang S. LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus. Elife. 2019 02 11; 8. PMID: 30741632; PMCID: PMC6370342.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Lu YW, Wang DZ. Non-coding RNA in Ischemic and Non-ischemic Cardiomyopathy. Curr Cardiol Rep. 2018 09 26; 20(11):115. PMID: 30259174.
    Citations: 6     Fields:    Translation:HumansAnimals
  23. Huang ZP, Wang DZ. miR-22 in Smooth Muscle Cells: A Potential Therapy for Cardiovascular Disease. Circulation. 2018 04 24; 137(17):1842-1845. PMID: 29685931; PMCID: PMC5918419.
    Citations: 7     Fields:    Translation:HumansCells
  24. Diniz GP, Huang ZP, Liu J, Chen J, Ding J, Fonseca RI, Barreto-Chaves ML, Donato J, Hu X, Wang DZ. Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy. Clin Sci (Lond). 2017 Dec 15; 131(24):2885-2900. PMID: 29101298; PMCID: PMC5822437.
    Citations: 18     Fields:    Translation:AnimalsCells
  25. Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. PMID: 29021295; PMCID: PMC5756124.
    Citations: 49     Fields:    Translation:AnimalsCells
  26. Espinoza-Lewis RA, Yang Q, Liu J, Huang ZP, Hu X, Chen D, Wang DZ. Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts. J Biol Chem. 2017 06 09; 292(23):9540-9550. PMID: 28381556.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Ding J, Lin ZQ, Jiang JM, Seidman CE, Seidman JG, Pu WT, Wang DZ. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118). PMID: 28060283; PMCID: PMC5226409.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  28. Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554. PMID: 27557636; PMCID: PMC5079274.
    Citations: 36     Fields:    
  29. Haque ZK, Wang DZ. How cardiomyocytes sense pathophysiological stresses for cardiac remodeling. Cell Mol Life Sci. 2017 03; 74(6):983-1000. PMID: 27714411; PMCID: PMC6990138.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  30. Naya FJ, Wang DZ. (MYO)SLIDing Our Way Into the Vascular Pool of Long Noncoding RNAs. Arterioscler Thromb Vasc Biol. 2016 10; 36(10):2033-4. PMID: 27655778; PMCID: PMC5108579.
    Citations: 1     Fields:    
  31. Diniz GP, Wang DZ. Regulation of Skeletal Muscle by microRNAs. Compr Physiol. 2016 06 13; 6(3):1279-94. PMID: 27347893.
    Citations: 34     Fields:    Translation:Humans
  32. Ding J, Nie M, Liu J, Hu X, Ma L, Deng ZL, Wang DZ. Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle. PLoS One. 2016; 11(5):e0155349. PMID: 27159388.
    Citations: 6     Fields:    Translation:Animals
  33. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. PMID: 26436652; PMCID: PMC4639982.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  34. Nie M, Deng ZL, Liu J, Wang DZ. Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases. Biomed Res Int. 2015; 2015:676575. PMID: 26258142.
    Citations: 50     Fields:    Translation:HumansAnimals
  35. Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng ZL, Pu WT, Wang DZ. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. PMID: 26029872; PMCID: PMC4485565.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  36. Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. PMID: 26023924.
    Citations: 23     Fields:    Translation:AnimalsCells
  37. Ding J, Wang DZ. Mystery of Trbp, tale of a RBP in the miRNA pathway. Cell Cycle. 2015; 14(19):3007-8. PMID: 26496166; PMCID: PMC4825566.
    Citations: 2     Fields:    Translation:HumansAnimals
  38. Liu J, Wang DZ. An epigenetic "LINK(RNA)" to pathological cardiac hypertrophy. Cell Metab. 2014 Oct 07; 20(4):555-7. PMID: 25295782.
    Citations: 10     Fields:    Translation:HumansAnimals
  39. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. PMID: 25249570; PMCID: PMC4282610.
    Citations: 131     Fields:    Translation:AnimalsCells
  40. Espinoza-Lewis RA, Wang DZ. Generation of a Cre knock-in into the Myocardin locus to mark early cardiac and smooth muscle cell lineages. Genesis. 2014 Oct; 52(10):879-87. PMID: 25174608.
    Citations: 2     Fields:    Translation:AnimalsCells
  41. Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, Cai Y, Huang H, Yang Y, Liu Y, Xu Z, He D, Zhang X, Hu X, Pinello L, Zhong D, He F, Yuan GC, Wang DZ, Zeng C. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation. 2014 Oct 21; 130(17):1452-1465. PMID: 25156994; PMCID: PMC4244705.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  42. Kataoka M, Wang DZ. Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease. Cells. 2014 Aug 22; 3(3):883-98. PMID: 25153164.
    Citations: 56     Fields:    
  43. Huang ZP, Wang DZ. miR-22 in cardiac remodeling and disease. Trends Cardiovasc Med. 2014 Oct; 24(7):267-72. PMID: 25218673.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  44. Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63. PMID: 24833660; PMCID: PMC4104149.
    Citations: 179     Fields:    Translation:HumansAnimalsCells
  45. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. PMID: 24813252; PMCID: PMC4172922.
    Citations: 405     Fields:    Translation:HumansCells
  46. Neppl RL, Kataoka M, Wang DZ. Crystallin-aB regulates skeletal muscle homeostasis via modulation of argonaute2 activity. J Biol Chem. 2014 Jun 13; 289(24):17240-8. PMID: 24782307.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  47. Seok HY, Chen J, Kataoka M, Huang ZP, Ding J, Yan J, Hu X, Wang DZ. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 2014 May 09; 114(10):1585-95. PMID: 24657879.
    Citations: 69     Fields:    Translation:AnimalsCells
  48. Neppl RL, Wang DZ. The myriad essential roles of microRNAs in cardiovascular homeostasis and disease. Genes Dis. 2014 Mar 01; 1(1):18-39. PMID: 25328909.
    Citations: 11     
  49. Jiang Y, Singh P, Yin H, Zhou YX, Gui Y, Wang DZ, Zheng XL. Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation. J Cell Physiol. 2013 Oct; 228(10):1989-95. PMID: 23526547.
    Citations: 3     Fields:    Translation:AnimalsCells
  50. Wu G, Huang ZP, Wang DZ. MicroRNAs in cardiac regeneration and cardiovascular disease. Sci China Life Sci. 2013 Oct; 56(10):907-13. PMID: 23974704.
    Citations: 11     Fields:    Translation:HumansAnimals
  51. Kataoka M, Huang ZP, Wang DZ. Build a braveheart: the missing linc (RNA). Circ Res. 2013 Jun 07; 112(12):1532-4. PMID: 23743224.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  52. Chen J, Huang ZP, Seok HY, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang DZ. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013 Jun 07; 112(12):1557-66. PMID: 23575307.
    Citations: 204     Fields:    Translation:AnimalsCells
  53. Huang ZP, Chen J, Seok HY, Zhang Z, Kataoka M, Hu X, Wang DZ. MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress. Circ Res. 2013 Apr 26; 112(9):1234-43. PMID: 23524588.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  54. Cao D, Wang C, Tang R, Chen H, Zhang Z, Tatsuguchi M, Wang DZ. Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes. J Biol Chem. 2012 Nov 09; 287(46):38495-504. PMID: 23007391.
    Citations: 14     Fields:    Translation:AnimalsCells
  55. Wang Q, Lin JL, Wu KH, Wang DZ, Reiter RS, Sinn HW, Lin CI, Lin CJ. Xin proteins and intercalated disc maturation, signaling and diseases. Front Biosci (Landmark Ed). 2012 06 01; 17(7):2566-93. PMID: 22652799; PMCID: PMC3368345.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  56. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. PMID: 22343712.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  57. Chen J, Wang DZ. microRNAs in cardiovascular development. J Mol Cell Cardiol. 2012 May; 52(5):949-57. PMID: 22300733.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  58. Huang ZP, Espinoza-Lewis R, Wang DZ. Determination of miRNA targets in skeletal muscle cells. Methods Mol Biol. 2012; 798:475-90. PMID: 22130855.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  59. Espinoza-Lewis RA, Wang DZ. MicroRNAs in heart development. Curr Top Dev Biol. 2012; 100:279-317. PMID: 22449848.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  60. Wang C, Cao D, Wang Q, Wang DZ. Synergistic activation of cardiac genes by myocardin and Tbx5. PLoS One. 2011; 6(8):e24242. PMID: 21897873.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  61. Seok HY, Tatsuguchi M, Callis TE, He A, Pu WT, Wang DZ. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-35346. PMID: 21868385.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  62. Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011 Aug 22; 194(4):551-65. PMID: 21859860.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  63. Neppl RL, Wang DZ. 'CArG'ing for microRNAs. Gastroenterology. 2011 Jul; 141(1):24-7. PMID: 21620846.
    Citations:    Fields:    Translation:HumansAnimalsCells
  64. Deng Z, Chen JF, Wang DZ. Transgenic overexpression of miR-133a in skeletal muscle. BMC Musculoskelet Disord. 2011 May 26; 12:115. PMID: 21615921.
    Citations: 24     Fields:    Translation:AnimalsCells
  65. Malizia AP, Wang DZ. MicroRNAs in cardiomyocyte development. Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr; 3(2):183-90. PMID: 21305703.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  66. Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 01; 25(3):263-74. PMID: 21289070.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  67. Ding J, Wang DZ. "RISCing" the heart: In vivo identification of cardiac microRNA targets by RISCome. Circ Res. 2011 Jan 07; 108(1):3-5. PMID: 21212388.
    Citations: 3     Fields:    Translation:Animals
  68. Huang ZP, Neppl RL, Wang DZ. Application of microRNA in cardiac and skeletal muscle disease gene therapy. Methods Mol Biol. 2011; 709:197-210. PMID: 21194029.
    Citations: 9     Fields:    Translation:HumansCells
  69. Chen J, Yin H, Jiang Y, Radhakrishnan SK, Huang ZP, Li J, Shi Z, Kilsdonk EP, Gui Y, Wang DZ, Zheng XL. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):368-75. PMID: 21051663.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  70. Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ. Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2575-86. PMID: 20884876; PMCID: PMC2988089.
    Citations: 37     Fields:    Translation:HumansAnimals
  71. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 2010 Sep 06; 190(5):867-79. PMID: 20819939.
    Citations: 282     Fields:    Translation:AnimalsCells
  72. Mandel EM, Kaltenbrun E, Callis TE, Zeng XX, Marques SR, Yelon D, Wang DZ, Conlon FL. The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development. 2010 Jun; 137(11):1919-29. PMID: 20460370.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  73. Seok HY, Wang DZ. The emerging role of microRNAs as a therapeutic target for cardiovascular disease. BioDrugs. 2010 Jun; 24(3):147-55. PMID: 20462281.
    Citations: 5     Fields:    Translation:HumansAnimals
  74. Huang ZP, Neppl RL, Wang DZ. MicroRNAs in cardiac remodeling and disease. J Cardiovasc Transl Res. 2010 Jun; 3(3):212-8. PMID: 20560042.
    Citations: 15     Fields:    Translation:HumansAnimals
  75. Wang DZ. MicroRNAs in cardiac development and remodeling. Pediatr Cardiol. 2010 Apr; 31(3):357-62. PMID: 20135107.
    Citations: 8     Fields:    Translation:Humans
  76. Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang DZ, Zimmer WE, Dulin NO, Miano JM. Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem. 2009 Nov 20; 284(47):32582-90. PMID: 19797053.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  77. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009 Sep; 119(9):2772-86. PMID: 19726871; PMCID: PMC2735902.
    Citations: 395     Fields:    Translation:AnimalsCells
  78. Neppl RL, Wang DZ. Smooth(ing) muscle differentiation by microRNAs. Cell Stem Cell. 2009 Aug 07; 5(2):130-2. PMID: 19664984.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  79. Yang L, Jiang J, Drouin LM, Agbandje-McKenna M, Chen C, Qiao C, Pu D, Hu X, Wang DZ, Li J, Xiao X. A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3946-51. PMID: 19234115; PMCID: PMC2656185.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  80. Chen JF, Callis TE, Wang DZ. microRNAs and muscle disorders. J Cell Sci. 2009 Jan 01; 122(Pt 1):13-20. PMID: 19092056.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  81. Chen JF, Wang S, Wu Q, Cao D, Nguyen T, Chen Y, Wang DZ. Myocardin marks the earliest cardiac gene expression and plays an important role in heart development. Anat Rec (Hoboken). 2008 Oct; 291(10):1200-11. PMID: 18780304.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  82. Callis TE, Wang DZ. Taking microRNAs to heart. Trends Mol Med. 2008 Jun; 14(6):254-60. PMID: 18457996.
    Citations: 59     Fields:    Translation:HumansAnimals
  83. Tang RH, Zheng XL, Callis TE, Stansfield WE, He J, Baldwin AS, Wang DZ, Selzman CH. Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3362-7. PMID: 18296632.
    Citations: 62     Fields:    Translation:AnimalsCells
  84. Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2111-6. PMID: 18256189.
    Citations: 269     Fields:    Translation:HumansAnimals
  85. Callis TE, Deng Z, Chen JF, Wang DZ. Muscling through the microRNA world. Exp Biol Med (Maywood). 2008 Feb; 233(2):131-8. PMID: 18222968.
    Citations: 61     Fields:    Translation:HumansAnimals
  86. Kim Y, Phan D, van Rooij E, Wang DZ, McAnally J, Qi X, Richardson JA, Hill JA, Bassel-Duby R, Olson EN. The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest. 2008 Jan; 118(1):124-32. PMID: 18079970; PMCID: PMC2129240.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  87. Long X, Creemers EE, Wang DZ, Olson EN, Miano JM. Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16570-5. PMID: 17940050.
    Citations: 44     Fields:    Translation:AnimalsCells
  88. Gustafson-Wagner EA, Sinn HW, Chen YL, Wang DZ, Reiter RS, Lin JL, Yang B, Williamson RA, Chen J, Lin CI, Lin JJ. Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H2680-92. PMID: 17766470; PMCID: PMC2394510.
    Citations: 35     Fields:    Translation:AnimalsCells
  89. Zhang XJ, Yan KL, Wang ZM, Yang S, Zhang GL, Fan X, Xiao FL, Gao M, Cui Y, Wang PG, Sun LD, Zhang KY, Wang B, Wang DZ, Xu SJ, Huang W, Liu JJ. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. J Invest Dermatol. 2007 Nov; 127(11):2544-51. PMID: 17554368.
    Citations: 22     Fields:    Translation:HumansCells
  90. Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2007 Jun; 42(6):1137-41. PMID: 17498736; PMCID: PMC1934409.
    Citations: 189     Fields:    Translation:AnimalsCells
  91. Callis TE, Chen JF, Wang DZ. MicroRNAs in skeletal and cardiac muscle development. DNA Cell Biol. 2007 Apr; 26(4):219-25. PMID: 17465888.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  92. Willis MS, Ike C, Li L, Wang DZ, Glass DJ, Patterson C. Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res. 2007 Mar 02; 100(4):456-9. PMID: 17272810; PMCID: PMC4112093.
    Citations: 105     Fields:    Translation:Animals
  93. Yan KL, Huang W, Zhang XJ, Yang S, Chen YM, Xiao FL, Fan X, Gao M, Cui Y, Zhang GL, Sun LD, Wang PG, Chen JJ, Li W, Chen ZH, Wang ZM, Wang DZ, Zhang KY, Liu JJ. Follow-up analysis of PSORS9 in 151 Chinese families confirmed the linkage to 4q31-32 and refined the evidence to the families of early-onset psoriasis. J Invest Dermatol. 2007 Feb; 127(2):312-8. PMID: 17139270.
    Citations: 2     Fields:    Translation:Humans
  94. Wang H, Gilner JB, Bautch VL, Wang DZ, Wainwright BJ, Kirby SL, Patterson C. Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. J Biol Chem. 2007 Jan 05; 282(1):782-91. PMID: 17098737.
    Citations: 35     Fields:    Translation:AnimalsCells
  95. Yang S, Yan KL, Zhang XJ, Xiao FL, Fan X, Gao M, Cui Y, Wang PG, Zhang GL, Sun LD, Wang ZM, Wang DZ, Zhang KY, Huang W, Liu JJ. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. Arch Dermatol Res. 2006 Aug; 298(3):107-12. PMID: 16773312.
    Citations: 1     Fields:    Translation:HumansCells
  96. Wang DZ. Micro or mega: how important are microRNAs in muscle? Cell Cycle. 2006 May; 5(10):1015-6. PMID: 16639081.
    Citations: 1     Fields:    Translation:HumansAnimals
  97. Xing W, Zhang TC, Cao D, Wang Z, Antos CL, Li S, Wang Y, Olson EN, Wang DZ. Myocardin induces cardiomyocyte hypertrophy. Circ Res. 2006 Apr 28; 98(8):1089-97. PMID: 16556869.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  98. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet. 2006 Feb; 38(2):228-33. PMID: 16380711; PMCID: PMC2538576.
    Citations: 1260     Fields:    Translation:AnimalsCells
  99. Callis TE, Cao D, Wang DZ. Bone morphogenetic protein signaling modulates myocardin transactivation of cardiac genes. Circ Res. 2005 Nov 11; 97(10):992-1000. PMID: 16224060; PMCID: PMC2930260.
    Citations: 19     Fields:    Translation:AnimalsCells
  100. Qiu P, Ritchie RP, Fu Z, Cao D, Cumming J, Miano JM, Wang DZ, Li HJ, Li L. Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ Res. 2005 Nov 11; 97(10):983-91. PMID: 16224064.
    Citations: 75     Fields:    Translation:AnimalsCells
  101. Jung-Ching Lin J, Gustafson-Wagner EA, Sinn HW, Choi S, Jaacks SM, Wang DZ, Evans S, Li-Chun Lin J. Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. J Med Sci. 2005 Oct; 25(5):215-222. PMID: 16708114.
    Citations: 19     
  102. Small EM, Warkman AS, Wang DZ, Sutherland LB, Olson EN, Krieg PA. Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. Development. 2005 Mar; 132(5):987-97. PMID: 15673566.
    Citations: 37     Fields:    Translation:AnimalsCells
  103. Cao D, Wang Z, Zhang CL, Oh J, Xing W, Li S, Richardson JA, Wang DZ, Olson EN. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan; 25(1):364-76. PMID: 15601857; PMCID: PMC538763.
    Citations: 79     Fields:    Translation:AnimalsCells
  104. Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C. Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest. 2004 Oct; 114(8):1058-71. PMID: 15489953; PMCID: PMC522252.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  105. Oh J, Wang Z, Wang DZ, Lien CL, Xing W, Olson EN. Target gene-specific modulation of myocardin activity by GATA transcription factors. Mol Cell Biol. 2004 Oct; 24(19):8519-28. PMID: 15367672; PMCID: PMC516760.
    Citations: 25     Fields:    Translation:AnimalsCells
  106. Wang DZ, Olson EN. Control of smooth muscle development by the myocardin family of transcriptional coactivators. Curr Opin Genet Dev. 2004 Oct; 14(5):558-66. PMID: 15380248.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  107. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 2004 Mar 11; 428(6979):185-9. PMID: 15014501.
    Citations: 259     Fields:    Translation:AnimalsCells
  108. Li S, Wang DZ, Wang Z, Richardson JA, Olson EN. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9366-70. PMID: 12867591; PMCID: PMC170924.
    Citations: 162     Fields:    Translation:AnimalsCells
  109. Wang Z, Wang DZ, Pipes GC, Olson EN. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7129-34. PMID: 12756293; PMCID: PMC165841.
    Citations: 242     Fields:    Translation:AnimalsCells
  110. Yoshida T, Sinha S, Dandré F, Wamhoff BR, Hoofnagle MH, Kremer BE, Wang DZ, Olson EN, Owens GK. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res. 2003 May 02; 92(8):856-64. PMID: 12663482.
    Citations: 144     Fields:    Translation:AnimalsCells
  111. Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14855-60. PMID: 12397177; PMCID: PMC137508.
    Citations: 208     Fields:    Translation:HumansAnimalsCells
  112. Shin CH, Liu ZP, Passier R, Zhang CL, Wang DZ, Harris TM, Yamagishi H, Richardson JA, Childs G, Olson EN. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell. 2002 Sep 20; 110(6):725-35. PMID: 12297046.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  113. Wang DZ, Valdez MR, McAnally J, Richardson J, Olson EN. The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development. Development. 2001 Nov; 128(22):4623-33. PMID: 11714687.
    Citations: 75     Fields:    Translation:AnimalsCells
  114. Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001 Jun 29; 105(7):851-62. PMID: 11439182.
    Citations: 391     Fields:    Translation:AnimalsCells
  115. Wang DZ, Reiter RS, Lin JL, Wang Q, Williams HS, Krob SL, Schultheiss TM, Evans S, Lin JJ. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar; 126(6):1281-94. PMID: 10021346.
    Citations: 30     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.