Harvard Catalyst Profiles

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Jay Ram Thiagarajah, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kalashyan M, Raghunathan K, Oller H, Theres MB, Jimenez L, Roland JT, Kolobova E, Hagen SJ, Goldsmith JD, Shub MD, Goldenring JR, Kaji I, Thiagarajah JR. Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids. bioRxiv. 2023 Jan 29. PMID: 36747680; PMCID: PMC9900906.
  2. Devant P, Boršic E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovic I, Evavold CL, Kagan JC. Gasdermin D pore-forming activity is redox-sensitive. Cell Rep. 2023 01 31; 42(1):112008. PMID: 36662620; PMCID: PMC9947919.
    Citations: 1     Fields:    Translation:Cells
  3. Thiagarajah JR. The Immune Ghosts of Pandemics Past. Gastroenterology. 2023 Jan 03. PMID: 36608717.
    Citations:    Fields:    
  4. Babcock SJ, Flores-Marin D, Thiagarajah JR. The genetics of monogenic intestinal epithelial disorders. Hum Genet. 2022 Nov 23. PMID: 36422736.
    Citations: 1     Fields:    
  5. Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 10 27; 185(22):4190-4205.e25. PMID: 36243004; PMCID: PMC9617795.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  6. Grey MJ, De Luca H, Ward DV, Kreulen IA, Bugda Gwilt K, Foley SE, Thiagarajah JR, McCormick BA, Turner JR, Lencer WI. The epithelial-specific ER stress sensor ERN2/IRE1ß enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022 09 01; 132(17). PMID: 35727638; PMCID: PMC9435652.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Thiagarajah JR. Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene. Gastroenterology. 2022 09; 163(3):777. PMID: 35728684.
    Citations:    Fields:    Translation:HumansCells
  8. Bugda Gwilt K, Thiagarajah JR. Membrane Lipids in Epithelial Polarity: Sorting out the PIPs. Front Cell Dev Biol. 2022; 10:893960. PMID: 35712665; PMCID: PMC9197455.
  9. Dannheim K, Ouahed J, Field M, Snapper S, Raphael BP, Glover SC, Bishop PR, Bhesania N, Kamin D, Thiagarajah J, Goldsmith JD. Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestinal Atresias, Severe Combined Immunodeficiency, and Congenital Enteropathy. Am J Surg Pathol. 2022 06 01; 46(6):846-853. PMID: 34985046; PMCID: PMC9106838.
    Citations: 2     Fields:    Translation:Humans
  10. Otuya DO, Gavgiotaki E, Carlson CJ, Shi SQ, Lee AJ, Krall AA, Chung A, Grant CG, Bhat NM, Choy P, Giddings SL, Gardecki JA, Thiagarajah JR, Rowe SM, Tearney GJ. Minimally Invasive Image-Guided Gut Transport Function Measurement Probe. Front Phys. 2021 Sep; 9. PMID: 36382063; PMCID: PMC9648666.
  11. Evavold CL, Hafner-Bratkovic I, Devant P, D'Andrea JM, Ngwa EM, Boršic E, Doench JG, LaFleur MW, Sharpe AH, Thiagarajah JR, Kagan JC. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021 08 19; 184(17):4495-4511.e19. PMID: 34289345; PMCID: PMC8380731.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  12. Pinkard H, Stuurman N, Ivanov IE, Anthony NM, Ouyang W, Li B, Yang B, Tsuchida MA, Chhun B, Zhang G, Mei R, Anderson M, Shepherd DP, Hunt-Isaak I, Dunn RL, Jahr W, Kato S, Royer LA, Thiagarajah JR, Eliceiri KW, Lundberg E, Mehta SB, Waller L. Pycro-Manager: open-source software for customized and reproducible microscope control. Nat Methods. 2021 03; 18(3):226-228. PMID: 33674797; PMCID: PMC8532176.
    Citations: 18     Fields:    
  13. Zhang YJ, Jimenez L, Azova S, Kremen J, Chan YM, Elhusseiny AM, Saeed H, Goldsmith J, Al-Ibraheemi A, O'Connell AE, Kovbasnjuk O, Rodan L, Agrawal PB, Thiagarajah JR. Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Eur J Hum Genet. 2021 06; 29(6):998-1007. PMID: 33526876; PMCID: PMC8187348.
    Citations: 3     Fields:    Translation:Humans
  14. Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. PMID: 33087577.
    Citations: 8     Fields:    Translation:HumansCells
  15. Khoshnevisan R, Anderson M, Babcock S, Anderson S, Illig D, Marquardt B, Sherkat R, Schröder K, Moll F, Hollizeck S, Rohlfs M, Walz C, Adibi P, Rezaei A, Andalib A, Koletzko S, Muise AM, Snapper SB, Klein C, Thiagarajah JR, Kotlarz D. NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency. Inflamm Bowel Dis. 2020 07 17; 26(8):1166-1176. PMID: 32064493.
    Citations: 3     Fields:    Translation:HumansCells
  16. Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI. IRE1ß negatively regulates IRE1a signaling in response to endoplasmic reticulum stress. J Cell Biol. 2020 Feb 03; 219(2). PMID: 31985747; PMCID: PMC7041686.
    Citations: 11     Fields:    Translation:HumansCells
  17. Luong P, Li Q, Chen PF, Wrighton PJ, Chang D, Dwyer S, Bayer MT, Snapper SB, Hansen SH, Thiagarajah JR, Goessling W, Lencer WI. A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Mol Biol Cell. 2020 03 19; 31(7):511-519. PMID: 31774722.
    Citations: 4     Fields:    Translation:HumansCells
  18. Jardine S, Anderson S, Babcock S, Leung G, Pan J, Dhingani N, Warner N, Guo C, Siddiqui I, Kotlarz D, Dowling JJ, Melnyk RA, Snapper SB, Klein C, Thiagarajah JR, Muise AM. Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. Gastroenterology. 2020 03; 158(4):1000-1015. PMID: 31743734; PMCID: PMC7062591.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  19. Duan T, Cil O, Thiagarajah JR, Verkman AS. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 02 21; 4(4). PMID: 30668547; PMCID: PMC6478423.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Anez-Bustillos L, Dao DT, Potemkin AK, Perez-Atayde AR, Raphael BP, Carey AN, Kamin DS, Thiagarajah JR, Crowley M, Gura KM, Puder M. An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease. Hepatology. 2019 03; 69(3):1353-1356. PMID: 30311684; PMCID: PMC6507398.
    Citations: 4     Fields:    Translation:HumansCells
  21. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 10 25; 7. PMID: 30355448.
    Citations: 8     Fields:    Translation:HumansCells
  22. O'Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. PMID: 29909964; PMCID: PMC6035368.
    Citations: 6     Fields:    Translation:HumansCells
  23. Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG. Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology. 2018 Jun; 154(8):2045-2059.e6. PMID: 29654747; PMCID: PMC6044208.
    Citations: 51     Fields:    Translation:HumansCells
  24. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. PMID: 28049834; PMCID: PMC5255594.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  25. Frank SR, Köllmann CP, van Lidth de Jeude JF, Thiagarajah JR, Engelholm LH, Frödin M, Hansen SH. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene. 2017 03 30; 36(13):1816-1828. PMID: 27669437.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  26. Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI. Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30. PMID: 26864627; PMCID: PMC4814219.
    Citations: 4     Fields:    Translation:HumansCells
  27. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. PMID: 27127798.
    Citations: 27     Fields:    
  28. Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):446-57. PMID: 26122478.
    Citations: 65     Fields:    Translation:Humans
  29. Reimold FR, Balasubramanian S, Doroquez DB, Shmukler BE, Zsengeller ZK, Saslowsky D, Thiagarajah JR, Stillman IE, Lencer WI, Wu BL, Villalpando-Carrion S, Alper SL. Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. Front Physiol. 2015; 6:179. PMID: 26157392; PMCID: PMC4477073.
    Citations: 3     
  30. Thiagarajah JR, Yildiz H, Carlson T, Thomas AR, Steiger C, Pieretti A, Zukerberg LR, Carrier RL, Goldstein AM. Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. PLoS One. 2014; 9(6):e99944. PMID: 24945437.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  31. Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clin Gastroenterol Hepatol. 2014 Feb; 12(2):204-9. PMID: 24316107.
    Citations: 24     Fields:    Translation:HumansAnimals
  32. Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS. Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014 Jul; 63(7):1120-9. PMID: 24052273; PMCID: PMC4048772.
    Citations: 33     Fields:    Translation:AnimalsCells
  33. Thiagarajah JR, Verkman AS. Chloride channel-targeted therapy for secretory diarrheas. Curr Opin Pharmacol. 2013 Dec; 13(6):888-94. PMID: 23992767.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  34. Jin BJ, Thiagarajah JR, Verkman AS. Response to "Diffusion versus convection". J Gen Physiol. 2013 Aug; 142(2):173. PMID: 23898009.
    Citations:    Fields:    Translation:HumansAnimalsCells
  35. Jin BJ, Thiagarajah JR, Verkman AS. Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. J Gen Physiol. 2013 Feb; 141(2):261-72. PMID: 23359285.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  36. Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. CFTR inhibitors. Curr Pharm Des. 2013; 19(19):3529-41. PMID: 23331030.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Thiagarajah JR, Verkman AS. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep; 92(3):287-90. PMID: 22850599; PMCID: PMC3643514.
    Citations: 27     Fields:    Translation:HumansAnimals
  38. Thiagarajah JR, Song Y, Derichs N, Verkman AS. Airway surface liquid depth imaged by surface laser reflectance microscopy. J Gen Physiol. 2010 Sep; 136(3):353-62. PMID: 20713545.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  39. Namkung W, Thiagarajah JR, Phuan PW, Verkman AS. Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J. 2010 Nov; 24(11):4178-86. PMID: 20581223.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  40. Thiagarajah JR, Zhao D, Verkman AS. Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut. 2007 Nov; 56(11):1529-35. PMID: 17573386; PMCID: PMC2095633.
    Citations: 51     Fields:    Translation:AnimalsCells
  41. Thiagarajah JR, Kim JK, Magzoub M, Verkman AS. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat Methods. 2006 Apr; 3(4):275-80. PMID: 16554832.
    Citations: 13     Fields:    Translation:AnimalsCells
  42. Thiagarajah JR, Papadopoulos MC, Verkman AS. Noninvasive early detection of brain edema in mice by near-infrared light scattering. J Neurosci Res. 2005 Apr 15; 80(2):293-9. PMID: 15765520.
    Citations: 21     Fields:    Translation:Animals
  43. Thiagarajah JR, Verkman AS. New drug targets for cholera therapy. Trends Pharmacol Sci. 2005 Apr; 26(4):172-5. PMID: 15808339.
    Citations: 17     Fields:    Translation:HumansAnimals
  44. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. PMID: 15596485.
    Citations: 44     Fields:    Translation:HumansCells
  45. Thiagarajah JR, Song Y, Haggie PM, Verkman AS. A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J. 2004 May; 18(7):875-7. PMID: 15001557.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  46. Thiagarajah JR, Broadbent T, Hsieh E, Verkman AS. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology. 2004 Feb; 126(2):511-9. PMID: 14762788.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  47. Thiagarajah JR, Verkman AS. CFTR pharmacology and its role in intestinal fluid secretion. Curr Opin Pharmacol. 2003 Dec; 3(6):594-9. PMID: 14644010.
    Citations: 35     Fields:    Translation:AnimalsCells
  48. Song Y, Thiagarajah J, Verkman AS. Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. J Gen Physiol. 2003 Nov; 122(5):511-9. PMID: 14557401; PMCID: PMC2229580.
    Citations: 26     Fields:    Translation:Animals
  49. Verkman AS, Song Y, Thiagarajah JR. Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C2-15. PMID: 12475759.
    Citations: 83     Fields:    Translation:HumansAnimals
  50. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec; 110(11):1651-8. PMID: 12464670; PMCID: PMC151633.
    Citations: 302     Fields:    Translation:HumansAnimalsCells
  51. Naftalin RJ, Thiagarajah JR, Pedley KC, Pocock VJ, Milligan SR. Progesterone stimulation of fluid absorption by the rat uterine gland. Reproduction. 2002 May; 123(5):633-8. PMID: 12006091.
    Citations: 15     Fields:    Translation:AnimalsCells
  52. Thiagarajah JR, Verkman AS. Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J Biol Chem. 2002 May 24; 277(21):19139-44. PMID: 11891232.
    Citations: 46     Fields:    Translation:AnimalsCells
  53. Thiagarajah JR, Griffiths NM, Pedley KC, Naftalin RJ. Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by transforming growth factor beta and angiotensin II. BMC Gastroenterol. 2002; 2:4. PMID: 11872151.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  54. Sonawane ND, Thiagarajah JR, Verkman AS. Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. J Biol Chem. 2002 Feb 15; 277(7):5506-13. PMID: 11741919.
    Citations: 61     Fields:    Translation:AnimalsCells
  55. Thiagarajah JR, Jayaraman S, Naftalin RJ, Verkman AS. In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1898-903. PMID: 11698248.
    Citations: 9     Fields:    Translation:Animals
  56. Thiagarajah JR, Pedley KC, Naftalin RJ. Evidence of amiloride-sensitive fluid absorption in rat descending colonic crypts from fluorescence recovery of FITC-labelled dextran after photobleaching. J Physiol. 2001 Oct 15; 536(Pt 2):541-53. PMID: 11600688; PMCID: PMC2278881.
    Citations: 9     Fields:    Translation:Animals
  57. Thiagarajah JR, Gourmelon P, Griffiths NM, Lebrun F, Naftalin RJ, Pedley KC. Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts. Gut. 2000 Nov; 47(5):675-84. PMID: 11034584; PMCID: PMC1728123.
    Citations: 17     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.